Cardiorenal Syndrome Type 1: A Defective Regulation of Monocyte Apoptosis Induced by Proinflammatory and Proapoptotic Factors
In this study, we examined the possible immune-mediated mechanisms in cardiorenal syndrome (CRS) type 1 pathogenesis. We enrolled 40 patients with acute heart failure (AHF), 11 patients with CRS type 1 and 15 controls. Plasma from the different groups was incubated with monocytes; subsequently, cell apoptosis was evaluated by DNA fragmentation, caspase activity and cytofluorometric assay. Cytokine quantification in plasma and supernatant was performed by ELISA. Monocytes treated with CRS type 1 plasma showed significantly higher apoptosis compared with those treated with AHF and the controls (p < 0.05). Caspase-3 (CRS type...
Source: Cardiorenal Medicine - February 11, 2015 Category: Urology & Nephrology Source Type: research
Association between Platelet-to-Lymphocyte Ratio and Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome
Conclusions: The admission PLR level is an independent predictor of the development of CIN after PCI in ACS.Cardiorenal Med 2015;5:96-104 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 7, 2015 Category: Urology & Nephrology Source Type: research
High Levels of Soluble Tumor Necrosis Factor Receptors 1 and 2 and Their Association with Mortality in Patients Undergoing Hemodialysis
Conclusions: Prevalent hemodialysis patients have several-fold higher levels of sTNFRs compared to previous studies in CKD stage 4 patients. As no consistent association between TNFR and mortality was observed, clinical implications of measuring these receptors to predict outcome end-stage renal disease patients provide limited results.Cardiorenal Med 2015;5:89-95 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 29, 2015 Category: Urology & Nephrology Source Type: research
Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment
Conclusions: These results suggest that hyperphosphate conditions induce myocardial hypertrophy through the ERK signaling pathway in H9c2 cells. Our findings provide a link between the hyperphosphate-induced response and the ERK/NFAT-3 signaling pathway that mediates the development of cardiac hypertrophy. In view of the potent and selective activity of the ERK inhibitor U0126, this agent warrants further investigation as a candidate for preventing hyperphosphate-induced cardiac hypertrophy in CKD and dialysis patients.Cardiorenal Med 2015;5:79-88 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 27, 2015 Category: Urology & Nephrology Source Type: research
Neuronal Nitric Oxide Synthase-Dependent Amelioration of Diastolic Dysfunction in Rats with Chronic Renocardiac Syndrome
We have recently described the chronic renocardiac syndrome (CRCS) in rats with renal failure, cardiac dysfunction and low nitric oxide (NO) availability by combining subtotal nephrectomy and transient low-dose NO synthase (NOS) inhibition. Cardiac gene expression of the neuronal isoform of NOS (nNOS) was induced. Hence, we studied the role of nNOS, in vivo cardiac function and β-adrenergic response in our CRCS model by micromanometer/conductance catheter. Left ventricular (LV) hemodynamics were studied during administration of dobutamine (dobu), the highly specific irreversible inhibitor of nNOS L-VNIO [L-N5-(1-Imino-3-b...
Source: Cardiorenal Medicine - January 15, 2015 Category: Urology & Nephrology Source Type: research
Acknowledgement to Reviewers
Cardiorenal Med 2014;4:290 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 14, 2015 Category: Urology & Nephrology Source Type: research
Contents Vol. 3-4, 2014
Cardiorenal Med 2014;4:I-IV (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 14, 2015 Category: Urology & Nephrology Source Type: research
The Importance of Contrast Volume/Glomerular Filtration Rate Ratio in Contrast-Induced Nephropathy Patients after Transcatheter Aortic Valve Implantation
Conclusion: After TAVI, CIN may develop due to various reasons. In patients to whom TAVI was applied, the CV/GFR ratio may be a guideline helping to prevent the development of renal pathologies. The amount of contrast medium that can be given to a patient can be calculated in terms of baseline GFR.Cardiorenal Med 2015;5:31-39 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 14, 2015 Category: Urology & Nephrology Source Type: research
One-Year Survival and Renal Function Recovery of Acute Kidney Injury Patients with Chronic Heart Failure
Conclusion: AKI patients with preexisting CHF were mainly elderly patients who had an advanced AKI stage and NYHA classification. Their 1-year mortality and nonrecovery from kidney dysfunction rates were high. Identifying risk factors may help to improve their outcome.Cardiorenal Med 2015;5:40-47 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 14, 2015 Category: Urology & Nephrology Source Type: research
Kidney Dysfunction and Left Ventricular Assist Device Support: A Comprehensive Perioperative Review
Left ventricular assist devices (LVADs) are used increasingly as a bridge to transplantation or as destination therapy in end-stage heart failure patients who do not respond to optimal medical therapy. Many of these patients have end-organ dysfunction, including advanced kidney dysfunction, before and after LVAD implantation. Kidney dysfunction is a marker of adverse outcomes, such as increased morbidity and mortality. This review discusses kidney dysfunction and associated management strategies during the dynamic perioperative time period of LVAD implantation. Furthermore, we suggest potential future research directions t...
Source: Cardiorenal Medicine - January 14, 2015 Category: Urology & Nephrology Source Type: research
Contrast Volume/Raw eGFR Ratio for Predicting Contrast-Induced Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention for Myocardial Infarction
Conclusions: Raw eGFR is a better predictor for CI-AKI than BSA-normalized eGFR.Cardiorenal Med 2015;5:61-68 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 14, 2015 Category: Urology & Nephrology Source Type: research
Cardiac, Inflammatory and Metabolic Parameters: Hemodialysis versus Peritoneal Dialysis
Conclusions: Our data indicate that HD patients present more effective BP control than PD patients. Adequate fluid and metabolic control are necessary to assess the adequacy of BP, which is strongly correlated with the increase in LVMI and with the increased CTR in dialysis patients. PD is a home therapy and allows a better quality of life, but PD patients may present a further increased cardiovascular risk if not adequately monitored.Cardiorenal Med 2015;5:20-30 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 12, 2014 Category: Urology & Nephrology Source Type: research
Clinical Prediction Scores for Type 1 Cardiorenal Syndrome Derived and Validated in Chinese Cohorts
Type 1 cardiorenal syndrome is one of the major diseases threatening human life in China. The incidence of acute kidney injury (AKI) associated with acute heart failure (AHF), acute myocardial infarction (AMI), cardiac surgery, and coronary angiography has been reported to be 32.2, 14.7, 40.2, and 4.5%, respectively. In the past 2 years, we derived and validated 4 risk scores for the prediction of AKI associated with the above acute heart diseases as well as for examination and treatment in Chinese cohorts. A univariable comparison and a subsequent multivariate logistic regression analysis of the potential predictive varia...
Source: Cardiorenal Medicine - December 12, 2014 Category: Urology & Nephrology Source Type: research
β2-Microglobulin and TIMP1 Are Linked Together in Cardiorenal Remodeling and Failure
Conclusions: In CHF patients, the plasma levels of b2M and TIMP1 were linked together and correlated with the severity of cardiorenal failure. Moreover, a strong correlation between b2M and TIMP1 characterized cardiovascular remodeling not only in CHF patients but also in AH subjects. These findings suggest that clinicians should use b2M and TIMP1 as associated biomarkers of cardiorenal remodeling and failure.Cardiorenal Med 2015;5:1-11 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 11, 2014 Category: Urology & Nephrology Source Type: research
Increased Arterial Stiffness after Coronary Artery Revascularization Correlates with Serious Coronary Artery Lesions and Poor Clinical Outcomes in Patients with Chronic Kidney Disease
Conclusion: These results highlight that CKD and arterial stiffness correlate with the severity of coronary artery lesions. CKD patients with impaired arterial stiffness have poor clinical outcomes, suggesting a further clinical use of the arterial stiffness index as a surrogate of worse cardiovascular prognosis in CKD than in non-CKD patients.Cardiorenal Med 2014;4:280-289 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 10, 2014 Category: Urology & Nephrology Source Type: research
