The Effect of Mitochondrial Complex I-Linked Respiration by Isoflurane Is Independent of Mitochondrial Nitric Oxide Production
Conclusion: Isoflurane has clearly distinguishable effects on different states of mitochondrial respiration during the oxidation of complex I substrates. The uncoupling effect during state 2 respiration and the attenuation of state 3 respiration may contribute to the mechanism of APC-induced cardioprotection. These effects of isoflurane do not depend on endogenous mitochondrial NO, as the NOS inhibitor L-NIO did not alter the effects of isoflurane on mitochondrial respiration.Cardiorenal Med 2018;8:113 –122 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 1, 2018 Category: Urology & Nephrology Source Type: research
The Role of Dendritic and Endothelial Cells in Cardiorenal Syndrome
Backgrounds: Dendritic cells (DCs) are antigen-presenting cells that play a central role in innate and adaptive immune responses; however, the cross talk between cardiac and renal DCs in cardiorenal syndrome (CRS) has not yet been fully elucidated. In this setting, endothelial cells (ECs) also contribute to immune responses.Summary: DC and EC activation and dysfunction have a central role in the pathogenesis of CRS. Regarding immune responses in CRS, it is unknown whether ECs may serve as antigen-presenting cells or act synergistically with DCs to actively participate in innate and adaptive immune responses. This review fi...
Source: Cardiorenal Medicine - January 22, 2018 Category: Urology & Nephrology Source Type: research
Statins and New-Onset Diabetes in Cardiovascular and Kidney Disease Cohorts: A Meta-Analysis
Conclusions: It is imperative that patients on statin therapy be monitored carefully for NODM. However, it can be argued that the risk of statin therapy is offset by the multitude of cardiovascular and kidney-protective effects provided by such an important and highly effective therapeutic agent.Cardiorenal Med 2018;8:105 –112 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 22, 2018 Category: Urology & Nephrology Source Type: research
Relevance of B-Lines on Lung Ultrasound in Volume Overload and Pulmonary Congestion: Clinical Correlations and Outcomes in Patients on Hemodialysis
Background: Volume overload in patients on hemodialysis (HD) is an independent risk factor for cardiovascular mortality. B-lines detected on lung ultrasound (BLUS) assess extravascular lung water. This raises interest in its utility for assessing volume status and cardiovascular outcomes.Methods: End-stage renal disease patients on HD at the Island Rehab Center being older than 18 years were screened. Patients achieving their dry weight (DW) had a lung ultrasound in a supine position. Scores were classified as mild (0-14), moderate (15-30), and severe (>30) for pulmonary congestion. Patients with more than 60 were further ...
Source: Cardiorenal Medicine - November 28, 2017 Category: Urology & Nephrology Source Type: research
Combination Therapy with Renin-Angiotensin System Blockers and Vitamin D Receptor Activators for Predialysis Patients Is Associated with the Incidence of Cardiovascular Events after Dialysis Initiation: A Multicenter Nonrandomized Prospective Cohort Study
Conclusion: Combination therapy with RASBs and VDRAs in patients before dialysis initiation was associated with a reduction in CV events during maintenance dialysis.Cardiorenal Med 2018;8:71-81 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 2, 2017 Category: Urology & Nephrology Source Type: research
Plasma Volume and Renal Function Predict Six-Month Survival after Hospitalization for Acute Decompensated Heart Failure
Conclusions: Increased %#x0394;PV and BUN at discharge predicted worse 6-month survival in patients with ADHF. Decreased %#x0394;PV with low BUN or high GFR at discharge was associated with improved survival.Cardiorenal Med 2018;8:61-70 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 2, 2017 Category: Urology & Nephrology Source Type: research
One-Year Conservative Care Using Sodium Bicarbonate Supplementation Is Associated with a Decrease in Electronegative LDL in Chronic Kidney Disease Patients: A Pilot Study
Background: Chronic kidney disease (CKD) patients develop metabolic acidosis when approaching stages 3 and 4, a period in which accelerated atherogenesis may ensue. Studies in vitro show that low pH may increase low-density lipoprotein (LDL) oxidation, suggesting a role for chronic metabolic acidosis in atherosclerosis. The present study attempted to evaluate the effects of conservative care using oral sodium bicarbonate (NaHCO3) supplementation on the electronegative LDL [LDL(-)], a minimally oxidized LDL, plasma levels in CKD patients.Methods: Thirty-one CKD patients were followed by a multidisciplinary team during 15 mo...
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research
A Profile of Renal Function in Northern Cameroonians with Essential Hypertension
Background/Aim: The two-way cause and effect relationship existing between high blood pressure and kidney dysfunction is currently a well-documented phenomenon with patients in either category being almost equally predisposed to the other pathology. Our goal was to assess the renal function capacity of hypertensive patients in our setting.Methods: This cross-sectional descriptive study involved the determination of blood pressure levels and the collection of blood and urine samples for the measurement of renal function markers. Hypertensive patients who came for medical follow-up constituted the study participants, and wer...
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research
Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study
Conclusion: This pilot study showed that a specific study to assess the link between endocan plasma levels and pulmonary infection after cardiac surgery in CKD patients is of potential utility.Cardiorenal Med 2018;8:1-8 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research
Eicosapentaenoic Acid as a Potential Therapeutic Approach to Reduce Cardiovascular Risk in Patients with End-Stage Renal Disease on Hemodialysis: A Review
Background: Patients with end-stage renal disease on hemodialysis have excess cardiovascular disease (CVD) burden with substantially increased CV event rates compared with the general population.Summary: Traditional interventions that, according to standard clinical guidelines, reduce CV risk such as antihypertensive therapy, diet, exercise, and statins are not similarly effective in the hemodialysis population. This raises the question of whether additional risk factors, such as enhanced inflammation and oxidative stress, may drive the increased CVD burden in hemodialysis patients. Eicosapentaenoic acid (EPA), an omega-3 ...
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research
Role of Body Mass Index in Acute Kidney Injury Patients after Cardiac Surgery
Background/Aims: To explore the association of body mass index (BMI) with the risk of developing acute kidney injury after cardiac surgery (CS-AKI) and for AKI requiring renal replacement therapy (AKI-RRT) after cardiac surgery.Methods: Clinical data of 8,455 patients undergoing cardiac surgery, including demographic preoperative, intraoperative, and postoperative data were collected. Patients were divided into underweight (BMI (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research
Insulin Resistance in Kidney Disease: Is There a Distinct Role Separate from That of Diabetes or Obesity
Insulin resistance is a central component of the metabolic dysregulation observed in obesity, which puts one at risk for the development of type 2 diabetes and complications related to diabetes such as chronic kidney disease. Insulin resistance and compensatory hyperinsulinemia place one at risk for other risk factors such as dyslipidemia, hypertension, and proteinuria, e.g., development of kidney disease. Our traditional view of insulin actions focuses on insulin-sensitive tissues such as skeletal muscle, liver, adipose tissue, and the pancreas. However, insulin also has distinct actions in kidney tissue that regulate gro...
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research
Elevated Phosphate Levels Trigger Autophagy-Mediated Cellular Apoptosis in H9c2 Cardiomyoblasts
Conclusion: The results suggest that hyperphosphate in H9c2 cardiomyoblasts would lead to cellular apoptosis via autophagy, which is mediated by the pAMPK signaling pathway. Our findings revealed the possible mechanism responsible for the heart damage under hyperphosphatemia.Cardiorenal Med 2018;8:31-40 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research
Acknowledgement to the Reviewers
Cardiorenal Med 2017;7:342 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research
Contents Vol. 7, 2017
Cardiorenal Med 2017;7:I-VI (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 25, 2017 Category: Urology & Nephrology Source Type: research
