Elevated Fibroblast Growth Factor 23 Concentration: Prediction of Mortality among Chronic Kidney Disease Patients
Conclusion: Elevated FGF23 levels may have a strong correlation with the disease pathogenesis. In addition, FGF23 might be a future therapeutic target to intervene against the progression of CKD as well as to increase patient survivability.Cardiorenal Med 2016;6:73-82 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 3, 2015 Category: Urology & Nephrology Source Type: research
The Role of Congestion in Cardiorenal Syndrome Type 2: New Pathophysiological Insights into an Experimental Model of Heart Failure
Conclusion: In this model of CHF with prevalent congestion, kidney injury is characterized by tubular damage and systemic inflammation. The upregulated NGAL complexed with MMP9 perpetuates the vicious circle of kidney/heart damage by enhancing the enzymatic activity of MMP9 with extracellular matrix degradation, worsening heart remodeling.Cardiorenal Med 2016;6:61-72 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 30, 2015 Category: Urology & Nephrology Source Type: research
Contents Vol. 5, 2015
Cardiorenal Med 2015;5:I-IV (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 22, 2015 Category: Urology & Nephrology Source Type: research
Acknowledgement to the Reviewers
Cardiorenal Med 2015;5:316 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 22, 2015 Category: Urology & Nephrology Source Type: research
Association of Body Mass Index with Clinical Outcomes in Non-Dialysis-Dependent Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Conclusion: Among the group of patients with stage 3-5 CKD, we found a differential association between obesity classes I-III and mortality compared to the general population, indicating an obesity paradox in the CKD population.Cardiorenal Med 2016;6:37-49 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - October 17, 2015 Category: Urology & Nephrology Source Type: research
Renalase and Biomarkers of Contrast-Induced Acute Kidney Injury
Background: Contrast-induced acute kidney injury (CI-AKI) remains one of the crucial issues related to the development of invasive cardiology. The massive use of contrast media exposes patients to a great risk of contrast-induced nephropathy and chronic kidney disease development, and increases morbidity and mortality rates. The serum creatinine concentration does not allow for a timely and accurate CI-AKI diagnosis; hence numerous other biomarkers of renal injury have been proposed. Renalase, a novel catecholamine-metabolizing amine oxidase, is synthesized mainly in proximal tubular cells and secreted into urine and blood...
Source: Cardiorenal Medicine - September 19, 2015 Category: Urology & Nephrology Source Type: research
Assessing the Relationship of Angiotensin II Type 1 Receptors with Erythropoietin in a Human Model of Endogenous Angiotensin II Type 1 Receptor Antagonism
Conclusions: The effect of the renin-angiotensin system on EPO cannot be solely mediated by Ang II via AT1R signaling, but rather, EPO levels are also determined by a complex interrelated set of signals that involve AT2R, nitric oxide levels, NOX4 and HO-1 activity.Cardiorenal Med 2016;6:16-24 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - September 17, 2015 Category: Urology & Nephrology Source Type: research
Clinical Practice of Two Measurements of Home Blood Pressure on Each Occasion in Patients with Chronic Kidney Disease
Conclusion: Although the 2nd SBP was 2-3 mm Hg lower than the 1st SBP in the population as a whole, various differences were found for each subject during 7 days. 2nd - 1st BP variability might be associated with day-by-day 1st BP variability.Cardiorenal Med 2016;6:8-15 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - September 15, 2015 Category: Urology & Nephrology Source Type: research
Serum Cortisol-to-Cortisone Ratio and Blood Pressure in Severe Obesity before and after Weight Loss
Conclusion: In our sample of nondiabetic, severely obese males, change in the serum F/E ratio was associated with change in BP after weight loss.Cardiorenal Med 2016;6:1-7 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - September 12, 2015 Category: Urology & Nephrology Source Type: research
Cardiorenal Syndrome Type 1: Activation of Dual Apoptotic Pathways
In this study, we examined the putative role of renal tubular epithelial cell (RTC) apoptosis as a pathogenic mechanism in CRS1. In particular, we investigated the caspase pathways involved in induced apoptosis. We enrolled 29 patients with acute heart failure (AHF), 11 patients with CRS1, and 15 controls (CTR) without AHF or acute kidney injury (AKI). Patients who had AKI prior to the episode of AHF or who had any other potential causes of AKI were excluded. Plasma from different groups was incubated with RTCs for 24 h. Subsequently, cell apoptosis, DNA fragmentation, and caspase-3, -8, and -9 activities were investigated...
Source: Cardiorenal Medicine - September 2, 2015 Category: Urology & Nephrology Source Type: research
Clinical SYNTAX Score Can Predict Acute Kidney Injury following On-Pump but Not Off-Pump Coronary Artery Bypass Surgery
Conclusion: The CSS may be a simple and successful means of risk prediction of postoperative AKI in on-pump coronary artery surgery.Cardiorenal Med 2015;5:297-305 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - August 20, 2015 Category: Urology & Nephrology Source Type: research
Comparison between Cystatin C- and Creatinine-Estimated Glomerular Filtration Rate in Cardiology Patients
Objective: Estimation of the glomerular filtration rate (GFR) is essential for identification, evaluation and risk prediction in patients with kidney disease. Estimated GFR (eGFR) is also needed for the correct dosing of drugs eliminated by the kidneys and to identify high-risk individuals in whom coronary angiography or other procedures may lead to kidney failure. Both cystatin C and creatinine are used for the determination of GFR, and we aimed to investigate if eGFR by the two methods differ in cardiology patients. Methods: We compared cystatin C and creatinine (CKD-EPI) eGFR calculated from the same request from a card...
Source: Cardiorenal Medicine - August 5, 2015 Category: Urology & Nephrology Source Type: research
Soluble Tumor Necrosis Factor Receptor 1 Is Associated with Glomerular Filtration Rate Progression and Incidence of Chronic Kidney Disease in Two Community-Based Cohorts of Elderly Individuals
Objective: We aimed to explore and validate the longitudinal associations between soluble tumor necrosis factor receptor 1 (sTNFR1), glomerular filtration rate (GFR) progression, and chronic kidney disease (CKD) incidence in two independent community-based cohorts of elderly individuals with prespecified subgroup analyses in individuals without prevalent diabetes. Research Design and Methods: Two community-based cohorts of elderly individuals were used with 5-year follow-up data on estimated GFR: the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 437 men; mean age: 78 years) and the Prospective Investigation of the Va...
Source: Cardiorenal Medicine - July 31, 2015 Category: Urology & Nephrology Source Type: research
Usefulness of an Upright T-Wave in Lead aVR for Predicting the Short-Term Prognosis of Incident Hemodialysis Patients: A Potential Tool for Screening High-Risk Hemodialysis Patients
Background/Aims: An upright T-wave in lead aVR (aVRT) has recently been reported to be associated with cardiovascular death and mortality among the general population and patients with prior cardiovascular disease (CVD). However, evidence for the predictive ability of aVRT in patients with chronic kidney disease is lacking. Therefore, a hospital-based, prospective, cohort study was conducted to evaluate the predictive ability of an upright aVRT for the short-term prognosis in incident hemodialysis patients. Methods: Among 208 patients who started maintenance hemodialysis, 79 with preexisting CVD (CVD cohort) and 129 with n...
Source: Cardiorenal Medicine - July 28, 2015 Category: Urology & Nephrology Source Type: research
Left Ventricular Hypertrophy in Chronic Kidney Disease Patients: From Pathophysiology to Treatment
Cardiovascular diseases represent the main causes of morbidity and mortality in patients with chronic kidney disease (CKD). According to a well-established classification, cardiovascular involvement in CKD can be set in the context of cardiorenal syndrome type 4. Left ventricular hypertrophy (LVH) represents a key feature to provide an accurate picture of systolic-diastolic left heart involvement in CKD patients. Cardiovascular involvement is present in about 80% of prevalent hemodialysis patients, and it is evident in CKD patients since stage IIIb-IV renal disease (according to the K/DOQI CKD classification). According to...
Source: Cardiorenal Medicine - July 15, 2015 Category: Urology & Nephrology Source Type: research
