Multi-Omics Approach: New Potential Key Mechanisms Implicated in Cardiorenal Syndromes
Cardiorenal syndromes (CRS) include a scenario of clinical interactions characterized by the heart and kidney dysfunction. The crosstalk between cardiac and renal systems is clearly evidenced but not completely understood. Multi-factorial mechanisms leading to CRS do not involve only hemodynamic parameters. In fact, in recent works on organ crosstalk endothelial injury, the alteration of normal immunologic balance, cell death, inflammatory cascades, cell adhesion molecules, cytokine and chemokine overexpression, neutrophil migration, leukocyte trafficking, caspase-mediated induction of apoptotic mechanisms and oxidative st...
Source: Cardiorenal Medicine - April 3, 2019 Category: Urology & Nephrology Source Type: research
Central Venous Stenosis after Hemodialysis: Case Reports and Relationships to Catheters and Cardiac Implantable Devices
We describe two cases of end-stage renal disease patients with CIED and tunneled central venous catheter (CVC) who developed venous cava stenosis: (1) a 70-year-old man with sinus node disease and pacemaker in 2013, CVC, and a Brescia-Cimino forearm fistula in 2015; (2) a 75-year-old woman with previous ventricular arrhythmia with implanted defibrillator in 2014 and CVC in 2016. In either case, after about 1 year from CVC insertion, patients developed superior vena cava (SVC) syndrome due to stenosis diagnosed by axial computerized tomography. In case 1, the patient was not treated by angioplasty of SVC and removed CVC wit...
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research
Multivessel Coronary Revascularization Strategies in Patients with Chronic Kidney Disease: A Meta-Analysis
Conclusions: PCI for patients with CKD and multivessel disease (multivessel CAD) had advantages over CABG with regard to short-term all-cause death and cerebrovascular accidents, but disadvantages regarding the risk of myocardial death, MI, and RR; there was no significant difference in the risk of long-term all-cause death and MACCE. Large randomized controlled trials are needed to confirm our findings.Cardiorenal Med 2019;9:145 –159 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research
Calculated Serum Osmolality, Acute Kidney Injury, and Relationship to Mortality after Percutaneous Coronary Intervention
Conclusion: sOsmo is a valid and easily obtainable predictor of AKI after PCI. High sOsmo is associated with increased risk of AKI and 1-year mortality in patients undergoing PCI. Further research is warranted to clarify whether the use of an sOsmo-directed hydration protocol might reduce the incidence of AKI in patients undergoing PCI.Cardiorenal Med 2019;9:160 –167 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research
A Novel Fluorescent Clinical Method to Rapidly Quantify Plasma Volume
Conclusions: This minimally invasive fluorescent dye approach safely allowed for rapid, accurate, and reproducible determination of PV, BV, and dynamic monitoring of changes following fluid administration.Cardiorenal Med 2019;9:168 –179 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research
Cardiac Abnormalities in Children with Autosomal Recessive Polycystic Kidney Disease
Conclusions: Children with ARPKD show significantly impaired cardiac phenotype, characterized by high rates of LV abnormal geometry paired with systolic mechanical dysfunction.Cardiorenal Med 2019;9:180 –189 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research
Grading of Left Ventricular Diastolic Dysfunction with Preserved Systolic Function by the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging Recommendations Contributes to Predicting Cardiovascular Events in Hemodialysis Patients
Conclusions: In maintenance hemodialysis patients with normal ventricular systolic function, a classification of LVDD by the 2016 ASE/EACVI recommendations may be a useful tool for predicting cardiovascular events.Cardiorenal Med 2019;9:190 –200 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 7, 2019 Category: Urology & Nephrology Source Type: research
Customization of Peritoneal Dialysis in Cardiorenal Syndrome by Optimization of Sodium Extraction
Conclusion: While these strategies could help with efficient sodium extraction and volume optimization, future studies are needed to evaluate their impact on the outcomes of this specific patient population.Cardiorenal Med 2019;9:117 –124 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 6, 2019 Category: Urology & Nephrology Source Type: research
NT-proBNP in the Prognosis of Death or Need for Renal Replacement Therapy in Patients with Stage 3 –5 Chronic Kidney Disease
Conclusions: NT-proBNP is an independent predictor of mortality in patients with CKD and can also be useful for CV risk stratification in this patient population.Cardiorenal Med 2019;9:125 –134 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 6, 2019 Category: Urology & Nephrology Source Type: research
Biomarkers of Inflammation, Fibrosis, and Acute Kidney Injury in Patients with Heart Failure with and without Left Ventricular Assist Device Implantation
Conclusions: The levels of NGAL and adiponectin were augmented in LVAD recipients, suggesting that renal functions were not restored with circulatory support. Larger studies should assess the predictability of these biomarkers of renal dysfunction in LVAD recipients.Cardiorenal Med 2019;9:108 –116 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 30, 2019 Category: Urology & Nephrology Source Type: research
Outcomes of Moderate-to-Severe Acute Kidney Injury following Left Ventricular Assist Device Implantation
Discussion: Risk-stratifying patients prior to LVAD placement in regard to AKI development may be a step toward improving surgical outcomes.Cardiorenal Med 2019;9:100 –107 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 23, 2019 Category: Urology & Nephrology Source Type: research
Prolonged Hyperglycemia and Renal Failure after Primary Percutaneous Coronary Intervention
Conclusion: HbA1c ≥7% was associated with a higher likelihood of AKI in STEMI patients treated with primary PCI.Cardiorenal Med 2019;9:92 –99 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 13, 2019 Category: Urology & Nephrology Source Type: research
Individualized Hemodialysis Treatment: A Perspective on Residual Kidney Function and Precision Medicine in Nephrology
Background: Residual kidney function (RKF) is often expected to inevitably and rapidly decline among hemodialysis patients and, hence, has been inadvertently ignored in clinical practice. The importance of RKF has been revisited in some recent studies. Given that patients with end-stage renal disease now tend to initiate maintenance hemodialysis therapy with higher RKF levels, there seem to be important opportunities for incremental hemo dialysis by individualizing the dose and frequency according to their RKF levels. This approach is realigned with precision medicine and patient-centeredness.Summary: In this article, we...
Source: Cardiorenal Medicine - December 13, 2018 Category: Urology & Nephrology Source Type: research
Echocardiographic and Hemodynamic Parameters Associated with Diminishing Renal Filtration among Patients with Heart Failure with Preserved Ejection Fraction
Conclusion: Novel hemodynamic indices obtained by RHC may have predictive value for long-term renal dysfunction in patients with HFpEF.Cardiorenal Med 2019;9:83 –91 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 13, 2018 Category: Urology & Nephrology Source Type: research
Impaired Left Ventricular Global Longitudinal Strain among Patients with Chronic Kidney Disease and End-Stage Renal Disease and Renal Transplant Recipients
Conclusions: Renal disease proved to be associated with early and subclinical impairment of LV systolic function, which persists after starting dialysis and even in spite of successful kidney transplantation. An increased E/e ’ resulted to be the most powerful independent predictor of abnormal GLS.Cardiorenal Med 2019;9:61 –68 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 28, 2018 Category: Urology & Nephrology Source Type: research
