Valvular Calcific Deposits and Mortality in Peritoneal Dialysis Patients: A Propensity Score-Matched Cohort Analysis
Conclusion: CVC is an independent risk factor for mortality in PD patients.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 28, 2021 Category: Urology & Nephrology Source Type: research
Outcomes after Acute Peritoneal Dialysis for Critical Cardiorenal Syndrome Type 1
Conclusions: PD is a viable dialysis option in CRS1, especially in a resource-limited setting. PD can save up to 27% of lives among patients with critically ill CRS1.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 27, 2021 Category: Urology & Nephrology Source Type: research
Performance of Prediction Models for Contrast-Induced Acute Kidney Injury after Transcutaneous Aortic Valve Replacement
Conclusions: None of the current models demonstrated validity in detecting AKI when its lower grades were evaluated. CR4EATME3AD3 was the best score in predicting moderate to severe AKI after TAVR. These findings suggest that contrast-induced AKI may not be the only factor related to kidney injury after TAVR.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - July 14, 2021 Category: Urology & Nephrology Source Type: research
Albumin Infusion in Patients with Cirrhosis: Time for POCUS-Enhanced Physical Examination
Objective assessment of fluid status is of utmost significance in the management of patients with complex disorders involving hemodynamics and multi-organ crosstalk such as cardiorenal or hepatorenal syndrome. The role of volume expansion using intravenous albumin in the setting of hepatorenal syndrome has been an everlasting debate among clinicians. With the accumulating evidence on the deleterious consequences of iatrogenic fluid overload, empiric albumin administration in these patients has been the focus of much attention, and the findings of recent studies suggest a higher incidence of pulmonary complications with alb...
Source: Cardiorenal Medicine - July 14, 2021 Category: Urology & Nephrology Source Type: research
Phosphate Control: The Next Frontier in Dialysis Cardiovascular Mortality
Background: Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney disease (CKD) on dialysis. Mortality rates are still unacceptably high even though they have fallen in the past 2 decades. Hyperphosphatemia (elevated serum phosphate levels) is seen in almost all patients with advanced CKD and is by far the largest remaining modifiable contributor to CKD mortality.Summary: Phosphate retention drives multiple physiological mechanisms linked to increased risk of CVD. Fibroblast growth factor 23 and parathyroid hormone (PTH) levels, both of which have been suggested to have direct pathogenic CV...
Source: Cardiorenal Medicine - June 11, 2021 Category: Urology & Nephrology Source Type: research
Nomenclature for Kidney Function from KDIGO: Shortcomings of Terminology Oversimplification
The recent Kidney Disease: Improving Global Outcomes (KDIGO) consensus conference proposed a universal nomenclature calling for “Kidney Disease” (KD) to be applied to every form of kidney dysfunction, regardless of etiology. We recognize that the estimated glomerular filtration rate and urine albumin:creatinine ratio are limited in their application to the broad spectrum of KD. However, there are additional in vitro and advanced diagnostic options that can help identify the underlying cause of KD and inform about prognosis and management. While the overarching benefit of generalizing KD as a medical problem lies with s...
Source: Cardiorenal Medicine - June 4, 2021 Category: Urology & Nephrology Source Type: research
Ultrasonographic Assessment of Extravascular Lung Water in Hospitalized Patients Requiring Hemodialysis: A Prospective Observational Study
Conclusion: The lung and IVC findings obtained from handheld and portable ultrasound scanners are comparable and concordant. Cardiovascular disease and smoking history were strong predictors of EVLW. The use of TBLN to assess EVLW in hospitalized HD patients is feasible. Further studies are needed to determine if TBLN can help guide volume removal in HD patients.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - June 4, 2021 Category: Urology & Nephrology Source Type: research
Cardio-Pulmonary-Renal Consequences of Severe COVID-19
Severe acute respiratory syndrome coronavirus 2 has rapidly spread worldwide and resulted in the coronavirus disease 2019 (COVID-19) pandemic. The disease raised an unprecedented demand for intensive care support due to severe pulmonary dysfunction and multiorgan failure. Although the pulmonary system is the potential target of the COVID-19, recent reports have demonstrated that COVID-19 profoundly influences the cardiovascular system and the kidneys. Research studies on cadavers have shown that direct heart and kidney injury can be frequently seen in patients deceased due to COVID-19 infection. On the other hand, function...
Source: Cardiorenal Medicine - June 3, 2021 Category: Urology & Nephrology Source Type: research
Performance versus Risk Factor-Based Approaches to Coronary Artery Disease Screening in Waitlisted Kidney Transplant Candidates
Conclusions: The 6MWT designates fewer patients as high risk and in need of further testing (compared to risk factor-based approaches), but its utility as a pure CAD risk stratification tool is modulated by the background waitlist removal rate. CAD screening before kidney transplant should be tailored according to a patient ’s actual chance of receiving a transplant.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - May 25, 2021 Category: Urology & Nephrology Source Type: research
The Role of Serum Chloride in Acute and Chronic Heart Failure: A Narrative Review
This study is a review of the pathophysiologic effects of hypochloremia in HF, the genetics of chloride channels, and clinical trials that are underway to investigate novel approaches to HF management.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 19, 2021 Category: Urology & Nephrology Source Type: research
Right Ventricular Dysfunction and Adverse Outcomes after Renal Transplantation
Conclusion: RV dilation and dysfunction are associated with adverse outcomes after renal transplant. TTE assessment of RV size and function should be a standard part of the pre-kidney transplant cardiovascular risk assessment.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - April 14, 2021 Category: Urology & Nephrology Source Type: research
Clinical Outcomes of Dialysis Patients Treated with Drug-Eluting Stent for Left Main Distal Bifurcation Lesions
Conclusions: HD was strongly associated with adverse cardiac events after PCI for ULMCA distal bifurcation lesions with DES.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - March 3, 2021 Category: Urology & Nephrology Source Type: research
A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial of High-Dose, Short-Term Vitamin D Administration in the Prevention of Acute Kidney Injury after Cardiac Surgery
Conclusion: VitD pretreatment was unable to impose any changes in the incidence of AKI and the urinary level of renal biomarkers. However, high-dose administration of VitD may improve the anti-inflammatory state before and after the operation. Further studies are needed to assess the renoprotective effect of VitD on coronary surgery patients.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 26, 2021 Category: Urology & Nephrology Source Type: research
Lung Sestamibi Uptake on Myocardial Perfusion Imaging and Outcomes in Chronic Kidney Disease
Conclusions: LHR ≤0.28 and ≥0.33 are independently associated with higher risk for death in patients with CKD-ND and ESKD. Future studies are warranted to understand the association of extreme LHR values and outcomes in this high-risk population.Cardiorenal Med (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 25, 2021 Category: Urology & Nephrology Source Type: research
Point of Care Ultrasonography for Objective Assessment of Heart Failure: Integration of Cardiac, Vascular, and Extravascular Determinants of Volume Status
Background: Lingering congestion portends poor outcomes in patients with heart failure (HF) and is a key target in their management. Studies have shown that physical exam has low yield in this setting and conventional methods for more precise assessment and monitoring of volume status (e.g., body weight, natriuretic peptides, and chest radiography) have significant inherent shortcomings.Summary: Point of care ultrasonography (POCUS) is a noninvasive versatile bedside diagnostic tool that enhances the sensitivity of conventional physical examination to gauge congestion in these patients. It also aids in monitoring the effic...
Source: Cardiorenal Medicine - January 21, 2021 Category: Urology & Nephrology Source Type: research
