Circadian Blood Pressure Rhythm Is Changed by Improvement in Hypoalbuminemia and Massive Proteinuria in Patients with Minimal Change Nephrotic Syndrome
Conclusion: These findings suggest that reduced SAC in patients with proteinuria is associated with disrupted circadian BP rhythm.Cardiorenal Med 2016;6:209-215 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 29, 2016 Category: Urology & Nephrology Source Type: research
Plasma Neutrophil Gelatinase-Associated Lipocalin Reflects Both Inflammation and Kidney Function in Patients with Myocardial Infarction
Conclusions: eGFR determines the association of NGAL with either inflammation or kidney function; in patients with normal eGFR, plasma NGAL reflects inflammation but when eGFR is reduced, plasma NGAL reflects kidney function, highlighting the dual perception of plasma NGAL. From a clinical perspective, eGFR may be used to guide the interpretation of elevated NGAL levels in patients with STEMI.Cardiorenal Med 2016;6:180-190 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 26, 2016 Category: Urology & Nephrology Source Type: research
Psychological Distress and Hypertension: Results from the National Health Interview Survey for 2004-2013
Conclusion: The findings suggest that psychological distress is associated with higher odds of hypertension after adjusting for other risk factors for high blood pressure. Further studies are needed to confirm these findings and to elucidate the mechanisms by which stress increases hypertension risk.Cardiorenal Med 2016;6:198-208 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 26, 2016 Category: Urology & Nephrology Source Type: research
Serum Uric Acid Levels and Renal Impairment among ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Intervention
Background: Elevated serum uric acid (UA) levels are associated with adverse outcomes in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI). However, the relation between UA and acute kidney injury (AKI) in this population is unclear. We evaluated the effect of elevated UA levels on the risk to develop AKI among consecutive STEMI patients treated with primary PCI. Methods: We performed a retrospective analysis of 1,372 consecutive patients admitted with the diagnosis of STEMI between January 2008 and February 2015. Patients were stratified into quartiles ...
Source: Cardiorenal Medicine - February 26, 2016 Category: Urology & Nephrology Source Type: research
Determinants of Mortality in Patients with Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention
Conclusions: The mortality of patients with CKD undergoing PCI increases with age, worsening CKD stage and deteriorating left ventricular systolic function, and it is also higher in patients with acute coronary syndromes compared to those with stable coronary artery disease.Cardiorenal Med 2016;6:169-179 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 19, 2016 Category: Urology & Nephrology Source Type: research
Association between Plaque Score of the Carotid Artery and the Severity of Sleep Apnea Syndrome in Patients with Chronic Kidney Disease
Conclusions: Many patients with CKD also have SAS. Our findings demonstrate the relationship between plaque score and the severity of SAS.Cardiorenal Med 2016;6:159-168 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 5, 2016 Category: Urology & Nephrology Source Type: research
Risk Factors for New-Onset Cardiac Valve Calcification in Patients on Maintenance Peritoneal Dialysis
Conclusion: Serum P, Alb and CRP levels as well as dialysis duration are independent risk factors for CVC.Cardiorenal Med 2016;6:150-158 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 4, 2016 Category: Urology & Nephrology Source Type: research
Prognostic Implications of Acute Renal Impairment among ST Elevation Myocardial Infarction Patients with Preserved Left Ventricular Function
Conclusions: Among STEMI patients with preserved LV function undergoing primary PCI, AKI is associated with a higher long-term mortality.Cardiorenal Med 2016;6:143-149 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - February 2, 2016 Category: Urology & Nephrology Source Type: research
Left Ventricular Mass and Intrarenal Arterial Stiffness as Early Diagnostic Markers in Cardiorenal Syndrome Type 5 due to Systemic Sclerosis
Conclusions: SSc is characterized by the presence of microvascular and multiorgan injury. An early cardiac and renal impairment is very common. LVM and intrarenal arterial stiffness can be considered as early markers of CRS onset. The clinical use of these markers permits a prompt identification of organ damage. An early diagnosis allows the appropriate setting of pharmacological management, by slowing disease progression.Cardiorenal Med 2016;6:135-142 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - January 23, 2016 Category: Urology & Nephrology Source Type: research
A Possible New Multiple Endocrine Neoplasia Mutation in a Patient with a Prototypic Multiple Endocrine Neoplasia Presentation
We report the case of a 40-year-old male without significant family history of endocrine disease who was found to have primary hyperparathyroidism, a pituitary tumor causing acromegaly, thyroid cancer, renal cell carcinoma, and pancreatic cysts. We posit that this represents a new version of MEN-4. While renal tumors (angiomyolipoma) have been reported as part of the MEN-4 phenotype, to our knowledge, this is the first case reported of the association of MEN-1 and/or MEN-4 phenotype with this unique constellation of tumors, including renal cell carcinoma. Interestingly, this patient tested negative (DNA sequencing/deletion...
Source: Cardiorenal Medicine - January 15, 2016 Category: Urology & Nephrology Source Type: research
Acute Kidney Injury in Cardiorenal Syndrome Type 1 Patients: A Systematic Review and Meta-Analysis
Background: We evaluated the epidemiology and outcome of acute kidney injury (AKI) in patients with cardiorenal syndrome type 1 (CRS-1) and its subgroups: acute heart failure (AHF), acute coronary syndrome (ACS) and after cardiac surgery (CS). Summary: We performed a systematic review and meta-analysis. CRS-1 was defined by AKI (based on RIFLE, AKIN and KDIGO), worsening renal failure (WRF) and renal replacement therapy (RRT). We investigated the three most common clinical causes of CRS-1: AHF, ACS and CS. Out of 332 potential papers, 64 were eligible - with AKI used in 41 studies, WRF in 25 and RRT in 20. The occurrence r...
Source: Cardiorenal Medicine - December 19, 2015 Category: Urology & Nephrology Source Type: research
Metabolic Syndrome and Smoking Are Associated with Future Development of Advanced Chronic Kidney Disease in Older Adults
Introduction: Metabolic syndrome (MetS) and smoking have been identified as risk factors for chronic kidney disease (CKD) in cross-sectional studies in various age groups, but longitudinal data on progression of CKD in older adults are limited. Our objectives were to examine whether MetS and its components and smoking predict the onset of CKD stage 3b (CKD-3b) in older adults. Methods: A subset of participants of the Einstein Aging Study who were free of diabetes, dementia, and CKD-3b at enrollment were included in this analysis. CKD-3b was defined as an estimated glomerular filtration rate (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - December 2, 2015 Category: Urology & Nephrology Source Type: research
Crosstalk of Various Biomarkers That Might Provide Prompt Identification of Acute or Chronic Cardiorenal Syndromes
Conclusion: Cystatin C, glomerular filtration rate measured by the MDRD equation and XOD were independent risk factors for acute cardiorenal syndrome, while age remained an independent risk factor for chronic cardiorenal syndrome. When comparing ORs of evaluated parameters, the highest significance for acute cardiorenal syndrome was plasma concentration of cystatin C.Cardiorenal Med 2016;6:99-107 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - November 10, 2015 Category: Urology & Nephrology Source Type: research
Extracorporeal Membrane Oxygenation and the Kidney
Background: Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with reversible cardiac and/or respiratory failure. Acute kidney injury (AKI) often occurs in patients supported with ECMO; it frequently evolves into chronic kidney damage or end-stage renal disease and is associated with a reported 4-fold increase in mortality rate. Although AKI is generally due to the hemodynamic alterations associated with the baseline disease, ECMO itself may contribute to maintaining kidney dysfunction through several mechanisms. Summary: AKI may be related to conditions derived from or associated with extraco...
Source: Cardiorenal Medicine - November 9, 2015 Category: Urology & Nephrology Source Type: research
Current and Potential Therapeutic Strategies for Hemodynamic Cardiorenal Syndrome
Background: Cardiorenal syndrome (CRS) encompasses conditions in which cardiac and renal disorders co-exist and are pathophysiologically related. The newest classification of CRS into seven etiologically and clinically distinct types for direct patient management purposes includes hemodynamic, uremic, vascular, neurohumoral, anemia- and/or iron metabolism-related, mineral metabolism-related and protein-energy wasting-related CRS. This classification also emphasizes the pathophysiologic pathways. The leading CRS category remains hemodynamic CRS, which is the most commonly encountered type in patient care settings and in whi...
Source: Cardiorenal Medicine - November 6, 2015 Category: Urology & Nephrology Source Type: research
