Ischemic heart disease : More than just chronic CAD
Radiologie (Heidelb). 2022 Nov;62(11):960-970. doi: 10.1007/s00117-022-01078-4. Epub 2022 Oct 27.ABSTRACTCLINICAL/METHODOLOGICAL ISSUE: Myocardial ischemia as a reduction in perfusion with therefore oxygen deficiency of vital cardiomyocytes. Thus primary and secondary prophylaxis of myocardial infarction and it's complications.STANDARD RADIOLOGICAL METHODS: Adenosine-regadenoson stress magnetic resonance imaging (AR-stress MRI), computed tomography coronary angiography (CTCA).METHODOLOGICAL INNOVATIONS: Non-invasive stress testing using AR-stress MRI to exclude relevant obstructive coronary artery disease (CAD).PERFORMANCE...
Source: Nuklearmedizin - October 27, 2022 Category: Radiology Authors: Sebastian Reinartz Katharina Fischbach Source Type: research
Ischemic heart disease : More than just chronic CAD
Radiologie (Heidelb). 2022 Nov;62(11):960-970. doi: 10.1007/s00117-022-01078-4. Epub 2022 Oct 27.ABSTRACTCLINICAL/METHODOLOGICAL ISSUE: Myocardial ischemia as a reduction in perfusion with therefore oxygen deficiency of vital cardiomyocytes. Thus primary and secondary prophylaxis of myocardial infarction and it's complications.STANDARD RADIOLOGICAL METHODS: Adenosine-regadenoson stress magnetic resonance imaging (AR-stress MRI), computed tomography coronary angiography (CTCA).METHODOLOGICAL INNOVATIONS: Non-invasive stress testing using AR-stress MRI to exclude relevant obstructive coronary artery disease (CAD).PERFORMANCE...
Source: Nuklearmedizin - October 27, 2022 Category: Radiology Authors: Sebastian Reinartz Katharina Fischbach Source Type: research
Ischemic heart disease : More than just chronic CAD
Radiologie (Heidelb). 2022 Nov;62(11):960-970. doi: 10.1007/s00117-022-01078-4. Epub 2022 Oct 27.ABSTRACTCLINICAL/METHODOLOGICAL ISSUE: Myocardial ischemia as a reduction in perfusion with therefore oxygen deficiency of vital cardiomyocytes. Thus primary and secondary prophylaxis of myocardial infarction and it's complications.STANDARD RADIOLOGICAL METHODS: Adenosine-regadenoson stress magnetic resonance imaging (AR-stress MRI), computed tomography coronary angiography (CTCA).METHODOLOGICAL INNOVATIONS: Non-invasive stress testing using AR-stress MRI to exclude relevant obstructive coronary artery disease (CAD).PERFORMANCE...
Source: Nuklearmedizin - October 27, 2022 Category: Radiology Authors: Sebastian Reinartz Katharina Fischbach Source Type: research
Ischemic heart disease : More than just chronic CAD
Radiologie (Heidelb). 2022 Nov;62(11):960-970. doi: 10.1007/s00117-022-01078-4. Epub 2022 Oct 27.ABSTRACTCLINICAL/METHODOLOGICAL ISSUE: Myocardial ischemia as a reduction in perfusion with therefore oxygen deficiency of vital cardiomyocytes. Thus primary and secondary prophylaxis of myocardial infarction and it's complications.STANDARD RADIOLOGICAL METHODS: Adenosine-regadenoson stress magnetic resonance imaging (AR-stress MRI), computed tomography coronary angiography (CTCA).METHODOLOGICAL INNOVATIONS: Non-invasive stress testing using AR-stress MRI to exclude relevant obstructive coronary artery disease (CAD).PERFORMANCE...
Source: Nuklearmedizin - October 27, 2022 Category: Radiology Authors: Sebastian Reinartz Katharina Fischbach Source Type: research
Ischemic heart disease : More than just chronic CAD
Radiologie (Heidelb). 2022 Nov;62(11):960-970. doi: 10.1007/s00117-022-01078-4. Epub 2022 Oct 27.ABSTRACTCLINICAL/METHODOLOGICAL ISSUE: Myocardial ischemia as a reduction in perfusion with therefore oxygen deficiency of vital cardiomyocytes. Thus primary and secondary prophylaxis of myocardial infarction and it's complications.STANDARD RADIOLOGICAL METHODS: Adenosine-regadenoson stress magnetic resonance imaging (AR-stress MRI), computed tomography coronary angiography (CTCA).METHODOLOGICAL INNOVATIONS: Non-invasive stress testing using AR-stress MRI to exclude relevant obstructive coronary artery disease (CAD).PERFORMANCE...
Source: Nuklearmedizin - October 27, 2022 Category: Radiology Authors: Sebastian Reinartz Katharina Fischbach Source Type: research
Ischemic heart disease : More than just chronic CAD
Radiologie (Heidelb). 2022 Nov;62(11):960-970. doi: 10.1007/s00117-022-01078-4. Epub 2022 Oct 27.ABSTRACTCLINICAL/METHODOLOGICAL ISSUE: Myocardial ischemia as a reduction in perfusion with therefore oxygen deficiency of vital cardiomyocytes. Thus primary and secondary prophylaxis of myocardial infarction and it's complications.STANDARD RADIOLOGICAL METHODS: Adenosine-regadenoson stress magnetic resonance imaging (AR-stress MRI), computed tomography coronary angiography (CTCA).METHODOLOGICAL INNOVATIONS: Non-invasive stress testing using AR-stress MRI to exclude relevant obstructive coronary artery disease (CAD).PERFORMANCE...
Source: Nuklearmedizin - October 27, 2022 Category: Radiology Authors: Sebastian Reinartz Katharina Fischbach Source Type: research
Ischemic heart disease : More than just chronic CAD
Radiologie (Heidelb). 2022 Nov;62(11):960-970. doi: 10.1007/s00117-022-01078-4. Epub 2022 Oct 27.ABSTRACTCLINICAL/METHODOLOGICAL ISSUE: Myocardial ischemia as a reduction in perfusion with therefore oxygen deficiency of vital cardiomyocytes. Thus primary and secondary prophylaxis of myocardial infarction and it's complications.STANDARD RADIOLOGICAL METHODS: Adenosine-regadenoson stress magnetic resonance imaging (AR-stress MRI), computed tomography coronary angiography (CTCA).METHODOLOGICAL INNOVATIONS: Non-invasive stress testing using AR-stress MRI to exclude relevant obstructive coronary artery disease (CAD).PERFORMANCE...
Source: Nuklearmedizin - October 27, 2022 Category: Radiology Authors: Sebastian Reinartz Katharina Fischbach Source Type: research
Ischemic heart disease : More than just chronic CAD
Radiologie (Heidelb). 2022 Nov;62(11):960-970. doi: 10.1007/s00117-022-01078-4. Epub 2022 Oct 27.ABSTRACTCLINICAL/METHODOLOGICAL ISSUE: Myocardial ischemia as a reduction in perfusion with therefore oxygen deficiency of vital cardiomyocytes. Thus primary and secondary prophylaxis of myocardial infarction and it's complications.STANDARD RADIOLOGICAL METHODS: Adenosine-regadenoson stress magnetic resonance imaging (AR-stress MRI), computed tomography coronary angiography (CTCA).METHODOLOGICAL INNOVATIONS: Non-invasive stress testing using AR-stress MRI to exclude relevant obstructive coronary artery disease (CAD).PERFORMANCE...
Source: Nuklearmedizin - October 27, 2022 Category: Radiology Authors: Sebastian Reinartz Katharina Fischbach Source Type: research
Biomimetic Dp44mT-nanoparticles selectively induce apoptosis in Cu-loaded glioblastoma resulting in potent growth inhibition
Biomaterials. 2022 Aug 28;289:121760. doi: 10.1016/j.biomaterials.2022.121760. Online ahead of print.ABSTRACTSelective targeting of elevated copper (Cu) in cancer cells by chelators to induce tumor-toxic reactive oxygen species (ROS) may be a promising approach in the treatment of glioblastoma multiforme (GBM). Previously, the Cu chelator di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT) attracted much interest due to its potent anti-tumor activity mediated by the formation of a highly redox-active Cu-Dp44mT complex. However, its translational potential was limited by the development of toxicity in murine models...
Source: Biomaterials - August 31, 2022 Category: Materials Science Authors: Muhammad Ismail Wen Yang Yanfei Li Yibin Wang Wenya He Jiefei Wang Pir Muhammad Timothy B Chaston Fawad Ur Rehman Meng Zheng David B Lovejoy Bingyang Shi Source Type: research
Biomimetic Dp44mT-nanoparticles selectively induce apoptosis in Cu-loaded glioblastoma resulting in potent growth inhibition
Biomaterials. 2022 Aug 28;289:121760. doi: 10.1016/j.biomaterials.2022.121760. Online ahead of print.ABSTRACTSelective targeting of elevated copper (Cu) in cancer cells by chelators to induce tumor-toxic reactive oxygen species (ROS) may be a promising approach in the treatment of glioblastoma multiforme (GBM). Previously, the Cu chelator di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT) attracted much interest due to its potent anti-tumor activity mediated by the formation of a highly redox-active Cu-Dp44mT complex. However, its translational potential was limited by the development of toxicity in murine models...
Source: Biomaterials - August 31, 2022 Category: Materials Science Authors: Muhammad Ismail Wen Yang Yanfei Li Yibin Wang Wenya He Jiefei Wang Pir Muhammad Timothy B Chaston Fawad Ur Rehman Meng Zheng David B Lovejoy Bingyang Shi Source Type: research
Diagnostic value of regional myocardial flow reserve measurements using Rubidium-82 PET
ConclusionsThe use of regional MFR instead of global MFR is recommended as it improves the diagnostic value of Rb-82 PET in the detection of oCAD. (Source: The International Journal of Cardiovascular Imaging)
Source: The International Journal of Cardiovascular Imaging - August 8, 2022 Category: Radiology Source Type: research
Hemodynamic Response and Safety of Vasodilator Stress Cardiovascular Magnetic Resonance in Patients with Permanent Pacemakers or Implantable Cardioverter ‐Defibrillators
ConclusionThis data supports the safety of vasodilator stress CMR with promising diagnostic quality images in patients with CMR conditional ICDs and PPMs. Despite a near uniform tachycardic response to regadenoson in the SPECT environment, high rates of asynchronous pacing during vasodilator stress CMR did not result in competitive pacing or adverse arrhythmic events. Further studies are needed to validate these findings and confirm the diagnostic and prognostic performance of stress CMR in these individuals.This article is protected by copyright. All rights reserved. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - July 16, 2022 Category: Cardiology Authors: Lauren Miller, Sergei Airapetov, Ajay Pillai, Gautham Kalahasty, Kenneth A. Ellenbogen, W. Gregory Hundley, Cory R. Trankle Tags: ORIGINAL ARTICLE Source Type: research
Safety and efficacy of IV theophylline for regadenoson-associated side effect reversal
ConclusionDue to limited availability of aminophylline, theophylline may be a safe and effective alternative to reverse regadenoson-associated side effects. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 7, 2022 Category: Nuclear Medicine Source Type: research
Buccal caffeine strips for reversal of adverse symptoms of vasodilator stress
ConclusionBuccal caffeine strips are a safe, well tolerated, and effective initial strategy to reverse adverse effects of vasodilator stress in the minority of patients who request it. Buccal caffeine alone or with IV rescue caffeine was highly effective in reversing adverse effects and was free of major adverse clinical events. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - July 6, 2022 Category: Nuclear Medicine Source Type: research
