Performance and safety profile of regadenoson myocardial perfusion imaging: first experience in Greece.
CONCLUSION: Our findings support previously published data indicating the optimal safety profile of regadenoson MPI, even in the group of patients suffering from chronic obstructive pulmonary disease. PMID: 29177261 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - November 29, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Effects of caffeine intake prior to stress cardiac magnetic resonance perfusion imaging on regadenoson- versus adenosine-induced hyperemia as measured by T1 mapping
AbstractThe antagonistic effects of caffeine on adenosine receptors are a possible cause of false-negative stress perfusion imaging. The purpose of this study was to determine the effects of coffee intake<4  h prior to stress perfusion cardiac magnetic resonance imaging (CMR) in regadenoson- versus adenosine-induced hyperemia as measured with T1-mapping. 98 consecutive patients with suspected coronary artery disease referred for either adenosine or regadenoson perfusion CMR were included in this analy sis. Twenty-four patients reported coffee consumption<4  h before CMR (15 patients with adenosine, and 9 patients w...
Source: The International Journal of Cardiovascular Imaging - November 1, 2017 Category: Radiology Source Type: research

Incidence of atrioventricular block with vasodilator stress SPECT: A meta-analysis
ConclusionAVB is seen in about 4% of patients undergoing vasodilator stress test. Both overall and high-grade AVB are more frequent with adenosine compared to regadenoson. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - October 17, 2017 Category: Nuclear Medicine Source Type: research

The prognostic value of heart rate response during vasodilator stress myocardial perfusion imaging in patients with end-stage renal disease undergoing renal transplantation
ConclusionIn asymptomatic ESRD patients being evaluated for RT, a blunted pre-transplant HRR was predictive of post-RT MACE. HRR may be a valuable tool in the risk assessment of RT candidates. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - September 18, 2017 Category: Nuclear Medicine Source Type: research

Feasibility and safety of exercise stress testing using an anti-gravity treadmill with Tc-99m tetrofosmin single-photon emission computed tomography (SPECT) myocardial perfusion imaging: A pilot non-randomized controlled study
ConclusionStress testing using an anti-gravity treadmill is feasible and may help some patients safely achieve target heart rate. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 31, 2017 Category: Nuclear Medicine Source Type: research

The heart rate response to regadenoson in patients with atrial fibrillation
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 30, 2017 Category: Nuclear Medicine Source Type: research

Influence of body mass index and type of low-level exercise on the side effect profile of regadenoson
ConclusionsRegadenoson in combination with low-level exercise is safe and well tolerated over a wide range of BMI, with TE exercise showing a better side effect profile than SS. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 25, 2017 Category: Nuclear Medicine Source Type: research

Regadenoson use for stress myocardial perfusion imaging in advance chronic kidney disease and dialysis: Safe, effective, and efficient
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 14, 2017 Category: Nuclear Medicine Source Type: research

[Asystole after regadenoson administration to perform a myocardial perfusion imaging test].
PMID: 28683710 [PubMed - in process] (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - July 1, 2017 Category: Drugs & Pharmacology Authors: Briegas Morera D, Martín Clavo S, Estepa Alonso MJ, Rangel Mayoral JF Tags: Farm Hosp Source Type: research

Regadenoson use in chronic kidney disease and end-stage renal disease: A focused review
AbstractRegadenoson is a selective A2A adenosine receptor agonist that has been approved as a vasodilator stress agent with single-photon emission-computed tomography (SPECT) myocardial perfusion imaging (MPI). Since its approval by the Food and Drug Administration (FDA) in 2008, it has become the most commonly used pharmacologic stress agent with SPECT-MPI. Given that it is predominantly renally excreted, its use in patients with chronic kidney disease has been the subject of active post-marketing clinical research. Until recently, prescribing information regarding the use of regadenoson in patients with end-stage renal d...
Source: Journal of Nuclear Cardiology - June 26, 2017 Category: Nuclear Medicine Source Type: research

Correspondence of Rb-82 PET stress regional myocardial asynchrony to stenosed arterial territories
Conclusion: Regional rest & stress phase maps should be generated routinely in the evaluation of patients for potential coronary artery disease, as abnormal regional phase indicates a high likelihood of CAD, particularly in LAD territories. Research Support: grant from Astellas, Inc T-test comparison of phase scores for stenosed versus non-stenosed territories ([asterisk] p < 0.05)StressRestStress-rest differenceLAD3.7±0.4 versus 1.1±1.4[asterisk]2.4±1.1 versus 1.2±1.3[asterisk]+1.4±1.4 versus -0.1±1.2[asterisk]LCX2.5±1.5 versus 1.1±1.3[asterisk]2.1±1.1 ...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Van Tosh, A., Mathew, J., Cooke, C., Palestro, C., Nichols, K. Tags: Novel Imaging Techniques for Myocardial Phenotyping (Basic Science) Source Type: research

Combined static-dynamic single-dose cardiac SPECT for quantitative myocardial perfusion imaging
Conclusion: This preliminary study shows the potential value and feasibility of combined static-dynamic SPECT in a clinical setting. Dynamic SPECT provides additional quantitation of CFR, which improves the accuracy of detection of CAD. Research Support: The study was supported in part by the National Institutes of Health. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Shrestha, U., Seo, Y., gullberg, G., Botvinick, E., Sciammarella, M. Tags: Novel Imaging Techniques for Myocardial Phenotyping (Basic Science) Source Type: research

Regadenoson stress during low-level exercise: The EXERRT trial —does it move the needle?
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 15, 2017 Category: Nuclear Medicine Source Type: research

Regadenoson versus Dipyridamole: A Comparison of the Frequency of Adverse Events in Patients Undergoing Myocardial Perfusion Imaging
ConclusionDipyridamole was associated with fewer adverse events than regadenoson in patients undergoing MPI. Dipyridamole offers a safe and cost‐effective alternative to regadenoson for cardiac imaging studies.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 5, 2017 Category: Drugs & Pharmacology Authors: Kallie A. Amer, Jeff R. Hurren, Stephanie B. Edwin, Gerald Cohen Tags: Original Research Article Source Type: research

Accuracy of Rb-82 PET/CT MPI With Regadenoson Stress Including Three Year Clinical Outcomes Reporting PRESENT: PET/CT REgadenoson Stress Experience at the VA North Texas.
Conclusion: Cardiac PET MPI with regadenoson stress demonstrates high accuracy when correlated with invasive catheterization and clinical outcomes. The SSS is highly predictive of cardiac events and patient survival in a VA population over a three year period of clinical follow up. PMID: 28408703 [PubMed - as supplied by publisher] (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - April 16, 2017 Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research