Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Global and Regional Variations in Transthyretin Cardiac Amyloidosis: A Comparison of Longitudinal Strain and 99mTechnetium Pyrophosphate Imaging
J Nucl Med Technol. 2021 Dec 21:jnmt.120.261893. doi: 10.2967/jnmt.120.261893. Online ahead of print.ABSTRACTBackground: There is limited data on the head-to-head comparison of 99mTc-pyrophosphate (PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. Methods: At Mayo Clinic Arizona, patients that had undergone both a 99mTc-PYP scan and transthoracic echocardiogram (TTE) within a 90-day period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into two groups according to their 99mTc-PYP results (PYP+ and PYP -) for the compa...
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Christopher Lee Chieh-Ju Chao Pradyumna Agasthi Amith Seri Amar Shere Lanyu Mi Lisa Brown Chance Marostica Timothy Barry Ming Yang Julie Rosenthal Samuel Unzek Farouk Mookadam Reza Arsanjani Source Type: research

Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites Following < sup > 177 < /sup > Lu-DOTATATE Infusion
Conclusion: Our findings suggest that paracenteses conducted as soon as 3 days after a standard dose of 177Lu-DOTATATE pose little to no risk in terms of radiation safety to staff performing the procedure.PMID:34933922 | DOI:10.2967/jnmt.121.262820 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Sameer Tipnis William J Rieter Vladimir Henderson-Suite Leonie Gordon Source Type: research

SNMMI Clinical Trials Network (CTN) Research Series for Technologists: "Clinical Research Primer - Regulatory Process Part I: How and when Radiopharmaceuticals Can be Used"
This article will familiarize the reader with the U.S. regulatory process by providing basic definitions and understanding of how and when radiopharmaceuticals can be used in clinical research including those involving investigational new drug (IND) applications and radioactive drug research committees (RDRCs). A later article will expand the reader's clinical research knowledge by focusing on the identity and role of the institutional review board (IRB).PMID:34933923 | DOI:10.2967/jnmt.121.263499 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 22, 2021 Category: Nuclear Medicine Authors: Charlotte Denise Jeffers Sarah A Frye John M Hoffman Source Type: research

Discordance between Histopathological grading and Dual Tracer PET-CT findings ( < sup > 68 < /sup > Ga-DOTATATE and FDG) in metastatic Neuroendocrine Neoplasms and outcome of < sup > 177 < /sup > Lu-DOTATATE PRRT: does in-vivo molecular PET imaging perform better from 'prediction of tumour biology' viewpoint?
Conclusion: In summary, in NET patients with discordance between the two parameters, dual tracer PET-CT with FDG and 68Ga-DOTATATE performed better than WHO grading, differentiation status and immunohistochemistry in prognosticating and predicting outcome.PMID:34876476 | DOI:10.2967/jnmt.121.261998 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 8, 2021 Category: Nuclear Medicine Authors: Aadil Adnan Sandip Basu Source Type: research

Re-Modelling 99m-Technetium Pertechnetate Thyroid Uptake; Statistical, Machine Learning and Deep Learning Approaches
Conclusion: Thyroid scintigraphy is useful in identifying hyperthyroid patients suitable for radioiodine therapy when using an appropriately validated cut-off for the patient population (4.5% in this population). ML ANN algorithms can be developed to improve accuracy as second readers systems when biochemistry results are available. DL CNN algorithms can be developed to improve accuracy in the absence of biochemistry results. ML and DL do not displace the role of the physician in thyroid scintigraphy but could be used as second reader systems to minimize errors and increase confidence.PMID:34876477 | DOI:10.2967/jnmt.121.2...
Source: Journal of Nuclear Medicine Technology - December 8, 2021 Category: Nuclear Medicine Authors: Geoffrey M Currie Basit M Iqbal Source Type: research

Discordance between Histopathological grading and Dual Tracer PET-CT findings ( < sup > 68 < /sup > Ga-DOTATATE and FDG) in metastatic Neuroendocrine Neoplasms and outcome of < sup > 177 < /sup > Lu-DOTATATE PRRT: does in-vivo molecular PET imaging perform better from 'prediction of tumour biology' viewpoint?
Conclusion: In summary, in NET patients with discordance between the two parameters, dual tracer PET-CT with FDG and 68Ga-DOTATATE performed better than WHO grading, differentiation status and immunohistochemistry in prognosticating and predicting outcome.PMID:34876476 | DOI:10.2967/jnmt.121.261998 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 8, 2021 Category: Nuclear Medicine Authors: Aadil Adnan Sandip Basu Source Type: research

Re-Modelling 99m-Technetium Pertechnetate Thyroid Uptake; Statistical, Machine Learning and Deep Learning Approaches
Conclusion: Thyroid scintigraphy is useful in identifying hyperthyroid patients suitable for radioiodine therapy when using an appropriately validated cut-off for the patient population (4.5% in this population). ML ANN algorithms can be developed to improve accuracy as second readers systems when biochemistry results are available. DL CNN algorithms can be developed to improve accuracy in the absence of biochemistry results. ML and DL do not displace the role of the physician in thyroid scintigraphy but could be used as second reader systems to minimize errors and increase confidence.PMID:34876477 | DOI:10.2967/jnmt.121.2...
Source: Journal of Nuclear Medicine Technology - December 8, 2021 Category: Nuclear Medicine Authors: Geoffrey M Currie Basit M Iqbal Source Type: research

Discordance between Histopathological grading and Dual Tracer PET-CT findings ( < sup > 68 < /sup > Ga-DOTATATE and FDG) in metastatic Neuroendocrine Neoplasms and outcome of < sup > 177 < /sup > Lu-DOTATATE PRRT: does in-vivo molecular PET imaging perform better from 'prediction of tumour biology' viewpoint?
Conclusion: In summary, in NET patients with discordance between the two parameters, dual tracer PET-CT with FDG and 68Ga-DOTATATE performed better than WHO grading, differentiation status and immunohistochemistry in prognosticating and predicting outcome.PMID:34876476 | DOI:10.2967/jnmt.121.261998 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 8, 2021 Category: Nuclear Medicine Authors: Aadil Adnan Sandip Basu Source Type: research