Exploring variations in recommended first ‐choice therapy for complicated urinary tract infections in males: Insights from outpatient settings across age, race, and ethnicity
ConclusionsNearly half of the patients included in this study did not receive recommended first-choice therapies; however, racial and ethnic disparities were not identified. Underutilization of recommended first-choice antibiotic therapy in complicated UTIs continues to be an area of focus for antimicrobial stewardship programs. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 14, 2024 Category: Drugs & Pharmacology Authors: Kathryn Sine, Thomas Lavoie, Aisling R. Caffrey, Vrishali V. Lopes, David Dosa, Kerry L. LaPlante, Haley J. Appaneal Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 12, 2024 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Optimal starting dosing regimen of intravenous oxytocin for labor induction based on the population kinetic ‐pharmacodynamic model of uterine contraction frequency
ConclusionThe K-PD model of oxytocin effectively described the changes in UCF during labor induction. Furthermore, it revealed that parity, cervical dilation, and membrane integrity are key factors that influence the effectiveness of oxytocin. The optimal starting dosing regimens obtained through model simulations provide valuable clinical references for oxytocin treatment. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 29, 2024 Category: Drugs & Pharmacology Authors: Zhiheng Yu, Rong Chen, Cheng Zhao, Renwei Zhang, Tianyan Zhou, Yangyu Zhao Tags: RESEARCH ARTICLE Source Type: research

Response to comment on “International consensus recommendations for the use of prolonged‐infusion β‐lactams endorsed by the American College of Clinical Pharmacy (ACCP), the British Society for Antimicrobial Chemotherapy (BSAC), the Cystic Fibrosis Foundation (CFF), the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), the Infectious Diseases Society of American (IDSA), the Society of Critical Care Medicine (SCCM), and the Society of Infectious Diseases Pharmacists”
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 20, 2024 Category: Drugs & Pharmacology Authors: Lisa T. Hong, Kevin J. Downes, Alireza FakhriRavari, Jacinda C. Abdul ‐Mutakabbir, Joseph L. Kuti, Sarah Jorgensen, David C. Young, Mohammad H. Alshaer, Matteo Bassetti, Robert A. Bonomo, Mark Gilchrist, Soo Min Jang, Thomas Lodise, Jason A Tags: LETTER TO THE EDITOR Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 16, 2024 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

“Comment on ‘international consensus recommendations for the use of prolonged‐infusion β‐lactams endorsed by the American College of Clinical Pharmacy (ACCP), the British Society for Antimicrobial Chemotherapy (BSAC), the Cystic Fibrosis Foundation (CFF), the European Society of Clinical Mi crobiology and Infectious Diseases (ESCMID), the infectious diseases Society of American (IDSA), the Society of Critical Care Medicine (SCCM), and the Society of Infectious Diseases Pharmacists’”
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 16, 2024 Category: Drugs & Pharmacology Authors: Carlos Augusto Espinoza  Cobeñas Tags: LETTER TO THE EDITOR Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 16, 2024 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

“Comment on ‘international consensus recommendations for the use of prolonged‐infusion β‐lactams endorsed by the American College of Clinical Pharmacy (ACCP), the British Society for Antimicrobial Chemotherapy (BSAC), the Cystic Fibrosis Foundation (CFF), the European Society of Clinical Mi crobiology and Infectious Diseases (ESCMID), the infectious diseases Society of American (IDSA), the Society of Critical Care Medicine (SCCM), and the Society of Infectious Diseases Pharmacists’”
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 16, 2024 Category: Drugs & Pharmacology Authors: Carlos Augusto Espinoza  Cobeñas Tags: LETTER TO THE EDITOR Source Type: research

Use of bivalirudin after initial heparin management among adult patients on long ‐term venovenous extracorporeal support as a bridge to lung transplant: A case series
AbstractA growing body of evidence supports the use of bivalirudin as an alternative to unfractionated heparin (UFH) for the prevention of thrombotic events in patients on venovenous (VV) extracorporeal membrane oxygenation (ECMO). However, data in patients bridged to lung transplantation are limited. In this case series, we describe the outcomes of six patients who were transitioned from UFH to bivalirudin during their course of VV ECMO support as a bridge to lung transplantation. All six patients were on VV ECMO support until transplant, with a median duration of 73  days. Bivalirudin demonstrated a shorter time to fir...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 3, 2024 Category: Drugs & Pharmacology Authors: Hala Halawi, Jesse E. Harris, Ahmad Goodarzi, Simon Yau, Jihad G. Youssef, Mena Botros, Howard J. Huang Tags: CASE REPORT Source Type: research

Updates in pulmonary drug ‐resistant tuberculosis pharmacotherapy: A focus on BPaL and BPaLM
AbstractDrug-resistant tuberculosis (TB) is a major public health concern and contributes to high morbidity and mortality. New evidence supports the use of shorter duration, all-oral regimens, which represent an encouraging treatment strategy for drug-resistant TB. As a result, the landscape of drug-resistant TB pharmacotherapy has drastically evolved regarding treatment principles and preferred agents. This narrative review focuses on the key updates of drug-resistant TB treatment, including the use of short-duration all-oral regimens, while calling attention to current gaps in knowledge that may be addressed in future ob...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - January 25, 2024 Category: Drugs & Pharmacology Authors: Dana J. Holger, Ali Althubyani, Taylor Morrisette, Nicholas Rebold, Marylee Tailor Tags: REVIEW Source Type: research

Combination eravacycline therapy for ventilator ‐associated pneumonia due to carbapenem‐resistant Acinetobacter baumannii in patients with COVID‐19: A case series
ConclusionWith limited viable salvage treatment options, combination eravacycline therapy showed favorable microbiological and clinical outcomes in patients with CRAB pneumonia. In light of this, eravacycline could be considered as a potential treatment option when designing CRAB pneumonia salvage therapy regimens. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - January 25, 2024 Category: Drugs & Pharmacology Authors: Melissa N. W. Jackson, Wenjing Wei, Norman S. Mang, Bonnie C. Prokesch, Jessica K. Ortwine Tags: RESEARCH ARTICLE Source Type: research