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Antiviral influenza treatments and hemorrhage ‐related adverse events in the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database
ConclusionIn this study, some signals for GI hemorrhage were observed, particularly for peramivir and baloxavir marboxil. Further investigation is warranted to better understand and evaluate the potential risks of GI hemorrhage associated with antiviral treatments for influenza. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 25, 2024 Category: Drugs & Pharmacology Authors: Jyotirmoy Sarker, Emir Carkovic, Karolina Ptaszek, Todd A. Lee Tags: RESEARCH ARTICLE Source Type: research

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(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 24, 2024 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Warfarin dosage in a postpartum woman while breastfeeding: A case report
AbstractWarfarin is the only oral anticoagulant recommended in women who are breastfeeding. Although warfarin is a compatible and recommended agent in the postpartum period and during lactation, little is known regarding changes to warfarin dose requirements in this patient population. Here, we report the case of a 40-year-old woman who transitioned from enoxaparin monotherapy back to warfarin at 2  months postpartum, while she was breastfeeding. Despite resuming warfarin at her previously therapeutic dose, her international normalized ratio (INR) remained subtherapeutic and required multiple dose increases. She ultimate...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 18, 2024 Category: Drugs & Pharmacology Authors: Ellen Uppuluri, Niha Idrees, Nancy Shapiro Tags: CASE REPORT Source Type: research

Simulated cost ‐effectiveness of a novel precision‐guided dosing strategy in adult patients with Crohn's disease initiating infliximab maintenance therapy
ConclusionsPGD provides clinical and QoL benefits by maintaining remission and avoiding IFX failure; it is the most cost-effective under conservative assumptions. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 5, 2024 Category: Drugs & Pharmacology Authors: Elmar R. Alizadeh, Thierry Dervieux, Severine Vermeire, Marla Dubinsky, Geert D'Haens, David Laharie, Andrew Shim, Byron P. Vaughn Tags: RESEARCH ARTICLE Source Type: research

Vancomycin AUC0 –24 estimation using first‐order pharmacokinetic methods in pediatric patients
ConclusionsOur data describe the relationship between vancomycin dose,Cmin, and AUC0 –24 in pediatric patients. We demonstrated the feasibility of using first-order equations to estimate AUC0 –24, using two concentrations obtained at steady state to monitor efficacy and safety in pediatric patients receiving intravenous vancomycin. Our data showed suboptimal correlation between AUC0 –24 andCmin, which indicates thatCmin should not be used as a surrogate marker for a therapeutic AUC0 –24 in pediatric patients. In alignment with the 2020 vancomycin consensus guidelines, we suggest utilizing AUC0 –24 for efficacy an...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 2, 2024 Category: Drugs & Pharmacology Authors: Hope H. Brandon, David S. Burgess, Katie L. Wallace, Elizabeth B. Autry, Katie B. Olney Tags: RESEARCH ARTICLE Source Type: research

Exploring variations in recommended first ‐choice therapy for complicated urinary tract infections in males: Insights from outpatient settings across age, race, and ethnicity
ConclusionsNearly half of the patients included in this study did not receive recommended first-choice therapies; however, racial and ethnic disparities were not identified. Underutilization of recommended first-choice antibiotic therapy in complicated UTIs continues to be an area of focus for antimicrobial stewardship programs. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 14, 2024 Category: Drugs & Pharmacology Authors: Kathryn Sine, Thomas Lavoie, Aisling R. Caffrey, Vrishali V. Lopes, David Dosa, Kerry L. LaPlante, Haley J. Appaneal Tags: RESEARCH ARTICLE Source Type: research

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(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 12, 2024 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Optimal starting dosing regimen of intravenous oxytocin for labor induction based on the population kinetic ‐pharmacodynamic model of uterine contraction frequency
ConclusionThe K-PD model of oxytocin effectively described the changes in UCF during labor induction. Furthermore, it revealed that parity, cervical dilation, and membrane integrity are key factors that influence the effectiveness of oxytocin. The optimal starting dosing regimens obtained through model simulations provide valuable clinical references for oxytocin treatment. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 29, 2024 Category: Drugs & Pharmacology Authors: Zhiheng Yu, Rong Chen, Cheng Zhao, Renwei Zhang, Tianyan Zhou, Yangyu Zhao Tags: RESEARCH ARTICLE Source Type: research

Response to comment on “International consensus recommendations for the use of prolonged‐infusion β‐lactams endorsed by the American College of Clinical Pharmacy (ACCP), the British Society for Antimicrobial Chemotherapy (BSAC), the Cystic Fibrosis Foundation (CFF), the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), the Infectious Diseases Society of American (IDSA), the Society of Critical Care Medicine (SCCM), and the Society of Infectious Diseases Pharmacists”
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 20, 2024 Category: Drugs & Pharmacology Authors: Lisa T. Hong, Kevin J. Downes, Alireza FakhriRavari, Jacinda C. Abdul ‐Mutakabbir, Joseph L. Kuti, Sarah Jorgensen, David C. Young, Mohammad H. Alshaer, Matteo Bassetti, Robert A. Bonomo, Mark Gilchrist, Soo Min Jang, Thomas Lodise, Jason A Tags: LETTER TO THE EDITOR Source Type: research

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(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 16, 2024 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research