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ACCP Virtual Poster Symposium
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 18, 2017 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 18, 2017 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Fidaxomicin versus Vancomycin as a First ‐Line Treatment for Clostridium difficile‐Associated Diarrhea (CDAD) in Specific Patient Populations: A Pharmacoeconomic Evaluation
ConclusionsFidaxomicin as first‐line CDAD therapy is associated with similar total costs as compounded vancomycin oral solution in the general population. In elderly and renally‐impaired patients, slight increases in hospital cost were observed with fidaxomicin therapy, while in patients with cancer or concomitant antibiotic use hospital cost savings were observed.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 17, 2017 Category: Drugs & Pharmacology Authors: Kelly R. Reveles, Jennifer L. Backo, Frank A. Corvino, Marko Zivkovic, Kelly C. Broderick Tags: Original Research Article Source Type: research

Impact of Insulin Detemir Administration Time on Hypoglycemia Rates in Hospitalized Patients
Abstract Study ObjectiveTo determine if insulin detemir administration time affects the frequency of hypoglycemia (blood glucose level
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 13, 2017 Category: Drugs & Pharmacology Authors: Jennifer L. Grelle, Sydney N. Kutter, Megan E. Giruzzi, John C. Tawwater Tags: Original Research Article Source Type: research

Comparison of weight ‐based dosing strategies for intravenous immunoglobulin in patients with hematologic malignancies
ConclusionNo differences in infection rate and IgG level response were identified when a precision‐dosing strategy was used. Implementation of an IVIG precision‐dosing strategy provided institutional cost savings.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 13, 2017 Category: Drugs & Pharmacology Authors: Sarah E. Stump, Allison J. Schepers, Alexis R. Jones, Maurice D. Alexander, Jessica J. Auten Tags: Original Research Article Source Type: research

Impact of Ketamine Use on Adjunctive Analgesic and Sedative Medications in Critically Ill Trauma Patients
ConclusionsAlthough the use of ketamine in critically ill, mechanically ventilated, adult trauma patients was associated with decreased opioid use, it was also associated with increased use of dexmedetomidine and ziprasidone to achieve and maintain sedation. Further examination of clinical outcomes associated with these differences in drug use in a larger population of trauma patients is warranted before routine use of ketamine for analgesia and sedation can be recommended.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 10, 2017 Category: Drugs & Pharmacology Authors: Kaitlin A. Pruskowski, Kelly Harbourt, Mehrnaz Pajoumand, Sai ‐Ho Jason Chui, H. Neal Reynolds Tags: Original Research Article Source Type: research

A Pharmacist ‐Led Program to Evaluate and Reduce Polypharmacy and Potentially Inappropriate Prescribing in Older, HIV‐Positive Patients
ConclusionsResults suggest that targeting individuals with 11 or more chronic medications would have the highest yield and greatest impact. Pharmacist‐led review of medication prescribing employing Beers and STOPP criteria revealed a large number of PIP, many amenable to immediate clinical pharmacist intervention.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 10, 2017 Category: Drugs & Pharmacology Authors: I R McNicholl, M Gandhi, C Bradley Hare, M Greene, E Pierluissi Tags: Original Research Article Source Type: research

A comparison of insulin doses for the treatment of hyperkalemia in patients with renal insufficiency
ConclusionIn patients with renal insufficiency and hyperkalemia, 5 units of insulin reduced serum potassium to the same extent as 10 units of insulin, but with a lower rate of hypoglycemia. Further controlled studies are needed to confirm these findings.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 4, 2017 Category: Drugs & Pharmacology Authors: Heather LaRue, Gary Daniel Peksa, Shital Shah Tags: Original Research Article Source Type: research

Renal Transplant Acute Rejection with Lower Mycophenolate Mofetil Dosing and Proton Pump Inhibitors or Histamine ‐2 Receptor Antagonists
ConclusionDespite taking lower MMF doses than previously studied, subjects on a PPI compared to an H2RA were not at increased risk of acute rejection within 1‐year post‐transplant.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 4, 2017 Category: Drugs & Pharmacology Authors: Kajal S. Patel, Brian R. Stephany, Julie F. Barnes, Seth R. Bauer, Michael L. Spinner Tags: Original Research Article Source Type: research

Trowels and Tribulations: Review of Antimicrobial ‐Impregnated Bone Cements in Prosthetic Joint Surgery
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 4, 2017 Category: Drugs & Pharmacology Authors: Vasilios Athans, Michael P. Veve, Susan L. Davis Tags: Review of Therapeutics Source Type: research

Empirical Vancomycin Dosing in Pediatric Patients with Congenital Heart Disease and the Impact of Cardiopulmonary Bypass on Trough Concentrations
ConclusionsEmpirical vancomycin dosing to achieve troughs of 8–15 μg/dl in patients with congenital heart disease without evidence of significant acute kidney injury should be 30 mg/kg/day for neonates, 35–40 mg/kg/day for infants, and 45 mg/kg/day in children, with adjustments required for patients with elevated creatinine or significant aortic cross‐clamp time. The receipt and duration of CPB did not affect total daily vancomycin dose requirements. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 28, 2017 Category: Drugs & Pharmacology Authors: Christopher A. Thomas, Amy Picone, Sharad Menon, Brigham C. Willis Tags: Original Research Article Source Type: research

The Effect of Morphine Dosing on Length of Stay in Neonatal Abstinence Syndrome – An Alternative Viewpoint
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Kirsten H. Ohler, Jennifer T. Pham Tags: Alternative Viewpoints Source Type: research

Influence of Kidney Transplant Status on Warfarin Dose, Anticoagulation Control, and Risk of Hemorrhage
ConclusionKTRs initiating warfarin require lower doses and closer monitoring to optimize anticoagulation therapy. Additional studies are needed to confirm these findings.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Megan V. Yanik, Marguerite R. Irvin, T.Mark Beasley, Pamala A. Jacobson, Bruce A. Julian, Nita A. Limdi Tags: Original Research Article Source Type: research

Early administration of adjuvant β‐lactam therapy in combination with vancomycin among patients with methicillin‐resistant Staphylococcus aureus bloodstream infection: a retrospective, multicenter analysis
Abstract Study ObjectiveTo determine whether early administration of adjuvant β‐lactam in combination with vancomycin (COMBO) affects clinical outcomes compared to standard vancomycin therapy alone (STAN) among patients with methicillin‐resistant Staphylococcus aureus (MRSA) bloodstream infection. DesignRetrospective, multicenter cohort study. SettingFive academic or community hospitals throughout the United States. PatientsAdults with MRSA bloodstream infections treated with vancomycin (≥72 hours) ± an intravenous β‐lactam (≥48 hours) initiated within 24 hours of initiating vancomycin. Measure...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Anthony M. Casapao, David M. Jacobs, Dana R. Bowers, Nicholas D. Beyda, Thomas J. Dilworth, Tags: Original Research Article Source Type: research

Pharmacovigilance Assessment of Immune ‐Mediated Reactions Reported for Checkpoint Inhibitor Cancer Immunotherapies
ConclusionCancer immunotherapy with CPI is associated with a multitude of IMR, especially colitis and pneumonitis. Individual CPI had variable IMR signals, and pharmacoepidemiologic studies are required to evaluate the identified signals.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Ayad K. Ali, David E. Watson Tags: Original Research Article Source Type: research

Efficacy and effectiveness of RSV immunoprophylaxis in children with cystic fibrosis – an unsolved question with more to be asked
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Rees L. Lee, Rebekah F. Brown, Tebeb Gebretsadik, Tina V. Hartert, William D. Dupont, Pingsheng Wu Tags: Alternative Viewpoints Source Type: research

A Review of Immune Checkpoint Inhibitors for the Management of Locally Advanced or Metastatic Urothelial Carcinoma
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Kirollos S. Hanna Tags: Review of Therapeutics Source Type: research

Contemporary Time Trends in Use of Antiplatelet Agents Among Patients with Acute Coronary Syndrome and Comorbid Diabetes Mellitus or Chronic Kidney Disease
ConclusionsWe observed lower or similar use of prasugrel and ticagrelor compared with clopidogrel in patients with ACS and comorbid DM and/or CKD. Given the potential for worse clinical outcomes with clopidogrel in these patients, our findings highlight the need to investigate the implications of these trends on recurrent ACS and bleeding events. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 19, 2017 Category: Drugs & Pharmacology Authors: Rishi J. Desai, Julia Spoendlin, Helen Mogun, Joshua J. Gagne Tags: Brief Report Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 15, 2017 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Eteplirsen for the Treatment of Duchenne Muscular Dystrophy: Quality of Evidence Concerns —an Alternative Viewpoint
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 12, 2017 Category: Drugs & Pharmacology Authors: Adriane N. Irwin, Megan C. Herink Tags: Alternative Viewpoint Source Type: research

Thrombolysis for Massive Pulmonary Embolism in Pregnancy
This article summarizes the risks for thromboembolism in pregnancy, compares and contrasts thrombolytic agents in this setting, and provides a recommendation for management of massive PE in this special population. Overall, reports suggest that the use of these agents is associated with beneficial outcomes and relatively low risk of complications. The quality of this evidence is low and clinical judgment is required to assess individual patients for risks versus benefits of thrombolysis. This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 11, 2017 Category: Drugs & Pharmacology Authors: Mojdeh S. Heavner, Min Zhang, Chelsea E. Bast, Lindsey Parker, Rachel F. Eyler Tags: Review of Therapeutics Source Type: research

Alteplase for Acute Ischemic Stroke after Heparin Reversal with Protamine: A Case Report and Review
We describe the first reported case of a patient receiving full‐dose intravenous (IV) alteplase for AIS after heparin reversal with protamine. A 73‐year‐old man presented with AIS. He was treated with IV heparin, tirofiban, loading‐dose prasugrel, and aspirin before percutaneous coronary intervention (PCI) for placement of a right coronary artery stent. One hour following PCI, he abruptly developed left hemiparesis and dysphagia. The National Institutes of Health Stroke Scale was 12, and activated partial thromboplastin time (aPTT) was longer than 150 seconds. Head computed tomography (CT) showed no acute path...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 4, 2017 Category: Drugs & Pharmacology Authors: Gabriel V. Fontaine, Shawn M. Smith Tags: Case Report Source Type: research

Intravenous ‐only or intravenous transitioned to oral antimicrobials for Enterobacteriaceae‐associated bacteremic urinary tract infection
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 4, 2017 Category: Drugs & Pharmacology Authors: Krista L. Rieger, John A. Bosso, Shawn H. MacVane, Zachary Temple, Amy Wahlquist, Nicole Bohm Tags: Brief Report Source Type: research

Observational Comparative Effectiveness of Pharmaceutical Treatments for Obesity within the Veterans Health Administration
Abstract Study ObjectiveTo compare the effectiveness of weight‐management medications used to assist with weight loss in real‐world clinical practice in the Veterans Health Administration (VHA). DesignRetrospective, multicenter, observational cohort study. Data SourceNational VA Corporate Data Warehouse. PatientsA total of 66,035 VA patients aged 18 years or older with a body mass index of 25 kg/m2 or greater who had an initial fill for a study medication (orlistat [6153 patients], phentermine [304 patients], lorcaserin [298 patients], or phentermine‐topiramate extended release [233 patients]) or participation in the...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 1, 2017 Category: Drugs & Pharmacology Authors: Ted R. Grabarczyk Tags: Original Research Article Source Type: research

Comparison of treatment persistence with dabigatran or rivaroxaban versus vitamin K antagonist oral anticoagulants in atrial fibrillation patients: a competing risk analysis in the French nationwide healthcare databases
Abstract BackgroundDirect oral anticoagulants (DOACs) have been proposed as a more convenient alternative to vitamin K antagonists (VKAs), which are commonly associated with poor treatment persistence in nonvalvular atrial fibrillation (nv‐AF). MethodsUsing data from the French National Healthcare databases (Régime Général, 50 million beneficiaries), a cohort study was conducted to compare the 1‐year non‐persistence rates in nv‐AF patients initiating dabigatran (N=11,141) or rivaroxaban (N=11,126) versus VKA (N=11,998). Treatment discontinuation was defined as a switch between oral anticoagulan...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 1, 2017 Category: Drugs & Pharmacology Authors: G éric Maura, Cécile Billionnet, François Alla, Joshua J. Gagne, Antoine Pariente Tags: Original Research Article Source Type: research

Evaluation and Treatment of Acute and Subacute Hearing Loss: A Review of Pharmacotherapy
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 1, 2017 Category: Drugs & Pharmacology Authors: Maryam T. Fazel, Patrick M. Jedlowski, Robert B. Cravens, Brian L. Erstad Tags: Review of Therapeutics Source Type: research

Contemporary Use of Oral Antithrombotic Agents: Focus on Dual and Triple Therapeutic Approaches
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 1, 2017 Category: Drugs & Pharmacology Authors: Antoine T. Jenkins, Alexander Kantorovich, Luba Burman Tags: Review of Therapeutics Source Type: research

Midostaurin: A New Oral Agent Targeting FLT3 ‐Mutant Acute Myeloid Leukemia
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 1, 2017 Category: Drugs & Pharmacology Authors: Lindsay C. Stansfield, Daniel A. Pollyea Tags: Review of Therapeutics Source Type: research

Safety and Efficacy of Biologic Agents for the Management of Inflammatory Bowel Disease After Liver Transplantation
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 1, 2017 Category: Drugs & Pharmacology Authors: Suhail A Shaikh, Linda Stuckey, Sarah Tischer Tags: Review of Therapeutics Source Type: research

Alternative Viewpoint: Predictors of Response in Emergency Department Patients Receiving Intravenous Opioids for Severe Pain
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 1, 2017 Category: Drugs & Pharmacology Authors: James Priano, Brian Faley Tags: Alternative Viewpoints Source Type: research

Comparison of Bioavailability of Single ‐Dose Extended‐Release Venlafaxine Capsules in Obese Patients Before and After Gastric Bypass Surgery
ConclusionThis study suggests that RYGB does not significantly alter the amount of venlafaxine or its active metabolite, ODV, absorbed from a venlafaxine ER capsule or the time over which it is absorbed.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 28, 2017 Category: Drugs & Pharmacology Authors: Carrie A. Krieger, Julie L. Cunningham, Karen B. Grothe, Joel M. Reid, Loralie J. Langman, Matthew M. Clark, Ross A. Dierkhising Tags: Original Research Article Source Type: research

Precision Pharmacotherapy Enables Precision Medicine
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 23, 2017 Category: Drugs & Pharmacology Authors: Jeffrey R. Bishop, Vicki L. Ellingrod Tags: Editorial Source Type: research

Prothrombin Complex Concentrate Reduces Blood Product Utilization in Heart Transplantation
The objective of this study was to assess the efficacy of 4‐factor Prothrombin Complex Concentrate (4‐F PCC) administration in patients requiring warfarin reversal prior to heart transplantation by determining blood product utilization perioperatively. MethodsTwenty‐one patients who received 4‐F PCC for warfarin reversal prior to heart transplantation were compared to a similar cohort of 39 patients who did not receive 4‐F PCC from January 2011 to July 2015. Blood product utilization was collected retrospectively for the 24‐hour preoperative, intraoperative, and 48‐hour postoperative periods. ResultsPatients ...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 22, 2017 Category: Drugs & Pharmacology Authors: Daniel H. Enter, Anthony L. Zaki, Megan Marsh, Nikki Cool, Jane Kruse, Zhi Li, Adin ‐Cristian Andrei, Adam Iddriss, Patrick M. McCarthy, S.Chris Malaisrie, Allen Anderson, Jonathan D. Rich, Duc Thinh Pham Tags: Original Research Article Source Type: research

Assessment of an Extended Interval Fondaparinux Dosing Regimen for Venous Thromboembolism Prophylaxis in Critically Ill Patients with Severe Renal Dysfunction Using Antifactor Xa Levels
ConclusionsIn critically ill patients with SRD, an extended interval fondaparinux dosing regimen of 2.5 mg every 48 hours for VTE prophylaxis achieved peak and trough antifactor Xa levels similar to those reported in noncritically ill patients with normal renal function receiving once‐daily fondaparinux. This regimen offers an alternative for patients with SRD when heparinoids must be avoided.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 22, 2017 Category: Drugs & Pharmacology Authors: Krista A. Wahby, Lauren K. Riley, Steven D. Tennenberg Tags: Original Research Article Source Type: research

Pharmacotherapeutic Management of Gastrointestinal Bleeding in Patients with Continuous ‐Flow Left‐Ventricular Assist Devices
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 22, 2017 Category: Drugs & Pharmacology Authors: Adam Sieg, Jeremy D. Moretz, Edward Horn, Douglas L. Jennings Tags: Review of Therapeutics Source Type: research

Repurposing valproate, enteral clonidine, and phenobarbital for comfort in adult ICU patients: a literature review with practical considerations
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 22, 2017 Category: Drugs & Pharmacology Authors: David J. Gagnon, Gabriel V. Fontaine, Richard R. Riker, Gilles L. Fraser Tags: Review of Therapeutics Source Type: research

Contemporary time ‐trends in use of antiplatelet agents among patients with acute coronary syndrome and comorbid diabetes mellitus or chronic kidney disease
ConclusionsWe observed lower or similar use of prasugrel and ticagrelor compared with clopidogrel in patients with ACS and comorbid DM and/or CKD. Given the potential for worse clinical outcomes with clopidogrel in these patients, our findings highlight the need to investigate the implications of these trends on recurrent ACS and bleeding events.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 22, 2017 Category: Drugs & Pharmacology Authors: Rishi J Desai, Julia Spoendlin, Helen Mogun, Joshua J Gagne Tags: Brief Report Source Type: research

Empiric vancomycin dosing in pediatric patients with congenital heart disease and the impact of cardiopulmonary bypass on trough concentrations
ConclusionsEmpiric vancomycin dosing to achieve troughs of 8 – 15 μg/dl in patients with congenital heart disease without evidence of significant acute kidney injury should be 30 mg/kg/day for neonates, 35‐40 mg/kg/day for infants, and 45 mg/kg/day in children, with adjustments required for patients with elevated creatinine or significant aortic cross clamp time. The receipt and duration of cardiopulmonary bypass did not affect total daily vancomycin dose requirements.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 22, 2017 Category: Drugs & Pharmacology Authors: Christopher A. Thomas, Amy Picone, Sharad Menon, Brigham C. Willis Tags: Original Research Article Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 15, 2017 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

The Emergence of Second ‐Generation Lethal Injection Protocols: A Brief History and Review
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 12, 2017 Category: Drugs & Pharmacology Authors: Daniel R. Malcom, Frank Romanelli Tags: Special Article Source Type: research

Serotonin Transporter Gene Polymorphisms and Selective Serotonin Reuptake Inhibitor Tolerability: Review of Pharmacogenetic Evidence
In conclusion, the S allele of 5‐HTTLPR may be predictive of increased adverse event burden, and this effect appears specific to certain classes of adverse events. Limitations and challenges in interpreting this body of evidence include assay errors, dissimilar grouping of genotypes, the role of ethnicity in associations, and study methodological differences. The clinical utility of serotonin transporter genotypes is not yet delineated but will ultimately depend on genotypic effects on both tolerability and efficacy of SSRIs. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 11, 2017 Category: Drugs & Pharmacology Authors: Jing Zhu, Michele Klein ‐Fedyshin, James M. Stevenson Tags: Review of Therapeutics Source Type: research

A Novel Use for Olaparib for Treatment of Metastatic Castration ‐Recurrent Prostate Cancer
This study found that men with mCRPC and genetic mutations in DNA damage repair genes had an overall response rate of nearly 90% with olaparib treatment. In this review, we describe current therapies for mCRPC, the rationale for anti‐PARP therapies, the pharmacology of olaparib for prostate cancer, clinical trials of olaparib for mCRPC, our clinical experience with olaparib for prostate cancer at a comprehensive cancer center, and future directions of olaparib for the treatment of mCRPC. Olaparib may constitute a promising treatment to prolong survival in patients with mCRPC, with an acceptable adverse effect profile. As...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 1, 2017 Category: Drugs & Pharmacology Authors: Grace A. Martin, Adrienne H. Chen, Kinjal Parikh Tags: Review of Therapeutics Source Type: research

Opioid and Benzodiazepine Weaning in Pediatric Patients: Review of Current Literature
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 1, 2017 Category: Drugs & Pharmacology Authors: Norman E Fenn, Kimberly S Plake Tags: Review of Therapeutics Source Type: research

Comprehensive Guidance for Antibiotic Dosing in Obese Adults
ConclusionsAdditional studies are needed to better understand and resolve discrepant published results regarding the PK of antibiotics in order to establish optimal dosing strategies in obese adults. Alternative dosing strategies, such as extended infusions, should be considered for time‐dependent antibiotics (e.g. β‐lactams) in obese patients to reliably achieve pharmacodynamics targets. Therapeutic drug monitoring across the spectrum of antimicrobials is of increasing importance in this and other populations in order to assure optimized dosing.This article is protected by copyright. All rights reserved. (Source:...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 1, 2017 Category: Drugs & Pharmacology Authors: Lina Meng, Emily Mui, Marisa K Holubar, Stan C Deresinski Tags: Review of Therapeutics Source Type: research

Persistence of Delirium after Cessation of Sedatives and Analgesics and Impact on Clinical Outcomes in Critically Ill Patients
ConclusionDespite the cessation of medications for continuous sedation, delirium persisted for the majority of patients and was associated with worse outcomes, which attests to the importance of strategies to minimize sedation.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 1, 2017 Category: Drugs & Pharmacology Authors: Michael T. Kenes, Joanna L. Stollings, Li Wang, Timothy D. Girard, E. Wesley Ely, Pratik P. Pandharipande Tags: Original Research Article Source Type: research

Evaluation of Progesterone Utilization and Birth Outcomes in a State Medicaid Plan
ConclusionDespite similar birth outcomes in clinical trials and national trends, medication adherence is low in this state Medicaid program. Therefore, members may benefit from adherence support.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 1, 2017 Category: Drugs & Pharmacology Authors: Tasmina Hydery, Mylissa K. Price, Bonnie C. Greenwood, Mito Takeshita, Parag S. Kunte, Rose P. Mauro, Kimberly Lenz, Paul L. Jeffrey Tags: Brief Report Source Type: research

Eteplirsen for the treatment of Duchenne muscular dystrophy: Quality of evidence concerns – An alternative viewpoint
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 25, 2017 Category: Drugs & Pharmacology Authors: Adriane N Irwin, Megan C Herink Tags: Alternative Viewpoints Source Type: research

Pharmacologic Considerations in the Management of Patients Receiving Left Ventricular Percutaneous Mechanical Circulatory Support
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 25, 2017 Category: Drugs & Pharmacology Authors: J. Erin Allender, Brent N. Reed, Jenna L. Foster, Jeremy D. Moretz, Carrie S. Oliphant, Douglas L. Jennings, Robert J. DiDomenico, James C. Coons Tags: Review of Therapeutics Source Type: research

Alteplase for acute ischemic stroke after heparin reversal with protamine – a case report and review
ConclusionsGiven the lack of adverse events associated with IV alteplase in our patient, we advocate cautious evaluation for potential reversal of acutely administered anticoagulation to facilitate alteplase administration in severely disabled patients who are not eligible for mechanical intervention, and who would have been excluded from definitive AIS treatment.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 25, 2017 Category: Drugs & Pharmacology Authors: Gabriel V. Fontaine, Shawn M. Smith Tags: Case Report Source Type: research

Incorporating Comprehensive Management of Direct Oral Anticoagulants Into Anticoagulation Clinics
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 21, 2017 Category: Drugs & Pharmacology Authors: Insaf Mohammad, Bianca Korkis, Candice L. Garwood Tags: Review of Therapeutics Source Type: research