Log in to search using one of your social media accounts:

 

Association of Higher Daptomycin Dose ( ≥ 7 mg/kg) with Improved Survival in Patients with Methicillin‐Resistant Staphylococcus aureus Bacteremia
The objective of this study was to evaluate the comparative effectiveness of the daptomycin label dose versus higher daptomycin doses in patients with MRSA bacteremia. DesignRetrospective national cohort study. SettingVeterans Affairs medical centers. PatientsA total of 371 adults with MRSA bacteremia who were admitted between 2002 and 2015 and treated initially with vancomycin within 24 hours of initial culture collection and then switched to daptomycin therapy within 7 days; 138 patients (37.2%) received daptomycin doses higher than the daptomycin label dose (≥ 7mg/kg), and 233 (62.8%) received the daptomycin label do...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 13, 2017 Category: Drugs & Pharmacology Authors: Tristan T. Timbrook, Aisling R. Caffrey, Megan K. Luther, Vrishali Lopes, Kerry L. LaPlante Tags: Original Research Article Source Type: research

Refining a Claims ‐based Algorithm to Estimate Biologic Medication Effectiveness and Cost per Effectively‐treated Patient with Rheumatoid Arthritis
ConclusionsUsing the original six‐criteria claims‐based algorithm in a large claims database, infliximab was the least effective biologic agent and had the highest medication cost per effectively‐treated patient. However, when a follow‐up analysis removed the dose escalation exclusion criterion, the four groups had similar effectiveness and medication costs per effectively‐treated patient with RA.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 1, 2017 Category: Drugs & Pharmacology Authors: Ryan A. Popp, Karen Rascati, Matthew Davis, Ujas Patel Tags: Original Research Article Source Type: research

Community Health Workers Supporting Clinical Pharmacists in Diabetes Management: A Randomized Controlled Trial
ObjectivesTo evaluate the effectiveness of clinical pharmacists and community health workers (CHWs) in improving glycemic control within a low‐income ethnic minority population. MethodsIn a two‐arm 2‐year crossover trial, 179 African‐American and 65 Hispanic adult patients with uncontrolled diabetes mellitus (hemoglobin A1c [HbA1C] of 8% or higher) were randomized to CHW support either during the first or second year of the study. All participants received clinical pharmacist support for both years of the study. The primary outcome was change in HbA1C over 1 and 2 years. ResultsSimilar HbA1C declines were note...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 30, 2017 Category: Drugs & Pharmacology Authors: Lisa K. Sharp, Jessica J. Tilton, Daniel R. Touchette, Yinglin Xia, Daniel Mihailescu, Michael L. Berbaum, Ben S. Gerber Tags: Original Research Article Source Type: research

Fidaxomicin versus Vancomycin as a First ‐Line Treatment for Clostridium difficile–Associated Diarrhea in Specific Patient Populations: A Pharmacoeconomic Evaluation
ConclusionsFidaxomicin as first‐line CDAD therapy is associated with similar total costs as compounded vancomycin oral solution in the general population. In elderly and renally impaired patients, slight increases in hospital cost were observed with fidaxomicin therapy, and in patients with cancer or concomitant antibiotic use, hospital cost savings were observed. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 27, 2017 Category: Drugs & Pharmacology Authors: Kelly R. Reveles, Jennifer L. Backo, Frank A. Corvino, Marko Zivkovic, Kelly C. Broderick Tags: Original Research Article Source Type: research

Midostaurin: A New Oral Agent Targeting FMS ‐Like Tyrosine Kinase 3‐Mutant Acute Myeloid Leukemia
Acute myeloid leukemia (AML), a clonal hematologic malignancy that results in bone marrow failure, is the most common acute leukemia in adults (median age of diagnosis 67 yrs), and treatment options, especially in the elderly population, are limited. Induction chemotherapy with 7 + 3, the combination of continuous‐infusion cytarabine and intermittent dosing of an anthracycline administered over 7 and 3 days, respectively, has remained the standard of care since its introduction in 1973 in the United States. Midostaurin is a first‐generation FMS‐like tyrosine kinase 3 (FLT3) inhibitor (TKI) that was approved by the U....
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 23, 2017 Category: Drugs & Pharmacology Authors: Lindsay C. Stansfield, Daniel A. Pollyea Tags: Review of Therapeutics Source Type: research

The Philosophy of Practice for Comprehensive Medication Management: Evaluating its Meaning and Application by Practitioners
ConclusionThere was significant variability in how participants described their philosophy of practice. CMM requires a single and consistently applied philosophy of practice in order to guide practice and the role of the practitioner. We propose five core tenets that resulted from this assessment to be embraced by pharmacists providing CMM and included in their philosophy of practice.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 20, 2017 Category: Drugs & Pharmacology Authors: Deborah L. Pestka, Lindsay A. Sorge, Mary Roth McClurg, Todd D. Sorensen Tags: Original Research Article Source Type: research

Malignancy in Renal Transplant Recipients Exposed to Cyclophosphamide Prior to Transplantation for the Treatment of Native Glomerular Disease
ConclusionIn our observational study, renal transplant recipients exposed to pretransplantation cyclophosphamide appeared to have a higher risk of developing a malignancy compared with unexposed renal transplant recipients. Further investigation into the impact of pretransplantation immunosuppression on malignancy, particularly the compounded effect with lymphocyte‐depleting induction, is warranted.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 14, 2017 Category: Drugs & Pharmacology Authors: M R Jorgenson, J L Descourouez, T Singh, Brad C. Astor, Sarah E. Panzer Tags: Original Research Article Source Type: research

A Novel Use of Olaparib for the Treatment of Metastatic Castration ‐Recurrent Prostate Cancer
This study found that men with mCRPC and genetic mutations in DNA damage repair genes had an overall response rate of nearly 90% with olaparib treatment. In this review, we describe current therapies for mCRPC, the rationale for anti‐PARP therapies, the pharmacology of olaparib for prostate cancer, clinical trials of olaparib for mCRPC, our clinical experience with olaparib for prostate cancer at a comprehensive cancer center, and future directions of olaparib for the treatment of mCRPC. Olaparib may constitute a promising treatment to prolong survival in patients with mCRPC, with an acceptable adverse effect profile. As...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 10, 2017 Category: Drugs & Pharmacology Authors: Grace A. Martin, Adrienne H. Chen, Kinjal Parikh Tags: Review of Therapeutics Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 10, 2017 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Community Health Workers Supporting Clinical Pharmacists in Diabetes Management: A Randomized ‐Controlled Trial
Abstract ObjectivesTo evaluate the effectiveness of clinical pharmacists and community health workers (CHWs) in improving glycemic control within a low‐income, ethnic minority population. MethodsIn a two‐arm, 2‐year, crossover trial, 179 African‐American and 65 Hispanic adult patients with uncontrolled diabetes mellitus (hemoglobin A1c [HbA1c] ≥ 8%) were randomized to CHW support either during the first or second year of the study. All participants received clinical pharmacist support for both years of the study. The primary outcome was change in HbA1c over 1 and 2 years. ResultsSimilar HbA1c declines were noted...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 9, 2017 Category: Drugs & Pharmacology Authors: Lisa K. Sharp, Jessica J. Tilton, Daniel R. Touchette, Yinglin Xia, Daniel Mihailescu, Michael L. Berbaum, Ben S. Gerber Tags: Original Research Article Source Type: research

Medication Management of Patients Undergoing Transcatheter Aortic Valve Replacement
This article summarizes key literature supporting the pharmacologic management of patients receiving TAVR. This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 9, 2017 Category: Drugs & Pharmacology Authors: Bethany A. Kalich, J. Erin Ledford, Ian B. Hollis Tags: Review of Therapeutics Source Type: research

Impact of Penicillin Allergy on Empirical Carbapenem Use in Gram ‐Negative Bloodstream Infections: An Antimicrobial Stewardship Opportunity
ConclusionPenicillin allergy was a significant contributor to carbapenem use in community‐onset gram‐negative BSI. This was subject to modification by antimicrobial stewardship interventions which successfully reduced overall carbapenem use and duration of carbapenem therapy in patients with penicillin allergy.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 3, 2017 Category: Drugs & Pharmacology Authors: Majdi N. Al ‐Hasan, Emily C. Acker, Joseph E. Kohn, P. Brandon Bookstaver, Julie Ann Justo Tags: Original Research Article Source Type: research

Evaluation of the use of novel biomarkers to augment antimicrobial stewardship program activities
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 1, 2017 Category: Drugs & Pharmacology Authors: Kayla R. Stover, Rachel M. Kenney, Travis S. King, Alan E. Gross Tags: Review of Therapeutics Source Type: research

Providing Comprehensive Medication Management in Telehealth
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 1, 2017 Category: Drugs & Pharmacology Authors: Melissa E. Badowski, Scot Walker, Shaffeeulah Bacchus, Sandy Bartlett, Juliana Chan, Kelly A. Cochran, Scott Coon, Michelle Liedtke, Brad Phillips, Taylor White Tags: ACCP White Paper Source Type: research

Disaster Preparedness: Biological Threats and Treatment Options
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 1, 2017 Category: Drugs & Pharmacology Authors: Navaneeth Narayanan, Clifton R. Lacy, Joseph E. Cruz, Meghan Nahass, Jonathan Karp, Joseph A. Barone, Evelyn Hermes ‐DeSantis Tags: Review of Therapeutics Source Type: research

Addition of Allopurinol for Altering Thiopurine Metabolism to Optimize Therapy in Patients with Inflammatory Bowel Disease
In conclusion, the addition of allopurinol may be an option for optimizing thiopurine metabolite production in select patients with low 6‐thioguanine nucleotide levels. Appropriate care and monitoring of these patients is mandatory to prevent neutropenia or other adverse effects. This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 1, 2017 Category: Drugs & Pharmacology Authors: Geoffrey C. Wall, Hamid Muktar, Cassandra Effken, Pramod B. Mahajan Tags: Review of Therapeutics Source Type: research

Ketamine Infusion for Adjunct Sedation in Mechanically Ventilated Adults
ConclusionsContinuous ketamine infusion for adjunct light sedation was well tolerated in a cohort of critically ill adults, with an acceptable safety profile Prospective studies of ketamine infusion are warranted to further establish its efficacy as a sedative in this population.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 1, 2017 Category: Drugs & Pharmacology Authors: Lara M. Groetzinger, Ryan M. Rivosecchi, William Bain, Marshall Bahr, Katherine Chin, Ian Barbash, Bryan J. McVerry Tags: Original Research Article Source Type: research

Therapeutic Benefit of Smoked Cannabis in Randomized Placebo ‐Controlled Studies
Abstract The medicinal use of marijuana has been legalized in 28 states, with a wide range of specificity for approved medical conditions. Even with the emergence of non–combustion‐based delivery systems, in 2014, 90% of marijuana users used smoked marijuana. The purpose of this review is to summarize the data available on use of smoked marijuana for medical purposes. A literature search was performed to retrieve randomized controlled trials exploring the efficacy of smoked cannabis for treatment of a medical condition. Studies with the primary endpoint listed as the effect of smoked cannabis on a disease‐specifi...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 1, 2017 Category: Drugs & Pharmacology Authors: Lynneice L Bowen, Aimee L. McRae ‐Clark Tags: Review of Therapeutics Source Type: research

Lacosamide pharmacokinetics in a critically ill patient receiving continuous venovenous hemofiltration
ConclusionLacosamide was cleared by CVVH as demonstrated by the sieving coefficient, but plasma concentrations remained within goal range throughout the dosing interval. These results may suggest that lacosamide 200 mg twice daily is a useful dosing strategy for critically ill patients who require CVVH.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 1, 2017 Category: Drugs & Pharmacology Authors: Miguel J. Franquiz, Shamir N. Kalaria, Michael J. Armahizer, Mathangi Gopalakrishnan, Paul J. McCarthy, Neeraj Badjatia Tags: Case Report Source Type: research

Severe Hypoglycemia Caused by Lenalidomide
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 1, 2017 Category: Drugs & Pharmacology Authors: Daniel J Przybylski, Ruemu Birhiray, David J Reeves Tags: Case Report Source Type: research

Ketamine for the acute management of excited delirium and agitation in the prehospital setting
ConclusionKetamine has a role for agitation management in the prehospital setting; however, emergency personnel education and ketamine protocols should be utilized to aid in safe and effective pharmacotherapy and provide guidance on the management of adverse events. Future prospective comparative studies, with protocolized standard ketamine regimens are needed to further delineate the role of ketamine in agitation management and identify accurate adverse event incidence rates.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 1, 2017 Category: Drugs & Pharmacology Authors: Kyle A. Weant, Lauren M. Linder, Clint A. Ross Tags: Review of Therapeutics Source Type: research

Alternative Viewpoint: Efficacy and Effectiveness of Respiratory Syncytial Virus Immunoprophylaxis in Children with Cystic Fibrosis – An Unsolved Question with More to Be Asked
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 26, 2017 Category: Drugs & Pharmacology Authors: Rees L. Lee, Rebekah F. Brown, Tebeb Gebretsadik, Tina V. Hartert, William D. Dupont, Pingsheng Wu Tags: Alternative Viewpoint Source Type: research

Incidence of and Risk Factors for Severe Adverse Events in Elderly Patients Taking Angiotensin ‐Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers after an Acute Myocardial Infarction
ConclusionWe found a low incidence of ARF and hyperkalemia in elderly patients treated with ACEIs or ARBs after AMI hospitalization. However, a high rate of treatment discontinuation might prevent a higher rate of occurrence of these events. Long‐term careful monitoring of severe adverse events and timely discontinuation of ACEIs or ARBs among elderly patients with advancing age and CKD after an AMI is warranted in clinical practice.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 23, 2017 Category: Drugs & Pharmacology Authors: Gang Fang, Izabela E Annis, Joel F Farley, Nirosha Mahendraratnam, Ryan P Hickson, Til St ürmer, Jennifer G Robinson Tags: Original Research Article Source Type: research

ACCP Virtual Poster Symposium
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 18, 2017 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 18, 2017 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Fidaxomicin versus Vancomycin as a First ‐Line Treatment for Clostridium difficile‐Associated Diarrhea (CDAD) in Specific Patient Populations: A Pharmacoeconomic Evaluation
ConclusionsFidaxomicin as first‐line CDAD therapy is associated with similar total costs as compounded vancomycin oral solution in the general population. In elderly and renally‐impaired patients, slight increases in hospital cost were observed with fidaxomicin therapy, while in patients with cancer or concomitant antibiotic use hospital cost savings were observed.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 17, 2017 Category: Drugs & Pharmacology Authors: Kelly R. Reveles, Jennifer L. Backo, Frank A. Corvino, Marko Zivkovic, Kelly C. Broderick Tags: Original Research Article Source Type: research

Impact of Insulin Detemir Administration Time on Hypoglycemia Rates in Hospitalized Patients
Abstract Study ObjectiveTo determine if insulin detemir administration time affects the frequency of hypoglycemia (blood glucose level
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 13, 2017 Category: Drugs & Pharmacology Authors: Jennifer L. Grelle, Sydney N. Kutter, Megan E. Giruzzi, John C. Tawwater Tags: Original Research Article Source Type: research

Comparison of weight ‐based dosing strategies for intravenous immunoglobulin in patients with hematologic malignancies
ConclusionNo differences in infection rate and IgG level response were identified when a precision‐dosing strategy was used. Implementation of an IVIG precision‐dosing strategy provided institutional cost savings.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 13, 2017 Category: Drugs & Pharmacology Authors: Sarah E. Stump, Allison J. Schepers, Alexis R. Jones, Maurice D. Alexander, Jessica J. Auten Tags: Original Research Article Source Type: research

Impact of Ketamine Use on Adjunctive Analgesic and Sedative Medications in Critically Ill Trauma Patients
ConclusionsAlthough the use of ketamine in critically ill, mechanically ventilated, adult trauma patients was associated with decreased opioid use, it was also associated with increased use of dexmedetomidine and ziprasidone to achieve and maintain sedation. Further examination of clinical outcomes associated with these differences in drug use in a larger population of trauma patients is warranted before routine use of ketamine for analgesia and sedation can be recommended.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 10, 2017 Category: Drugs & Pharmacology Authors: Kaitlin A. Pruskowski, Kelly Harbourt, Mehrnaz Pajoumand, Sai ‐Ho Jason Chui, H. Neal Reynolds Tags: Original Research Article Source Type: research

A Pharmacist ‐Led Program to Evaluate and Reduce Polypharmacy and Potentially Inappropriate Prescribing in Older, HIV‐Positive Patients
ConclusionsResults suggest that targeting individuals with 11 or more chronic medications would have the highest yield and greatest impact. Pharmacist‐led review of medication prescribing employing Beers and STOPP criteria revealed a large number of PIP, many amenable to immediate clinical pharmacist intervention.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 10, 2017 Category: Drugs & Pharmacology Authors: I R McNicholl, M Gandhi, C Bradley Hare, M Greene, E Pierluissi Tags: Original Research Article Source Type: research

A comparison of insulin doses for the treatment of hyperkalemia in patients with renal insufficiency
ConclusionIn patients with renal insufficiency and hyperkalemia, 5 units of insulin reduced serum potassium to the same extent as 10 units of insulin, but with a lower rate of hypoglycemia. Further controlled studies are needed to confirm these findings.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 4, 2017 Category: Drugs & Pharmacology Authors: Heather LaRue, Gary Daniel Peksa, Shital Shah Tags: Original Research Article Source Type: research

Renal Transplant Acute Rejection with Lower Mycophenolate Mofetil Dosing and Proton Pump Inhibitors or Histamine ‐2 Receptor Antagonists
ConclusionDespite taking lower MMF doses than previously studied, subjects on a PPI compared to an H2RA were not at increased risk of acute rejection within 1‐year post‐transplant.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 4, 2017 Category: Drugs & Pharmacology Authors: Kajal S. Patel, Brian R. Stephany, Julie F. Barnes, Seth R. Bauer, Michael L. Spinner Tags: Original Research Article Source Type: research

Trowels and Tribulations: Review of Antimicrobial ‐Impregnated Bone Cements in Prosthetic Joint Surgery
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 4, 2017 Category: Drugs & Pharmacology Authors: Vasilios Athans, Michael P. Veve, Susan L. Davis Tags: Review of Therapeutics Source Type: research

Multiple ‐Dose Oritavancin Evaluation in a Retrospective Cohort of Patients With Complicated Infections
ConclusionsOff‐label oritavancin use may be a safe and effective alternative to daily antibiotic infusions to treat complicated infectious disease processes. This study is limited by small sample size and retrospective design, but provides information on using oritavancin in these complex gram‐positive infections.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 1, 2017 Category: Drugs & Pharmacology Authors: Lucas T Schulz, Emily Dworkin, Jennifer Dela ‐Pena, Warren E. Rose Tags: Brief Report Source Type: research

Strength in Amalgamation: Newer Combination Agents for HIV and Implications for Practice
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 1, 2017 Category: Drugs & Pharmacology Authors: Christopher McCoy, Melissa Badowski, Elizabeth Sherman, Rustin Crutchley, Ethan Smith, Daniel B. Chastain, Tags: Review of Therapeutics Source Type: research

What is Old is New Again: Delafloxacin, a Modern Fluoroquinolone
Abstract Delafloxacin is a new fluoroquinolone antimicrobial approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) in adults using dosage regimens of 300 mg intravenously every 12 hours, 450 mg orally every 12 hours, or switching from intravenous to oral regimens for a 5 to 14 day treatment duration. Dosage adjustments in patients with severe renal dysfunction (estimated glomerular filtration rate [eGFR] = 15‐29 ml/min/1.73m2) are not required for oral doses but should be decreased to 200 mg intravenously every 12 hours in patients requiring parenteral therapy. Due to insufficient dat...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 1, 2017 Category: Drugs & Pharmacology Authors: Jonathan C. Cho, Matthew P. Crotty, Bryan P. White, Marylee V. Worley Tags: Review of Therapeutics Source Type: research

Empirical Vancomycin Dosing in Pediatric Patients with Congenital Heart Disease and the Impact of Cardiopulmonary Bypass on Trough Concentrations
ConclusionsEmpirical vancomycin dosing to achieve troughs of 8–15 μg/dl in patients with congenital heart disease without evidence of significant acute kidney injury should be 30 mg/kg/day for neonates, 35–40 mg/kg/day for infants, and 45 mg/kg/day in children, with adjustments required for patients with elevated creatinine or significant aortic cross‐clamp time. The receipt and duration of CPB did not affect total daily vancomycin dose requirements. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 28, 2017 Category: Drugs & Pharmacology Authors: Christopher A. Thomas, Amy Picone, Sharad Menon, Brigham C. Willis Tags: Original Research Article Source Type: research

The Effect of Morphine Dosing on Length of Stay in Neonatal Abstinence Syndrome – An Alternative Viewpoint
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Kirsten H. Ohler, Jennifer T. Pham Tags: Alternative Viewpoints Source Type: research

Influence of Kidney Transplant Status on Warfarin Dose, Anticoagulation Control, and Risk of Hemorrhage
ConclusionKTRs initiating warfarin require lower doses and closer monitoring to optimize anticoagulation therapy. Additional studies are needed to confirm these findings.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Megan V. Yanik, Marguerite R. Irvin, T.Mark Beasley, Pamala A. Jacobson, Bruce A. Julian, Nita A. Limdi Tags: Original Research Article Source Type: research

Early administration of adjuvant β‐lactam therapy in combination with vancomycin among patients with methicillin‐resistant Staphylococcus aureus bloodstream infection: a retrospective, multicenter analysis
Abstract Study ObjectiveTo determine whether early administration of adjuvant β‐lactam in combination with vancomycin (COMBO) affects clinical outcomes compared to standard vancomycin therapy alone (STAN) among patients with methicillin‐resistant Staphylococcus aureus (MRSA) bloodstream infection. DesignRetrospective, multicenter cohort study. SettingFive academic or community hospitals throughout the United States. PatientsAdults with MRSA bloodstream infections treated with vancomycin (≥72 hours) ± an intravenous β‐lactam (≥48 hours) initiated within 24 hours of initiating vancomycin. Measure...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Anthony M. Casapao, David M. Jacobs, Dana R. Bowers, Nicholas D. Beyda, Thomas J. Dilworth, Tags: Original Research Article Source Type: research

Pharmacovigilance Assessment of Immune ‐Mediated Reactions Reported for Checkpoint Inhibitor Cancer Immunotherapies
ConclusionCancer immunotherapy with CPI is associated with a multitude of IMR, especially colitis and pneumonitis. Individual CPI had variable IMR signals, and pharmacoepidemiologic studies are required to evaluate the identified signals.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Ayad K. Ali, David E. Watson Tags: Original Research Article Source Type: research

Efficacy and effectiveness of RSV immunoprophylaxis in children with cystic fibrosis – an unsolved question with more to be asked
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Rees L. Lee, Rebekah F. Brown, Tebeb Gebretsadik, Tina V. Hartert, William D. Dupont, Pingsheng Wu Tags: Alternative Viewpoints Source Type: research

A Review of Immune Checkpoint Inhibitors for the Management of Locally Advanced or Metastatic Urothelial Carcinoma
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 26, 2017 Category: Drugs & Pharmacology Authors: Kirollos S. Hanna Tags: Review of Therapeutics Source Type: research

Contemporary Time Trends in Use of Antiplatelet Agents Among Patients with Acute Coronary Syndrome and Comorbid Diabetes Mellitus or Chronic Kidney Disease
ConclusionsWe observed lower or similar use of prasugrel and ticagrelor compared with clopidogrel in patients with ACS and comorbid DM and/or CKD. Given the potential for worse clinical outcomes with clopidogrel in these patients, our findings highlight the need to investigate the implications of these trends on recurrent ACS and bleeding events. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 19, 2017 Category: Drugs & Pharmacology Authors: Rishi J. Desai, Julia Spoendlin, Helen Mogun, Joshua J. Gagne Tags: Brief Report Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 15, 2017 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Eteplirsen for the Treatment of Duchenne Muscular Dystrophy: Quality of Evidence Concerns —an Alternative Viewpoint
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 12, 2017 Category: Drugs & Pharmacology Authors: Adriane N. Irwin, Megan C. Herink Tags: Alternative Viewpoint Source Type: research

Thrombolysis for Massive Pulmonary Embolism in Pregnancy
This article summarizes the risks for thromboembolism in pregnancy, compares and contrasts thrombolytic agents in this setting, and provides a recommendation for management of massive PE in this special population. Overall, reports suggest that the use of these agents is associated with beneficial outcomes and relatively low risk of complications. The quality of this evidence is low and clinical judgment is required to assess individual patients for risks versus benefits of thrombolysis. This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 11, 2017 Category: Drugs & Pharmacology Authors: Mojdeh S. Heavner, Min Zhang, Chelsea E. Bast, Lindsey Parker, Rachel F. Eyler Tags: Review of Therapeutics Source Type: research

Alteplase for Acute Ischemic Stroke after Heparin Reversal with Protamine: A Case Report and Review
We describe the first reported case of a patient receiving full‐dose intravenous (IV) alteplase for AIS after heparin reversal with protamine. A 73‐year‐old man presented with AIS. He was treated with IV heparin, tirofiban, loading‐dose prasugrel, and aspirin before percutaneous coronary intervention (PCI) for placement of a right coronary artery stent. One hour following PCI, he abruptly developed left hemiparesis and dysphagia. The National Institutes of Health Stroke Scale was 12, and activated partial thromboplastin time (aPTT) was longer than 150 seconds. Head computed tomography (CT) showed no acute path...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 4, 2017 Category: Drugs & Pharmacology Authors: Gabriel V. Fontaine, Shawn M. Smith Tags: Case Report Source Type: research

Intravenous ‐only or intravenous transitioned to oral antimicrobials for Enterobacteriaceae‐associated bacteremic urinary tract infection
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 4, 2017 Category: Drugs & Pharmacology Authors: Krista L. Rieger, John A. Bosso, Shawn H. MacVane, Zachary Temple, Amy Wahlquist, Nicole Bohm Tags: Brief Report Source Type: research

Observational Comparative Effectiveness of Pharmaceutical Treatments for Obesity within the Veterans Health Administration
Abstract Study ObjectiveTo compare the effectiveness of weight‐management medications used to assist with weight loss in real‐world clinical practice in the Veterans Health Administration (VHA). DesignRetrospective, multicenter, observational cohort study. Data SourceNational VA Corporate Data Warehouse. PatientsA total of 66,035 VA patients aged 18 years or older with a body mass index of 25 kg/m2 or greater who had an initial fill for a study medication (orlistat [6153 patients], phentermine [304 patients], lorcaserin [298 patients], or phentermine‐topiramate extended release [233 patients]) or participation in the...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 1, 2017 Category: Drugs & Pharmacology Authors: Ted R. Grabarczyk Tags: Original Research Article Source Type: research