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Hydroxyurea treatment for sickle cell anemia during pregnancy and lactation: current evidence and knowledge gaps
AbstractSickle cell anemia (SCA) is a life-threatening genetic condition contributing to high-risk pregnancies affecting both the mother and fetus. With improved management of children with SCA, this life-threatening hematological disorder has evolved into a chronic disease of adults, and consequently parenthood has now become a possible and important life goal for many patients. Providing continuous management with healthy red blood cell function and avoiding SCA-associated complications, such as pain crises, acute chest syndrome, and stroke, are crucial for a healthy pregnancy. Despite its excellent safety profile in non...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 17, 2023 Category: Drugs & Pharmacology Authors: Min Dong, Russell E. Ware, Andr é Dallmann, Alexander A. Vinks Tags: REVIEW Source Type: research

Accelerated approval drug labels often lack information for clinical decision ‐making
ConclusionLabels for accelerated approved clinical indications that do not yet have full approval should be revised to include the information required in the FDA guidance to help guide clinical decision-making. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 16, 2023 Category: Drugs & Pharmacology Authors: Jeromie Ballreich, Mariana Socal, Charles L. Bennett, Andrew Xuan, Antonio Trujillo, Gerard Anderson Tags: RESEARCH ARTICLE Source Type: research

Comparison of nimodipine formulations and administration techniques via enteral feeding tubes in patients with aneurysmal subarachnoid hemorrhage: A multicenter retrospective cohort study
ConclusionsOur findings suggest that enteral nimodipine formulations and administration techniques might not be equivalent. This could be attributed to excipient differences, inconsistency and inaccuracy in medication administration, and altered nimodipine bioavailability. Further studies are needed. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 16, 2023 Category: Drugs & Pharmacology Authors: Sherif Hanafy Mahmoud, Fatma R. Hefny, Nicholas G. Panos, Laura Delucilla, Zinquon Ngan, Marc M. Perreault, Leslie A. Hamilton, A. Shaun Rowe, Pamela L. Buschur, Jocelyn Owusu ‐Guha, Sulaiman Almohaish, Melissa Sandler, Michael J. Armahizer, Tags: RESEARCH ARTICLE Source Type: research

Dosing implications for liposomal amphotericin B in pregnancy
We describe the use of LAmB for a pregnant patient with mucocutaneous leishmaniasis (MCL) using a dosing strategy of 5 mg/kg/day for days 1–7 using ideal body weight followed by 4 mg/kg weekly using adjusted body weight. We reviewed the literature for LAmB dosing strategies, particularly dosing weight, in pregnancy. Of the 143 cases identified in 17 studies, only one reported a dosing weight, in which ideal b ody weight was used. Five Infectious Diseases Society of America guidelines in total discussed the use of amphotericin B in pregnancy but no guidelines included recommendations for dosing weight. This review de...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 16, 2023 Category: Drugs & Pharmacology Authors: Niamh O'Grady, Matthew Davis, Dayna McManus, Jeffrey Topal, Marwan M. Azar, Neima Briggs Tags: REVIEW Source Type: research

Antimicrobial susceptibility testing: An updated primer for clinicians in the era of antimicrobial resistance: Insights from the Society of Infectious Diseases Pharmacists
AbstractAntimicrobial susceptibility testing (AST) is a critical function of the clinical microbiology laboratory and is essential for optimizing care of patients with infectious diseases, monitoring antimicrobial resistance (AMR) trends, and informing public health initiatives. Several methods are available for performing AST including broth microdilution, agar dilution, and disk diffusion. Technological advances such as the development of commercial automated susceptibility testing platforms and the advent of rapid diagnostic tests have improved the rapidity, robustness, and clinical application of AST. Numerous accredit...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 16, 2023 Category: Drugs & Pharmacology Authors: Eric Wenzler, Mira Maximos, Tomefa E. Asempa, Lauren Biehle, Audrey N. Schuetz, Elizabeth B. Hirsch Tags: SPECIAL ARTICLE Source Type: research

Hydroxyurea treatment for sickle cell anemia during pregnancy and lactation: current evidence and knowledge gaps
AbstractSickle cell anemia (SCA) is a life-threatening genetic condition contributing to high-risk pregnancies affecting both the mother and fetus. With improved management of children with SCA, this life-threatening hematological disorder has evolved into a chronic disease of adults, and consequently parenthood has now become a possible and important life goal for many patients. Providing continuous management with healthy red blood cell function and avoiding SCA-associated complications, such as pain crises, acute chest syndrome, and stroke, are crucial for a healthy pregnancy. Despite its excellent safety profile in non...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 16, 2023 Category: Drugs & Pharmacology Authors: Min Dong, Russell E. Ware, Andr é Dallmann, Alexander A. Vinks Tags: REVIEW Source Type: research

Authors response to critique of “angiotensin‐converting enzyme inhibitors reduce community‐acquired pneumonia hospitalization and mortality”
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 14, 2023 Category: Drugs & Pharmacology Authors: Donald P. Alexander, Nancy A. Nickman, Anindit Chhibber, Gregory Stoddard, Joseph E. Biskupiak, Mark A. Munger Tags: LETTER TO THE EDITOR Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 14, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Critique of “Angiotensin‐converting enzyme inhibitors reduce community‐acquired pneumonia hospitalization and mortality”
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 14, 2023 Category: Drugs & Pharmacology Authors: Qoua L. Her, Neil Dhopeshwarkar, Timothy Feeney Tags: LETTER TO THE EDITOR Source Type: research

Review of novel β‐lactams and β‐lactam/β‐lactamase inhibitor combinations with implications for pediatric use
AbstractAntimicrobial resistance continues to surmount increasing concern globally, and treatment of difficult-to-treat (DTR)Pseudomonas aeruginosa, carbapenem-resistant (CR)Acinetobacter baumannii (CRAB), and CR Enterobacterales (CRE) remains a challenge for clinicians. Although previously rare, the incidence of multidrug-resistant (MDR) and CR infections in pediatric patients has increased drastically in the last decade and is associated with increased morbidity and mortality. To combat this issue, 14 novel antibiotics, including three β-lactam/novel β-lactamase inhibitor combinations (βL-βLIs) and two novel β-lacta...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 12, 2023 Category: Drugs & Pharmacology Authors: Katie B. Olney, Jenni K. Thomas, Wes M. Johnson Tags: REVIEW Source Type: research

Safety of elexacaftor/tezacaftor/ivacaftor dose reduction: Mechanistic exploration through physiologically based pharmacokinetic modeling and a clinical case series
ConclusionAlbeit in a small number of patients, this study provides evidence that reduced ETI doses in pwCF who have experienced AEs may be effective. The PBPK models enable exploration of a mechanistic basis for this finding by simulating target tissue concentrations of ETI that can be compared with drug efficacyin vitro. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 12, 2023 Category: Drugs & Pharmacology Authors: Eunjin Hong, Regina Li, Alan Shi, Lisa M. Almond, Joshua Wang, Amin Z. Khudari, Soumar Haddad, Sarkis Sislyan, Marissa Angelich, Peter S. Chung, Adupa P. Rao, Paul M. Beringer Tags: RESEARCH ARTICLE Source Type: research