Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Steno ‐sphere: Navigating the Enigmatic World of Emerging Multidrug‐Resistant Stenotrophomonas maltophilia
This article provides a review of available literature forS. maltophilia infection management focused on related epidemiology, resistance mechanisms, identification, susceptibility testing, antimicrobial PK/PD, and emerging therapeutic strategies. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 18, 2023 Category: Drugs & Pharmacology Authors: Ashlan J. Kunz Coyne, Shelbye Herbin, Kaylee Caniff, Michael J. Rybak Tags: REVIEW Source Type: research

A systematic review of opioid use and multimodal strategies in solid organ transplant recipients and living donors
AbstractThe opioid epidemic has impacted analgesia in the postoperative period for solid organ transplant (SOT) donors and recipients. However, optimal pain management and opioid stewardship strategies have not been identified across this unique population. The purpose of this systematic review was to evaluate the impact of perioperative opioid use and to describe multimodal analgesic strategies to reduce opiate use in SOT recipients and living donors. A systematic review was conducted. Electronic searches were performed in Medline, Embase, Google Scholar, and Web of Science through December 31, 2021. Title and abstracts w...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 17, 2023 Category: Drugs & Pharmacology Authors: Heather L. Kutzler, Alicia B. Lichvar, David Quan, Lyndsey J. Bowman, Adam Diamond, Christina Doligalski, Tina Griffin, Jennifer Melaragno, Helen Sweiss, James Fleming Tags: REVIEW Source Type: research

Precision ‐based approaches to delirium in critical illness: A narrative review
AbstractDelirium occurs in critical illness and is associated with poor clinical outcomes, having a longstanding impact on survivors. Understanding the complexity of delirium in critical illness and its deleterious outcome has expanded since early reports. Delirium is a culmination of predisposing and precipitating risk factors that result in a transition to delirium. Known risks range from advanced age, frailty, medication exposure or withdrawal, sedation depth, and sepsis. Because of its multifactorial nature, different clinical phenotypes, and potential neurobiological causes, a precise approach to reducing delirium in ...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 17, 2023 Category: Drugs & Pharmacology Authors: Melissa J. Ankravs, Cathrine A. McKenzie, Michael T. Kenes Tags: REVIEW Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 16, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Current clinical pharmacology issues in pregnancy and pediatrics
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 16, 2023 Category: Drugs & Pharmacology Authors: C. Lindsay DeVane Tags: EDITORIAL Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 16, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Current therapies and challenges for the treatment of Staphylococcus aureus biofilm ‐related infections
AbstractStaphylococcus aureus is a major cause of nosocomial and community-acquired infections and contributes to significant increase in morbidity and mortality especially when associated with medical devices and in biofilm form. Biofilm structure provides a pathway for the enrichment of resistant and persistent phenotypes ofS.  aureus leading to relapse and recurrence of infection. Minimal diffusion of antibiotics inside biofilm structure leads to heterogeneity and distinct physiological activity. Additionally, horizontal gene transfer between cells in proximity adds to the challenges associated with eradication of bio...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 15, 2023 Category: Drugs & Pharmacology Authors: Nikki N. Tran, Taylor Morrisette, Sarah C. J. Jorgensen, Jos é M. Orench‐Benvenutti, Razieh Kebriaei Tags: REVIEW Source Type: research

Neurokinin ‐1 Receptor Antagonists for the Prevention of Postoperative Nausea and Vomiting
AbstractDespite the availability of several classes of antiemetics, postoperative nausea and vomiting (PONV) remains a substantial burden for patients following surgery, resulting in patient dissatisfaction and prolonged stays in post-anesthesia care units and ultimately increasing the cost of care. Enhanced recovery protocols and PONV management guidelines are now centered on the assessment of the individual patient's risk for developing PONV, as well as multimodal prophylaxis using antiemetics targeting different mechanisms of action. Over the last two decades, the neurokinin-1 receptor (NK1R) has emerged as a therapeuti...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 12, 2023 Category: Drugs & Pharmacology Authors: Tricia A. Meyer, Ashraf S. Habib, Deborah Wagner, Tong J. Gan Tags: REVIEW Source Type: research

Evaluation of the change in efficacy of erenumab when used long ‐term for migraine prevention after initial established benefit in a Veteran population
ConclusionsA decrease in efficacy with long-term use of erenumab was observed for the majority of patients evaluated in this analysis. This suggests that patients with initial benefit on lower dose erenumab should be monitored for change to effectiveness. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 10, 2023 Category: Drugs & Pharmacology Authors: Alison W. Martin, Mara Cubellis Tags: RESEARCH ARTICLE Source Type: research

From Bottle to Beside: Implementation Considerations and Antimicrobial Stewardship Considerations for Bloodstream Infection Rapid Diagnostic Testing
AbstractAntimicrobial stewardship (AMS) programs have been quick to adopt novel molecular rapid diagnostic technologies (mRDTs) for bloodstream infections (BSIs) to improve antimicrobial management. As such, most of the literature demonstrating clinical and economic benefits of mRDTs for BSI is in the presence of active AMS intervention. Leveraging mRDTs to improve antimicrobial therapy for BSI is increasingly integral to AMS program activities. This narrative review discusses available and future mRDTs, the relationship between the clinical microbiology laboratory and AMS programs, and practical considerations for optimiz...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 9, 2023 Category: Drugs & Pharmacology Authors: Jonathan S. Lapin, Richard Smith, Krutika M. Hornback, J. Kristie Johnson, Kimberly C. Claeys Tags: REVIEW Source Type: research

A Systematic Review of Opioid Use and Multimodal Strategies in Solid Organ Transplant Recipients and Living Donors
Conclusions 1.1.1.Opioids are associated with select negative outcomes in post-transplant recipients. To minimize their use while also maintaining appropriate analgesia, multimodal pain regimens should be considered in SOT recipients and donors. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 9, 2023 Category: Drugs & Pharmacology Authors: Heather L. Kutzler, Alicia B. Lichvar, David Quan, Lyndsey J. Bowman, Adam Diamond, Christina Doligalski, Tina Griffin, Jennifer Melaragno, Helen Sweiss, James Fleming Tags: REVIEW Source Type: research

Comparative adherence trajectories of oral disease ‐modifying agents in multiple sclerosis
ConclusionsTER and DMF were associated with poorer adherence trajectories than FIN. More research is needed to evaluate the clinical implications of these adherence trajectories of oral DMAs to optimize the management of MS. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 9, 2023 Category: Drugs & Pharmacology Authors: Jagadeswara Rao Earla, Jieni Li, George J. Hutton, Michael L. Johnson, Rajender R. Aparasu Tags: RESEARCH ARTICLE Source Type: research

Hydrocortisone vs. Vasopressin for the Management of Adults Patients with Septic Shock Refractory to Norepinephrine: A Multicenter Retrospective Study
ConclusionAddition of hydrocortisone to norepinephrine was associated with a lower 28-day mortality in patients with septic shock, compared to the addition of vasopressin. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 7, 2023 Category: Drugs & Pharmacology Authors: Steven Kulesza, Lindsey Gignac, C. Allis Colvin, Skyler Boll, Christopher Giuliano, Bradley Haan, Bryan Allen, Mary M. Perez, Monica Allen, Stephanie B. Edwin Tags: RESEARCH ARTICLE Source Type: research