Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 12, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Comment on “Hydrocortisone versus vasopressin for the management of adult patients with septic shock refractory to norepinephrine: A multicenter retrospective study”
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 12, 2023 Category: Drugs & Pharmacology Authors: Patrick M. Wieruszewski, Seth R. Bauer Tags: LETTER TO THE EDITOR Source Type: research

Response to comment on “Hydrocortisone versus vasopressin for the management of adult patients with septic shock refractory to norepinephrine: A multicenter retrospective study”
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 12, 2023 Category: Drugs & Pharmacology Authors: Steven Kulesza, Lindsey Gignac, C. Allis Colvin, Skyler Boll, Christopher Giuliano, Bradley Haan, Bryan Allen, Mary M. Perez, Monica Allen, Stephanie B. Edwin Tags: LETTER TO THE EDITOR Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 12, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Comment on “Hydrocortisone versus vasopressin for the management of adult patients with septic shock refractory to norepinephrine: A multicenter retrospective study”
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 12, 2023 Category: Drugs & Pharmacology Authors: Patrick M. Wieruszewski, Seth R. Bauer Tags: LETTER TO THE EDITOR Source Type: research

Response to comment on “Hydrocortisone versus vasopressin for the management of adult patients with septic shock refractory to norepinephrine: A multicenter retrospective study”
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 12, 2023 Category: Drugs & Pharmacology Authors: Steven Kulesza, Lindsey Gignac, C. Allis Colvin, Skyler Boll, Christopher Giuliano, Bradley Haan, Bryan Allen, Mary M. Perez, Monica Allen, Stephanie B. Edwin Tags: LETTER TO THE EDITOR Source Type: research

Anticoagulant drug –drug interactions with cannabinoids: A systematic review
AbstractThis systematic review evaluates the extent to which the effect of anticoagulants may be altered in the presence of cannabinoids. The following databases were searched: EMBASE, PubMed, Web of Science, Scopus, PscycINFO, and CINAHL from database inception through May 2023. Search terms included cannabis AND anticoagulant AND drug interactions and related keywords. The major outcome was hemorrhage or thrombosis and if available the relative change in quantitative intensity of anticoagulation after cannabinoid exposure. The search generated 959 citations. After the removal of 440 duplicates, 519 citations were screene...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 11, 2023 Category: Drugs & Pharmacology Authors: Maureen A. Smythe, Wendy Wu, Candice L. Garwood Tags: REVIEW Source Type: research

Vancomycin Removal and Pharmacokinetics During Accelerated Venovenous Hemofiltration
ConclusionVancomycin is significantly removed by AVVH, which requires supplemental dosing after completion of the AVVH session to maintain desired serum concentrations. Therapeutic drug monitoring of vancomycin serum concentrations is recommended for patients undergoing AVVH. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 6, 2023 Category: Drugs & Pharmacology Authors: Natasha Lopez, Michael Griggs, Jonathan H. Sin, Russel J. Roberts, Andrew S. Allegretti Tags: RESEARCH ARTICLE Source Type: research

Fluid resuscitation and relation to respiratory support escalation in patients with and without pulmonary hypertension with sepsis
ConclusionsDuring initial sepsis management when compared with patients without PH, patients with PH had increased instances of respiratory support escalation within 72  h of sepsis time zero despite lower fluid resuscitation volumes. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 2, 2023 Category: Drugs & Pharmacology Authors: Mary J. Fronrath, Laura Hencken, Carolyn R. Martz, Bryan Kelly, Zachary R. Smith Tags: RESEARCH ARTICLE Source Type: research

Kidney Function as a Key Driver of the Pharmacokinetic Response to High ‐Dose L‐Carnitine in Septic Shock
ConclusionsHigh-dose L-carnitine supplementation is well-described by a two-compartment population PK model in patients with septic shock. Kidney function estimates that leverage cystatin C provided superior model fit. Future investigations into high-dose L-carnitine supplementation should consider baseline metabolic status and dose adjustments based on renal function over a fixed or weight-based dosing paradigm. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 30, 2023 Category: Drugs & Pharmacology Authors: Theodore S. Jennaro, Michael A. Puskarich, Thomas L. Flott, Laura A. McLellan, Alan E. Jones, Manjunath P. Pai, Kathleen A. Stringer Tags: RESEARCH ARTICLE Source Type: research

Developing precision ‐based multidisciplinary pharmacotherapy management plans in the critically ill
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 29, 2023 Category: Drugs & Pharmacology Authors: William E. Dager Tags: INVITED COMMENTARY Source Type: research

Metabolomic analysis of serum samples from a clinical study on ipragliflozin and metformin treatment in Japanese patients with type 2 diabetes: Exploring human metabolites associated with visceral fat reduction
ConclusionsMetabolites that may affect visceral fat reduction were detected in the ipragliflozin group. Studies are required to further elucidate the underlying mechanisms. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 29, 2023 Category: Drugs & Pharmacology Authors: Ayano Tsukagoshi ‐Yamaguchi, Masaya Koshizaka, Ryoichi Ishibashi, Ko Ishikawa, Takahiro Ishikawa, Mayumi Shoji, Shintaro Ide, Kana Ide, Yusuke Baba, Ryo Terayama, Akiko Hattori, Minoru Takemoto, Yasuo Ouchi, Yoshiro Maezawa, Koutaro Yokote Tags: RESEARCH ARTICLE Source Type: research