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Renal Function Estimating Equations Performance During Pregnancy and Postpartum
ConclusionThe new CKD-EPI 2021 equation did not perform well during pregnancy. When 24-hour CrCls are not available during pregnancy, CG (PPW or ABW) performed the best overall, whereas at 3 months postpartum, 100/SCr performed the best overall. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 7, 2023 Category: Drugs & Pharmacology Authors: Dina E. Zaghloul, Rachel Ryu, Bryan Kestenbaum, Chase Smith, Emily Fay, Mary F. Hebert Tags: RESEARCH ARTICLE Source Type: research

Patient Selection for Mineralocorticoid Receptor Antagonists in Heart Failure with Mildly Reduced or Preserved Ejection Fraction
AbstractThe mineralocorticoid receptor is a steroid hormone receptor that contributes to cardiac tissue inflammation, fibrosis, and cardiac dysfunction and plays an important role in the pathophysiology of heart failure. Mineralocorticoid receptor antagonists (MRA) are an important component of guideline-directed medical therapy for heart failure to improve clinical outcomes. Clinical trial evidence in heart failure with reduced ejection fraction (HFrEF) informed a strong guideline recommendation for use of MRA in symptomatic patients, barring contraindications. In heart failure with mildly reduced ejection fraction (HFmrE...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 6, 2023 Category: Drugs & Pharmacology Authors: Orly Vardeny, Hailee Houle Tags: REVIEW Source Type: research

The incidence of cytomegalovirus and BK polyomavirus infections in kidney transplant patients receiving mTOR inhibitors: a systematic review and meta ‐analysis
ConclusionThe mTOR inhibitor-based regimen is an attractive alternative with lower risk of CMV and BKPyV infections in kidney transplant recipients. The combination regimen is more appropriate and acceptable than the mTOR inhibitor monotherapy-based regimen. Early introduction of mTOR inhibitors is recommended, although it is worth noting that attention should be paid to wound healing when mTOR inhibitors are introduced early. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 1, 2023 Category: Drugs & Pharmacology Authors: Chen Ye, Jingjie Li, Xiaoman Liu, Jiajia Yan, Jie Chen, Changxi Wang, Min Huang, Xiao Chen, Kejing Tang, Pan Chen Tags: REVIEW Source Type: research

Personalized Antiseizure Medication Therapy in Critically Ill Adult Patients
AbstractPrecision medicine has the potential to have a significant impact on both drug development and patient care. It is crucial to not only provide prompt effective antiseizure treatment for critically ill patients after seizures start, but to also have a proactive mindset and concentrate on epileptogenesis and the underlying cause of the seizures or seizure disorder. Critical illness presents different treatment issues compared to the ambulatory population, which makes it challenging to choose the best antiseizure medications and to administer them at the right time and at the right dose. Since there is a paucity of in...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 31, 2023 Category: Drugs & Pharmacology Authors: Sulaiman Almohaish, Aaron M. Cook, Gretchen M. Brophy, Denise H. Rhoney Tags: REVIEW Source Type: research

Pharmacogenomics and Beyond! Customized Pharmacotherapy for Solid Organ Transplant Recipients
AbstractSolid organ transplant recipients are reliant on immunosuppressive drugs, which have a narrow therapeutic index, and are concurrently vulnerable to adverse drug events due to comorbidity burden and the complexity of their medication regimens. Urgent management of post-transplant complications often falls to the generalist clinician or critical care specialist. The purpose of this narrative review is to discuss innovations and bedside applications of pharmacogenomics and therapeutic drug monitoring applied to immunosuppression and agents frequently encountered in transplant recipients. Medication formulations will b...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 31, 2023 Category: Drugs & Pharmacology Authors: Adley Lemke, Jessica Wright, Heather May Tags: REVIEW Source Type: research

Reply to Comment on: Tacrolimus in the treatment of childhood nephrotic syndrome: Machine learning detects novel biomarkers and predicts efficacy
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 27, 2023 Category: Drugs & Pharmacology Authors: Xiaolan Mo, Xiujuan Chen, Huasong Zeng, Wei Zheng, Chifong Ieong, Huixian Li, Qiongbo Huang, Zichuan Xu, Jinlian Yang, Qianying Liang, Huiying Liang, Xia Gao, Min Huang, Jiali Li Tags: LETTER TO THE EDITOR Source Type: research

Management of Noncytotoxic Extravasation Injuries: A Focused Update on Medications, Treatment Strategies, and Peripheral Administration of Vasopressors and Hypertonic Saline
AbstractExtravasation is the leakage of intravenous solutions into surrounding tissues, which can be influenced by drug properties, infusion techniques, and patient-related risk factors. Although peripheral administration of vesicants may increase the risk of extravasation injuries, the time and resources required for central venous catheter placement may delay administration of time-sensitive therapies. Recent literature gathered from the growing use of peripheral vasopressors and hypertonic sodium suggests low risk of harm for initiating these emergent therapies peripherally, which may prevent delays and improve patient ...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 25, 2023 Category: Drugs & Pharmacology Authors: Sylvia S. Stefanos, Tyree H. Kiser, Robert MacLaren, Scott W. Mueller, Paul M. Reynolds Tags: REVIEW Source Type: research

Caring for Two in the ICU: Pharmacotherapy in the Critically Ill Pregnant Patient
AbstractSafe and thoughtful medication management of pregnant patients requiring intensive care unit (ICU) level of care is key to optimizing outcomes for both mother and fetus. Pregnancy induces physiologic alterations that closely mirror the changes expected in a critically ill patient. These changes can be predictable depending on the gestational age and trimester and will directly impact the pharmacokinetic profile of medications commonly used in the ICU; examples include decreased gastric emptying, increased blood and plasma volume, increased glomerular filtration, and increased cardiac output. When pregnant patients ...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 20, 2023 Category: Drugs & Pharmacology Authors: Mojdeh S. Heavner, Grace Erdman, Brooke Barlow, Mohammed Aldhaeefi, Michaelia Cucci, Claire C. Eng, W. Anthony Hawkins, Christina Rose, Susan E. Smith, Carolyn Magee Bell, Allison Lankford, Matthew Li, Melissa L. Thompson Bastin Tags: REVIEW Source Type: research

Personalizing Prevention: Advances in Pharmacotherapy for HIV Prevention
AbstractThe HIV epidemic continues to pose a significant burden on the health care system. Although the incidence of annual new infections is decreasing, health disparities persist and most new infections remain concentrated into different racial, ethnic, and minority groups. Pre-exposure prophylaxis (PrEP), which involves those at high-risk of acquiring HIV to take chronic medications to prevent acquisition of the virus, is key to preventing new HIV infections. The purpose of this article is to review medication therapies for PrEP and examine their role in personalizing PrEP in different patient populations. Additionally,...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 20, 2023 Category: Drugs & Pharmacology Authors: Marisa Brizzi, Elizabeth M. Sherman, Sarah B. Green, Diana N. Nowicki, Emily N. Drwiega, Melanie R. Nicol, Daniel B. Chastain, Eric G. Sahloff, William R. Truong, David Cluck, Melissa E. Badowski, Sarah M. Michienzi, Spencer H. Durham Tags: REVIEW Source Type: research