Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Transplacental methadone exposure and risk of Neonatal Opioid Withdrawal Syndrome
ConclusionsThe results suggest that methadone permeability across the blood-placental barrier may affect in utero exposure to methadone, and the maternal-to-cord methadone plasma concentration ratio could be a potential biomarker for predicting the need for NOWS treatment. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 14, 2023 Category: Drugs & Pharmacology Authors: Varsha Bhatt ‐Mehta, Xinyue Jing, Xinwen Wang, Hao‐Jie Zhu Tags: RESEARCH ARTICLE Source Type: research

Using population pharmacokinetics to optimize initial vancomycin dosing guidelines for neonates to treat sepsis caused by coagulase ‐negative staphylococcus
ConclusionA vancomycin dosing guideline derived from a validated popPK model in neonates with CoNS sepsis is recommended to improve target attainment. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 13, 2023 Category: Drugs & Pharmacology Authors: Erin Chung, Winnie Seto Tags: RESEARCH ARTICLE Source Type: research

Potential drug ‐drug interactions among U.S. adults treated with nirmatrelvir/ritonavir: A cross‐sectional study of the national covid cohort collaborative (N3C)
Conclusions and RelevanceOne in six of individuals receiving nirmatrelvir/ritonavir were at risk of a potential moderate or severe DDI, underscoring the importance of clinical and pharmacy systems to mitigate such risks. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 9, 2023 Category: Drugs & Pharmacology Authors: Xuya Xiao, Hemalkumar B. Mehta, Jill Curran, Brian T. Garibaldi, G. Caleb Alexander, National Covid Cohort Collaborative (N3C) Consortium Tags: RESEARCH ARTICLE Source Type: research

Anticoagulation strategies in patients with extracorporeal membrane oxygenation: a network meta ‐analysis and systematic review
ConclusionsCompared with UFH and Arg, Biv reduces the risk of thrombosis and appears to be a better choice for patients requiring ECMO. NM was associated with a reduced risk of in-hospital mortality. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 4, 2023 Category: Drugs & Pharmacology Authors: Jiale Chen, Guoquan Chen, Wenyi Zhao, Wenxing Peng Tags: REVIEW Source Type: research

Practical considerations for individualizing drug dosing in critically ill adults receiving renal replacement therapy
AbstractCritically ill patients with sepsis admitted to the intensive care unit (ICU) often present with or develop renal dysfunction requiring renal replacement therapy (RRT) in addition to antimicrobial therapy. While early and appropriate antimicrobials for sepsis have been associated with an increased probability of survival, adequate dosing is also required in these patients. Adequate dosing of antimicrobials refers to dosing strategies that achieve serum drug levels at the site of infection that are able to provide a microbiological and/or clinical response while avoiding toxicity from excessive antibiotic exposure. ...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 1, 2023 Category: Drugs & Pharmacology Authors: Salmaan Kanji, Claire Roger, Fabio Silvio Taccone, Laurent Muller Tags: REVIEW Source Type: research

Review of anticoagulation considerations in extracorporeal membrane oxygenation support
AbstractSince its first success in 1975 extracorporeal membrane oxygenation (ECMO) has been used with increasing frequency for pulmonary and cardiopulmonary bypass. Use in adults has increased exponentially since the early 2000s, but despite thousands of international cannulations using both veno-arterial (VA) and veno-venous (VV) ECMO, there are still significant hemocompatibility-related adverse events (HRAEs). Current management of anticoagulation has been based on the Extracorporeal Life Support Organization (ELSO) guidance published in 2014 with recent updates published in 2022. Despite this guidance, there is still l...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 31, 2023 Category: Drugs & Pharmacology Authors: Sydney D. T. Graboyes, Phillip S. Owen, Rickey A. Evans, Theodore J. Berei, Katarzyna M. Hryniewicz, Ian B. Hollis Tags: REVIEW Source Type: research

Practical considerations for individualizing drug dosing in critically ill adults receiving renal replacement therapy
AbstractCritically ill patients with sepsis admitted to the intensive care unit (ICU) often present with or develop renal dysfunction requiring renal replacement therapy (RRT) in addition to antimicrobial therapy. While early and appropriate antimicrobials for sepsis have been associated with an increased probability of survival, adequate dosing is also required in these patients. Adequate dosing of antimicrobials refers to dosing strategies that achieve serum drug levels at the site of infection that are able to provide a microbiological and/or clinical response, while avoiding toxicity from excessive antibiotic exposure....
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 26, 2023 Category: Drugs & Pharmacology Authors: Salmaan Kanji, Claire Roger, Fabio Silvio Taccone, Laurent Muller Tags: REVIEW Source Type: research

Fracture risk and opioid use in patients aged 17 –64 years: An analysis of administrative claims data
ConclusionsWe observed an increased fracture risk in all three higher categories of opioid exposure relative to the lowest category ( ⟨22 MME). The risk of a fracture should be considered in opioid treatment decisions. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 24, 2023 Category: Drugs & Pharmacology Authors: Jonathan Davis, Carri Casteel, Grant Brown, Ryan Carnahan Tags: RESEARCH ARTICLE Source Type: research

Empiric dosing strategies to predict lamotrigine concentrations during pregnancy
AbstractIntroductionMaintaining seizure control with lamotrigine is complicated by altered pharmacokinetics and existence of subpopulations in whom clearance increases or remains constant during pregnancy.ObjectiveOur objective was to characterize the potential for particular dosing scenarios to lead to increased seizure risk or toxicity.MethodsLamotrigine pharmacokinetic parameters obtained from our previous study were applied to a one-compartment model structure with subpopulations (75:25%) exhibiting different clearance changes. A single-patient simulation was conducted with typical pharmacokinetic parameter values from...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 23, 2023 Category: Drugs & Pharmacology Authors: Jessica M. Barry, Jacqueline A. French, Page B. Pennell, Ashwin Karanam, Cynthia L. Harden, Angela K. Birnbaum Tags: RESEARCH ARTICLE Source Type: research

Assessment of a Modified MINDS ‐based Protocol for Management of Alcohol Withdrawal Syndrome on an Inpatient Medical Service
ConclusionThe SDAWP has provided significant improvements in AWS management in our institution and may potentially serve as a template for wider use in other inpatient settings. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 21, 2023 Category: Drugs & Pharmacology Authors: Kevin M. Krcmarik, Benjamin J. Hulley, Jiayi Huang, Derek Juang, Brian Kwan, Peter Cadman, Charisma Urbiztondo, Christine Vo, Jaclyn Vargas, Ramin Motarjemi, Tarlan Moinizandi Tags: RESEARCH ARTICLE Source Type: research