Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Is reversal of anticoagulants necessary in neurologically intact traumatic intracranial hemorrhage?
ConclusionThis study found no difference in hospital outcomes between patients with minor traumatic ICH on oral anticoagulants who were neurologically intact that were reversed versus those who were not reversed. Further studies should continue to define the subset of traumatic ICH patients who may not require reversal of anticoagulation. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - January 2, 2024 Category: Drugs & Pharmacology Authors: Kelly Powell, William Curtiss III, Erin Sadek, Jason Hecht Tags: RESEARCH ARTICLE Source Type: research

Multicenter study evaluating target attainment of anti ‐Factor Xa levels using various enoxaparin prophylactic dosing practices in adult trauma patients
This study compared BMI-, TBW-, EBV-based, and hybrid enoxaparin dosing strategies at achieving target prophylactic anti-Factor Xa (anti-Xa) levels in trauma patients.This was a multicenter, retrospective review of adult trauma patients who received enoxaparin twice daily for VTE prophylaxis and had at least one appropriately timed anti-Xa level (collected 3 to 6 hours after the previous dose after three consecutive doses) from January 2017 through December 2020. Patients were excluded if the hospital-specific dosing protocol was not followed or if they had thermal burns with>  20% body surface area involvement. The p...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 27, 2023 Category: Drugs & Pharmacology Authors: Tyler Chanas, Gabrielle Gibson, Elizabeth Langenstroer, David J. Herrmann, Thomas W. Carver, Kaitlin Alexander, Sai Ho Jason Chui, Lisa Rein, Michael Ha, Kaylee M. Maynard, Kristen Bamberg, Mary O ’Keefe, Marisa O’Brien, Mariela Cardona G Tags: RESEARCH ARTICLE Source Type: research

Clinical outcomes associated with anti ‐Xa‐monitored enoxaparin for venous thromboembolism prophylaxis
ConclusionsThirty-day clinical outcomes in patients receiving enoxaparin for VTE prophylaxis were not improved by anti-Xa monitoring. Our results support current evidence-based guideline recommendations against anti-Xa monitoring for patients receiving enoxaparin for VTE prophylaxis. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 26, 2023 Category: Drugs & Pharmacology Authors: John A. Saunders, Sara R. Vazquez, Joseph A. Hill, Daniel M. Witt Tags: RESEARCH ARTICLE Source Type: research

Real world study on elexacaftor ‐tezacaftor‐ivacaftor impact on cholesterol levels in adults with cystic fibrosis
ConclusionIn this real-world cohort of PwCF, cholesterol parameters increased after initiation with ETI therapy. Further consideration may need to be given for PwCF in regards to screening for cardiometabolic risk factors as PwCF age as well as the potential need for cholesterol-lowering therapies. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 25, 2023 Category: Drugs & Pharmacology Authors: Kevin Lonabaugh, Galvin Li, Rhonda List, Reyna Huang, Amber James, Andrew Barros, Lindsay Somerville, Dana Albon Tags: RESEARCH ARTICLE Source Type: research

Is Reversal of Anticoagulants Necessary in Neurologically Intact Traumatic Intracranial Hemorrhage?
ConclusionThis study found no difference in hospital outcomes between patients with minor traumatic ICH on oral anticoagulants who were neurologically intact that were reversed versus those who were not reversed. Further studies should continue to define the subset of traumatic ICH patients who may not require reversal of anticoagulation. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 23, 2023 Category: Drugs & Pharmacology Authors: Kelly Powell, William Curtiss III, Erin Sadek, Jason Hecht Tags: RESEARCH ARTICLE Source Type: research

Identification of Risk Factors Associated with Acute Kidney Injury in Patients Taking Sodium ‐Glucose Cotransporter‐2 Inhibitors
ConclusionsThe transient eGFR decline with SGLT2 inhibitor initiation should be expected and is generally not an indication to discontinue therapy. Future initiatives should be directed at increasing knowledge of monitoring recommendations for these agents. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 22, 2023 Category: Drugs & Pharmacology Authors: Christie Schumacher, Amanda Chorpash, Charlotte Bolch, Kellye Eagan, Sara Nimer, Elizabeth Van Dril Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 16, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Clinical outcomes associated with anti ‐Xa‐monitored enoxaparin for venous thromboembolism prophylaxis
ConclusionsThirty-day clinical outcomes in patients receiving enoxaparin for venous thromboembolism prophylaxis were not improved by anti-Xa monitoring. Our results support current evidence-based guideline recommendations against anti-Xa monitoring for patients receiving enoxaparin for venous thromboembolism prophylaxis. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 13, 2023 Category: Drugs & Pharmacology Authors: John A. Saunders, Sara R. Vazquez, Joseph A. Hill, Daniel M. Witt Tags: RESEARCH ARTICLE Source Type: research

Pharmacokinetics/pharmacodynamics analysis and establishment of optimal dosing regimens using unbound cefmetazole concentration for patients infected with Extended ‐Spectrum β‐lactamase producing Enterobacterales (ESBL‐E)
ConclusionsThe nomogram for CMZ regimens established by PK/PD analysis of measured CMZ concentrations enables optimal CMZ dosing for ESBL-E-infected patients. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 11, 2023 Category: Drugs & Pharmacology Authors: Takaya Namiki, Yuta Yokoyama, Hideki Hashi, Rentaro Oda, Aya Jibiki, Hitoshi Kawazoe, Kazuaki Matsumoto, Sayo Suzuki, Tomonori Nakamura Tags: RESEARCH ARTICLE Source Type: research

Cardiovascular adverse events in patients with hepatocellular carcinoma receiving vascular endothelial growth factor inhibitors
ConclusionsCardiovascular risk was not significantly different between TKIs and bevacizumab. Lenvatinib appears to have the highest risk of cardiovascular adverse events among these first-line VEGF inhibitors. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 8, 2023 Category: Drugs & Pharmacology Authors: Fangzheng Yuan, Carrie Lenneman, Ronald Krone, Grant R. Williams, Darryl Outlaw Jr, Michael Katsnelson, Stephen Lirette Tags: RESEARCH ARTICLE Source Type: research

Evaluation of the safety and tolerability of intravenous undiluted levetiracetam at a pediatric institution
ConclusionUndiluted levetiracetam was not associated with an increased incidence of adverse effects compared to diluted levetiracetam in high-doses, up to 4500 mg given over 5 minutes in pediatric patients. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 5, 2023 Category: Drugs & Pharmacology Authors: Lily Price, Lisa Garrity, Sarah Stiehl Tags: RESEARCH ARTICLE Source Type: research

Pain Management Considerations in Patients Living with Both Pain Syndromes and Cardiovascular Diseases and Disorders
AbstractConcomitant pain syndromes and cardiovascular disease (CVD) and disorders are associated with significant morbidity, impaired quality of life, and neuropsychiatric disorders. There is an interplay between the mechanisms of pathophysiology of both CVD and pain syndromes. Patients with CVD (and/or disorders) as well as pain syndromes have an increased propensity for drug-drug/disease interactions. Therefore, an understanding of how to use pharmacotherapy to treat pain syndromes, in the context of patients who have diagnoses of CVD and/or disorders, is paramount to patients ’ success in achieving adequate pain contr...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 5, 2023 Category: Drugs & Pharmacology Authors: Emily E. Leppien, Erin E. Pauling, Eric Smith, Brady Wisniewski, Abigayle Carpenter, Nicholas C. Schwier Tags: REVIEW Source Type: research

Acid ‐suppressive drugs: A systematic review and network meta‐analysis of their nocturnal acid‐inhibitory effect
ConclusionsThis is the first study to compare the effect of ASDs on inhibiting nocturnal acid breakthrough. Overall, in terms of nocturnal acid-inhibitory effect, vonoprazan and tegoprazan had an advantage against other regimens including H2RAs, isomer PPIs, traditional PPIs, AHB, and new PPIs. Even in some subgroups, such as language classification (English), types of study design (crossover-RCT), age ( ≤40 years), BMI (18.5-24.9 kg/m2), continent (Asia and North America), disease status (health), the duration of therapy (2  weeks), and time of administration (at daytime or at night-time), the nocturnal acid-inhibit...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 5, 2023 Category: Drugs & Pharmacology Authors: Shupeng Zou, Mengling Ouyang, Qian Cheng, Xuan Shi, Minghui Sun Tags: RESEARCH ARTICLE Source Type: research