Enoxaparin Thromboprophylaxis Dosing and Anti –Factor Xa Levels in Low‐Weight Patients
IntroductionEnoxaparin is a widely used anticoagulant to prevent venous thromboembolism (VTE). A fixed dose is recommended for VTE prophylaxis. However, fixed prophylactic doses of enoxaparin in low ‐weight patients may be close to the weight‐based dosing recommended for VTE treatment.ObjectiveTo evaluate peak anti –factor Xa (aFXa) levels in low‐weight patients receiving enoxaparin for VTE prophylaxis.MethodsRetrospective cohort of adult patients weighing
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - June 13, 2019 Category: Drugs & Pharmacology Authors: Lily Yam, Khaled Bahjri, Van Geslani, Adrian Cotton, Lisa Hong Tags: Original Research Article Source Type: research

Issue Information
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 39, Issue 6, Page 621-623, June 2019. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - June 7, 2019 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Transition to oral versus continued intravenous antibiotics for patients with pyogenic liver abscesses: a retrospective analysis
ConclusionTransition to PO antibiotics, which consisted mostly of fluoroquinolones, for patients with pyogenic liver abscesses was associated with a higher rate of 30 ‐day readmission compared to patients treated with IV antibiotics, which consisted mostly of β‐lactams.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 30, 2019 Category: Drugs & Pharmacology Authors: Stephanie E. Giangiuli, Scott W. Mueller, Meghan N. Jeffres Tags: Original Research Article Source Type: research

Reappraisal of Contemporary Pharmacokinetic and Pharmacodynamic Principles for Informing Aminoglycoside Dosing
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 23, 2019 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: research

Enoxaparin thromboprophylaxis dosing and antifactor Xa levels in low ‐weight patients
ConclusionA lower dose of enoxaparin may be reasonable in low ‐weight patients for VTE prophylaxis. There appears to be no safety concerns with reduced enoxaparin dosing in low‐weight patients. More robust data is needed to confirm these findings.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 21, 2019 Category: Drugs & Pharmacology Authors: Lily Yam, Khaled Bahjri, Van Geslani, Adrian Cotton, Lisa Hong Tags: Original Research Article Source Type: research

Pharmacologic Issues in Treating Neurodevelopmental Disorders
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 21, 2019 Category: Drugs & Pharmacology Authors: C. Lindsay DeVane Tags: Editorial Source Type: research

Drs. He et  al. Reply to Drs. Lai and Brown
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 21, 2019 Category: Drugs & Pharmacology Authors: Bonnie He, Bruce Carleton, Mahyar Etminan Tags: Letter to the Editor Source Type: research

Enoxaparin thromboprophylaxis dosing and antifactor Xa levels in low ‐weight patients
ConclusionA lower dose of enoxaparin may be reasonable in low ‐weight patients for VTE prophylaxis. There appears to be no safety concerns with reduced enoxaparin dosing in low‐weight patients. More robust data is needed to confirm these findings.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 21, 2019 Category: Drugs & Pharmacology Authors: Lily Yam, Khaled Bahjri, Van Geslani, Adrian Cotton, Lisa Hong Tags: Original Research Article Source Type: research

Pharmacologic Issues in Treating Neurodevelopmental Disorders
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 21, 2019 Category: Drugs & Pharmacology Authors: C. Lindsay DeVane Tags: Editorial Source Type: research

Drs. He et  al. Reply to Drs. Lai and Brown
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 21, 2019 Category: Drugs & Pharmacology Authors: Bonnie He, Bruce Carleton, Mahyar Etminan Tags: Letter to the Editor Source Type: research

Implementation of a Stewardship Initiative on Respiratory Viral PCR ‐based Antibiotic Deescalation
ConclusionA third of patients receiving broad ‐spectrum antibiotics with a positive RV PCR had an opportunity for antimicrobial optimization, although this did not translate into a significant impact on the time to antibiotic deescalation or overall antibiotic use. Combination of RV PCR results with biomarkers to rule out bacterial coinfectio ns and chest radiographic findings may help enhance the likelihood of accepted antibiotic deescalation recommendations and represents an area of future research. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 20, 2019 Category: Drugs & Pharmacology Authors: Pavithra Srinivas, Kaitlyn R. Rivard, Andrea M. Pallotta, Vasilios Athans, Kristin Martinez, Samantha Loutzenheiser, Simon W. Lam, Gary W. Procop, Sandra S. Richter, Elizabeth A. Neuner Tags: Original Research Article Source Type: research

The Potential for QT Interval Prolongation with Chronic Azithromycin Therapy in Adult Cystic Fibrosis Patients
ConclusionAn association between chronic AZM therapy and longer QTc intervals or significant QTc prolongation was not shown. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 20, 2019 Category: Drugs & Pharmacology Authors: Sean N. Avedissian, Nathaniel J. Rhodes, Tien M.H. Ng, Adupa P. Rao, Paul M. Beringer Tags: Brief Report Source Type: research

Implementation of a Stewardship Initiative on Respiratory Viral PCR ‐based Antibiotic Deescalation
ConclusionA third of patients receiving broad ‐spectrum antibiotics with a positive RV PCR had an opportunity for antimicrobial optimization, although this did not translate into a significant impact on the time to antibiotic deescalation or overall antibiotic use. Combination of RV PCR results with biomarkers to rule out bacterial coinfectio ns and chest radiographic findings may help enhance the likelihood of accepted antibiotic deescalation recommendations and represents an area of future research. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 20, 2019 Category: Drugs & Pharmacology Authors: Pavithra Srinivas, Kaitlyn R. Rivard, Andrea M. Pallotta, Vasilios Athans, Kristin Martinez, Samantha Loutzenheiser, Simon W. Lam, Gary W. Procop, Sandra S. Richter, Elizabeth A. Neuner Tags: Original Research Article Source Type: research

Insulin Glargine Dose and Weight Changes in Underweight, Normal Weight, and Overweight Children Newly Diagnosed with Type 1 Diabetes Mellitus
ConclusionFor children who presented underweight, the McLaren IBW method was the best predictor of outpatient dose and body weight, whereas ABW was the best estimate in overweight and obese patients. Further investigation of the role of IBW or adjusted body weight –based dosing methods in underweight pediatric patients with T1D may assist in optimal dosing.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 18, 2019 Category: Drugs & Pharmacology Authors: Bethany Sharpless Chalk, Janet Crane, Gayane Yenokyan, Erika May Pineda, Carlton K.K. Lee Tags: Original Research Article Source Type: research

Kratom Use and Toxicities in the United States
ConclusionsKratom use is increasing and is associated with significant toxicities. Our findings suggest kratom is not reasonably expected to be safe and poses a public health threat due to its availability as an herbal supplement.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 16, 2019 Category: Drugs & Pharmacology Authors: William Eggleston, Robert Stoppacher, Kyle Suen, Jeanna M Marraffa, Lewis S Nelson Tags: Brief Report Source Type: research

Falsely Elevated Vancomycin Concentrations in a Patient Not Receiving Vancomycin
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 11, 2019 Category: Drugs & Pharmacology Authors: Vivian Tsoi, Vipin Bhayana, Anne Marie Bombassaro, Rommel G. Tirona, Saranya Kittanakom Tags: Case Report Source Type: research

Alteplase Therapy for Acute Ischemic Stroke in Pregnancy: Two Case Reports and a Systematic Review of the Literature
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 11, 2019 Category: Drugs & Pharmacology Authors: Klayton M. Ryman, Wilson D. Pace, Shawn Smith, Gabriel V. Fontaine Tags: Review of Therapeutics Source Type: research

Falsely Elevated Vancomycin Concentrations in a Patient Not Receiving Vancomycin
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 11, 2019 Category: Drugs & Pharmacology Authors: Vivian Tsoi, Vipin Bhayana, Anne Marie Bombassaro, Rommel G. Tirona, Saranya Kittanakom Tags: Case Report Source Type: research

Alteplase Therapy for Acute Ischemic Stroke in Pregnancy: Two Case Reports and a Systematic Review of the Literature
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 11, 2019 Category: Drugs & Pharmacology Authors: Klayton M. Ryman, Wilson D. Pace, Shawn Smith, Gabriel V. Fontaine Tags: Review of Therapeutics Source Type: research

Treatment of Relapsed Chronic Subdural Hematoma in Four Young Children with Atorvastatin and Low ‐dose Dexamethasone
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 9, 2019 Category: Drugs & Pharmacology Authors: Jinhao Huang, Lihong Li, Jingyi Zhang, Chuang Gao, Wei Quan, Ye Tian, Jian Sun, Qilong Tian, Dong Wang, Jingfei Dong, Jianning Zhang, Rongcai Jiang Tags: Case Report Source Type: research

Drs. He et al. reply to Drs. Lai and Brown
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 9, 2019 Category: Drugs & Pharmacology Authors: Bonnie He, Bruce Carleton, Mahyar Etminan Tags: Letter To The Editor Source Type: research

Treatment of Relapsed Chronic Subdural Hematoma in Four Young Children with Atorvastatin and Low ‐dose Dexamethasone
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 9, 2019 Category: Drugs & Pharmacology Authors: Jinhao Huang, Lihong Li, Jingyi Zhang, Chuang Gao, Wei Quan, Ye Tian, Jian Sun, Qilong Tian, Dong Wang, Jingfei Dong, Jianning Zhang, Rongcai Jiang Tags: Case Report Source Type: research

Alternative Viewpoint of “Risk of Gynecomastia with Users of Proton Pump Inhibitors”
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 8, 2019 Category: Drugs & Pharmacology Authors: Shih ‐Wei Lai Tags: Letter to the Editor Source Type: research

Predicting Unbound Phenytoin Concentrations: Effects of Albumin Concentration and Kidney Dysfunction
AbstractStudy ObjectiveSeveral methods are available to predict unbound (free) phenytoin concentrations in patients with hypoalbuminemia; however, predictive methods have not been evaluated in patients with concurrent hypoalbuminemia and kidney dysfunction or in patients with mild to moderate (estimated glomerular filtration rate [eGFR] 30 ‐90 ml/min/1.73 m2) kidney dysfunction alone. Thus, the objective was to evaluate the accuracy and precision of predictive methods to estimate free phenytoin concentrations in patients with varying albumin concentrations and/or kidney dysfunction.DesignRetrospective chart review.Settin...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 8, 2019 Category: Drugs & Pharmacology Authors: Margaret C. Montgomery, Jennifer W. Chou, Thomas O. McPharlin, Geoffrey S. Baird, Gail D. Anderson Tags: Original Research Article Source Type: research

Alternative Viewpoint of “Risk of Gynecomastia with Users of Proton Pump Inhibitors”
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 8, 2019 Category: Drugs & Pharmacology Authors: Shih ‐Wei Lai Tags: Letter to the Editor Source Type: research

Predicting Unbound Phenytoin Concentrations: Effects of Albumin Concentration and Kidney Dysfunction
AbstractStudy ObjectiveSeveral methods are available to predict unbound (free) phenytoin concentrations in patients with hypoalbuminemia; however, predictive methods have not been evaluated in patients with concurrent hypoalbuminemia and kidney dysfunction or in patients with mild to moderate (estimated glomerular filtration rate [eGFR] 30 ‐90 ml/min/1.73 m2) kidney dysfunction alone. Thus, the objective was to evaluate the accuracy and precision of predictive methods to estimate free phenytoin concentrations in patients with varying albumin concentrations and/or kidney dysfunction.DesignRetrospective chart review.Settin...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 8, 2019 Category: Drugs & Pharmacology Authors: Margaret C. Montgomery, Jennifer W. Chou, Thomas O. McPharlin, Geoffrey S. Baird, Gail D. Anderson Tags: Original Research Article Source Type: research

Pharmacotherapy of Autism Spectrum Disorder: Results from the Randomized BAART Clinical Trial
The objective of this trial —Biomarkers in Autism of Aripiprazole and Risperidone Treatment (BAART)—was to provide support and guidance for an evidence‐based approach for the selection and monitoring of initial pharmacotherapy in patients with autism by assessing predictors of efficacy, tolerability, and safety.DesignRandomized, double ‐blind, parallel‐group study.SettingThree academic medical centers and a single private pediatric practice.PatientsEighty children or adolescents (aged 6 –17 years) with autistic disorder were enrolled, and 61 patients were randomized to study drug. Of those patients,...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 7, 2019 Category: Drugs & Pharmacology Authors: C. Lindsay De Vane, Jane M. Charles, Ruth K. Abramson, John E. Williams, Laura A. Carpenter, Sarah Raven, Frampton Gwynette, Craig A. Stuck, Mark E. Geesey, Catherine Bradley, Jennifer L. Donovan, Alicia G. Hall, Shelley T. Sherk, Nancy R. Po Tags: SI on Neurodevelopmental Disorders Source Type: research

Critique of “Risk of Gynecomastia with Users of Proton Pump Inhibitors”
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 7, 2019 Category: Drugs & Pharmacology Authors: Joshua D. Brown Tags: Letter to the Editor Source Type: research

Pharmacotherapy of Autism Spectrum Disorder: Results from the Randomized BAART Clinical Trial
The objective of this trial —Biomarkers in Autism of Aripiprazole and Risperidone Treatment (BAART)—was to provide support and guidance for an evidence‐based approach for the selection and monitoring of initial pharmacotherapy in patients with autism by assessing predictors of efficacy, tolerability, and safety.DesignRandomized, double ‐blind, parallel‐group study.SettingThree academic medical centers and a single private pediatric practice.PatientsEighty children or adolescents (aged 6 –17 years) with autistic disorder were enrolled, and 61 patients were randomized to study drug. Of those patients,...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 7, 2019 Category: Drugs & Pharmacology Authors: C. Lindsay De Vane, Jane M. Charles, Ruth K. Abramson, John E. Williams, Laura A. Carpenter, Sarah Raven, Frampton Gwynette, Craig A. Stuck, Mark E. Geesey, Catherine Bradley, Jennifer L. Donovan, Alicia G. Hall, Shelley T. Sherk, Nancy R. Po Tags: SI on Neurodevelopmental Disorders Source Type: research

Critique of “Risk of Gynecomastia with Users of Proton Pump Inhibitors”
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 7, 2019 Category: Drugs & Pharmacology Authors: Joshua D. Brown Tags: Letter to the Editor Source Type: research

The Potential for QTc Prolongation with Chronic Azithromycin Therapy in Adult Cystic Fibrosis Patients
ConclusionAn association between chronic AZM therapy and longer QTc intervals or significant QTc prolongation was not shown.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 2, 2019 Category: Drugs & Pharmacology Authors: Sean N. Avedissian, Nathaniel J. Rhodes, Tien M.H. Ng, Adupa P. Rao, Paul M. Beringer Tags: Brief Report Source Type: research

Implementation of a stewardship initiative on respiratory viral PCR ‐based antibiotic de‐escalation
ConclusionA third of patients receiving broad ‐spectrum antibiotics with a positive RV PCR had an opportunity for antimicrobial optimization, although this did not translate into a significant impact on the time to antibiotic de‐escalation or overall antibiotic use. Combination of RV PCR results with biomarkers to rule out bacterial co‐in fections and chest radiographic findings may help enhance the likelihood of accepted antibiotic de‐escalation recommendations and represents an area of future research.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharm...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 2, 2019 Category: Drugs & Pharmacology Authors: Pavithra Srinivas, Kaitlyn R. Rivard, Andrea M. Pallotta, Vasilios Athans, Kristin Martinez, Samantha Loutzenheiser, Simon W. Lam, Gary W. Procop, Sandra S. Richter, Elizabeth A. Neuner Tags: Original Research Article Source Type: research

The Potential for QTc Prolongation with Chronic Azithromycin Therapy in Adult Cystic Fibrosis Patients
ConclusionAn association between chronic AZM therapy and longer QTc intervals or significant QTc prolongation was not shown.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 2, 2019 Category: Drugs & Pharmacology Authors: Sean N. Avedissian, Nathaniel J. Rhodes, Tien M.H. Ng, Adupa P. Rao, Paul M. Beringer Tags: Brief Report Source Type: research

Efficacy of Tramadol for Pain Management in Patients Receiving Strong Cytochrome P450 2D6 Inhibitors
The objective was to determine whether a clinically relevant decrease in pain control is observed in patients taking scheduled tramadol concomitantly with a strong CYP2D6 inhibitor.DesignRetrospective cohort study.SettingLarge health care system.PatientsOne hundred fifty ‐two adult inpatients who received scheduled tramadol for at least 24 hours with (76 patients) or without (76 patients) a strong CYP2D6 inhibitor between January 1, 2012, and February 28, 2017, were included in the analysis. Patients hospitalized for opioid use disorder or those receiving substand ard dosing of tramadol were excluded.Measurements and Mai...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 30, 2019 Category: Drugs & Pharmacology Authors: Derek A. Frost, Mate M. Soric, Ricky Kaiser, Rachel E. Neugebauer Tags: Brief Report Source Type: research

Issue Information
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 39, Issue 5, Page 527-529, May 2019. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 26, 2019 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Fixed ‐Dose Four‐Factor Prothrombin Complex Concentrate for Vitamin K Antagonist Reversal: Does One Dose Fit All?
Four ‐factor prothrombin complex concentrate (4F‐PCC) has emerged as the preferred option for emergent reversal of vitamin K antagonists (VKAs); however, the optimal dosing strategy is unknown. Although several studies have attempted to determine the optimal dose of 4F‐PCC using a variety of dosing regimens, no dosing strategy has been found to be superior. Many of these studies have evaluated a low, fixed dose of 4F‐PCC rather than individualized dosing as recommended in product labeling. The purpose of this review was to evaluate the efficacy and safety of various fixed‐dose strategies of 4F‐PCC for emergent ...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 21, 2019 Category: Drugs & Pharmacology Authors: Alyson A. Schwebach, Ryan A. Waybright, Thomas J. Johnson Tags: Review of Therapeutics Source Type: research

Efficacy and Safety of Once ‐Weekly versus Twice‐Weekly Bortezomib in Patients with Hematologic Malignancies: A Meta‐analysis with Trial Sequential Analysis
AbstractStudy ObjectiveTo compare the efficacy and safety of once ‐weekly and twice‐weekly bortezomib therapy in patients with hematologic malignancies.DesignMeta ‐analysis of 13 clinical or randomized controlled trials, with trial sequential analysis (TSA).PatientsA total of 1567 patients with hematologic malignancies who received either once ‐weekly or twice‐weekly bortezomib therapy.Measurements And Main ResultsWe conducted a comprehensive literature search of the PubMed, EMBASE, and Cochrane Library databases. A meta ‐analysis was conducted to calculate the pooled effect size; TSA was performed to assess th...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 15, 2019 Category: Drugs & Pharmacology Authors: Bin Hu, Quan Zhou, Yang ‐yang Hu, Lan Zhuang, Li‐ping Yi, Jin‐xia Cao, Tian‐qi Li, Jun Wang Tags: Original Research Article Source Type: research