Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Bayesian Optimization of Tacrolimus Exposure in Stable Kidney Transplant Patients
ConclusionMAP-Bayesian estimation for patient-specific AUC0-12 using sparse, two-specimen sampling is comparable to NCA and may enhance tacrolimus TDM in stable KTRs. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 16, 2023 Category: Drugs & Pharmacology Authors: Thomas D. Nguyen, Nicholas M. Smith, Kris Attwood, Aijaz Gundroo, Shirley Chang, Mahfuz Yonis, Brian Murray, Kathleen M. Tornatore Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 12, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Enhancing pharmacokinetic and pharmacodynamic knowledge in pediatrics
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 12, 2023 Category: Drugs & Pharmacology Authors: Jennifer Le, Laura B. Ramsey Tags: EDITORIAL Source Type: research

Theophylline for the management of respiratory disorders in adults in the 21st century: a scoping review from the American College of Clinical Pharmacy Pulmonary Practice and Research Network
AbstractTheophylline is an oral methylxanthine bronchodilator recommended as alternate therapy for the treatment of asthma and chronic obstructive pulmonary disease (COPD). However, it is not generally recommended for the treatment of other respiratory disorders such as obstructive sleep apnea (OSA) or hypoxia. Most clinical practice guidelines rely on evidence published prior to the year 2000 to make these recommendations. This scoping review aimed to gather and characterize evidence describing theophylline for the management of respiratory disorders in adults between January 1, 2000 and December 31, 2020. Databases searc...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 10, 2023 Category: Drugs & Pharmacology Authors: Paul M. Boylan, Maha Abdalla, Brittany Bissell, Mark A. Malesker, Melissa Santiba ñez, Zachary Smith Tags: REVIEW Source Type: research

Impact of Model ‐Informed Precision Dosing on Achievement of Vancomycin Exposure Targets in Pediatric Patients with Cystic Fibrosis
ConclusionAn MIPD approach implemented within a cloud-based, EHR integrated CDS tool safely supported vancomycin AUC-guided dosing and resulted in high rates of target achievement. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - July 5, 2023 Category: Drugs & Pharmacology Authors: Adam Frymoyer, Hayden T. Schwenk, Jake M. Brockmeyer, Laura Bio Tags: RESEARCH ARTICLE Source Type: research

Oral Fluoroquinolones and Risk of Aortic Aneurysm or Dissection: A Nationwide Population ‐Based Propensity Score Matched Cohort Study
ConclusionFluoroquinolone use was associated with a 34% increased risk of aortic aneurysm or dissection compared to macrolide use among a general US population. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - June 29, 2023 Category: Drugs & Pharmacology Authors: Mahek Garg, Veena Venugopalan, Scott M. Vouri, Vakaramoko Diaby, Nicole M. Iovine, Haesuk Park Tags: RESEARCH ARTICLE Source Type: research

Expanded use of sodium ‐glucose cotransporter 2 inhibitors: Evidence beyond heart failure with reduced ejection fraction
AbstractFollowing the results observed in the DAPA-HF trial and subsequent FDA approval of dapagliflozin in patients living with heart failure with reduced ejection fraction (HFrEF), numerous trials quickly began to assess the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in a wide range of cardiovascular (CV) conditions. Since the publication of those findings, multiple SGLT2i have demonstrated benefit in patients regardless of left ventricular ejection fraction (LVEF) —allowing the drug class to establish itself within the first line of guideline-directed medication therapy. Although the full mechanisti...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - June 28, 2023 Category: Drugs & Pharmacology Authors: Erika Michelle Schoenborn, Preston Trudell Skersick, Claire Maxine Thrasher, Robert L. Page Tags: REVIEW Source Type: research

Biomarkers in the intensive care setting: A focus on using procalcitonin and C ‐reactive protein to optimize antimicrobial duration of therapy
AbstractManaging the critically ill patient with infection is complex, requiring clinicians to synthesize considerable information relating to antimicrobial efficacy and treatment duration. The use of biomarkers may play an important role in identifying variation in treatment response and providing information about treatment efficacy. Though a vast number of biomarkers for clinical application have been described, procalcitonin and C-reactive protein (CRP) are the most thoroughly investigated in the critically ill. However, the presence of heterogeneous populations, variable end points, and incongruent methodology in the ...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - June 24, 2023 Category: Drugs & Pharmacology Authors: Benjamin A. August, Pramodini B. Kale ‐Pradhan, Christopher Giuliano, Leonard B. Johnson Tags: REVIEW Source Type: research

Caring for two in the ICU: Pharmacologic management of pregnancy ‐related complications
AbstractMaternal mortality continues to be an issue globally despite advances in technology and pharmacotherapy. Pregnancy can lead to complications that necessitate immediate action to prevent severe morbidity and mortality. Patients may need escalation to the ICU setting for close monitoring and administration of advanced therapies not available elsewhere. Obstetric emergencies are rare but high-stakes events that require clinicians to have prompt identification and management. The purpose of this review is to describe complications of pregnancy and provide a focused resource of pharmacotherapy considerations that clinic...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - June 23, 2023 Category: Drugs & Pharmacology Authors: Mojdeh S. Heavner, Michaelia D. Cucci, Brooke Barlow, Carolyn Magee Bell, Claire C. Eng, Grace Erdman, Matthew Li, Susan E. Smith, Mohammed Aldhaeefi, Melissa L. Thompson Bastin, W. Anthony Hawkins, Christina Rose, Allison Lankford Tags: REVIEW Source Type: research