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Bicarbonate as a Predictor of Successful Insulin Transition in Critically Ill Patients with Diabetic Ketoacidosis: A Retrospective Cohort Study
ConclusionIn patients with a normal anion gap at the time of insulin transition, serum bicarbonate levels of ≤ 16 mEq/L were associated with a significantly increased odds of transition failure. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 3, 2023 Category: Drugs & Pharmacology Authors: Erin C. Price, Brianne M. Wolfe, Raymond J. Pan, Benjamin C. Gebhart, Scott K. Aberegg Tags: RESEARCH ARTICLE Source Type: research

Precision ‐Based Approaches to Delirium in Critical Illness: A Narrative Review
AbstractDelirium occurs in critical illness and is associated with poor clinical outcomes, having a longstanding impact on survivors. Understanding the complexity of delirium in critical illness and its deleterious outcome has expanded since early reports. Delirium is a culmination of predisposing and precipitating risk factors that result in transition to delirium. Known risks range from advanced age, frailty, medication exposure or withdrawal, sedation depth, and sepsis. Because of its multifactorial nature, different clinical phenotypes and potential neurobiological causes, a precise approach to reducing delirium in cri...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 3, 2023 Category: Drugs & Pharmacology Authors: Melissa J. Ankravs, Cathrine A. McKenzie, Michael T. Kenes Tags: REVIEW Source Type: research

Micafungin pharmacodynamics predict clinical outcomes in hospitalized patients with candidemia caused by certain Candida species
ConclusionsCART-derived micafungin MIC and AUC/MIC breakpoints predicted patient mortality and treatment failure for certain Candida species. These results support the need for further PK/PD studies to optimize echinocandin dosing and improve patient outcomes. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 30, 2023 Category: Drugs & Pharmacology Authors: Ahmed Zaki, Anne J. Gonzales ‐Luna, Nicholas D. Beyda, Todd Lasco, Kevin W. Garey Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 19, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Comment on “Tacrolimus in the treatment of childhood nephrotic syndrome: Machine learning detects novel biomarkers and predicts efficacy”
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 19, 2023 Category: Drugs & Pharmacology Authors: William L. Baker Tags: LETTER TO THE EDITOR Source Type: research

Micafungin Pharmacodynamics Predict Clinical Outcomes in Hospitalized Patients with Candidemia caused by certain Candida species
ConclusionsCART-derived micafungin MIC and AUC/MIC breakpoints predicted patient mortality and treatment failure for certain Candida species. These results support the need for further PK/PD studies to optimize echinocandin dosing and improve patient outcomes. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 18, 2023 Category: Drugs & Pharmacology Authors: Ahmed Zaki, Anne J. Gonzales ‐Luna, Nicholas D. Beyda, Todd Lasco, Kevin W. Garey Tags: RESEARCH ARTICLE Source Type: research

Venlafaxine Deprescribing and Thyroid Function
ConclusionsThere was a direct relationship between antidepressant dosage reduction and levothyroxine dosage requirements. Cautious monitoring is recommended during venlafaxine deprescribing in patients with pre-existing thyroid disease. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 14, 2023 Category: Drugs & Pharmacology Authors: Barbara J. Zarowitz, Shaily Jain Tags: CASE REPORT Source Type: research

Sulbactam ‐durlobactam: A Novel β‐lactam‐β‐lactamase Inhibitor Combination Targeting Carbapenem‐Resistant Acinetobacter baumannii Infections
AbstractCarbapenem-resistantAcinetobacter baumannii (CRAB), is a difficult-to-treat nosocomial pathogen responsible for significant morbidity and mortality. Sulbactam-durlobactam (SUL-DUR), formerly ETX2514SUL, is a novel β-lactam-β-lactamase inhibitor designed specifically for the treatment of CRAB infections. The United States Food and Drug Administration (FDA) fast-track approval of SUL-DUR for the treatment of CRAB infections is currently pending after completion of the phase III ATTACK trial, which compared SU L-DUR to colistin, both in combination with imipenem-cilastatin (IMI) for patients with CRAB-associated hos...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 13, 2023 Category: Drugs & Pharmacology Authors: Amer El ‐Ghali, Ashlan J. Kunz Coyne, Kaylee Caniff, Callan Bleick, Michael J. Rybak Tags: REVIEW Source Type: research

Pharmacogenomics and beyond! Customized pharmacotherapy for solid organ transplant recipients
AbstractSolid organ transplant recipients are reliant on immunosuppressive drugs, which have a narrow therapeutic index, and are concurrently vulnerable to adverse drug events due to comorbidity burden and the complexity of their medication regimens. Urgent management of post-transplant complications often falls to the generalist clinician or critical care specialist. The purpose of this narrative review is to discuss innovations and bedside applications of pharmacogenomics and therapeutic drug monitoring applied to immunosuppression and agents frequently encountered in transplant recipients. Medication formulations will b...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 12, 2023 Category: Drugs & Pharmacology Authors: Adley Lemke, Jessica Wright, Heather May Tags: REVIEW Source Type: research

The incidence of cytomegalovirus and BK polyomavirus infections in kidney transplant patients receiving mTOR inhibitors: A systematic review and meta ‐analysis
The objective of this systematic review and meta-analysis was to investigate the incidence of CMV and BKPyV infections in kidney transplantation recipients receiving mTOR inhibitors. This meta-analysis included three comparisons of immunosuppressant regimens commonly used after kidney transplantation: Comparison 1: mTOR inhibitors versus calcineurin inhibitors (CNI); Comparison 2: mTOR inhibitors versus antimetabolites (AM); and Comparison 3: mTOR inhibitors plus a reduced-dose of CNI versus AM plus a standard-dose of CNI. The group containing mTOR inhibitors was the study group and the remaining one was the control group....
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 10, 2023 Category: Drugs & Pharmacology Authors: Chen Ye, Jingjie Li, Xiaoman Liu, Jiajia Yan, Jie Chen, Changxi Wang, Min Huang, Xiao Chen, Kejing Tang, Pan Chen Tags: REVIEW Source Type: research

Personalized antiseizure medication therapy in critically ill adult patients
AbstractPrecision medicine has the potential to have a significant impact on both drug development and patient care. It is crucial to not only provide prompt effective antiseizure treatment for critically ill patients after seizures start but also have a proactive mindset and concentrate on epileptogenesis and the underlying cause of the seizures or seizure disorders. Critical illness presents different treatment issues compared with the ambulatory population, which makes it challenging to choose the best antiseizure medications and to administer them at the right time and at the right dose. Since there is a paucity of inf...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 9, 2023 Category: Drugs & Pharmacology Authors: Sulaiman Almohaish, Aaron M. Cook, Gretchen M. Brophy, Denise H. Rhoney Tags: REVIEW Source Type: research

Renal Function Estimating Equations Performance During Pregnancy and Postpartum
ConclusionThe new CKD-EPI 2021 equation did not perform well during pregnancy. When 24-hour CrCls are not available during pregnancy, CG (PPW or ABW) performed the best overall, whereas at 3 months postpartum, 100/SCr performed the best overall. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 7, 2023 Category: Drugs & Pharmacology Authors: Dina E. Zaghloul, Rachel Ryu, Bryan Kestenbaum, Chase Smith, Emily Fay, Mary F. Hebert Tags: RESEARCH ARTICLE Source Type: research