Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hydroxyurea for Children with Sickle Cell Disease in sub ‐Saharan Africa: A Summary of the Evidence, Opportunities, and Challenges
AbstractSickle cell disease (SCD) is a common and life-threatening inherited blood disorder that affects more than 300,000 newborns per year. Because of the origins of the sickle gene mutation as a protective mechanism against malaria for those with sickle cell trait, more than 90% of annual SCD births are in sub-Saharan Africa (sSA). Over the past several decades, there have been many important advances in the care of individuals with SCD, including early diagnosis through newborn screening programs (NBS), prophylactic penicillin, the development of vaccines to prevent invasive bacterial infections, and the emergence of h...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 12, 2023 Category: Drugs & Pharmacology Authors: Daniel Dexter, Patrick T. McGann Tags: REVIEW Source Type: research

Emerging therapies for eosinophilic esophagitis
AbstractEosinophilic esophagitis (EoE) is an inflammatory condition of the esophagus that is quickly becoming a more recognized cause of esophageal dysfunction and dysphagia. The cause of EoE is thought to be due to an inflammatory response triggered by exposure to dietary or environmental antigens. Symptoms may be progressive and include reflux, nausea, vomiting, dysphagia, and reduction in quality of life. Both children and adults may be affected. Initial treatments for EoE have focused on elimination diets to potentially identify and remove dietary triggers, acid suppression with proton pump inhibitors, and topical deli...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 11, 2023 Category: Drugs & Pharmacology Authors: Patrick D. Meek, Brian Hemstreet Tags: REVIEW Source Type: research

Comparison of Nimodipine Formulations and Administration Techniques via Enteral Feeding Tubes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Multicenter Retrospective Cohort Study
ConclusionsOur findings suggest that enteral nimodipine formulation and administration techniques might not be equivalent. This could be attributed to excipient differences, inconsistency and inaccuracy in medication administration, and altered nimodipine bioavailability. Further studies are needed. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 8, 2023 Category: Drugs & Pharmacology Authors: Sherif Hanafy Mahmoud, Fatma R. Hefny, Nicholas G. Panos, Laura Delucilla, Zinquon Ngan, Marc M. Perreault, Leslie A. Hamilton, A. Shaun Rowe, Pamela L. Buschur, Jocelyn Owusu ‐Guha, Sulaiman Almohaish, Melissa Sandler, Michael J. Armahizer, Tags: RESEARCH ARTICLE Source Type: research

Associations between antidepressant use patterns during pregnancy and birth outcomes among periconception antidepressant users
ConclusionsPericonception antidepressant users who continue use during pregnancy, particularly into the second and third trimesters, may be at higher risk of adverse birth outcomes. This evidence should be considered alongside the risks associated with depression relapse. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 6, 2023 Category: Drugs & Pharmacology Authors: Nerissa Nance, Sylvia E. Badon, Kathryn Ridout, Jennifer Ahern, De ‐Kun Li, Charles Quesenberry, Lyndsay A. Avalos Tags: RESEARCH ARTICLE Source Type: research

Accelerated approval drug labels often lack information for clinical decision making
CONCLUSIONLabels for accelerated approved clinical indications that do not yet have full approval should be revised to include the information required in the FDA guidance to help guide clinical decision making. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 6, 2023 Category: Drugs & Pharmacology Authors: Jeromie Ballreich, Mariana Socal, Charles L. Bennett, Andrew Xuan, Antonio Trujillo, Gerard Anderson Tags: RESEARCH ARTICLE Source Type: research

New ways of using old antibiotics in pediatrics: Focus on fosfomycin
AbstractFosfomycin, originally named phosphonomycin when it was first isolated from fermentation broth of Streptomyces species and synthesized at Merck in 1969. The phosphonic acid containing a structurally strained and reactive epoxide ring confers broad spectrum, bactericidal activity against gram-positive and gram-negative bacteria. Fosfomycin's small size and hydrophilicity permits broad tissues penetration. Although only fosfomycin tromethamine oral is approved for urinary tract infections (UTI) in the United States since 1996, the intravenous form has been utilized worldwide for over four decades. The increasing rate...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 4, 2023 Category: Drugs & Pharmacology Authors: Martin Tuan Tran Tags: REVIEW Source Type: research

Safety of elexacaftor/tezacaftor/ivacaftor dose reduction: mechanistic exploration through physiologically ‐based pharmacokinetic modeling and a clinical case series
ConclusionAlbeit in a small number of patients, this study provides evidence that reduced ETI doses in pwCF who have experienced AEs may be effective. The PBPK models enable exploration of a mechanistic basis for this finding by simulating target tissue concentrations of ETI that can be compared with drug efficacyin vitro. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 3, 2023 Category: Drugs & Pharmacology Authors: Eunjin Hong, Regina Li, Alan Shi, Lisa M. Almond, Joshua Wang, Amin Z. Khudari, Soumar Haddad, Sarkis Sislyan, Marissa Angelich, Peter S. Chung, Adupa P. Rao, Paul M. Beringer Tags: RESEARCH ARTICLE Source Type: research

Impact of dexmedetomidine in conjunction with a weaning protocol on post ‐surgical opioid use in a Neonatal Intensive Care Unit
ConclusionWe have been unable to demonstrate a reduction in opioid exposure with use of alpha-2 agonists alone in post-operative newborns. addition of a weaning protocol to the use of dexmedetomidine showed a reduction in opioid duration and exposure (although not statistically significant). At this point dexmedetomidine and clonidine should not be introduced outside standardized protocols and scheduled acetaminophen post-operatively. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 2, 2023 Category: Drugs & Pharmacology Authors: Deonne Dersch ‐Mills, Alixe Howlett, Jan Lind, Allison Marchuk, Khorshid Mohammad Tags: RESEARCH ARTICLE Source Type: research

Dosing Implications for Liposomal Amphotericin B in Pregnancy
We describe the use of LAmB for a pregnant patient with mucocutaneous leishmaniasis (MCL) using a dosing strategy of 5 mg/kg/day for days 1-7 using ideal body weight followed by 4 mg/kg weekly using adjusted body weight. We reviewed the literature for LAmB dosing strategies, particularly dosing weight, in pregnancy.ResultsOf the 143 cases identified in 17 studies only one reported a dosing weight, in which ideal body weight was used. Five Infectious Diseases Society of America (IDSA) guidelines in total discussed the use of amphotericin B in pregnancy but no guidelines included recommendations for dosing weight.DiscussionT...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 2, 2023 Category: Drugs & Pharmacology Authors: Niamh O ’Grady, Matthew Davis, Dayna McManus, Jeffrey Topal, Marwan M. Azar, Neima Briggs Tags: REVIEW Source Type: research

Emerging Therapies for Eosinophilic Esophagitis
AbstractEosinophilic esophagitis (EoE) is an inflammatory condition of the esophagus that is quickly becoming a more recognized cause of esophageal dysfunction and dysphagia. The cause of EoE is thought to be due to an inflammatory response triggered by exposure to dietary or environmental antigens. Symptoms may be progressive and include reflux, nausea, vomiting, dysphagia, and reduction in quality of life. Both children and adults may be affected. Initial treatments for EoE have focused on elimination diets to potentially identify and remove dietary triggers, acid suppression with proton pump inhibitors, and topical deli...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 26, 2023 Category: Drugs & Pharmacology Authors: Patrick D. Meek, Brian Hemstreet Tags: REVIEW Source Type: research

Review of Novel β‐lactams and β‐lactam/β‐lactamase Inhibitor Combinations with Implications for Pediatric Use
AbstractAntimicrobial resistance continues to surmount increasing concern globally, and treatment of difficult-to-treat (DTR)Pseudomonas aeruginosa, carbapenem-resistant (CR)Acinetobacter baumannii (CRAB), and CR Enterobacterales (CRE) remains a challenge for clinicians. Although previously rare, the incidence of multi-drug resistant (MDR) and CR infections in pediatric patients has increased drastically in the last decade and is associated with increased morbidity and mortality. To combat this issue, 14 novel antibiotics, including three β-lactam/novel β-lactamase inhibitor combinations (βL-βLIs) and two novel β-lact...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 25, 2023 Category: Drugs & Pharmacology Authors: Katie B. Olney, Jenni K. Thomas, Wes M. Johnson Tags: REVIEW Source Type: research

New ways of using old antibiotics in pediatrics: focus on Fosfomycin
AbstractFosfomycin, originally named phosphonomycin when it was first isolated from fermentation broth of Streptomyces species and synthesized at Merck in 1969. The phosphonic acid containing a structurally strained and reactive epoxide ring confers broad spectrum, bactericidal activity against gram-positive and gram-negative bacteria. Fosfomycin's small size and hydrophilicity permits broad tissues penetration. Although only fosfomycin tromethamine oral is approved for urinary tract infections (UTI) in the United States since 1996, the intravenous form has been utilized worldwide for over four decades. The increasing rate...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 24, 2023 Category: Drugs & Pharmacology Authors: M. Tuan Tran Tags: REVIEW Source Type: research

Antimicrobial Susceptibility Testing: An Updated Primer for Clinicians in the Era of Antimicrobial Resistance: Insights from the Society of Infectious Diseases Pharmacists
AbstractAntimicrobial susceptibility testing (AST) is a critical function of the clinical microbiology laboratory and is essential for optimizing care of patients with infectious diseases, monitoring antimicrobial resistance (AMR) trends, and informing public health initiatives. Several methods are available for performing AST including broth microdilution, agar dilution, and disk diffusion. Technological advances such as the development of commercial automated susceptibility testing platforms and the advent of rapid diagnostic tests have improved the rapidity, robustness, and clinical application of AST. Numerous accredit...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 24, 2023 Category: Drugs & Pharmacology Authors: Eric Wenzler, Mira Maximos, Tomefa E. Asempa, Lauren Biehle, Audrey N. Schuetz, Elizabeth B. Hirsch Tags: SPECIAL ARTICLE Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 16, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research