Effect of Cilostazol on Preventing Paclitaxel ‐Induced Neuropathy in Patients with Breast Cancer: A Randomized Controlled Trial
ConclusionAdjunctive use of cilostazol may be considered as a novel option that might reduce the incidence of paclitaxel-induced peripheral neuropathy and improve the patients ’ QoL. Future larger clinical trials are warranted to confirm these findings. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 18, 2023 Category: Drugs & Pharmacology Authors: Esraa A. Haroun, Noha O. Mansour, Ahmed Eltantawy, Mohamed E. E. Shams Tags: RESEARCH ARTICLE Source Type: research

Metformin use is associated with reduced acute kidney injury following coronary artery bypass grafting in patients with type 2 diabetes: An inverse probability of treatment weighting analysis
ConclusionIn this study, we provided evidence that preoperative metformin was associated with a significant reduction of postoperative AKI following CABG in patients with diabetes. Metformin showed significant protective effects in patients with mild to moderate renal insufficiency. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 18, 2023 Category: Drugs & Pharmacology Authors: Wenxing Peng, Bo Yang, Huanyu Qiao, Yongmin Liu, Yang Lin Tags: RESEARCH ARTICLE Source Type: research

Correlation between Heparin Anti ‐Xa Activity and Thromboelastography in Adult Critically Ill COVID‐19 Patients
ConclusionsA low correlation was found between the TEG R time and anti-Xa activity, while no relationship existed between TEG R time and aPTT during therapeutic UFH anticoagulation in critically ill COVID-19 patients. The role of TEG to routinely monitor and guide UFH anticoagulation dosing remains inconclusive. Further research is necessary to address the laboratory tests needed to help with decision-making on anticoagulation dosing in patients with severe COVID-19. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 18, 2023 Category: Drugs & Pharmacology Authors: Mitchell S. Buckley, Grace E. Benanti, Brian Gilbert, Jordan Meckel, Amy L. Dzierba, Robert MacLaren Tags: RESEARCH ARTICLE Source Type: research

Steno ‐sphere: Navigating the Enigmatic World of Emerging Multidrug‐Resistant Stenotrophomonas maltophilia
This article provides a review of available literature forS. maltophilia infection management focused on related epidemiology, resistance mechanisms, identification, susceptibility testing, antimicrobial PK/PD, and emerging therapeutic strategies. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 18, 2023 Category: Drugs & Pharmacology Authors: Ashlan J. Kunz Coyne, Shelbye Herbin, Kaylee Caniff, Michael J. Rybak Tags: REVIEW Source Type: research

A systematic review of opioid use and multimodal strategies in solid organ transplant recipients and living donors
AbstractThe opioid epidemic has impacted analgesia in the postoperative period for solid organ transplant (SOT) donors and recipients. However, optimal pain management and opioid stewardship strategies have not been identified across this unique population. The purpose of this systematic review was to evaluate the impact of perioperative opioid use and to describe multimodal analgesic strategies to reduce opiate use in SOT recipients and living donors. A systematic review was conducted. Electronic searches were performed in Medline, Embase, Google Scholar, and Web of Science through December 31, 2021. Title and abstracts w...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 17, 2023 Category: Drugs & Pharmacology Authors: Heather L. Kutzler, Alicia B. Lichvar, David Quan, Lyndsey J. Bowman, Adam Diamond, Christina Doligalski, Tina Griffin, Jennifer Melaragno, Helen Sweiss, James Fleming Tags: REVIEW Source Type: research

Precision ‐based approaches to delirium in critical illness: A narrative review
AbstractDelirium occurs in critical illness and is associated with poor clinical outcomes, having a longstanding impact on survivors. Understanding the complexity of delirium in critical illness and its deleterious outcome has expanded since early reports. Delirium is a culmination of predisposing and precipitating risk factors that result in a transition to delirium. Known risks range from advanced age, frailty, medication exposure or withdrawal, sedation depth, and sepsis. Because of its multifactorial nature, different clinical phenotypes, and potential neurobiological causes, a precise approach to reducing delirium in ...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 17, 2023 Category: Drugs & Pharmacology Authors: Melissa J. Ankravs, Cathrine A. McKenzie, Michael T. Kenes Tags: REVIEW Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 16, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Current clinical pharmacology issues in pregnancy and pediatrics
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 16, 2023 Category: Drugs & Pharmacology Authors: C. Lindsay DeVane Tags: EDITORIAL Source Type: research

Issue Information
(Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 16, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Current therapies and challenges for the treatment of Staphylococcus aureus biofilm ‐related infections
AbstractStaphylococcus aureus is a major cause of nosocomial and community-acquired infections and contributes to significant increase in morbidity and mortality especially when associated with medical devices and in biofilm form. Biofilm structure provides a pathway for the enrichment of resistant and persistent phenotypes ofS.  aureus leading to relapse and recurrence of infection. Minimal diffusion of antibiotics inside biofilm structure leads to heterogeneity and distinct physiological activity. Additionally, horizontal gene transfer between cells in proximity adds to the challenges associated with eradication of bio...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 15, 2023 Category: Drugs & Pharmacology Authors: Nikki N. Tran, Taylor Morrisette, Sarah C. J. Jorgensen, Jos é M. Orench‐Benvenutti, Razieh Kebriaei Tags: REVIEW Source Type: research

Neurokinin ‐1 Receptor Antagonists for the Prevention of Postoperative Nausea and Vomiting
AbstractDespite the availability of several classes of antiemetics, postoperative nausea and vomiting (PONV) remains a substantial burden for patients following surgery, resulting in patient dissatisfaction and prolonged stays in post-anesthesia care units and ultimately increasing the cost of care. Enhanced recovery protocols and PONV management guidelines are now centered on the assessment of the individual patient's risk for developing PONV, as well as multimodal prophylaxis using antiemetics targeting different mechanisms of action. Over the last two decades, the neurokinin-1 receptor (NK1R) has emerged as a therapeuti...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 12, 2023 Category: Drugs & Pharmacology Authors: Tricia A. Meyer, Ashraf S. Habib, Deborah Wagner, Tong J. Gan Tags: REVIEW Source Type: research