Current therapies and challenges for the treatment of Staphylococcus aureus biofilm ‐related infections

AbstractStaphylococcus aureus is a major cause of nosocomial and community-acquired infections and contributes to significant increase in morbidity and mortality especially when associated with medical devices and in biofilm form. Biofilm structure provides a pathway for the enrichment of resistant and persistent phenotypes ofS.  aureus leading to relapse and recurrence of infection. Minimal diffusion of antibiotics inside biofilm structure leads to heterogeneity and distinct physiological activity. Additionally, horizontal gene transfer between cells in proximity adds to the challenges associated with eradication of biofilms. This narrative review focuses on biofilm-associated infections caused byS.  aureus, the impact of environmental conditions on biofilm formation, interactions inside biofilm communities, and the clinical challenges that they present. Conclusively, potential solutions, novel treatment strategies, combination therapies, and reported alternatives are discussed.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 15, 2023 Category: Drugs & Pharmacology Authors: Nikki N. Tran, Taylor Morrisette, Sarah C. J. Jorgensen, Jos é M. Orench‐Benvenutti, Razieh Kebriaei Tags: REVIEW Source Type: research