Vancomycin AUC0 –24 estimation using first‐order pharmacokinetic methods in pediatric patients

ConclusionsOur data describe the relationship between vancomycin dose,Cmin, and AUC0 –24 in pediatric patients. We demonstrated the feasibility of using first-order equations to estimate AUC0 –24, using two concentrations obtained at steady state to monitor efficacy and safety in pediatric patients receiving intravenous vancomycin. Our data showed suboptimal correlation between AUC0 –24 andCmin, which indicates thatCmin should not be used as a surrogate marker for a therapeutic AUC0 –24 in pediatric patients. In alignment with the 2020 vancomycin consensus guidelines, we suggest utilizing AUC0 –24 for efficacy and safety monitoring.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: RESEARCH ARTICLE Source Type: research