Caring for Pediatric Patients Requiring Cardiac Stress MRI: I Can't Run but I Can Be Medicated
Cardiac MRI allows the cardiologist and cardiac radiologist to view the anatomy and function of the heart as it has the ability to assess blood flow through the blood vessels. Additionally, Cardiac Stress MRI with the use of various pharmacological agents produces coronary vasodilation and/or increase myocardial oxygen demand. This diagnostic study is used in lieu of physical exercise as in a treadmill stress test. Using the combinations of either dobutamine and atropine or regadenoson and aminophylline these regimens are effective pharmacological stressors to the heart. (Source: Journal of Radiology Nursing)
Source: Journal of Radiology Nursing - May 25, 2018 Category: Radiology Authors: Arlene Bangilan De La Cruz, Cory V. Noel, Laura L. Backus Tags: ARIN Poster Abstracts Source Type: research
Interaction of patient motion and RV spillover correction on septal wall MBF and MFR
CONCLUSIONS: The incidence and magnitude of motion artifacts were greater in the blood pool phase. The predominance of motion artifact during this phase tended to amplify RV spillover bias. When motion correction was omitted, large increases in septal MBF and MFR variability were observed which were not mitigated by RV spillover correction. Correction for dynamic PET motion artifact is clinically necessary to reduce regional MBF and MFR variability. RV spillover correction provides an additional smaller reduction in variability but its clinical impact is yet to be determined. Number of septal segments with % difference gr...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Moody, J., Lee, B., Poitrasson-Riviere, A., Weinberg, R., Corbett, J., Ficaro, E., Murthy, V. Tags: Myocardial Blood Flow Using Dynamic Imaging Source Type: research
82Rb PET measurement of diastolic dyssynchrony during physiologic stress
Conclusion: In a referral population being evaluated for CAD, DDys measurements closely paralleled SDys parameters, & had additive diagnostic value for identifying coronary stenosis. Research Support: Grant from Astellas, Inc. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Van Tosh, A., Mathew, J., Cooke, C., Palestro, C., Nichols, K. Tags: Cardiovascular Clinical Science Poster Session Source Type: research
Myocardial Stress Perfusion MRI: Experience in Pediatric and Young-Adult Patients Following Arterial Switch Operation Utilizing Regadenoson
AbstractDextro-transposition of the great arteries (D-TGA) is one of the most common cyanotic heart lesions. The arterial switch operation (ASO) is the preferred surgical palliation for D-TGA. One of the primary concerns following the ASO is complications arising from the coronary artery transfer. There is a need for myocardial perfusion assessment within ASO patients. There is no report on the utility of regadenoson as a stress agent in children following ASO. Our objective was to observe the safety and feasibility of regadenoson as a pharmacologic stressor for perfusion cardiac MR in a pilot cohort of pediatric and young...
Source: Pediatric Cardiology - May 10, 2018 Category: Cardiology Source Type: research
Correction to: Adverse effects associated with regadenoson myocardial perfusion imaging
Near the beginning of the first sentence in the second paragraph of the Introduction the parenthetical phrase should read: (single bolus of 400 mcg given intravenously, IV). The dosage of mcg was incorrectly published as 200. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - April 17, 2018 Category: Nuclear Medicine Source Type: research
Abstract 144: Nuclear Stress Testing- Exercise vs. Chemical [Session Title: Poster Session AM]
Conclusion: There has been a marked increase in CST with SPECT performed at CAMC between 2007-2016. While most patients may have the physical capacity and baseline EKG characteristics to qualify for an ETT with SPECT, a clear explanation for this pattern remains unknown. A possible analysis of changes in patient characteristics over this time may provide some insight into this trend. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: Sharma, P., Kochar, T., Memon, A., Bhagat, A., Whelan, M. E., Kemper, S., Carter, W. Tags: Session Title: Poster Session AM Source Type: research
Trials and Tribulations of Assessing New Imaging Protocols: Combining Vasodilator Stress With Exercise
Abstract
Among all patients referred for stress myocardial perfusion imaging (MPI), a substantial proportion in contemporary practice cannot exercise. Another group of patients are those who are thought to be able to achieve an adequate workload with treadmill (or bicycle) exercise but do not achieve at least 85% of maximum predicted heart rate without developing symptoms. There has been substantial interest and literature on the adjunctive use of vasodilator stress during the same visit to generate best-quality results for patients who do not exercise adequately. Current American Society of Nuclear Cardiology Guidelines r...
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - March 5, 2018 Category: Radiology Authors: Davila, C. D., Udelson, J. E. Tags: MOC Source Type: research
Adverse effects associated with regadenoson myocardial perfusion imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - February 21, 2018 Category: Nuclear Medicine Source Type: research
Detrimental effects of nitroglycerin use during regadenoson vasodilator stress testing: A cautionary tale
AbstractVasodilator agents such as adenosine and regadenoson are commonly used pharmacologic stressors to assess for ischemia in patients undergoing myocardial perfusion studies. The recommended reversal agent for this mode of stress is aminophylline, although nitroglycerin is commonly administered as an attempt to reverse the symptoms or electrocardiographic (EKG) changes during the stress test. We demonstrate through two cases that incorrect administration of nitroglycerin can induce hypotension and worsen coronary steal, whereas appropriate administration of aminophylline can reverse the effects of pharmacologic vasodil...
Source: Journal of Nuclear Cardiology - January 23, 2018 Category: Nuclear Medicine Source Type: research
The effect of an adenosine A 2A agonist on intra-tumoral concentrations of temozolomide in patients with recurrent glioblastoma
ConclusionsAlthough previously shown to be efficacious in rodents to increase varied size agents to cross the BBB, our data suggest that regadenoson does not increase temozolomide concentrations in brain. Further studies exploring alternative doses and schedules are needed; as transiently disrupting the BBB to facilitate drug entry is of critical importance in neuro-oncology. (Source: Fluids and Barriers of the CNS)
Source: Fluids and Barriers of the CNS - January 15, 2018 Category: Neuroscience Source Type: research
The effect of an adenosine A2A agonist on intra-tumoral concentrations of temozolomide in patients with recurrent glioblastoma
The blood –brain barrier (BBB) severely limits the entry of systemically administered drugs including chemotherapy to the brain. In rodents, regadenoson activation of adenosine A2A receptors causes transient BBB d... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - January 15, 2018 Category: Neurology Authors: Sadhana Jackson, Jon Weingart, Edjah K. Nduom, Thura T. Harfi, Richard T. George, Dorothea McAreavey, Xiaobu Ye, Nicole M. Anders, Cody Peer, William D. Figg, Mark Gilbert, Michelle A. Rudek and Stuart A. Grossman Tags: Research Source Type: research
Cardiac displacement during 13N-Ammonia myocardial perfusion PET/CT: comparison between adenosine and regadenoson induced stress.
CONCLUSIONS: The displacement during regadenoson stress is of lower amplitude and lasts shorter, and may therefore contribute to the lower incidence of motion artifacts on regadenoson compared to adenosine induced stress PET/CT scans.
PMID: 29273695 [PubMed - as supplied by publisher] (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - December 25, 2017 Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
Pediatric tolerogenic DCs expressing CD4 and immunoglobulin-like transcript receptor (ILT)-4 secrete IL-10 in response to Fc and adenosine.
In conclusion, although DCs are classically viewed as antigen presenting cells that activate T cells, we show an independent role of tmDCs in pediatric immune regulation that may be important for suppressing T cell responses to neoantigens in infants and young children. This article is protected by copyright. All rights reserved.
PMID: 29244203 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
Source: European Journal of Immunology - December 15, 2017 Category: Allergy & Immunology Authors: Franco A, Kumar J, Lin G, Behnamfar N, Hisieh LE, Shimizu C, Tremoulet AH, Burns JC, Linden J Tags: Eur J Immunol Source Type: research
Effects of adenosine and regadenoson on hemodynamics measured using cardiovascular magnetic resonance imaging
Adenosine or regadenoson vasodilator stress cardiovascular magnetic resonance (CMR) is an effective non-invasive strategy for evaluating symptomatic coronary artery disease. Vasodilator injection typically pre... (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - December 4, 2017 Category: Radiology Authors: Dustin M. Thomas, Matthew R. Minor, James K. Aden, Christopher J. Lisanti and Kevin E. Steel Tags: Research Source Type: research
Pediatric tolerogenic DCs expressing CD4 and immunoglobulin ‐like transcript receptor (ILT)‐4 secrete IL‐10 in response to Fc and adenosine
In conclusion, although DCs are classically viewed as antigen presenting cells that activate T cells, we show an independent role of tmDCs in pediatric immune regulation that may be important for suppressing T cell responses to neoantigens in infants and young children.
This article is protected by copyright. All rights reserved (Source: European Journal of Immunology)
Source: European Journal of Immunology - December 1, 2017 Category: Allergy & Immunology Authors: Alessandra Franco, Jeetendra Kumar, Gene Lin, Negar Behnamfar, Li ‐En Hisieh, Chisato Shimizu, Adriana H. Tremoulet, Jane C. Burns, Joel Linden Tags: Research Article Source Type: research
