Effects of two patient-specific dosing protocols on measurement of myocardial blood flow with 3D 82Rb cardiac PET
ConclusionsPatient-specific dosing according to BMI is an effective method for guideline-directed dose reduction while maintaining image quality and accuracy for routine MBF and MFR quantification. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 12, 2021 Category: Nuclear Medicine Source Type: research
Adenosine A2A receptor activation enhances blood-tumor barrier permeability in a rodent glioma model
This study provides insight on the use of a vasoactive agent to increase exposure of the blood-tumor barrier to chemotherapy with intention to improve glioma treatment efficacy.PMID:34521765 | DOI:10.1158/1541-7786.MCR-19-0995 (Source: Cell Research)
Source: Cell Research - September 15, 2021 Category: Cytology Authors: Amelie Vezina Monica Manglani DreeAnna Morris Brandon Foster Matthew McCord Hua Song Meili Zhang Dionne Davis Wei Zhang Jessica Bills Kunio Nagashima Priya Shankarappa Jessica Kindrick Stuart Walbridge Cody J Peer William D Figg Mark R Gilbert Dorian B Mc Source Type: research
Adenosine A2A receptor activation enhances blood-tumor barrier permeability in a rodent glioma model
This study provides insight on the use of a vasoactive agent to increase exposure of the blood-tumor barrier to chemotherapy with intention to improve glioma treatment efficacy.PMID:34521765 | DOI:10.1158/1541-7786.MCR-19-0995 (Source: Cell Research)
Source: Cell Research - September 15, 2021 Category: Cytology Authors: Amelie Vezina Monica Manglani DreeAnna Morris Brandon Foster Matthew McCord Hua Song Meili Zhang Dionne Davis Wei Zhang Jessica Bills Kunio Nagashima Priya Shankarappa Jessica Kindrick Stuart Walbridge Cody J Peer William D Figg Mark R Gilbert Dorian B Mc Source Type: research
Cardiac MRI and blood biomarkers for evaluation of radiation-induced cardiotoxicity in breast cancer patients: results of a phase II clinical trial
CONCLUSIONS: In this prospective study of women with left-sided breast cancer treated with contemporary treatment planning, cardiac radiation doses were very low relative to historical doses reported by Darby et al. Although we observed significant changes in T1 and RV EF shortly after RT, these changes were not correlated with whole heart or substructure doses. Serum biomarker analysis of cardiac injury demonstrates an interesting trend between markers and MHD that warrants further investigation.PMID:34509552 | DOI:10.1016/j.ijrobp.2021.08.039 (Source: Ann Oncol)
Source: Ann Oncol - September 12, 2021 Category: Cancer & Oncology Authors: Corey Speers Venkatesh L Murthy Eleanor M Walker Carri K Glide-Hurst Robin Marsh Ming Tang Emily L Morris Matthew J Schipper Richard L Weinberg Hunter C Gits James Hayman Mary Feng James Balter Jean Moran Reshma Jagsi Lori J Pierce Source Type: research
Cardiac MRI and blood biomarkers for evaluation of radiation-induced cardiotoxicity in breast cancer patients: results of a phase II clinical trial
CONCLUSIONS: In this prospective study of women with left-sided breast cancer treated with contemporary treatment planning, cardiac radiation doses were very low relative to historical doses reported by Darby et al. Although we observed significant changes in T1 and RV EF shortly after RT, these changes were not correlated with whole heart or substructure doses. Serum biomarker analysis of cardiac injury demonstrates an interesting trend between markers and MHD that warrants further investigation.PMID:34509552 | DOI:10.1016/j.ijrobp.2021.08.039 (Source: Ann Oncol)
Source: Ann Oncol - September 12, 2021 Category: Cancer & Oncology Authors: Corey Speers Venkatesh L Murthy Eleanor M Walker Carri K Glide-Hurst Robin Marsh Ming Tang Emily L Morris Matthew J Schipper Richard L Weinberg Hunter C Gits James Hayman Mary Feng James Balter Jean Moran Reshma Jagsi Lori J Pierce Source Type: research
Clinical implications of compromised 82Rb PET data acquisition
ConclusionIt is important to verify integrity of82Rb data to ensure MFR computation quality. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 20, 2021 Category: Nuclear Medicine Source Type: research
Stress cardiomyopathy as a cause of reverse redistribution with Tc-99m tetrofosmin regadenoson-rest myocardial perfusion imaging
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 18, 2021 Category: Nuclear Medicine Source Type: research
Clinical experience with regadenoson SPECT myocardial perfusion imaging: insights into patient characteristics, safety, and impact of results on clinical management
Abstract
The Henry Ford Hospital (HFH) regadenoson (REG) registry includes patients with a variety of comorbidities allowing for the evaluation of outcomes in a large, unselected population. Using a database of electronic medical records and nuclear cardiology reports, patients aged > 18 years who underwent REG-facilitated single-photon emission computed tomography (SPECT) testing at HFH between January 2009 and August 2012 were identified. The primary objective was to describe the clinical and demographic characteristics of patients who had undergone REG only vs REG WALK (RE G + low-level exercise) SPECT....
Source: The International Journal of Cardiovascular Imaging - August 13, 2021 Category: Radiology Source Type: research
Left ventricular ejection fraction, myocardial blood flow and hemodynamic variables in adenosine and regadenoson vasodilator 82-Rubidium PET
ConclusionsRest/stress LVEF, LVEF reserve and MBF values are lower in abnormal compared to normal scans. Adenosine and regadenoson seem to have similar effect on stress LVEF, MBF and hemodynamics. A stress LVEF ≥70% has a high NPV to exclude relevant ischemia. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 13, 2021 Category: Nuclear Medicine Source Type: research
Quantitative myocardial perfusion response to adenosine and regadenoson in patients with suspected coronary artery disease
ConclusionThe correlation between regadenoson- and adenosine-induced hyperemic MBF was strong but the agreement was only moderate indicating that established cut-off values for150-water PET should be used cautiously if using regadenoson as vasodilator. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - August 12, 2021 Category: Nuclear Medicine Source Type: research
