Cardiac MRI and blood biomarkers for evaluation of radiation-induced cardiotoxicity in breast cancer patients: results of a phase II clinical trial

CONCLUSIONS: In this prospective study of women with left-sided breast cancer treated with contemporary treatment planning, cardiac radiation doses were very low relative to historical doses reported by Darby et al. Although we observed significant changes in T1 and RV EF shortly after RT, these changes were not correlated with whole heart or substructure doses. Serum biomarker analysis of cardiac injury demonstrates an interesting trend between markers and MHD that warrants further investigation.PMID:34509552 | DOI:10.1016/j.ijrobp.2021.08.039

Source: Ann Oncol - September 12, 2021 Category: Cancer & Oncology Authors: Corey Speers Venkatesh L Murthy Eleanor M Walker Carri K Glide-Hurst Robin Marsh Ming Tang Emily L Morris Matthew J Schipper Richard L Weinberg Hunter C Gits James Hayman Mary Feng James Balter Jean Moran Reshma Jagsi Lori J Pierce Source Type: research