Evaluation of absolute myocardial blood flow and flow reserve using [13N]ammonia-PET/CT in comparison with 99mTc-tetrofosmin-CZT SPECT
Conclusions: Reliable measures of MBF and MFR can be obtained by CZT with dynamic acquisition. A correct methodology is mandatory, applying crosstalk subtraction of residual activity, motion correction during dynamic acquisition and attenuation correction are required to obtain physiological MBF values. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Camoni, L., Rinaldi, R., Cerudelli, E., Bertoli, M., Peli, A., Giubbini, R., Domenico, A., Milan, E. Tags: Tech Papers V: Cardiovascular Science & amp; Neuroscience Technologist Papers Source Type: research
Value of SiPM PET in myocardial perfusion imaging using Rubidium-82
ConclusionSiPM PET provides an improved image quality in comparison with PMT PET. Defect interpretation, interpreter ’s confidence, and absolute blood flow measurements were comparable between both systems. SiPM PET is therefore a reliable technique for MPI using Rb-82.Trial registrationToetsingOnline NL63853.075.17. Registered 13 November, 2017. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 13, 2020 Category: Nuclear Medicine Source Type: research
Safety of regadenoson with theophylline reversal during dynamic computed tomography perfusion and magnetic resonance imaging in patients with CAD.
CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients. Theophylline administration after perfusion examinations is safe and reverses regadenoson side effects.
PMID: 32395975 [PubMed - as supplied by publisher] (Source: Polish Heart Journal)
Source: Polish Heart Journal - May 11, 2020 Category: Cardiology Authors: Oleksiak A, Kruk M, Śpiewak M, Miłosz-Wieczorek B, Marczak M, Demkow M, Kępka C Tags: Kardiol Pol Source Type: research
The prognostic value of regadenoson SPECT myocardial perfusion imaging: The largest cohort to date
ConclusionIn the largest cohort to date, we demonstrated that the presence and severity of perfusion abnormality and myocardial ischemia on regadenoson stress SPECT-MPI are associated with an independent increase in MACE. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 6, 2020 Category: Nuclear Medicine Source Type: research
Considerations for Stress Testing Performed in Conjunction with Myocardial Perfusion Imaging.
This article was prepared to focus on considerations for performing stress (exercise and pharmacologic) testing in conjunction with MPI. It is meant to: 1) provide a basic overview of the principles of exercise stress testing, 2) discuss indications, contraindication, patient preparation and protocols for exercise stress testing, 3) discuss the contraindications administration protocols and side effects for performing vasodilator (adenosine, dipyridamole and regadenoson) stress testing and 4) discuss the contraindications, administration protocols, and side effects for performing dobutamine stress testing.
PMID: 32...
Source: Journal of Nuclear Medicine Technology - April 13, 2020 Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
Regadenoson to the rescue: On the road toward prevention of primary graft dysfunction after lung transplantation
Primary graft dysfunction (PGD), defined as the presence of lung allograft infiltrates consistent with pulmonary edema and hypoxemia, is a devastating early complication of lung transplantation.1 PGD is a major risk factor for poor outcomes after lung transplant, including death and development of chronic lung allograft dysfunction.2 –4 Numerous studies have defined clinical risk factors for PGD,4 and there is extensive literature studying mechanisms of ischemia-reperfusion injury in experimental model systems. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 28, 2020 Category: Transplant Surgery Authors: Ciara M. Shaver Tags: EDITORIAL COMMENTARY Source Type: research
Regadenoson to the rescue: on the road towards prevention of primary graft dysfunction after lung transplantation
Primary graft dysfunction (PGD), defined as the presence of lung allograft infiltrates consistent with pulmonary edema and hypoxemia, is a devastating early complication of lung transplantation (1). PGD is a major risk factor for poor outcomes after lung transplant including death and development of chronic lung allograft dysfunction (CLAD) (2-4). Numerous studies have defined clinical risk factors for PGD (4) and there is extensive literature studying mechanisms of ischemia-reperfusion injury in experimental model systems (5). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 28, 2020 Category: Transplant Surgery Authors: Ciara M. Shaver Tags: Editorial Source Type: research
Molecules, Vol. 25, Pages 1245: Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches
Cleydson B. R. Santos
Adenosine Receptor Type 2A (A2AAR) plays a role in important processes, such as anti-inflammatory ones. In this way, the present work aimed to search for compounds by pharmacophore-based virtual screening. The pharmacokinetic/toxicological profiles of the compounds, as well as a robust QSAR, predicted the binding modes via molecular docking. Finally, we used molecular dynamics to investigate the stability of interactions from ligand-A2AAR. For the search for A2AAR agonists, the UK-432097 and a set of 20 compounds available in the BindingDB database were studied. These compounds were used to genera...
Source: Molecules - March 9, 2020 Category: Chemistry Authors: Kelton L. B. dos Santos Jorddy N. Cruz Luciane B. Silva Ryan S. Ramos Moys és F. A. Neto Cleison C. Lobato Sirlene S. B. Ota Franco H. A. Leite Rosivaldo S. Borges Carlos H. T. P. da Silva Joaqu ín M. Campos Cleydson B. R. Santos Tags: Article Source Type: research
First in human lung transplantation: adenosine a2a receptor agonist (regadenoson)
Background: Currently, no clinically available treatment exists for ischemia-reperfusion injury (IRI) following lung transplantation. Pre-clinical animal models have shown adenosine 2A receptor (A2AR) agonists are effective treatment options for reducing IRI. The purpose of this first in human study was to conduct a Phase I clinical trial to evaluate the safety of continuous infusion of an A2AR agonist in lung transplant recipients.Methods: An adaptive, 2-stage continual reassessment trial was designed to evaluate the safety of regadenoson (A2AR agonist) in the setting of lung transplantation. (Source: The Journal of Heart...
Source: The Journal of Heart and Lung Transplantation - February 12, 2020 Category: Transplant Surgery Authors: Christine L. Lau, Jared P. Beller, Joshua A. Boys, Yunge Zhao, Jennifer Phillips, Michael Cosner, Mark R. Conaway, Gina Petroni, Eric J. Charles, J. Hunter Mehaffey, Hannah C. Mannem, Irving L. Kron, Alexander S. Krupnick, Joel Linden Tags: Original Clinical Science Source Type: research
Adenosine A2A receptor agonist (regadenoson) in human lung transplantation
Currently, there are no clinically approved treatments for ischemia-reperfusion injury after lung transplantation. Pre-clinical animal models have demonstrated a promising efficacy of adenosine 2A receptor (A2AR) agonists as a treatment option for reducing ischemia-reperfusion injury. The purpose of this human study, is to conduct a Phase I clinical trial for evaluating the safety of continuous infusion of an A2AR agonist in lung transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 12, 2020 Category: Transplant Surgery Authors: Christine L. Lau, Jared P. Beller, Joshua A. Boys, Yunge Zhao, Jennifer Phillips, Michael Cosner, Mark R. Conaway, Gina Petroni, Eric J. Charles, J.H. Mehaffey, Hannah C. Mannem, Irving L. Kron, Alexander S. Krupnick, Joel Linden Source Type: research
Utility of discovery approach using proteomics to create a biomarker profile for coronary microvascular dysfunction
ConclusionMass spectrometry using discovery approach may not be an adequate method for quantitative assessment of serum proteins in CMD patients. Future MS studies should evaluate other approaches including tissue samples or serial measurements. (Source: Microvascular Research)
Source: Microvascular Research - January 30, 2020 Category: Biochemistry Source Type: research
Regadenoson dynamic computed tomography myocardial perfusion using low-dose protocol for evaluation of the ischemic burden. ULYSSES study
The purpose of this study was to assess the feasibility of low-dose dynamic regadenoson computed tomography perfusion (CTP) protocol, and to determine which parameters provide the best diagnostic yield for the presence and burden of ischemia in reference to the magnetic resonance myocardial perfusion imaging (MR MPI). (Source: Journal of Cardiovascular Computed Tomography)
Source: Journal of Cardiovascular Computed Tomography - January 20, 2020 Category: Radiology Authors: Anna Oleksiak, Mariusz Kruk, Francesca Pugliese, Mateusz Spiewak, Barbara Milosz-Wieczorek, Magdalena Marczak, Marcin Demkow, Cezary Kepka Source Type: research
Molecules, Vol. 25, Pages 130: Adenosine Receptor Agonists Exhibit Anti-Platelet Effects and the Potential to Overcome Resistance to P2Y12 Receptor Antagonists
In conclusion, a combination of anti-platelet agents acting via the P1 and P2 purinergic receptors represents a promising alternative to existing antithrombotic therapy. (Source: Molecules)
Source: Molecules - December 27, 2019 Category: Chemistry Authors: Wolska Boncler Polak Wzorek Przygodzki Gapinska Watala Rozalski Tags: Article Source Type: research
Safety of regadenoson for vasodilation in cardiac MRI stress tests.
CONCLUSION: Regadenoson is well tolerated and can be safely used for cardiac MRI stress tests.
PMID: 31862182 [PubMed - as supplied by publisher] (Source: Radiologia)
Source: Radiologia - December 16, 2019 Category: Radiology Authors: Bastarrika G, Ezponda A, Baizan AG, Calvo M, Pueyo JC, Gavira JJ, Caballeros M Tags: Radiologia Source Type: research
Regadenoson myocardial perfusion scintigraphy for the evaluation of coronary artery disease in patients with lung disease: A series of five cases
AbstractCoronary artery disease (CAD) is a leading cause of death and morbidity globally. Myocardial perfusion scintigraphy (MPS) is commonly used for the diagnosis of CAD, necessitating hyperaemia achieved either by physical exertion or by pharmacological stress, most commonly through use of a coronary arteriolar dilator. This is challenging in patients with respiratory conditions because exercise may be submaximal and adenosine is contraindicated because of the risk of bronchoconstriction. Regadenoson is the only selective adenosine A2A receptor agonist approved as a vasodilator in MPS. The risk of bronchospasm with rega...
Source: Journal of Nuclear Cardiology - December 2, 2019 Category: Nuclear Medicine Source Type: research
