Blood flow velocity comparison in the eye capillaries and postcapillary venules between normal pregnant and non-pregnant women
Publication date: Available online 12 September 2019Source: Microvascular ResearchAuthor(s): Stamatina Moka, Aristotle G. Koutsiaris, Antonios Garas, Ioannis Messinis, Sophia V. Tachmitzi, Athanassios Giannoukas, Evangelia E. TsironiAbstractBackgroundThere is no consensus on how much and at what diameters the blood flow velocity changes in the female microcirculation during normal pregnancy.MethodsA non-contact, digital slit-lamp biomicroscopy system was used to measure axial blood velocity (Vax) and diameter (D) in the conjunctival microcirculation of 28 normal non-pregnant women (Control Group), 17 women in the first sem...
Source: Microvascular Research - September 13, 2019 Category: Biochemistry Source Type: research

Angiogenic effects of mesenchymal stem cells in combination with different scaffold materials
In conclusion, seeding β-TCP scaffolds with MSCs can accelerate vitalization and a combination of both significantly improves angiogenesis. (Source: Microvascular Research)
Source: Microvascular Research - September 13, 2019 Category: Biochemistry Source Type: research

miR-23c regulates wound healing by targeting stromal cell-derived factor-1α (SDF-1α/CXCL12) among patients with diabetic foot ulcer
In conclusion, miR-23c may function as a new regulator to inhibit angiogenesis by targeting SDF-1α.Graphical abstract (Source: Microvascular Research)
Source: Microvascular Research - September 13, 2019 Category: Biochemistry Source Type: research

Toll-like receptor protein 4 monoclonal antibody inhibits mmLDL-induced endothelium-dependent vasodilation dysfunction of mouse mesenteric arteries
In conclusion, pretreatment with TLR4 mAb lessens mmLDL-induced EDV dysfunction and inhibits overexpression of inflammatory factors. Regulation of the TLR4 pathway, as well as its downstream NF-κB p65 and p38 MAPK pathways, may be an effective strategy for the prevention and treatment of cardiovascular diseases. (Source: Microvascular Research)
Source: Microvascular Research - September 7, 2019 Category: Biochemistry Source Type: research

The effects of the analysis strategy on the correlation between the NIRS reperfusion measures and the FMD response
This study aimed to investigate the correlation between near-infrared spectroscopy (NIRS)-derived measures of microvascular responses using a range of different analysis and flow-mediated dilation (FMD). Additionally, we aimed to investigate whether assessing NIRS and FMD simultaneously or non-simultaneously would affect this association. Thirty-five healthy young individuals (26 ± 13 years old) participated in the study. Twenty were submitted to a simultaneous NIRS/FMD test (NIRS probe placed below the cuff during FMD test) and fifteen to a non-simultaneous FMD and NIRS intervention (NIRS test performed 20 ...
Source: Microvascular Research - August 31, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: November 2019Source: Microvascular Research, Volume 126Author(s): (Source: Microvascular Research)
Source: Microvascular Research - August 31, 2019 Category: Biochemistry Source Type: research

Assessment of microvascular function in vivo using flow mediated skin fluorescence (FMSF) in patients with obstructive lung diseases: A preliminary study
Publication date: Available online 28 August 2019Source: Microvascular ResearchAuthor(s): Sebastian Majewski, Karolina Szewczyk, Adam Jerzy Białas, Joanna Miłkowska-Dymanowska, Zofia Kurmanowska, Paweł GórskiAbstractBackgroundCardiovascular diseases play an important role in morbidity and mortality of patients with obstructive lung diseases. Impaired vascular endothelial function seems to be a key element linking obstructive lung disease and cardiovascular disease. Recently developed technique named flow mediated skin fluorescence (FMSF) is a novel, non-invasive tool to study microvascular function.MethodsTotal o...
Source: Microvascular Research - August 29, 2019 Category: Biochemistry Source Type: research

miR-320/VEGFA axis affects high glucose-induced metabolic memory during human umbilical vein endothelial cell dysfunction in diabetes pathology
Publication date: Available online 23 August 2019Source: Microvascular ResearchAuthor(s): Jing Gao, Maimaiti Ailifeire, Chenfei Wang, Li Luo, Jie Zhang, Li Yuan, Li Zhang, Xiaolan Li, Minzhe WangAbstractThe “metabolic memory”, a phenomenon that the target cell remembers the early hyperglycemia, has been reported to be a critical issue in diabetes pathogenesis. Here, we confirmed the inducible effects of high glucose (HG) and HG followed by normal glucose (HN) upon the proliferation and the tube formation capacity of human umbilical vein endothelial cells (HUVECs), as well as the suppressive effects of HG and HN...
Source: Microvascular Research - August 23, 2019 Category: Biochemistry Source Type: research

Reproducible hindlimb ischemia model based on photochemically induced thrombosis to evaluate angiogenic effects
Publication date: Available online 18 August 2019Source: Microvascular ResearchAuthor(s): Sang-Soo Han, Zhen Jin, Byoung-Seok Lee, Ji-Seok Han, Jong-Jin Choi, Soon-Jung Park, Hyung-Min Chung, Anthony Safaa Mukhtar, Sung-Hwan Moon, Sun-Woong KangAbstractCritical limb ischemia is one of the most common types of peripheral arterial disease. Preclinical development of ischemia therapeutics relies on the availability of a relevant and reproducible in vivo disease model. Thus, establishing appropriate animal disease models is essential for the development of new therapeutic strategies. Currently, the most commonly employed model...
Source: Microvascular Research - August 20, 2019 Category: Biochemistry Source Type: research

The effects of aging and cardiovascular risk factors on microvascular function assessed by near-infrared spectroscopy
In conclusion, this study demonstrated that even though the effects of aging per se on microvascular function should not be completely neglected, the CVD risk factors seem to be determinant on microvascular responsiveness impairment associated with aging. (Source: Microvascular Research)
Source: Microvascular Research - August 17, 2019 Category: Biochemistry Source Type: research

Nailfold microvascular changes in patients with systemic lupus erythematosus and their associative factors
ConclusionMost nailfold capillaroscopic abnormalities were more common in SLE patients than in controls. Hydroxychloroquine, corticosteroids, SLEDAI, low complement and lupus nephritis may be the major prognostic factors for microvascular changes in SLE patients. (Source: Microvascular Research)
Source: Microvascular Research - August 10, 2019 Category: Biochemistry Source Type: research

Retinal and peripheral vascular function in healthy individuals with low cardiovascular risk
Publication date: Available online 31 July 2019Source: Microvascular ResearchAuthor(s): Said Elyas Karimzad, Hala Shokr, Doina GherghelAbstractObjectiveTo assess retinal and peripheral microvascular function in individuals with low cardiovascular risk.Methods and resultsRetinal microvascular function was assessed using the dynamic vessel analyser (DVA) and peripheral vascular reactivity was measured using the digital thermal monitor (DTM) in 136 healthy participants. In addition, systemic blood pressure (BP) profiles, blood analyses for glucose and lipid metabolism markers (CHOL, HDL-c, LDL-c), as well as the Framingham Ri...
Source: Microvascular Research - August 1, 2019 Category: Biochemistry Source Type: research

Dissociation between macro- and microvascular parameters in the early phase of hemorrhagic shock
Publication date: Available online 31 July 2019Source: Microvascular ResearchAuthor(s): Ronald Lima, Nivaldo Villela, Raquel Castiglione, Maria das Graças C. de Souza, Eliete BouskelaAbstractHemorrhagic shock (HS) therapy is based on macrohemodynamic improvement, but it is not clear if this therapy correlates directly with increases in tissue perfusion. Aiming to clarify this point, we compared norepinephrine (NE, a vasoconstrictor), sodium nitroprusside (NP, a vasodilator) and levosimendan (LEV, an inodilator) treatments on macro and microvascular parameters using the hamster dorsal skinfold chamber preparation. On...
Source: Microvascular Research - July 31, 2019 Category: Biochemistry Source Type: research

Quantitative assessment of the conjunctival microcirculation using a smartphone and slit-lamp biomicroscope
We report the feasibility of smartphone video acquisition and subsequent haemodynamic measure quantification via semi-automated means.MethodsUsing an Apple iPhone 6 s and a Topcon SL-D4 slit-lamp biomicroscope, we obtained videos of the conjunctival microcirculation in 4 fields of view per patient, for 17 low cardiovascular risk patients. After image registration and processing, we quantified the diameter, mean axial velocity, mean blood volume flow, and wall shear rate for each vessel studied. Vessels were grouped into quartiles based on their diameter i.e. group 1 (22 μm).ResultsFrom the 17 healthy controls (mean ...
Source: Microvascular Research - July 21, 2019 Category: Biochemistry Source Type: research

The acute influence of sucrose consumption with and without vitamin C co-ingestion on microvascular reactivity in healthy young adults
Publication date: Available online 19 July 2019Source: Microvascular ResearchAuthor(s): S. West, O. Smail, B. BondAbstractBackgroundSugar sweetened beverages (SSB) are a major source of dietary sugar and a public health concern. Glucose consumption acutely influences microvascular reactivity in healthy adults, possibly via oxidative stress. The purpose of this study was to observe the acute influence of a more relevant dose of sucrose on microvascular reactivity, and to identify whether this response is influenced by the amount of vitamin C typically contained in SSB.MethodsThirteen ostensibly healthy adults (8 male, 5 fem...
Source: Microvascular Research - July 19, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: September 2019Source: Microvascular Research, Volume 125Author(s): (Source: Microvascular Research)
Source: Microvascular Research - July 13, 2019 Category: Biochemistry Source Type: research

Transmural pressure drives proliferation of human arterial smooth muscle cells via mechanism associated with NADPH oxidase and Survivin
In this study, we show that transmural pressure (TP) promotes the proliferation of human arterial smooth muscle cells (HASMCs) and its related mechanism. HASMCs were treated with different TPs (0,100,120,140,160,180 and 200 mmHg) in a custom-made pressure loading apparatus for 6 h. Results showed that proliferation of HASMCs was significantly promoted when the TP was over 160 mmHg compared with 0 mmHg (atmosphere pressure). In like manner, the expressions of NADPH oxidase 2(Nox2) and Survivin (SVV) and production of intracellular reactive oxygen species (ROS) were all elevated distinctly when TP exceeded 160 mmHg...
Source: Microvascular Research - July 8, 2019 Category: Biochemistry Source Type: research

Sidestream Dark Field (SDF) imaging of oral microcirculation in the assessment of systemic sclerosis
This study aims to investigate the potential of using SDF as a diagnostic tool in SSc.MethodOral microcirculation of 20 patients with SSc was compared to 20 age and gender matched controls using SDF imaging. Sublingual, buccal and incisor regions of the mouth were examined. All volunteers were female averaging 48.0 (24–64) years old. Vasculature was assessed by calculating the De Backer score and Functional Capillary Density (FCD) on an imaging software.ResultsAt all regions of the mouth, SSc patients had a significantly lower De Backer score compared to controls (SSc 3.484 ± 0.1361/mm vs Control 5.184 &...
Source: Microvascular Research - July 6, 2019 Category: Biochemistry Source Type: research

Tert-butylhydroquinone enhanced angiogenesis and astrocyte activation by activating nuclear factor-E2-related factor 2/heme oxygenase-1 after focal cerebral ischemia in mice
In this study, we investigated whether tert-butylhydroquinone enhanced angiogenesis and astrocyte activation through Nrf2 pathway. Wild-type (Nrf2+/+) and Nrf2-deficient (Nrf2−/−) mice were subjected to permanent distal middle cerebral artery occlusion (dMCAO). We established 6 experimental groups (sham Nrf2+/+ group, vehicle Nrf2+/+ group, tBHQ Nrf2+/+ group; sham Nrf2−/− group, vehicle Nrf2−/− group, and tBHQ Nrf2−/− group). The infarct volume, neurological function, microvessel density (MVD), astrocytic endfeet covered ratio and the expression of Nrf2, HO-1 and VEGF in the...
Source: Microvascular Research - July 6, 2019 Category: Biochemistry Source Type: research

Side Stream Dark Field (SDF) imaging of oral microcirculation in the assessment of systemic sclerosis
This study aims to investigate the potential of using SDF as a diagnostic tool in SSc.MethodOral microcirculation of 20 patients with SSc was compared to 20 age and gender matched controls using SDF imaging. Sublingual, buccal and incisor regions of the mouth were examined. All volunteers were female averaging 48.0 (24–64) years old. Vasculature was assessed by calculating the De Backer score and Functional Capillary Density (FCD) on an imaging software.ResultsAt all regions of the mouth, SSc patients had a significantly lower De Backer score compared to controls (SSc 3.484 ± 0.1361/mm vs Control 5.184 &...
Source: Microvascular Research - July 1, 2019 Category: Biochemistry Source Type: research

A new approach to the analysis of skin blood flow oscillations in human
Publication date: Available online 27 June 2019Source: Microvascular ResearchAuthor(s): Andrey Grinevich, Arina Tankanag, Irina Tikhonova, Nikolay ChemerisAbstractIt is considered that there are six non-overlapping frequency intervals with constant boundaries. These intervals correspond to different mechanisms of skin blood flow regulation. The boundaries do not depend on functional conditions but this statement should be verified. Also it remains unclear how the oscillatory components of skin blood flow are related. Thus the study is aimed to verify statistically the boundaries of frequency intervals, to test the hypothes...
Source: Microvascular Research - June 27, 2019 Category: Biochemistry Source Type: research

Publisher’s Note
Publication date: Available online 26 June 2019Source: Microvascular ResearchAuthor(s): (Source: Microvascular Research)
Source: Microvascular Research - June 26, 2019 Category: Biochemistry Source Type: research

Exploring the microcirculatory effects of an exercise programme including aerobic and resistance training in people with limited cutaneous systemic sclerosis
Publication date: Available online 17 June 2019Source: Microvascular ResearchAuthor(s): Alexandros Mitropoulos, Anil Gumber, Mohammed Akil, Markos KlonizakisAbstractPurpose of the studyHigh intensity interval training (HIIT) is able to improve the endothelial-dependent microvascular function is people with limited cutaneous systemic sclerosis (lcSSc). Resistance training (RT) alone has shown significant improvements in the function of the vasculature; moreover, a combination of aerobic and RT have shown both in the past and recently to significantly improve the vascular function and the microcirculation. Therefore, the pur...
Source: Microvascular Research - June 18, 2019 Category: Biochemistry Source Type: research

Superoxide and NADPH oxidase do not modulate skin blood flow in older exercising adults with and without type 2 diabetes
ConclusionSuperoxide and NADPH oxidase do not modulate cutaneous vasodilation in healthy low- or high-fit older adults exercising in the heat, regardless of aerobic fitness level or relative exercise intensity employed, nor do they influence cutaneous vasodilation during an exercise-heat stress in those with type 2 diabetes. However, NOS remains an important modulator of cutaneous vasodilation during exercise in all groups. (Source: Microvascular Research)
Source: Microvascular Research - June 12, 2019 Category: Biochemistry Source Type: research

Phase-contrast computed tomography: A correlation study between portal pressure and three dimensional microvasculature of ex vivo liver samples from carbon tetrachloride-induced liver fibrosis in rats
This study aims to investigate the 3D microvascular changes in the whole fibrotic livers via X-ray phase-contrast computed tomography (PCCT) and explore the correlations between portal pressures and microvascular changes in liver fibrosis progression.MethodsTwenty-three fibrotic rats were imaged ex vivo using PCCT. Morphological changes of the microvasculature were characterized using tortuosity, texture features of the vascular inner wall, fractal dimension (FD) and Murray's deviation (MD), and quantitative changes were evaluated by microvascular density (MVD). The degree of liver fibrosis was assessed by histochemistry, ...
Source: Microvascular Research - June 7, 2019 Category: Biochemistry Source Type: research

Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death
ConclusionLung inhalation with 3% hydrogen during the warm ischemia phase attenuated lung graft IRI via NF-κB-dependent anti-inflammatory and antioxidative effects in rat donors after cardiac death. (Source: Microvascular Research)
Source: Microvascular Research - June 6, 2019 Category: Biochemistry Source Type: research

Sample size determination in the laser-Doppler measurements of skin blood flow
Publication date: Available online 16 May 2019Source: Microvascular ResearchAuthor(s): Rodion Stepanov, Sergey Podtaev, Kirill TsiberkinAbstractPre-study calculations of the required sample size are vital to a large majority of studies. Using the method based on the Monte-Carlo simulations, we have illustrated how the sample size is related to the statistic power value, the significance level, the variability of observations and the minor magnitude of the effect of interest under study. If the study has been already completed, one should not perform any ‘post hoc’ power calculations. In this case, calculation o...
Source: Microvascular Research - May 18, 2019 Category: Biochemistry Source Type: research

Cutaneous microvascular function in patients with obstructive or non-obstructive coronary artery disease evaluated by laser speckle contrast imaging
ConclusionNObCAD patients are more likely to develop cutaneous microvascular dysfunction than ObCAD patients, which may reflect the difference in the underlying mechanisms of myocardial ischemia. (Source: Microvascular Research)
Source: Microvascular Research - May 10, 2019 Category: Biochemistry Source Type: research

Imbalanced serum levels of Ang1, Ang2 and VEGF in systemic sclerosis: Integrated effects on microvascular reactivity
Publication date: Available online 7 May 2019Source: Microvascular ResearchAuthor(s): Małgorzata Michalska-Jakubus, Maurizio Cutolo, Vanessa Smith, Dorota KrasowskaAbstractIntroduction and aimMicroangiopathy is a hallmark of systemic sclerosis (SSc). It is a progressive process from an early inflammatory and proangiogenic environment to insufficient microvascular repair with loss of microvessels. The exact underlying mechanisms remain ill-defined. Aim of the study was to investigate whether imbalanced angiopoietins/VEGF serum profile should be related in SSc to the altered microvascular reactivity characterized by aberran...
Source: Microvascular Research - May 9, 2019 Category: Biochemistry Source Type: research

Investigation into the diversity in the fractal dimensions of arterioles and venules in a microvascular network – A quantitative analysis
Publication date: Available online 7 May 2019Source: Microvascular ResearchAuthor(s): Ruofan Wang, Peilun Li, Qing Pan, John K.-J. Li, Wolfgang M. Kuebler, Axel R. Pries, Gangmin NingAbstractFractal dimension is a robust fractal parameter for estimating the morphology of vascular networks. It reflects the property of vascular networks that may vary and thus, differentiate between individual networks and/or identify physiological and pathological conditions. As such, fractal dimension differs also between arteriolar and venular compartments, yet the underlying reason is so far unclear. In order to understand the mechanisms ...
Source: Microvascular Research - May 7, 2019 Category: Biochemistry Source Type: research

Characterization of microvascular disease in patients with sickle cell disease using nailfold capillaroscopy
In conclusion, SCD is associated with lower capillary density and more dilated capillaries on NFC. These changes appear unrelated to markers of disease severity including frequency of sickle crises, number of transfusions, and HbS levels. The relation between NFC and target organ involvement merits further study. (Source: Microvascular Research)
Source: Microvascular Research - May 1, 2019 Category: Biochemistry Source Type: research

Computational analysis of nitric oxide biotransport in a microvessel influenced by red blood cells
Publication date: Available online 30 April 2019Source: Microvascular ResearchAuthor(s): Yajie Wei, Lizhong Mu, Yuanliang Tang, Zaiyi Shen, Ying HeAbstractIt is pivotal that Nitric Oxide (NO) produced in endothelium, consumed by hemoglobin (Hb) wrapped in red blood cells (RBCs) membrane, regulates the vascular tone. The whole processes of NO transport in vessel containing flowing RBCs is still not clear, such as NO production in endothelium, diffusion in plasma and consumption inside RBCs. In this work, the motion of RBCs in a microvessel is investigated by using immersed boundary lattice Boltzmann method (IB-LBM) first an...
Source: Microvascular Research - May 1, 2019 Category: Biochemistry Source Type: research

Perfusion-related changes in intestinal diffusion detected by NMR-MOUSE® monitoring in minipigs
Publication date: Available online 30 April 2019Source: Microvascular ResearchAuthor(s): Paula R. Keschenau, Nina Simons, Hanna Klingel, Silke Reuter, Ann Christina Foldenauer, Jochen Vieß, Dennis Weidener, Julia Andruszkow, Bernhard Blümich, René Tolba, Michael J. Jacobs, Johannes KalderAbstractObjectiveThe aim was to investigate perfusion-related changes in the intestinal diffusion assessed by NMR-MOUSE monitoring in minipigs. This was a follow-up study of previous experiments on landrace pigs demonstrating the feasibility of NMR-MOUSE monitoring in large animals.Methods5 mature female minipigs (mean bo...
Source: Microvascular Research - May 1, 2019 Category: Biochemistry Source Type: research

Near-infrared spectroscopy detects transient decrements and recovery of microvascular responsiveness following prolonged forearm ischemia
ConclusionThese findings show that NIRS-derived reoxygenation slope detects the transient detrimental effects of prolonged ischemia within the forearm microvasculature. Additionally, this study found that the reduction in forearm microvascular responsiveness might have induced to decreased brachial artery FMD responsiveness. (Source: Microvascular Research)
Source: Microvascular Research - May 1, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: July 2019Source: Microvascular Research, Volume 124Author(s): (Source: Microvascular Research)
Source: Microvascular Research - April 17, 2019 Category: Biochemistry Source Type: research

Retinal microvascular development in the first two years
We present retinal microvasculature measurement from the first two years of life. Retinal images suitable for analysis were available from 18 infants in our proof-of-concept study. The mean and standard deviation (SD) for birth weight and gestation was 3410 (384) g and 39.1(1.4) weeks, respectively. Retinal vessel calibres were summarized as the mean(SD) central retinal arteriolar equivalent (CRAE) at six months of age was 156 (32) μm, increased to 175 (75) μm by 12 months and a slightly declined by 24 months of age to 168 (50) μm. In a similar pattern, mean(SD) central retinal venular equivalent (CRVE) at six...
Source: Microvascular Research - April 13, 2019 Category: Biochemistry Source Type: research

Myogenic tone contributes to the regulation of permeability in mesenteric microvessels
Publication date: Available online 8 April 2019Source: Microvascular ResearchAuthor(s): Laurel Haines, Nuria Villalba, Adrian M. Sackheim, Daniel M. Collier, Kalev FreemanAbstractThe microvascular endothelium plays a key role in regulating solute permeability in the gut, but the contribution of vascular smooth muscle to barrier function is unknown. We sought to determine the role of vascular smooth muscle and its myogenic tone in the vascular barrier to solutes in mesenteric microvessels. We determined vascular permeability to 4.4 kDa and 70 kDa dextrans in isolated mouse mesenteric arteries at increasing pressure incr...
Source: Microvascular Research - April 10, 2019 Category: Biochemistry Source Type: research

Correlations between nailfold microvascular damage and skin involvement in systemic sclerosis patients
Publication date: Available online 8 April 2019Source: Microvascular ResearchAuthor(s): B. Ruaro, C. Pizzorni, S. Paolino, V. Smith, M. Ghio, A. Casabella, E. Alessandri, M. Patané, A. Sulli, M. CutoloAbstractObjectiveThe aim of this study was to identify any correlations between microvascular damage, assessed by nailfold videocapillaroscopy and skin impairment, evaluated by three different methods, the modified Rodnan skin score (mRSS), skin high-frequency ultrasound (US) and the plicometer skin test (PST) in systemic sclerosis (SSc) patients.MethodsSixty-three SSc patients and 63 healthy subjects were enrolled. Na...
Source: Microvascular Research - April 10, 2019 Category: Biochemistry Source Type: research

Corrigendum to “The radiosensitivity of endothelial cells isolated from human breast cancer and normal tissue in vitro” [Microvasc. Res. 84 (2012) 140-148]
Publication date: Available online 5 April 2019Source: Microvascular ResearchAuthor(s): Moon-Taek Park, Eun-Taex Oh, Min-Jeong Song, Woo-Jean Kim, Young Up Cho, Sei Joong Kim, Jee-Young Han, Jun-Kyu Suh, Eun Kyung Choi, Byung Uk Lim, Chang Won Song, Heon Joo Park (Source: Microvascular Research)
Source: Microvascular Research - April 7, 2019 Category: Biochemistry Source Type: research

Assessment of cutaneous microcirculation by laser Doppler flowmetry in type 1 diabetes
Publication date: Available online 6 April 2019Source: Microvascular ResearchAuthor(s): Michele Sorelli, Piergiorgio Francia, Leonardo Bocchi, Alessandra De Bellis, Roberto AnichiniAbstractBackgroundThe burden of type 1 diabetes (T1D) is growing worldwide, stressing the requirement to limit the threat of its long-term complications. In this regard, the development of methods for the early diagnosis and non-invasive monitoring of vascular abnormalities is widely recognized as one of the greatest priorities of the clinical research in this field.ObjectiveTo assess the deterioration of physiological properties extracted from ...
Source: Microvascular Research - April 7, 2019 Category: Biochemistry Source Type: research

DLL4 and Jagged1 are angiogenic targets of orphan nuclear receptor TR3/Nur77
Publication date: Available online 28 March 2019Source: Microvascular ResearchAuthor(s): Jin Peng, Shengqiang Zhao, Yan Li, Gengming Niu, Chen Chen, Taiyang Ye, Dezheng Zhao, Huiyan ZengAbstractPathological angiogenesis is a hallmark of many diseases. Previously, we reported that orphan nuclear receptor TR3/Nur77 was a critical mediator of angiogenesis to regulate tumor growth and skin wound healing via regulating the expression of the junctional proteins and integrins. However, the molecular mechanism, by which TR3/Nur77 regulates angiogenesis is not completely understood. Here, we were the first to find that TR3/Nur77, v...
Source: Microvascular Research - March 30, 2019 Category: Biochemistry Source Type: research

Comparison of transport of chemotherapeutic drugs in voxelized heterogeneous model of human brain tumor
In this study, a voxelized numerical model based on dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) and computational fluid dynamics (CFD) is employed to study the transport and efficacy of three different chemotherapeutic drugs, namely methotrexate, doxorubicin and cisplatin in human brain tumors. DCE-MRI data provides realistic heterogeneous vasculature of the tumor, the permeability of tissue to contrast agent, interstitial volume fraction (porosity) of the tissue and patient-specific arterial input function (AIF). The permeability of tissue to aforementioned drugs is determined by correlating it with the...
Source: Microvascular Research - March 28, 2019 Category: Biochemistry Source Type: research

Monomeric α-synuclein induces blood–brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro
Publication date: Available online 15 March 2019Source: Microvascular ResearchAuthor(s): Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Ikuya Kimura, Atsushi Yamauchi, Yasufumi KataokaAbstractBlood–brain barrier (BBB) disruption is often mediated by neuroinflammation, and occurs during various neurodegenerative diseases including Parkinson's disease (PD). PD is characterized by loss of dopaminergic neurons and aggregated α-synuclein protein in inclusions known as Lewy bodies. Misfolded α-synuclein has been implicated in neurodegeneration and neuroinflammation through activation of microglia and astrocyte...
Source: Microvascular Research - March 15, 2019 Category: Biochemistry Source Type: research

Microvascular abnormalities in asymptomatic chronic smokers: A videocapillaroscopic study
In this study we aim to investigate the capillaroscopic abnormalities of asymptomatic chronic smokers (N = 30), and compare findings to those of healthy nonsmokers (N = 30). Nailfold videocapillaroscopy was performed with a videodermatoscope, with images recorded at 40× magnification. Capillary morphologies were assessed as normal, enlargement, tortuosity, and microhemorrhages.Capillaroscopic abnormalities were seen in 16 (53.3%) of subjects within the smoker group and seven (23.3%) within the nonsmoker group (p 
Source: Microvascular Research - March 13, 2019 Category: Biochemistry Source Type: research

The microvascular response in the skin to topical application of methyl nicotinate: Effect of concentration and variation between skin sites
Publication date: Available online 12 March 2019Source: Microvascular ResearchAuthor(s): Sherif Elawa, Robin Mirdell, Erik Tesselaar, Simon FarneboAbstractBackgroundMethyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be used as a local provocation in the assessment of microcirculation and skin viability. The aims were to measure the effects of increasing doses of MN, to find the concentration that yields the most reproducible effect from day to day and between sites, and to study the variation between skin sites.MethodsMicrovascular responses to topically applied MN at different concentrations wer...
Source: Microvascular Research - March 13, 2019 Category: Biochemistry Source Type: research

Correlation between acute degradation of the endothelial glycocalyx and microcirculation dysfunction during cardiopulmonary bypass in cardiac surgery
ConclusionsGlycocalyx components are closely related to microcirculation perfusion disorders. Damage to the glycocalyx during surgery with CPB may play a key role in microcirculation perfusion dysfunction. (Source: Microvascular Research)
Source: Microvascular Research - March 11, 2019 Category: Biochemistry Source Type: research

miR-205-5p suppresses pulmonary vascular smooth muscle cell proliferation by targeting MICAL2-mediated Erk1/2 signaling
In this study, we found that miR-205-5p was lowly expressed in hypoxia-induced PAH mouse model and hypoxia-treated PASMCs. Restoration of miR-205-5p suppressed PASMCs proliferation. In contrast, molecule interacting with CasL 2 (MICAL2) was highly expressed in hypoxia-induced PAH mouse model and hypoxia-treated PASMCs. Overexpression of MICAL2 promoted cell proliferation. Furthermore, miR-205-5p inhibited MICAL2 expression levels by targeting the MICAL2 3′ untranslated region. In addition, MICAL2 activated ERK1/2 signaling in PASMCs and ERK1/2 inhibitor blocked MICAL2-mediated-promotion effect on PASMCs proliferation...
Source: Microvascular Research - March 8, 2019 Category: Biochemistry Source Type: research

Migration velocity of red blood cells in microchannels
Publication date: Available online 2 March 2019Source: Microvascular ResearchAuthor(s): Sylvain Losserand, Gwennou Coupier, Thomas PodgorskiAbstractThe lateral migration of red blood cells (RBCs) in confined channel flows is an important ingredient of microcirculatory hydrodynamics and is involved in the development of a cell free layer near vessel walls and influences the distribution of RBCs in networks. It is also relevant to a number of lab-on-chip applications. This migration is a consequence of their deformability and is due to the combined effects of hydrodynamic wall repulsion and the curvature of the fluid velocit...
Source: Microvascular Research - March 4, 2019 Category: Biochemistry Source Type: research

Microvascular reactivity in rehabilitating cardiac patients based on measurements of retinal blood vessel diameters
ConclusionsArteriolar and venular retinal microvascular responses in cardiac patients were different from the ones of healthy controls. Retinal microvascular response of cardiac patients improved during rehabilitation. (Source: Microvascular Research)
Source: Microvascular Research - February 25, 2019 Category: Biochemistry Source Type: research

Flow Mediated Skin Fluorescence technique reveals remarkable effect of age on microcirculation and metabolic regulation in type 1 diabetes
This study describes the diagnostic potential of FMSF for type 1 diabetes (DM1).Study populationAll study participants, in both the control (n = 31) and DM1 (n = 40) groups, were between the ages of 30–49 y. The patients in the DM1 group had all been suffering from diabetes for at least 10 y.ResultsThe parameters HRindex, HRmax and MR inversely correlate with age and BMI. An unidentified compensatory effect was observed among the younger members of the DM1 group. The majority of DM1 patients (HRindex 
Source: Microvascular Research - February 25, 2019 Category: Biochemistry Source Type: research