Editorial Board
Publication date: July 2019Source: Microvascular Research, Volume 124Author(s): (Source: Microvascular Research)
Source: Microvascular Research - April 17, 2019 Category: Biochemistry Source Type: research

Retinal microvascular development in the first two years
We present retinal microvasculature measurement from the first two years of life. Retinal images suitable for analysis were available from 18 infants in our proof-of-concept study. The mean and standard deviation (SD) for birth weight and gestation was 3410 (384) g and 39.1(1.4) weeks, respectively. Retinal vessel calibres were summarized as the mean(SD) central retinal arteriolar equivalent (CRAE) at six months of age was 156 (32) μm, increased to 175 (75) μm by 12 months and a slightly declined by 24 months of age to 168 (50) μm. In a similar pattern, mean(SD) central retinal venular equivalent (CRVE) at six...
Source: Microvascular Research - April 13, 2019 Category: Biochemistry Source Type: research

Myogenic tone contributes to the regulation of permeability in mesenteric microvessels
Publication date: Available online 8 April 2019Source: Microvascular ResearchAuthor(s): Laurel Haines, Nuria Villalba, Adrian M. Sackheim, Daniel M. Collier, Kalev FreemanAbstractThe microvascular endothelium plays a key role in regulating solute permeability in the gut, but the contribution of vascular smooth muscle to barrier function is unknown. We sought to determine the role of vascular smooth muscle and its myogenic tone in the vascular barrier to solutes in mesenteric microvessels. We determined vascular permeability to 4.4 kDa and 70 kDa dextrans in isolated mouse mesenteric arteries at increasing pressure incr...
Source: Microvascular Research - April 10, 2019 Category: Biochemistry Source Type: research

Correlations between nailfold microvascular damage and skin involvement in systemic sclerosis patients
Publication date: Available online 8 April 2019Source: Microvascular ResearchAuthor(s): B. Ruaro, C. Pizzorni, S. Paolino, V. Smith, M. Ghio, A. Casabella, E. Alessandri, M. Patané, A. Sulli, M. CutoloAbstractObjectiveThe aim of this study was to identify any correlations between microvascular damage, assessed by nailfold videocapillaroscopy and skin impairment, evaluated by three different methods, the modified Rodnan skin score (mRSS), skin high-frequency ultrasound (US) and the plicometer skin test (PST) in systemic sclerosis (SSc) patients.MethodsSixty-three SSc patients and 63 healthy subjects were enrolled. Na...
Source: Microvascular Research - April 10, 2019 Category: Biochemistry Source Type: research

Corrigendum to “The radiosensitivity of endothelial cells isolated from human breast cancer and normal tissue in vitro” [Microvasc. Res. 84 (2012) 140-148]
Publication date: Available online 5 April 2019Source: Microvascular ResearchAuthor(s): Moon-Taek Park, Eun-Taex Oh, Min-Jeong Song, Woo-Jean Kim, Young Up Cho, Sei Joong Kim, Jee-Young Han, Jun-Kyu Suh, Eun Kyung Choi, Byung Uk Lim, Chang Won Song, Heon Joo Park (Source: Microvascular Research)
Source: Microvascular Research - April 7, 2019 Category: Biochemistry Source Type: research

Assessment of cutaneous microcirculation by laser Doppler flowmetry in type 1 diabetes
Publication date: Available online 6 April 2019Source: Microvascular ResearchAuthor(s): Michele Sorelli, Piergiorgio Francia, Leonardo Bocchi, Alessandra De Bellis, Roberto AnichiniAbstractBackgroundThe burden of type 1 diabetes (T1D) is growing worldwide, stressing the requirement to limit the threat of its long-term complications. In this regard, the development of methods for the early diagnosis and non-invasive monitoring of vascular abnormalities is widely recognized as one of the greatest priorities of the clinical research in this field.ObjectiveTo assess the deterioration of physiological properties extracted from ...
Source: Microvascular Research - April 7, 2019 Category: Biochemistry Source Type: research

DLL4 and Jagged1 are angiogenic targets of orphan nuclear receptor TR3/Nur77
Publication date: Available online 28 March 2019Source: Microvascular ResearchAuthor(s): Jin Peng, Shengqiang Zhao, Yan Li, Gengming Niu, Chen Chen, Taiyang Ye, Dezheng Zhao, Huiyan ZengAbstractPathological angiogenesis is a hallmark of many diseases. Previously, we reported that orphan nuclear receptor TR3/Nur77 was a critical mediator of angiogenesis to regulate tumor growth and skin wound healing via regulating the expression of the junctional proteins and integrins. However, the molecular mechanism, by which TR3/Nur77 regulates angiogenesis is not completely understood. Here, we were the first to find that TR3/Nur77, v...
Source: Microvascular Research - March 30, 2019 Category: Biochemistry Source Type: research

Comparison of transport of chemotherapeutic drugs in voxelized heterogeneous model of human brain tumor
In this study, a voxelized numerical model based on dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) and computational fluid dynamics (CFD) is employed to study the transport and efficacy of three different chemotherapeutic drugs, namely methotrexate, doxorubicin and cisplatin in human brain tumors. DCE-MRI data provides realistic heterogeneous vasculature of the tumor, the permeability of tissue to contrast agent, interstitial volume fraction (porosity) of the tissue and patient-specific arterial input function (AIF). The permeability of tissue to aforementioned drugs is determined by correlating it with the...
Source: Microvascular Research - March 28, 2019 Category: Biochemistry Source Type: research

Monomeric α-synuclein induces blood–brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro
Publication date: Available online 15 March 2019Source: Microvascular ResearchAuthor(s): Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Ikuya Kimura, Atsushi Yamauchi, Yasufumi KataokaAbstractBlood–brain barrier (BBB) disruption is often mediated by neuroinflammation, and occurs during various neurodegenerative diseases including Parkinson's disease (PD). PD is characterized by loss of dopaminergic neurons and aggregated α-synuclein protein in inclusions known as Lewy bodies. Misfolded α-synuclein has been implicated in neurodegeneration and neuroinflammation through activation of microglia and astrocyte...
Source: Microvascular Research - March 15, 2019 Category: Biochemistry Source Type: research

Microvascular abnormalities in asymptomatic chronic smokers: A videocapillaroscopic study
In this study we aim to investigate the capillaroscopic abnormalities of asymptomatic chronic smokers (N = 30), and compare findings to those of healthy nonsmokers (N = 30). Nailfold videocapillaroscopy was performed with a videodermatoscope, with images recorded at 40× magnification. Capillary morphologies were assessed as normal, enlargement, tortuosity, and microhemorrhages.Capillaroscopic abnormalities were seen in 16 (53.3%) of subjects within the smoker group and seven (23.3%) within the nonsmoker group (p 
Source: Microvascular Research - March 13, 2019 Category: Biochemistry Source Type: research

The microvascular response in the skin to topical application of methyl nicotinate: Effect of concentration and variation between skin sites
Publication date: Available online 12 March 2019Source: Microvascular ResearchAuthor(s): Sherif Elawa, Robin Mirdell, Erik Tesselaar, Simon FarneboAbstractBackgroundMethyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be used as a local provocation in the assessment of microcirculation and skin viability. The aims were to measure the effects of increasing doses of MN, to find the concentration that yields the most reproducible effect from day to day and between sites, and to study the variation between skin sites.MethodsMicrovascular responses to topically applied MN at different concentrations wer...
Source: Microvascular Research - March 13, 2019 Category: Biochemistry Source Type: research

Correlation between acute degradation of the endothelial glycocalyx and microcirculation dysfunction during cardiopulmonary bypass in cardiac surgery
ConclusionsGlycocalyx components are closely related to microcirculation perfusion disorders. Damage to the glycocalyx during surgery with CPB may play a key role in microcirculation perfusion dysfunction. (Source: Microvascular Research)
Source: Microvascular Research - March 11, 2019 Category: Biochemistry Source Type: research

miR-205-5p suppresses pulmonary vascular smooth muscle cell proliferation by targeting MICAL2-mediated Erk1/2 signaling
In this study, we found that miR-205-5p was lowly expressed in hypoxia-induced PAH mouse model and hypoxia-treated PASMCs. Restoration of miR-205-5p suppressed PASMCs proliferation. In contrast, molecule interacting with CasL 2 (MICAL2) was highly expressed in hypoxia-induced PAH mouse model and hypoxia-treated PASMCs. Overexpression of MICAL2 promoted cell proliferation. Furthermore, miR-205-5p inhibited MICAL2 expression levels by targeting the MICAL2 3′ untranslated region. In addition, MICAL2 activated ERK1/2 signaling in PASMCs and ERK1/2 inhibitor blocked MICAL2-mediated-promotion effect on PASMCs proliferation...
Source: Microvascular Research - March 8, 2019 Category: Biochemistry Source Type: research

Migration velocity of red blood cells in microchannels
Publication date: Available online 2 March 2019Source: Microvascular ResearchAuthor(s): Sylvain Losserand, Gwennou Coupier, Thomas PodgorskiAbstractThe lateral migration of red blood cells (RBCs) in confined channel flows is an important ingredient of microcirculatory hydrodynamics and is involved in the development of a cell free layer near vessel walls and influences the distribution of RBCs in networks. It is also relevant to a number of lab-on-chip applications. This migration is a consequence of their deformability and is due to the combined effects of hydrodynamic wall repulsion and the curvature of the fluid velocit...
Source: Microvascular Research - March 4, 2019 Category: Biochemistry Source Type: research

Microvascular reactivity in rehabilitating cardiac patients based on measurements of retinal blood vessel diameters
ConclusionsArteriolar and venular retinal microvascular responses in cardiac patients were different from the ones of healthy controls. Retinal microvascular response of cardiac patients improved during rehabilitation. (Source: Microvascular Research)
Source: Microvascular Research - February 25, 2019 Category: Biochemistry Source Type: research

Flow Mediated Skin Fluorescence technique reveals remarkable effect of age on microcirculation and metabolic regulation in type 1 diabetes
This study describes the diagnostic potential of FMSF for type 1 diabetes (DM1).Study populationAll study participants, in both the control (n = 31) and DM1 (n = 40) groups, were between the ages of 30–49 y. The patients in the DM1 group had all been suffering from diabetes for at least 10 y.ResultsThe parameters HRindex, HRmax and MR inversely correlate with age and BMI. An unidentified compensatory effect was observed among the younger members of the DM1 group. The majority of DM1 patients (HRindex 
Source: Microvascular Research - February 25, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: May 2019Source: Microvascular Research, Volume 123Author(s): (Source: Microvascular Research)
Source: Microvascular Research - February 16, 2019 Category: Biochemistry Source Type: research

Continuous monitoring of interstitial tissue oxygen using subcutaneous oxygen microsensors: In vivo characterization in healthy volunteers
Publication date: Available online 8 February 2019Source: Microvascular ResearchAuthor(s): Stephen C. Kanick, Peter A. Schneider, Bruce Klitzman, Natalie A. Wisniewski, Kerstin RebrinAbstractMeasurements of regional tissue oxygen serve as a proxy to monitor local perfusion and have the potential to guide therapeutic decisions in multiple clinical disciplines. Transcutaneous oximetry (tcpO2) is a commercially available noninvasive technique that uses an electrode to warm underlying skin tissue and measure the resulting oxygen tension at the skin surface. A novel approach is to directly measure interstitial tissue oxygen usi...
Source: Microvascular Research - February 9, 2019 Category: Biochemistry Source Type: research

Extended-wavelength diffuse reflectance spectroscopy for a comprehensive view of blood perfusion and tissue response in human forearm skin
ConclusionsEW-DRS appears to be a promising technique for monitoring perfusion, and could provide a useful tool in plastic and reconstructive surgery. The broad spectrum provides detailed information on the molecular changes taking place in the tissue. However, the technique must be thoroughly validated before it can be implemented in clinical practice. (Source: Microvascular Research)
Source: Microvascular Research - February 3, 2019 Category: Biochemistry Source Type: research

Image-based spatio-temporal model of drug delivery in a heterogeneous vasculature of a solid tumor — Computational approach
Publication date: Available online 31 January 2019Source: Microvascular ResearchAuthor(s): Farshad M. Kashkooli, M. Soltani, M. Rezaeian, Erfan Taatizadeh, Mohammad-Hossein HamediAbstractThe solute transport distribution in a tumor is an important criterion in the evaluation of the cancer treatment efficacy. The fraction of killed cells after each treatment can quantify the therapeutic effect and plays as a helpful tool to evaluate the chemotherapy treatment schedules. In the present study, an image-based spatio-temporal computational model of a solid tumor is provided for calculation of interstitial fluid flow and solute ...
Source: Microvascular Research - February 2, 2019 Category: Biochemistry Source Type: research

Inhaled carbon monoxide increases vasodilation in the microvascular circulation
Publication date: Available online 15 January 2019Source: Microvascular ResearchAuthor(s): Karalyn E. McRae, Jessica Pudwell, Nichole Peterson, Graeme N. SmithAbstractPreeclampsia (PE) is characterized by systemic maternal endothelial dysfunction. Changes in endothelial reactivity have been reported before the onset of clinical signs of PE, and continuing into the post-partum period. Women who smoke during pregnancy have a 33% reduced risk of developing PE. This reduced risk is hypothesized to be, in part, attributed to carbon monoxide (CO), a by-product of cigarette combustion and a known endogenous vasodilator. Determini...
Source: Microvascular Research - January 16, 2019 Category: Biochemistry Source Type: research

Effect of Varying Viscosity on Two-Fluid Model of Pulsatile Blood Flow through Porous Blood Vessels: A Comparative Study
Publication date: Available online 11 January 2019Source: Microvascular ResearchAuthor(s): Ashish Tiwari, Satyendra Singh ChauhanAbstractPresent work concerns the pulsatile blood flow of two-fluid model through porous blood vessels under the effect of radially varying viscosity. Blood is modeled as two-phase fluid model consisting a core region by non-Newtonian (Herschel-Bulkley) fluid and a plasma region modeled as Newtonian fluid. No slip condition has been used on wall and pressure gradient has been taken as periodic function of time. Up to first order approximate solutions of governing equations are obtained using pert...
Source: Microvascular Research - January 12, 2019 Category: Biochemistry Source Type: research

The impact of autoimmune thyroiditis on skin microcirculation in children with non-complicated type 1 diabetes mellitus
ConclusionsCoexisting autoimmune thyroiditis significantly deteriorates skin microcirculation function in pediatric non-complicated type 1 diabetic patients. This process is independent of patient age, diabetes duration and age of diabetes onset. (Source: Microvascular Research)
Source: Microvascular Research - January 4, 2019 Category: Biochemistry Source Type: research

Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke
In this study, the middle cerebral artery occlusion and reperfusion surgery were conducted on rats, and mesenchymal stem cells were then engrafted into the injured cerebrovascular system. Our results showed that the host cells of injured cerebral microvasculature accepted the mitochondria transferred from the transplanted stem cells, thereby resulting in significantly improving in mitochondrial activity of injured microvasculature, enhancing angiogenesis, reducing infarct volume, and improving functional recovery. Our data provided the evidence that stem cells can rescue damaged cerebrovascular system in stroke through a m...
Source: Microvascular Research - January 4, 2019 Category: Biochemistry Source Type: research

The role of reactive oxygen species in angiogenesis and preventing tissue injury after brain ischemia
Publication date: Available online 27 December 2018Source: Microvascular ResearchAuthor(s): Jiping YangAbstractOxidative stress, which is defined as an imbalance between proxidant and antioxidant systems, is the essential mechanism involving in the ischemic process. During the early stage of brain ischemia, reactive oxygen species (ROS) are increased. Increased ROS are thought of a consequence of brain ischemia and exacerbating disease due to inducing cell death, apoptosis and senescence by oxidative stress. During brain tissue repair, ROS are act as signaling molecules and may be benefical for regulating angiogenesis and ...
Source: Microvascular Research - December 28, 2018 Category: Biochemistry Source Type: research

Absolute quantification (ml blood/sec ∗ mm2 tissue) of normal vs. diabetic foot skin microvascular blood perfusion: Feasibility of FM-PPG measurements under clinical conditions
Publication date: Available online 24 December 2018Source: Microvascular ResearchAuthor(s): R.W. Flower, Z. Mirza, S.R. ThomAbstractFluorescence-mediated photoplethysmography (FM-PPG) is the first routine clinical methodology by which to quantifiably measure tissue blood perfusion in absolute terms (mL blood/sec ∗ mm2 tissue). The FM-PPG methodology has been described in detail previously in this journal (MVR 114, 2017, 92-100), along with initial proof-of-concept measurements of blood perfusion in both ocular and forearm skin tissues. The motivation for the current study was to investigate whether FM-PPG can be...
Source: Microvascular Research - December 24, 2018 Category: Biochemistry Source Type: research

Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter
In conclusion, the iChEC-1 line presents a suitable immortalized human ChEC line for future in vitro studies of AMD. (Source: Microvascular Research)
Source: Microvascular Research - December 18, 2018 Category: Biochemistry Source Type: research

Evaluation of skeletal muscle perfusion in canine hind limb ischemia model using color-coded digital subtraction angiography
ConclusionCC-DSA provided real-time measurement of changes in vascular hemodynamics and skeletal muscle perfusion without increasing X-ray usage or contrast agent dose. (Source: Microvascular Research)
Source: Microvascular Research - December 18, 2018 Category: Biochemistry Source Type: research

Oxidative stress in the choroid plexus contributes to blood–cerebrospinal fluid barrier disruption during sepsis development
ConclusionsIn experimental sepsis the BCSFB dysfunction occurs and oxidative stress seems to be a major step in this dysfunction. (Source: Microvascular Research)
Source: Microvascular Research - December 13, 2018 Category: Biochemistry Source Type: research

Editorial Board
Publication date: March 2019Source: Microvascular Research, Volume 122Author(s): (Source: Microvascular Research)
Source: Microvascular Research - December 11, 2018 Category: Biochemistry Source Type: research

Electroosmosis Modulated Transient Blood Flow in Curved Microvessels: Study of a Mathematical Model
Publication date: Available online 10 December 2018Source: Microvascular ResearchAuthor(s): V.K. Narla, Dharmendra TripathiAbstractThe flow through curved microvessels has more realistic applications in physiological transport phenomena especially in blood flow through capillary and microvessels. Motivated by the biomicrofluidics applications, a mathematical model is developed to describe the blood flow inside a curved microvessel driven by electroosmosis. In addition to this flow, the channel experiences electric double layer phenomenon due to zeta potential about -25mV. Lubrication theory and Debye-Hückel approximat...
Source: Microvascular Research - December 10, 2018 Category: Biochemistry Source Type: research

Editorial Board
Publication date: January 2019Source: Microvascular Research, Volume 121Author(s): (Source: Microvascular Research)
Source: Microvascular Research - December 4, 2018 Category: Biochemistry Source Type: research

Altered blood rheology and impaired pressure-induced cutaneous vasodilation in a mouse model of combined type 2 diabetes and sickle cell trait
ConclusionsAlthough neither T2D nor SCT alone had significant effects on blood rheology parameters or vascular function, combined T2D-SCT mice had significantly altered blood rheology and significantly impaired vascular function. (Source: Microvascular Research)
Source: Microvascular Research - December 2, 2018 Category: Biochemistry Source Type: research

High thoracic sympathetic block improves coronary microcirculation disturbance in rats with chronic heart failure
Publication date: Available online 1 December 2018Source: Microvascular ResearchAuthor(s): Guifang Sun, Fengqi Liu, Chunhong XiuAbstractIntroductionCoronary microcirculation disturbance plays an important role in chronic heart failure (CHF). High thoracic sympathetic block (HTSB) is effective to treat CHF, but its impact on coronary microcirculation is unclear.MethodsForty male Wistar rats were subcutaneously injected with isoproterenol (340 mg/kg) for 2 days. Eight weeks later, 24 surviving rats were randomized to the CHF and HTSB groups and 10 rats were used as the control group. 50 μl of saline and ropivacaine ...
Source: Microvascular Research - December 1, 2018 Category: Biochemistry Source Type: research

Evaluation of serum sST2 and sCD40L values in patients with microvascular angina
Publication date: Available online 28 November 2018Source: Microvascular ResearchAuthor(s): Gamze Aslan, Veli Polat, Evin Bozcali, Selçuk Opan, Nurcan Çetin, Dilek UralAbstractObjectivesCoronary microvascular dysfunction plays a major role in the pathogenesis of microvascular angina (MVA). Along with endothelial dysfunction, microvascular atherosclerosis and inflammation seem to contribute to the development of coronary microvascular dysfunction. Serum soluble ST2 (sST2) and serum soluble CD40 ligand (sCD40L) are two biomarkers associated with inflammation and atherosclerosis. The aim of this study was to inv...
Source: Microvascular Research - November 30, 2018 Category: Biochemistry Source Type: research

A simple automated method for continuous fieldwise measurement of microvascular hemodynamics
Publication date: Available online 28 November 2018Source: Microvascular ResearchAuthor(s): Sherry G. Clendenon, Xiao Fu, Robert A. Von Hoene, Jeffrey L. Clendenon, James P. Sluka, Seth Winfree, Henry Mang, Michelle Martinez, Adele J. Filson, James E. Klaunig, James A. Glazier, Kenneth W. DunnAbstractMicrovascular perfusion dynamics are vital to physiological function and are frequently dysregulated in injury and disease. Typically studies measure microvascular flow in a few selected vascular segments over limited time, failing to capture spatial and temporal variability. To quantify microvascular flow in a more complete a...
Source: Microvascular Research - November 30, 2018 Category: Biochemistry Source Type: research

Geometric, elastic and contractile-relaxation changes in coronary arterioles induced by Vitamin D deficiency in normal and hyperandrogenic female rats
Publication date: Available online 28 November 2018Source: Microvascular ResearchAuthor(s): Leila Hadjadj, Anna Monori-Kiss, Eszter M. Horváth, Andrea Heinzlmann, Attila Magyar, Réka E. Sziva, Zsuzsanna Miklós, Éva Pál, János Gál, István Szabó, Zoltán Benyó, György L. Nádasy, Szabolcs VárbíróAbstractVitamin D (VitD) hypovitaminosis and androgen excess (AE) are both risk factors for cardiovascular diseases in fertile women. However, the possible early interaction between AE and VitD status is not clear. Our goal was...
Source: Microvascular Research - November 28, 2018 Category: Biochemistry Source Type: research

Positive pressure ventilation compresses pulmonary acinar microvessels but not their supply vessels
Publication date: Available online 24 November 2018Source: Microvascular ResearchAuthor(s): Robert L. Conhaim, Gilad S. Segal, Kal E. WatsonAbstractPulmonary alveolar septal capillaries receive their perfusion from a web of larger surrounding acinar vessels. Using 4 μm diam. Latex particles, we showed that positive pressure ventilation narrowed the acinar vessels as evidenced by venous 4 μm particle concentrations and perfusate flows
Source: Microvascular Research - November 25, 2018 Category: Biochemistry Source Type: research

Comparison of organ-specific endothelial cells in terms of microvascular formation and endothelial barrier functions
Publication date: Available online 22 November 2018Source: Microvascular ResearchAuthor(s): Hiroyuki Uwamori, Yuuichi Ono, Tadahiro Yamashita, Ken Arai, Ryo SudoAbstractEvery organ demonstrates specific vascular characteristics and functions maintained by interactions of endothelial cells (ECs) and parenchymal cells. Particularly, brain ECs play a central role in the formation of a functional blood brain barrier (BBB). Organ-specific ECs have their own morphological features, and organ specificity must be considered when investigating interactions between ECs and other cell types constituting a target organ. Here we constr...
Source: Microvascular Research - November 23, 2018 Category: Biochemistry Source Type: research

Improvement of microvascular endothelial dysfunction induced by exercise and diet is associated with microRNA-126 in obese adolescents
Publication date: Available online 22 November 2018Source: Microvascular ResearchAuthor(s): Tang Donghui, Bai Shuang, Li Xulong, Yao Meng, Gong Yujing, Hou Yujie, Li Juan, Yang DongshengAbstractObjectiveMicrovascular endothelial dysfunction, which is at the early stage of atherosclerosis, precedes macrovascular endothelial dysfunction. The study is aimed to investigate the mechanism underlying the improvement of microvascular endothelial dysfunction by exercise and diet in obese adolescents.MethodsA quasi-randomized study was carried out with 2 cohorts: the experimental group (57 obese male adolescents; age: 15.38 &plusm...
Source: Microvascular Research - November 23, 2018 Category: Biochemistry Source Type: research

Numerical simulations of the microvascular fluid balance with a non-linear model of the lymphatic system
Publication date: Available online 16 November 2018Source: Microvascular ResearchAuthor(s): Luca Possenti, Giustina Casagrande, Simone Di Gregorio, Paolo Zunino, Maria Laura CostantinoAbstractFluid homeostasis is required for life. Processes involved in fluid balance are strongly related to exchanges at the microvascular level. Computational models have been presented in the literature to analyze the microvascular-interstitial interactions. As far as we know, none of those models consider a physiological description for the lymphatic drainage-interstitial pressure relation. We develop a computational model that consists of...
Source: Microvascular Research - November 16, 2018 Category: Biochemistry Source Type: research

Differences in capillary recruitment between cardiac surgery and septic patients after fluid resuscitation
ConclusionsTVD after fluid administration is not different between 2 subtypes of intensive care patients. However, only in septic patients we observed a lack of coherence between the amount of fluids administered and TVD. Further research is needed to determine if TVD may serve as potential endpoint for fluid administration. (Source: Microvascular Research)
Source: Microvascular Research - November 16, 2018 Category: Biochemistry Source Type: research

Endothelial nitric oxide synthase protein distribution and nitric oxide production in endothelial cells along the coronary vascular tree
ConclusionsThese findings demonstrate increased eNOS protein and NOx content in endothelial cells of conduit arteries compared with the microcirculation and underscore the importance of comparing endothelial-specific molecules in freshly isolated endothelial cells, rather than whole lysate of different sized vessels. (Source: Microvascular Research)
Source: Microvascular Research - November 14, 2018 Category: Biochemistry Source Type: research

The association between near-infrared spectroscopy-derived and flow-mediated dilation assessment of vascular responsiveness in the arm
ConclusionThe significant correlation between the reperfusion slope in the forearm muscle and %FMD in the brachial artery, reinforces the relationship between downstream and upstream vascular reactivity in healthy human limbs. (Source: Microvascular Research)
Source: Microvascular Research - November 14, 2018 Category: Biochemistry Source Type: research

Application of optical flow algorithms to laser speckle imaging
Publication date: Available online 8 November 2018Source: Microvascular ResearchAuthor(s): AmirHessam Aminfar, Nami Davoodzadeh, Guillermo Aguilar, Marko PrincevacAbstractSince of its introduction in 1980s, laser speckle imaging has become a powerful tool in flow imaging. Its high performance and low cost made it one of the preferable imaging methods. Initially, speckle contrast measurements were the main algorithm for analyzing laser speckle images in biological flows. Speckle contrast measurements, also referred as Laser Speckle Contrast Imaging (LSCI), use statistical properties of speckle patterns to create mapped imag...
Source: Microvascular Research - November 9, 2018 Category: Biochemistry Source Type: research

Differences in skin blood flow oscillations between the plantar and dorsal foot in people with diabetes mellitus and peripheral neuropathy
ConclusionsIn people with DM and PN, higher SBF on the plantar foot is attributed to the metabolic and myogenic controls, and SBF on the plantar foot exhibits a higher degree of regularity compared to the dorsal foot. People with DM and PN also had higher plantar and dorsal SBF compared to the healthy controls. This study provides evidence to document differences in SBF of the plantar and dorsal foot in people with DM and PN. (Source: Microvascular Research)
Source: Microvascular Research - November 9, 2018 Category: Biochemistry Source Type: research

Painless local pressure application to test microvascular reactivity to ischemia
Publication date: Available online 3 November 2018Source: Microvascular ResearchAuthor(s): Samir Henni, Jeanne Hersant, Laurent Loufrani, Guillaume Duval, Anne Humeau-Heurtier, The SIMS Group, Jeremie Riou, Pierre Abraham, SOCOS GroupAbstractBackgroundForearm cutaneous blood flux (CBF) measurement with post-occlusive reactive hyperemia (PORH) is uncomfortable and may not be devoid of risks. We aimed to investigate post-compression reactive hyperemia (PCRH) with a custom-made indenter that was designed to be easily used routinely by inexperienced observers.MethodsMedical students evaluated PCRH with 1- to 4-min pressure app...
Source: Microvascular Research - November 4, 2018 Category: Biochemistry Source Type: research

Orphan nuclear receptor TR3/Nur77 differentially regulates the expression of integrins in angiogenesis
In this report by analyzing the integrin expression profile in endothelial cells, we found that the TR3/Nur77 expression highly increased the expression of integrins α1 and β5, decreased the expression of integrins α2 and β3, but had some or no effect on the expression of integrins αv, α3, α4, α5, α6, β1 and β7. In the angiogenic responses mediated by TR3/Nur77, integrin α1 regulated endothelial cell proliferation and adhesion, but not migration. Integrin β5 shRNA inhibited cell migration, but increased proliferation and adhesion. Integrin α2 re...
Source: Microvascular Research - November 2, 2018 Category: Biochemistry Source Type: research

Nailfold videocapillaroscopy changes in Takayasu arteritis and their association with disease activity and subclavian artery involvement
ConclusionIn the present study, we have shown that the hands with subclavian artery involvement have short, thin and tortuous capillaries which could be secondary to hypoperfusion. To the best of our knowledge, this is the first report describing NVC changes in TA. (Source: Microvascular Research)
Source: Microvascular Research - October 31, 2018 Category: Biochemistry Source Type: research

Age-related changes in gingival blood flow parameters measured using laser speckle flowmetry
Publication date: Available online 27 October 2018Source: Microvascular ResearchAuthor(s): Yuko Ohsugi, Yoshinao Nagashima, Susumu Nakatsu, Kayo Sato, Atsuko Chiba, Hidetake Fujinaka, Yoshitaka Yano, Yoshifumi NikiAbstractPrevious studies have suggested a possible relationship between age-related changes to human gingival hemodynamics and periodontal disease. However, firmly establishing this has been difficult because of a lack of suitable tools. Our study investigated whether a non-invasive laser speckle flowgraphy (LSFG)-based 2-dimensional technique could be used to assess maxillary anterior gingival blood flow under r...
Source: Microvascular Research - October 27, 2018 Category: Biochemistry Source Type: research