The presence of synchronized perfusion dips in the microcirculation of the resting nail bed
ConclusionThe observed perfusion dips are of a centrally mediated nervous origin but are also affected by local factors. They are affected by seating duration and differ between left and right hands, likely because of local micro perfusion dips. This phenomenon seems related to digital thermoregulation. (Source: Microvascular Research)
Source: Microvascular Research - October 13, 2018 Category: Biochemistry Source Type: research

MiR-150 promotes angiogensis and proliferation of endothelial progenitor cells in deep venous thrombosis by targeting SRCIN1
In this study, we investigate the effect of miR-150 on EPCs function ex vivo and thrombus resolution in vivo. We determined miR-150 expression in EPCs isolated from DVT patients and control subjects by RT-PCR. Potential target of miR-150 was confirmed by bioinformatics analysis and luciferase reporter respectively. The angiogenesis and proliferation were tested by MTT and tube formation assay. A murine model of venous thrombosis was developed as in vivo model. Finally, the effect of miR-150 on EPCs with inferior venous thrombosis were evaluated in vivo. Our data showed that miR-150 was downregulated in EPCs from DVT patien...
Source: Microvascular Research - October 11, 2018 Category: Biochemistry Source Type: research

Dermal microvessel density and maturity is closely associated with atherogenic dyslipidemia and accumulation of advanced glycation end products in adult patients with type 1 diabetes
The objective of this study was to evaluate the association between established vascular risk factors and density, maturity, and reactivity of dermal blood vessels in adults with type 1 diabetes (DM1). We included 148 DM1 patients (87 men) with a median (IQR) age of 40.5 (30.5–49) years and a median diabetes duration of 21 (17–29.5) years. The control group consisted of 13 healthy volunteers (6 men) with a median (IQR) age of 36 (31–43). Accumulation of advanced glycation end products (AGEs) was assessed using the AGE-Reader device. In the immunohistochemical (IHC) analyses, anti-CD133, anti-CD34, anti-CD...
Source: Microvascular Research - October 11, 2018 Category: Biochemistry Source Type: research

Reliability of microvascular responsiveness measures derived from near-infrared spectroscopy across a variety of ischemic periods in young and older individuals
ConclusionNIRS-derived StO2 reperfusion slope, has good reliability across a range of occlusion durations with the strongest reliability during longer occlusion durations. (Source: Microvascular Research)
Source: Microvascular Research - October 5, 2018 Category: Biochemistry Source Type: research

Evaluating changes of blood flow in retina, choroid, and outer choroid in rats in response to elevated intraocular pressure by 1300 nm swept-source OCT
We report the development of a 1300 nm swept-source optical coherence tomography (SS-OCT) system specifically designed to perform OCT imaging and optical microangiography (OMAG) in rat eyes in vivo and its use in evaluating the effects of intraocular pressure (IOP) elevation on ocular circulation. The swept laser is operated in single longitude mode with a 90 nm bandwidth centered at 1300 nm and 200 kHz A-line rate, providing remarkable sensitivity fall-off performance along the imaging depth, a larger field of view of 2.5 × 2.5 mm2 (approximately 35°), and more time-efficient imaging acquisition. T...
Source: Microvascular Research - October 5, 2018 Category: Biochemistry Source Type: research

Effect of reperfusion on vascular smooth muscle reactivity in three contraction models
ConclusionsResults of our experiments suggest that mastoparan-7 significantly induces contraction of vascular smooth muscle cells not only for controls but in the presence of ischemia and reperfusion too. Potential therapeutic applications of the observed reactions are important. They may include regenerative processes within the nervous system, studies on the improvement of blood flow within the microcirculation, or antimicrobial activity. Modulation of the G protein-phospholipase C response may also be an interesting point of action of future drugs modifying the response to stimulation during ischemia in particular, such...
Source: Microvascular Research - September 12, 2018 Category: Biochemistry Source Type: research

Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation
ConclusionHence this study identifies Triphala and its chief compounds CA and CI as potential adjuvants in the management of DR. (Source: Microvascular Research)
Source: Microvascular Research - September 5, 2018 Category: Biochemistry Source Type: research

The cardioprotective effect of dexmedetomidine on regional ischemia/reperfusion injury in type 2 diabetic rat hearts
ConclusionsThese results suggested that DEX preconditioning exerted a cardioprotective effect against regional I/R injury in diabetic rats. (Source: Microvascular Research)
Source: Microvascular Research - September 2, 2018 Category: Biochemistry Source Type: research

Hypoperfusion following the injection of epinephrine in human forearm skin can be measured by RGB analysis but not with laser speckle contrast imaging
ConclusionsRGB analysis of digital images proved to be a valid technique for monitoring the effect of local anesthetics with epinephrine in human skin. The technique requires only a commercial digital camera and constitutes a cheap, simple method. The optimal delay between epinephrine injection and incision, to minimize bleeding, was found to be 7 to 9 min, which is in good agreement with common surgical practice. (Source: Microvascular Research)
Source: Microvascular Research - August 26, 2018 Category: Biochemistry Source Type: research

The role of heat shock protein 27 phosphorylation in the proliferation and apoptosis of human umbilical vein endothelial cells induced by Visfatin
ConclusionVisfatin prompted cell proliferation and exerted a protective effect against high-glucose induced apoptosis in HUVECs through HSP27 phosphorylation. PI3K/Akt and ERK1/2 are important signaling pathways that contribute to HSP27 phosphorylation. (Source: Microvascular Research)
Source: Microvascular Research - August 24, 2018 Category: Biochemistry Source Type: research

Anti-angiogenic effect of adiponectin in human primary microvascular and macrovascular endothelial cells
In this study, we explored the effect of APN on tube formation in the primary culture of human umbilical vein macrovascular endothelial cells (HUVEC), human retinal microvascular endothelial cells (hREC) and human choroidal endothelial cells (hCEC). Anti-VEGF agent, bevacizumab (avastin) was used as a control. Full-length pAc-APN transfected in HUVEC, hRECs and hCECs inhibited basal tube formation and migration comparable to bevacizumab (Avastin™). In hRECs, full length pAc-APN reduced VEGF or PDR vitreous mediated migration. In a similar way, rAPN significantly disrupted VEGF and PDR vitreous induced tube formation ...
Source: Microvascular Research - August 23, 2018 Category: Biochemistry Source Type: research

The effect of hypoxia on ZEB1 expression in a mimetic system of the blood-brain barrier
Publication date: Available online 23 August 2018Source: Microvascular ResearchAuthor(s): Desiree Leduc-Galindo, Per Qvist, Andrea E. Tóth, Tue Fryland, Morten S. Nielsen, Anders D. Børglum, Jane H. ChristensenAbstractThe blood-brain barrier consists of a tightly sealed monolayer of endothelial cells being vital in maintaining a stable intracerebral microenvironment. The barrier is receptive to leakage upon exposure to environmental factors, like hypoxia, and its disruption has been suggested as a constituent in the pathophysiology of both neurological and psychiatric disorders. The schizophrenia associated Z...
Source: Microvascular Research - August 23, 2018 Category: Biochemistry Source Type: research

Reliability of vulvar blood perfusion in women with provoked vestibulodynia using laser Doppler perfusion imaging and laser speckle imaging
Publication date: Available online 16 August 2018Source: Microvascular ResearchAuthor(s): Marie-Pierre Cyr, Alexandra Pinard, Olivia Dubois, Mélanie MorinAbstractBackgroundMicrovascular assessment has become increasingly used in gynecology to better understand the pathophysiology of various vulvar conditions and to study sexual function. Alteration in blood perfusion of the vulvar area has been observed using laser technologies in women with provoked vestibulodynia (PVD), the leading cause of vulvar pain. However, no studies have thus far investigated the reliability of an agreement between lasers for evaluating vul...
Source: Microvascular Research - August 16, 2018 Category: Biochemistry Source Type: research

Constitutive DPP4 activity, inflammation, and microvascular reactivity in subjects with excess body weight and without diabetes
Publication date: Available online 30 July 2018Source: Microvascular ResearchAuthor(s): Wellington Santana da Silva Júnior, Maria das Graças Coelho de Souza, José Firmino Nogueira Neto, Eliete Bouskela, Luiz Guilherme Kraemer-AguiarAbstractObjectiveIn patients with diabetes, dipeptidyl peptidase 4 (DPP4) inhibition is associated with attenuation of inflammation and endothelial dysfunction. Here, we investigated the associations between constitutive DPP4 activity, inflammatory biomarkers, and microvascular reactivity in subjects with excess body weight without diabetes.MethodsForty subjects of BMI &ge...
Source: Microvascular Research - July 31, 2018 Category: Biochemistry Source Type: research

Advanced glycation end products evoke inflammatory reactions in proximal tubular cells via autocrine production of dipeptidyl peptidase-4
Publication date: Available online 26 July 2018Source: Microvascular ResearchAuthor(s): Kumiko Kaifu, Seiji Ueda, Nobutaka Nakamura, Takanori Matsui, Nana Yamada-Obara, Ryotaro Ando, Yusuke Kaida, Masami Nakata, Maki Matsukuma-Toyonaga, Yuichiro Higashimoto, Kei Fukami, Yusuke Suzuki, Seiya Okuda, Sho-ichi YamagishiAbstractWe have previously shown that albuminuria and renal levels of advanced glycation end products (AGEs), receptor for AGEs (RAGE), and oxidative stress are suppressed in dipeptidyl peptidase-4 (DPP-4)-deficient diabetic rats, thus suggesting the crosstalk between AGE-RAGE axis and DPP-4 in experimental diab...
Source: Microvascular Research - July 27, 2018 Category: Biochemistry Source Type: research

Effects of different endurance exercise modalities on retinal vessel diameters in unipolar depression
ConclusionBoth exercise interventions improved AVR as well as BDI-II. HILV may be more effective in improving cerebrovascular health. The exercise-induced effects on retinal vessel diameter changes were relatively small and the clinical relevance remains to be investigated in larger and longer-term exercise trials. (Source: Microvascular Research)
Source: Microvascular Research - July 24, 2018 Category: Biochemistry Source Type: research

The relationship between sudomotor function and skin microvascular reactivity in individuals with type 1 diabetes of long duration
Publication date: Available online 22 July 2018Source: Microvascular ResearchAuthor(s): A. Gandecka, A. Araszkiewicz, S. Piłaciński, B. Wierusz-Wysocka, D. Zozulińska-ZiółkiewiczAbstractAimThe aim of this study was to assess the relationship between sudomotor function and microvascular perfusion in patients with type 1 diabetes (DM1).MethodsWe evaluated 415 patients (206 women), with DM1, median age of 41 (IQR: 33–53) years, disease duration of 25 (IQR: 20–32) years. We assessed metabolic control of diabetes and the presence of peripheral and cardiac autonomic neuropathy. Sudomotor function was asses...
Source: Microvascular Research - July 22, 2018 Category: Biochemistry Source Type: research

Image enhancement effect on inter and intra-observer reliability of nailfold capillary assessment
ConclusionBy improving the image quality, more capillary details will be visible, and an observer can document more details that may not be visible in the original image and can do so more efficiently. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Evidence of macro- and micro-angiopathy in scleroderma: An integrated approach combining 22-MHz power Doppler ultrasonography and video-capillaroscopy
ConclusionMacro- and micro-vascular involvement in SSc patients are different processes and are not present at the same time in every patient. Thus, both these aspects should be carefully evaluated in SSc patients. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Editorial Board
Publication date: September 2018Source: Microvascular Research, Volume 119Author(s): (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Circulating CD34+ and CD34+VEGFR2+ progenitor cells are associated with KLOTHO KL-VS polymorphism
ConclusionOne of the mechanisms that are responsible for previously described KL-VS heterozygote advantage may be connected with maintaining greater size of hematopoietic and endothelial progenitor cells population. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?
Publication date: September 2018Source: Microvascular Research, Volume 119Author(s): Matthew F. Yuyun, Leong L. Ng, G. André NgAbstractHomeostasis around vascular endothelium is a function of the equilibrium between the bioavailability of nitric oxide (NO) and oxidizing reactive oxygen species (ROS). Within the vascular endothelium, NO enhances vasodilatation, reduces platelet aggression and adhesion (anti-thrombotic), prevents smooth muscle proliferation, inhibits adhesion of leukocytes and expression of pro-inflammatory cytokines genes (anti-inflammatory), and counters the oxidation of low density lipoprotein (LDL...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Homocysteine up-regulates ETB receptors via suppression of autophagy in vascular smooth muscle cells
In conclusion, this suggested that Hcy up-regulated ETB receptors by inhibiting autophagy in VSMCs via AMPK/mTOR signaling pathway. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

The effect of repeated bouts of hyperaemia on sensory nerve-mediated cutaneous vasodilatation in humans
Publication date: September 2018Source: Microvascular Research, Volume 119Author(s): Gary J. Hodges, Stephen S. CheungAbstractPurposeTo investigate cutaneous sensory nerve contribution to hyperaemia following chronic shear stress training.MethodsEleven males underwent a shear stress intervention (forearm occlusion 5 s, rest 10 s) for 30 min, 5 times·week−1 for 6 weeks on one arm, the other was an untreated control. Skin blood flow was measured using laser-Doppler flowmetry, and sensory nerve function was assessed with and without blockade with EMLA cream in response to 3 levels of local heating (39, ...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Anti-angiogenic effect of a humanized antibody blocking the Wnt/β-catenin signaling pathway
ConclusionsH1L1 exhibits anti-angiogenic activities through blocking the Wnt/β-catenin pathway. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Interaction between blood and solid particles propagating through a capillary with slip effects
This article describes the interaction between solid particles and blood propagating through a capillary. A slip condition is considered on the walls of the capillary. The rheological features of the blood are discussed by considering as a two-phase Newtonian fluid model, i.e., the suspension of cells in plasma. A perturbation method is successfully applied to obtain the series solution of the governing coupled differential equations. The series solution for both fluid and particle phase are presented up to second order approximation. The expressions for the velocity and pressure distributions under slip effects are determ...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Nitric oxide signaling regulates tumor-induced intussusceptive-like angiogenesis
In this study, we developed an ex-ovo egg yolk angiogenesis model to screen the angiogenic potency of tumor cells (HeLa and SiHa cell lines). The egg yolk angiogenesis assay was applied to study the nitric oxide (NO) influence on switching from sprouting angiogenesis (SA) to intussusceptive angiogenesis (IA) under tumor microenvironment. Morphological analysis and SA-like or IA-like markers expression were determined during the development of chicken chorioallantoic membrane (CAM) from day 5 to 13. Expression of Notch1, Notch2, EphrinB2, and Tie2 were considered as SA-like while TEM8, CALD1, CXCR4 and HOMX1 were followed a...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Statins reduce testicular and ocular VEGF: A potential compromise to microcirculation
ConclusionStatin use decreased in VEGF levels of testicular and ocular tissues in diabetic and non-diabetic rats. Statin treatment (anti-VEGF effect) had a protective effect in the development of diabetic retinopathy, yet statins may have a negative impact on tissues that depend on microcirculation by reducing VEGF levels. Further research is needed for statins' microcellular effects. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Impaired function of cerebral parenchymal arterioles in experimental preeclampsia
Publication date: September 2018Source: Microvascular Research, Volume 119Author(s): Abbie C. Johnson, Marilyn J. CipollaAbstractPreeclampsia (PE), a dangerous hypertensive complication of pregnancy, is associated with widespread maternal vascular dysfunction. However, the effect of PE on the cerebral vasculature that can lead to stroke and cognitive decline is not well understood. We hypothesized that function of cortical parenchymal arterioles (PAs) would be impaired during PE. Using a high cholesterol diet to induce experimental PE in rats (ePE), we studied the function and structure of isolated and pressurized PAs supp...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

YAP1-TEAD1 signaling controls angiogenesis and mitochondrial biogenesis through PGC1α
Publication date: September 2018Source: Microvascular Research, Volume 119Author(s): Akiko Mammoto, Megan Muyleart, Andrew Kadlec, David Gutterman, Tadanori MammotoAbstractMitochondria contribute to key processes of cellular function, while mitochondrial dysfunction is implicated in metabolic disorders, neurodegenerative diseases, and cardiovascular diseases, in which angiogenesis - the formation of new blood capillaries - is dysregulated. The Hippo signaling transducer, Yes-associated protein (YAP1) binds to the TEA domain (TEAD1) transcription factor and controls angiogenesis. YAP1 also regulates glucose metabolism throu...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

The role of Rho-kinase and calcium ions in constriction triggered by ET-1
Publication date: September 2018Source: Microvascular Research, Volume 119Author(s): Michał Wiciński, Katarzyna Szadujkis-Szadurska, Mateusz M. Węclewicz, Bartosz Malinowski, Grzegorz Matusiak, Maciej Walczak, Eryk Wódkiewicz, Grzegorz Grześk, Katarzyna Pawlak-OsińskaAbstractEndothelin-1 (ET-1) is one of the key factors regulating tension of smooth muscles in blood vessels. It is believed that ET-1 plays an important role in pathogenesis of hypertension, and cardiovascular diseases; therefore, research in order to limit ET-1-mediated action is still in progress. The main objective of this paper was to evaluate ...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Effect of p-tyrosol on hemorheological parameters and cerebral capillary network in young spontaneously hypertensive rats
ConclusionWhen Tyr is administered to young SHRs during the development of hypertension, it limits the development of hyperviscosity syndrome, improves the oxygen transport capacity and eliminates microvascular rarefaction in the cerebral cortex. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Ticagrelor protects against AngII-induced endothelial dysfunction by alleviating endoplasmic reticulum stress
In conclusion, ticagrelor protects against AngII-induced endothelial dysfunction via alleviating ER stress. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

The pivotal role of angiogenesis in a multi-scale modeling of tumor growth exhibiting the avascular and vascular phases
Publication date: September 2018Source: Microvascular Research, Volume 119Author(s): Hooman Salavati, M. Soltani, Saeid AmanpourAbstractThe mechanisms involved in tumor growth mainly occur at the microenvironment, where the interactions between the intracellular, intercellular and extracellular scales mediate the dynamics of tumor. In this work, we present a multi-scale model of solid tumor dynamics to simulate the avascular and vascular growth as well as tumor-induced angiogenesis. The extracellular and intercellular scales are modeled using partial differential equations and cellular Potts model, respectively. Also, few ...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Impact of insulin on the intestinal microcirculation in a model of sepsis-related hyperglycemia
ConclusionsInsulin administration, as well as an endogenous insulin response triggered by HD glucose administration, improved the FCD and decreased leukocyte activation in endotoxemic rats. The results of this study give insight into the immune and vaso-modulatory role of insulin administration during experimental endotoxemia, and may be extrapolated for clinical sepsis and other critical illnesses with marked microcirculatory dysfunction. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Resting cerebral blood flow alterations specific to the comitant exophoria patients revealed by arterial spin labeling perfusion magnetic resonance imaging
ConclusionComitant exophoria showed increased resting CBF in eye movement-related brain areas including supplementary eye field, cingulate eye field and frontal eye field, which could be an explanation of the brain function compensation for the ocular motility disorders in the CE patients. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Sublethal mechanical trauma alters the electrochemical properties and increases aggregation of erythrocytes
Publication date: November 2018Source: Microvascular Research, Volume 120Author(s): Antony P. McNamee, Geoff D. Tansley, Michael J. SimmondsAbstractCirculation of blood depends, in part, on the ability of red blood cells (RBCs) to aggregate, disaggregate, and deform. The primary intrinsic disaggregating force of RBCs is derived from their electronegativity, which is largely determined by sialylated glycoproteins on the plasma membrane. Given supraphysiological shear exposure – even at levels below those which induce hemolysis – alters cell morphology, we hypothesized that exposure to supraphysiological and subh...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Homocysteine induces vascular inflammatory response via SMAD7 hypermethylation in human umbilical vein smooth muscle cells
Publication date: November 2018Source: Microvascular Research, Volume 120Author(s): Li-hua Wei, Nai-xia Chao, Si Gao, Ya-ting Yu, Lin Shi, Xin-bo Ma, Na Liao, Ke Lan, Yu Luo, Zheng-yi Xie, Yuan-yuan LiAbstractHomocysteine (Hcy) can induce atherosclerosis through the inflammatory response and DNA methylation disorder. Our recent study has reported a novel epigenetic modified gene related to atherosclerosis –SMAD7. To further understand the pathogenesis of atherosclerosis, the current study was designed to investigate an inflammatory role of Hcy in human umbilical vein smooth muscle cells (HUVSMCs) through interfering ...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Spectral analysis of the blood flow in the foot microvascular bed during thermal testing in patients with diabetes mellitus
In this study Laser Doppler flowmetry, a noninvasive technique for the cutaneous blood flow monitoring, was utilized together with local temperature tests and wavelet analysis. The study of the blood flow in the microvascular bed of toes was carried out in the control group of 40 healthy subjects and in two groups of 17 type 1 and 23 type 2 diabetic patients.The local temperature tests demonstrated that the diabetic patients have impaired vasodilation in response to local heating. The tendency for impaired low frequency pulsations of the blood flow associated with endothelial and neurogenic activities in both diabetes grou...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Human cancer cells suppress behaviors of endothelial progenitor cells through miR-21 targeting IL6R
In this study, we determined miR-21 expressed higher in human breast cancer, colon cancer and hepatocellular cancer tissues compared with normal tissues and expressed higher in exosomes of breast cancer and hepatocellular cancer cell lines compared with normal cells. MiR-21 dramatically suppressed proliferation, migration and invasion of endothelial progenitor cells (EPCs), which performed promoting role in thrombus repairment and resolution. High levels of miR-21 in exosomes of human cancers dramatically inhibited behaviors of EPCs, and depletion of miR-21 abrogated the decreased proliferation, migration and invasion of E...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Exercise preconditioning and low dose copper nanoparticles exhibits cardioprotection through targeting GSK-3β phosphorylation in ischemia/reperfusion induced myocardial infarction
ConclusionTreatment with CuNP and exercise training either alone or in combination favourably phosphorylate GSK-3β kinase pathways and further diminish oxidative stress, inflammatory cytokines, apoptosis and increase serum bioavailability of NO in the I/R insulted rats which tends to protect myocardial damage.Graphical abstract (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Association of cardiorespiratory fitness with retinal vessel diameters as a biomarker of cardiovascular risk
ConclusionsHigher cardiorespiratory fitness is associated with beneficial retinal microvascular health. Higher BMI and BP were associated with an impairment of retinal microvascular health. Exercise is known for its potential to improve body composition and reduce BP but may also prove to be an efficient therapy to counteract small vessel disease in cardiometabolic disease. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Impact of lipid modulation on the intestinal microcirculation in experimental sepsis
Publication date: November 2018Source: Microvascular Research, Volume 120Author(s): Annette Wegner, Dragan Pavlovic, Sebastian Haußmann-Vopel, Christian LehmannAbstractIt has been observed, that patients who were treated medically for dyslipoproteinemia had a potentially lower risk of complications during infection and sepsis, regarding both morbidity and mortality. Aim of this study in experimental sepsis was to elucidate the impact of lipid metabolism modulation by simvastatin, HDL, or bezafibrate, respectively, on the intestinal microcirculation which plays a crucial role in the development of multiple organ failu...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Quantitative protein profiling and pathway analysis of spinal arteriovenous malformations
In this study, we compared four sAVM specimens obtained during surgery and donated control samples in a Tandem Mass Tag (TMT)-labeled proteomic analysis. We identified 3101 proteins, 654 of which were differentially expressed in sAVM samples compared with the controls. Of these, 96 proteins were upregulated and 358 proteins were downregulated. Gene ontology (GO) analysis revealed that extracellular matrix organization in the biological process category and integrin-binding proteins in the molecular function category were the most enriched items. Two significant differentially expressed proteins (MYLK and MMP9) were verifie...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Microvascular endothelial dysfunction during cardiopulmonary bypass in surgery for correction of cyanotic and acyanotic congenital heart disease
ConclusionThe evaluation of systemic microvascular reactivity on the forehead skin of infants and children using LDPM appears to be a valuable tool for optimizing microvascular perfusion during CPB in pediatric cardiac surgery.Graphical abstractBaseline values (BL) of skin microvascular flow and skin microvascular vasodilator responses induced by local thermal hyperemia (TH), expressed as cutaneous vascular conductance [arbitrary perfusion units (APU)/mean arterial pressure, in APU/mmHg] after the induction of general anesthesia (postinduction, PI), 20 min after the beginning of cardiopulmonary bypass (CPB) and 20 min ...
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

The effects of hydrogen sulfide on microvascular circulation in the axial pattern flap ear model in hairless mice
ConclusionsIn summary H2S treatment is a promising attempt to improve microcirculation in critically perfused skin flaps and consequently to preserve flap viability. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

l-Citrulline restores nitric oxide level and cellular uptake at the brain capillary endothelial cell line (TR-BBB cells) with glutamate cytotoxicity
Conclusionl-Citrulline can restore NO level and its cellular uptake in TR-BBB cells with glutamate cytotoxicity. Supplying l-citrulline at the BBB may provide neuroprotective effect to improve cerebrovascular dysfunction such as a brain ischemia. (Source: Microvascular Research)
Source: Microvascular Research - July 11, 2018 Category: Biochemistry Source Type: research

Evidence of macro- and micro-angiopathy in scleroderma: An integrated approach combining 22-MHz power Doppler ultrasonography and video-capillaroscopy
ConclusionMacro- and micro-vascular involvement in SSc patients are different processes and are not present at the same time in every patient. Thus, both these aspects should be carefully evaluated in SSc patients. (Source: Microvascular Research)
Source: Microvascular Research - July 6, 2018 Category: Biochemistry Source Type: research

Image enhancement effect on inter and intra-observer reliability of nailfold capillary assessment
ConclusionBy improving the image quality, more capillary details will be visible, and an observer can document more details that may not be visible in the original image and can do so more efficiently. (Source: Microvascular Research)
Source: Microvascular Research - July 5, 2018 Category: Biochemistry Source Type: research

Resting cerebral blood flow alterations specific to the comitant exophoria patients revealed by arterial spin labeling perfusion magnetic resonance imaging
ConclusionComitant exophoria showed increased resting CBF in eye movement-related brain areas including supplementary eye field, cingulate eye field and frontal eye field, which could be an explanation of the brain function compensation for the ocular motility disorders in the CE patients. (Source: Microvascular Research)
Source: Microvascular Research - July 5, 2018 Category: Biochemistry Source Type: research