Regadenoson to the rescue: on the road towards prevention of primary graft dysfunction after lung transplantation

Primary graft dysfunction (PGD), defined as the presence of lung allograft infiltrates consistent with pulmonary edema and hypoxemia, is a devastating early complication of lung transplantation (1). PGD is a major risk factor for poor outcomes after lung transplant including death and development of chronic lung allograft dysfunction (CLAD) (2-4). Numerous studies have defined clinical risk factors for PGD (4) and there is extensive literature studying mechanisms of ischemia-reperfusion injury in experimental model systems (5).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research