The saturated fat Controversy: Finding calmness in chaos.
PMID: 31543190 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Gupta MD, Girish MP, Yadav R Tags: Indian Heart J Source Type: research

Lipoprotein(a): An underrecognized genetic risk factor for malignant coronary artery disease in young Indians.
Abstract Malignant coronary artery disease (CAD) refers to a severe and extensive atherosclerotic process involving multiple coronary arteries in young individuals (aged
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Enas EA, Varkey B, Dharmarajan TS, Pare G, Bahl VK Tags: Indian Heart J Source Type: research

The Gene  Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis.
CONCLUSIONS: Our meta-analysis reveals that the D allele of ACE I/D and the A allele of ACE G2350A are associated with increasing the risk of left ventricular hypertrophy. PMID: 31543192 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Fajar JK, Pikir BS, Sidarta EP, Berlinda Saka PN, Akbar RR, Heriansyah T Tags: Indian Heart J Source Type: research

Guidelines for the management of common congenital heart diseases in India: A consensus statement on indications and timing of intervention.
ar K, Marwah A, Mishra S, Mohanty SR, Murthy KS, Koneti NR, Suresh PV, Radhakrishnan S, Rajashekar P, Ramakrishnan S, Rao N, Rao SG, Reddy CHM, Sharma R, Shivaprakasha K, Subramanyan R, Suresh Kumar R, Talwar S, Tomar M, Verma S, Raju V Abstract INTRODUCTION: A number of guidelines are available for management of congenital heart diseases from infancy to adult life. However, these guidelines are for patients living in high-income countries. Separate guidelines, applicable to Indian children, are required when recommending an intervention for congenital heart diseases, as often these patients present late in t...
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Saxena A, Relan J, Agarwal R, Awasthy N, Azad S, Chakrabarty M, Dagar KS, Devagourou V, Dharan BS, Gupta SK, Iyer KS, Jayranganath M, Joshi R, Kannan BRJ, Katewa A, Kohli V, Kothari SS, Krishnamoorthy KM, Kulkarni S, Kumar RM, Kumar RK, Maheshwari S, Mano Tags: Indian Heart J Source Type: research

Early thrombolysis is associated with decreased operative mortality in postinfarction ventricular septal rupture.
CONCLUSIONS: Preoperative thrombolysis is associated with decreased odds of operative and overall mortality after surgical repair in PMIVSR patients. PMID: 31543194 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Dogra N, Puri GD, Thingnam SKS, Arya VK, Kumar B, Mahajan S, Verma M Tags: Indian Heart J Source Type: research

Cardiac resynchronization therapy in patients with heart failure and moderately reduced ejection fraction: Could it trigger a super-response?
The objective of the study is to evaluate the effects of CRT in optimally treated patients with New York Heart Association (NYHA) classes II-IV, LVEF of 36-45%, and left bundle branch (LBBB), including clinical, structural and biochemical response. METHODS: A selected group of HF patients have been implanted with CRT-P devices and were followed up for 6 months at 4, 12 and 24 weeks. Clinical assessment included NYHA class, quality of life and 6-min walk distance (6 MWD) test. Echocardiographic assessment included LV dimensions and function and left atrial volume. Serum N-terminal pro b-type natriuretic peptide (NT-Pro...
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Tawfik Ghanem M, Allam LE, Samir Ahmed R Tags: Indian Heart J Source Type: research

Facilitators and barriers of heart failure care in Kerala, India: A qualitative analysis of health-care providers and administrators.
CONCLUSIONS: Key themes emerged regarding heart failure care in Kerala in the context of a health system that is increasingly emphasizing health-care quality and safety. Targeted in-hospital quality improvement interventions for heart failure should account for these themes to improve cardiovascular outcomes in the region. PMID: 31543196 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Agarwal A, Davies D, Goenka S, Prabhakaran D, Huffman MD, Mohanan PP Tags: Indian Heart J Source Type: research

Clinical profile and one-year survival of patients with heart failure with reduced ejection fraction: The largest report from India.
CONCLUSIONS: This represents the largest single-center data of HF patients reported so far and the largest study describing clinical outcomes from HF patients in India. Our patients were younger, had high proportion of CAD, and there was higher usage of beta-blockers. Despite this, the one-year mortality was substantial. Given the enormous magnitude of HF burden in India and the paucity of information on this subject, these findings should be of help in identifying key problem areas and potential solutions for management of HF in India. PMID: 31543197 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Chopra VK, Mittal S, Bansal M, Singh B, Trehan N Tags: Indian Heart J Source Type: research

Impairment of left and right ventricular longitudinal strain in asymptomatic children with type 1 diabetes.
Abstract AIM: The relationship between type 1 diabetes (T1DM) and cardiac function in children is not well established. The purpose of this study was to investigate whether children and adolescents with T1DM present early asymptomatic abnormalities of left ventricular (LV) and right ventricular (RV) function. In addition, we evaluated the relationship of any such abnormalities with glycemic control and diabetes duration. METHODS: This was a prospective study. Standard echocardiography, tissue Doppler imaging, and two-dimensional strain analysis were performed prospectively in 52 children with T1DM. The result...
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Zairi I, Mzoughi K, Kamoun S, Moussa FB, Rezgallah R, Maatoug J, Mazigh S, Kraiem S Tags: Indian Heart J Source Type: research

Comparison of three-dimensional echocardiography and speckle tracking echocardiography in quantification and mapping of intraventricular mechanical dyssynchrony.
Abstract OBJECTIVES: The aim of the study is to compare two advanced methods of evaluation of left ventricular mechanical dyssynchrony (LVMD), the speckle tracking echocardiography (STE) and the three-dimensional echocardiography (3DE). METHODS: One hundred thirty-six subjects, with or without LV dysfunction and with or without bundle branch block (BBB), were included in this study, designed to investigate agreement between magnitude and spatial pattern of LVMD as assessed by 3DE and STE. The frequency and severity of LVMD and localization of most asynchronous segments were compared. RESULTS: Both 3DE an...
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Bhambhani A, Mathew A Tags: Indian Heart J Source Type: research

Genetic variants of chromosome 9p21.3 region associated with coronary artery disease and premature coronary artery disease in an Asian Indian population.
CONCLUSION: Our study suggests that SNPs at the 9p21 risk locus may be used to generate a reliable genetic risk score along with markers at other loci. PMID: 31543200 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Kalpana B, Murthy DK, Balakrishna N, Aiyengar MT Tags: Indian Heart J Source Type: research

Isolated diastolic hypertension and its risk factors in semi-rural population of South India.
CONCLUSION: There is a significant prevalence of IDH below 50 years of age in the semiurban population of South India. As IDH in young and middle age is known to be associated with increased risk of cardiovascular events and end organ involvement, it highlights need for study and development of effective IDH management strategies to reduce associated morbidity and mortality. PMID: 31543201 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Mittal C, Singh M, Bakhshi T, Ram Babu S, Rajagopal S, Ram CVS Tags: Indian Heart J Source Type: research

Clinical significance of bendopnea in heart failure-Systematic review and meta-analysis.
Abstract BACKGROUND: Bendopnea is a symptom mediated by increased ventricular filling pressure during bending forward. Presence of bendopnea in patients can be easily evaluated without additional maneuver in several countries whose norms, habits, culture, and occupation relates to a higher frequency of bending forward. This information may prove valuable in routine clinical practice. We aimed to analyze the latest evidence on bendopnea in order to further define the clinical significance of this symptom. METHODS: We performed a comprehensive search on bendopnea in heart failure from inception up until January...
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Pranata R, Yonas E, Chintya V, Alkatiri AA, Budi Siswanto B Tags: Indian Heart J Source Type: research

Coronary artery disease is associated with valvular heart disease, but could it Be a predictive factor?
This study was conducted to evaluate the prevalence of significant coronary artery disease (CAD) in patients with severe valvular heart disease (VHD) and the association between these two cardiac entities. Our research aims to introduce the theory of a possible causal relationship. METHODS: A retrospective study was conducted on 1308 consecutive patients who underwent surgery for severe VHD in the cardiovascular department of Notre-Dame de Secours University Hospital (NDSUH) between December 2000 and December 2016. According to transthoracic echocardiography, patients were divided into 4 groups: patients with severe a...
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Matta A, Moussallem N Tags: Indian Heart J Source Type: research

Trial sequential analysis of studies comparing the frequency of target-vessel revascularization with drug-coated balloons as compared with second-generation drug-eluting stents in coronary in-stent restenosis: Have we generated enough evidence in the field?
PMID: 31543204 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - May 1, 2019 Category: Cardiology Authors: Kumar A, Shariff M Tags: Indian Heart J Source Type: research

Aspirin for primary prevention: Is this the end of the road?
This article reviews the history of aspirin through the last two decades, with special emphasis on these new trials. PMID: 31280821 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Singal AK, Karthikeyan G Tags: Indian Heart J Source Type: research

Prevalence of familial hypercholesterolemia in premature coronary artery disease patients admitted to a tertiary care hospital in North India.
CONCLUSION: FH prevalence is high among patients with premature CAD admitted to a cardiac unit. To detect patients with FH, routine screening with simple criteria such as family history of premature CAD combined with hypercholesterolemia, and a DLCN criteria score>5 may be effectively used. PMID: 31280822 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Sawhney JPS, Prasad SR, Sharma M, Madan K, Mohanty A, Passey R, Mehta A, Kandpal B, Makhija A, Jain R, Mantri RR, Vivek BS, Manchanda SC, Verma IC Tags: Indian Heart J Source Type: research

Incidence, predictors, and gradation of upper extremity venous obstruction after transvenous pacemaker implantation.
PMID: 31280823 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Shenthar J, Padmanabhan D, Banavalikar B, Parvez J, Vallapil SP, Singha I, Tripathi V Tags: Indian Heart J Source Type: research

Effect of morphine use on oral P2Y12 platelet inhibitors in acute myocardial infarction: Meta-analysis.
Abstract BACKGROUND: Morphine is the recommended analgesic in acute myocardial infarction (AMI). This recommendation has come under scrutiny because of possible slow uptake of oral antiplatelet agents. OBJECTIVE: We performed a meta-analysis of all available studies in AMI patients treated with prasugrel or ticagrelor (P2Y12 inhibitors) that reported use of morphine prior to loading the antiplatelet agents to critically assess the safety of co-administration of morphine and the newer P2Y12 inhibitors. METHODS: Several sources were searched from inception to December 2017 with inclusion of eight stud...
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Vaidya GN, Khan A, Ghafghazi S Tags: Indian Heart J Source Type: research

Incidence and predictors of forearm hematoma during the transradial approach for percutaneous coronary interventions.
CONCLUSIONS: Forearm hematoma following TRA-PCI occurs in about 10% patients. Most hematomas occur near the puncture area. The independent predictors for hematoma formation are age, body mass index, multiple puncture attempts, intensive antiplatelet therapy, and multiple catheter exchanges. PMID: 31280825 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Garg N, Umamaheswar KL, Kapoor A, Tewari S, Khanna R, Kumar S, Goel PK Tags: Indian Heart J Source Type: research

Door-to-Needle Time in Myocardial Infarction: Small Steps, Huge Dividends.
Abstract The Himachal Pradesh acute coronary syndrome registry highlighted a prehospital delay of 780 min. Additional door-to-needle time delay by 1 h increases the hazard ratio of death by 20%. We conducted a retrospective (group 1) and a prospective (group 2) analysis of 63 patients each to measure the impact of a fast-track protocol in the emergency department (ED) on the door-to-needle time in ST-elevation myocardial infarction (STEMI). The fast-track protocol involved zero cost to the hospital and saved 63 precious door-to-needle minutes for patients with STEMI. Thrombolysis in ED can save 33 precio...
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Chauhan V, Negi BD, Sharma G Tags: Indian Heart J Source Type: research

The report on the Indian coronary intervention data for the year 2017-National Interventional Council.
PMID: 31280827 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Arramraju SK, Koganti S, Janapati R, Emmareddy SK, Mandala GR Tags: Indian Heart J Source Type: research

Twelve-month comparative analysis of clinical outcomes using biodegradable polymer-coated everolimus-eluting stents versus durable polymer-coated everolimus-eluting stents in all-comer  patients.
This study was designed as a multicentre, observational, retrospective, investigator-initiated study between January 2016 and October 2016. Two hundred thirteen patients who underwent percutaneous coronary intervention (PCI) with the BDP-EES were compared with 204 patients who underwent PCI with the DP-EES, irrespective of lesion complexity, comorbidities and acute presentation. The primary end point was MACE defined as a composite of cardiac death, myocardial infarction and target lesion revascularization. RESULTS: Baseline clinical and lesion characteristics of both the groups were similar, although the BD...
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Abhyankar A, Sandhu MS, Polavarapu RS Tags: Indian Heart J Source Type: research

Atherogenic index of plasma and its association with cardiovascular disease risk factors among postmenopausal rural women of Bangladesh.
Abstract OBJECTIVES: There is absolute lacking of evidences on atherogenic index of plasma (AIP) and its association with cardiovascular disease (CVD) risk factors among postmenopausal women of Bangladesh. This prompted us to investigate this association between AIP and CVD risk factors among postmenopausal women in a rural setting. METHODS: This cross-sectional study recruited 265 postmenopausal women aged 40-70 years who visited a primary health-care center of Bangladesh. We used modified STEP-wise approach for the Surveillance of Noncommunicable diseases risk factors questionnaire of the World Health Organ...
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Barua L, Faruque M, Banik PC, Ali L Tags: Indian Heart J Source Type: research

Effects of home-based exercise training on functional outcomes and quality of life in patients with pulmonary hypertension: A randomized clinical trial.
The objective of this study was to assess the effects of home-based exercise training (HBET) on function and quality of life (QoL) in patients with pulmonary hypertension (PH). METHODS: A prospective, nonblinded, randomized clinical trial was carried out on 84 medically stable patients with PH belonging to any functional class or etiology and of either sex. Patients were randomized to either standard care or HBET. Both groups also received education using the Pulmonary Hypertension Manual (PulHMan). Outcomes included functional capacity from 6-min walk distance (6MWD), QoL using the Medical Outcomes Survey Short ...
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Babu AS, Padmakumar R, Nayak K, Shetty R, Mohapatra AK, Maiya AG Tags: Indian Heart J Source Type: research

Resolution of Primary Aortic Thrombosis after Dabigatran therapy-A New Hope for the Rare and Old Disease.
We present a case of PAT where the use of dabigatran leads to complete resolution and prevented the recurrence of the disease during two-year follow-up, which is the first and unique case report of the literature. PMID: 31280831 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Jariwala P, Kale SS Tags: Indian Heart J Source Type: research

Image-Based Simulative Training for Myectomy in Hypertrophic Cardiomyopathy: An Emerging Necessity.
Abstract Surgical myectomy was initially advocated only for patients with symptoms refractory to maximal tolerated medical therapy. These were mainly symptoms of cardiac failure. In recent times, there has been a call for revision of guidelines to include patients earlier. As the disease progression cannot be reversed by most currently used drugs which become ineffective with time, this need for earlier myectomy seems mandatory. Presently, surgical expertise in myectomy is limited to specialized centers. The complexity of surgical myectomy is enhanced by the complex and variable anatomic substrate. With the need f...
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Parachuri VR, Adhyapak SM Tags: Indian Heart J Source Type: research

Letter to the editor regarding "Role of cytochrome epoxygenase (CYP2J2) in the pathophysiology of coronary artery disease in South Indian Population."
Letter to the editor regarding "Role of cytochrome epoxygenase (CYP2J2) in the pathophysiology of coronary artery disease in South Indian Population." Indian Heart J. 2019 Mar - Apr;71(2):174-175 Authors: Kumar U A, Shariff M PMID: 31280833 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Kumar U A, Shariff M Tags: Indian Heart J Source Type: research

Letter to the Editor Regarding "Ticagrelor for Asian Patients With Acute Coronary Syndrome in Real-World Practice: A Systematic Review and Meta-analysis of Observational Studies." The Benefit of Using Person-Year When the Follow-up Period Varies in a Meta-analysis.
Letter to the Editor Regarding "Ticagrelor for Asian Patients With Acute Coronary Syndrome in Real-World Practice: A Systematic Review and Meta-analysis of Observational Studies." The Benefit of Using Person-Year When the Follow-up Period Varies in a Meta-analysis. Indian Heart J. 2019 Mar - Apr;71(2):176-177 Authors: Kumar U A, Shariff M PMID: 31280834 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Kumar U A, Shariff M Tags: Indian Heart J Source Type: research

Authors' reply to the letter regarding "Ticagrelor for Asian patients with acute coronary syndrome in real-world practice: A systematic review and meta-analysis of observational studies".
Authors' reply to the letter regarding "Ticagrelor for Asian patients with acute coronary syndrome in real-world practice: A systematic review and meta-analysis of observational studies". Indian Heart J. 2019 Mar - Apr;71(2):178-180 Authors: Galimzhanov AM, Azizov BS PMID: 31280835 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Authors' reply to the letter regarding "Ticagrelor for Asian patients with acute coronary syndrome in real-world practice: A systematic review and meta-analysis of observational studies". Tags: Indian Heart J Source Type: research

Lipoprotein(a): An independent, genetic, and causal factor for cardiovascular disease and acute myocardial infarction.
Abstract Lipoprotein(a) [Lp(a)] is a circulating lipoprotein, and its level is largely determined by variation in the Lp(a) gene (LPA) locus encoding apo(a). Genetic variation in the LPA gene that increases Lp(a) level also increases coronary artery disease (CAD) risk, suggesting that Lp(a) is a causal factor for CAD risk. Lp(a) is the preferential lipoprotein carrier for oxidized phospholipids (OxPL), a proatherogenic and proinflammatory biomarker. Lp(a) adversely affects endothelial function, inflammation, oxidative stress, fibrinolysis, and plaque stability, leading to accelerated atherothrombosis and...
Source: Indian Heart J - March 1, 2019 Category: Cardiology Authors: Enas EA, Varkey B, Dharmarajan TS, Pare G, Bahl VK Tags: Indian Heart J Source Type: research

Prevalence and One-year Outcome of Carotid Sinus Hypersensitivity in Unexplained Syncope: A Prospective Cohort Study from South India.
Abstract BACKGROUND: Carotid sinus syndrome accounts for one third of patients who presents with unexplained syncope. Prevalence of carotid sinus hypersensitivity (CSH) in Indians has not been studied till now. OBJECTIVES: To assess the prevalence and associations of CSH in symptomatic patients above 50 years and to study its prognostic significance pertaining to sudden cardiac death, syncope, recurrent pre syncope and falls on 1 year follow up. METHODS: Patients above 50 years who presented with unexplained syncope, recurrent syncope or falls were considered cases and those without these symptoms were c...
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Kadermuneer P, Sandeep R, Haridasan V, George B, Sajeev CG, Krishnan MN Tags: Indian Heart J Source Type: research

Premature battery depletion with St. Jude Medical ICD and CRT-D devices: Indian Heart Rhythm Society Guidelines for physicians.
PMID: 31000177 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Bhargava K, Arora V, Jaswal A, Vora A, Indian Heart Rhythm Society Tags: Indian Heart J Source Type: research

Ticagrelor for Asian patients with acute coronary syndrome in real-world practice: A systematic review and meta-analysis of observational studies.
Abstract OBJECTIVE: We aimed to assess the efficacy and safety of ticagrelor compared to clopidogrel in Asian patients with acute coronary syndrome (ACS) in real-world practice. METHODS: PubMed, Web of Science and Scopus databases were searched systematically to obtain relevant Asian observational studies. RESULTS: The meta-analysis included six studies with 27959 participants. Compared with clopidogrel, ticagrelor was significantly beneficial in prevention of major adverse cardiac events (MACCEs) (OR=0.62; 95% CI: 0.46-0.83, I2=69%, p=0.001) mainly driven by reducing stroke (OR=0.62; 95% CI: 0.49-0.78, I2=0%, p
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Galimzhanov AM, Azizov BS Tags: Indian Heart J Source Type: research

Short- and long-term follow-up of antithrombotic management patterns in patients hospitalized with acute coronary syndrome: Indian subgroup of EPICOR Asia study.
CONCLUSION: This study showed a gap between international recommendations and implementation for managing ACS in Indian patients. Most of the patients prefer to undergo invasive management instead of non-invasive therapy. At the end of the 2-year follow-up, more than half of the population was receiving DAPT, with most patients on receiving a combination of aspirin and clopidogrel. The mortality along with composite events of death, MI, or ischemic stroke was highest for patients with NSTEMI. PMID: 31000179 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Sawhney JPS, Mullasari A, Kahali D, Mehta V, Nair T, Kaul U, Hirematth MS Tags: Indian Heart J Source Type: research

Amlodipine alters hemorheological parameters: Increased efficacy at the cost of edema?
Abstract BACKGROUND: Despite several decades of use of calcium channel blockers, the side effect of edema persists as a class effect, and its mechanism is unresolved. Amlodipine has effects on hemorheology (HR), and its hemodilutory property may partly contribute to its antihypertensive action. This aspect is not well studied, and the literature is sparse in this regard. OBJECTIVE: This experiment was planned to determine effect of a single-dose administration of amlodipine on HR parameters in normal human volunteers. METHODS AND RESULTS: Amlodipine (5 mg) or S (-) amlodipine (2.5 mg) was ...
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Ravindra RP, Arunkumar S, Puniyani RR, Padgaonkar K, Vadivelu R, Sharma R, Panicker G, Lokhandwala Y Tags: Indian Heart J Source Type: research

Epidemiology of confirmed coronary heart disease among population older than 60 years in rural central India-A community-based cross-sectional study.
CONCLUSION: Prevalence of confirmed CHD has increased in agrarian rural community in central India, which requires further studies to find out causative factors. PMID: 31000181 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Bodkhe S, Jajoo SU, Jajoo UN, Ingle S, Gupta SS, Taksande BA Tags: Indian Heart J Source Type: research

Prevalence and risk determinants of metabolic syndrome in obese worksite workers in hill city of Himachal Pradesh, India.
CONCLUSIONS: MS is highly prevalent among obese employees of organized sector. The consumption of alcohol and extra salt were major behavioral risk factors for MS and therefore have important implications in behavioral modifications for prevention of MS among obese employees in organized sectors. PMID: 31000182 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Negi PC, Sondhi S, Merwaha R, Asotra S Tags: Indian Heart J Source Type: research

Cognitive impairment and 30-day rehospitalization rate in patients with acute heart failure: A systematic review and meta-analysis.
CONCLUSION: Our meta-analysis demonstrated that the presence of cognitive impairment is associated with 30-day rehospitalization in patients with HF. PMID: 31000183 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Kewcharoen J, Trongtorsak A, Kanitsoraphan C, Prasitlumkum N, Mekritthikrai R, Techorueangwiwat C, Limpruttidham N, Rattanawong P Tags: Indian Heart J Source Type: research

Role of cytochrome epoxygenase (CYP2J2) in the pathophysiology of coronary artery disease in South Indian population.
Abstract BACKGROUND: The cytochrome P-450 2J2 (CYP2J2) is known to be one of the major enzymes of epoxygenase pathway of arachidonic acid in extrahepatic tissues, which produces series of regioisomeric cis-epoxyeicosatrienoic acids (EETs) such as 5,6-, 8,9-, 11,12-, and 14,15-EETs. In the present study, we analyzed the impact of a genetic variant in CYP2J2 on coronary artery disease (CAD) in the Telangana region of Indian population. MATERIAL AND METHODS: The case-control study consisted of 100 CAD cases and 110 healthy controls. The deoxyribonucleic acid was extracted using the salting out method. Genotyping...
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Tantray JA, Reddy KP, Jamil K, Yerra SK Tags: Indian Heart J Source Type: research

Procedural and follow-up clinical outcomes after chronic total occlusion revascularization: Data from an Indian public hospital.
Abstract BACKGROUND: Chronic total occlusion (CTO) continues to be challenging lesion subset for percutaneous intervention. Last decade has seen tremendous increase in percutaneous coronary intervention (PCI) in this subset owing to improved understanding of the anatomy and enhanced skillset with availability of dedicated hardware. We sought to study the outcomes of CTO PCI in an Indian public hospital. METHODS: This was a single-center non-randomized descriptive follow-up study on CTO PCI. The end-points were procedural success, immediate, and late adverse cardiovascular events [major adverse cardiac ev...
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Pillai AA, Ramasamy S, Jagadheesan KS, Satheesh S, Selvaraj RJ, Jayaraman B Tags: Indian Heart J Source Type: research

Influence of atrial fibrillation on cardiac prognosis in chronic obstructive pulmonary disease.
Abstract BACKGROUND: Chronic obstructive pulmonary disease (COPD), a known risk factor for the development of congestive heart failure (CHF), was recently shown to predict the prevalence of atrial fibrillation (AF). Here, we explore the influence of AF on cardiac prognosis in COPD patients. METHODS: A total of 339 consecutive patients who underwent spirometry from 2010 to 2013 for various reasons were retrospectively examined. Based on the diagnostic criteria, patients were stratified into COPD and non-COPD groups, which were both further divided into those with AF (chronic AF or paroxysmal AF) or sinus rhyth...
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Tomioka T, Fukui K, Tanaka S, Ito Y, Shioiri H, Koyama J, Inoue K Tags: Indian Heart J Source Type: research

Comparison of resting and adenosine-free pressure indices with adenosine-induced hyperemic fractional flow reserve in intermediate coronary lesions.
Abstract OBJECTIVE: Fractional flow reserve (FFR) using adenosine has been the gold standard in the functional assessment of intermediate coronary stenoses in the catheterization laboratory. We aim to study the correlation of adenosine-free indices such as whole cycle Pd/Pa [the ratio of mean distal coronary pressure (Pd) to the mean pressure observed in the aorta (Pa)], instantaneous wave-free ratio (iFR), and contrast-induced submaximal hyperemia (cFFR) with FFR. METHODS: This multicenter, prospective, observational study included patients with stable angina or acute coronary syndrome (>48 h since o...
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Raja DC, Subban V, Mathew R, Abdullakutty J, Joseph J, George J, Chandra S, Livingston N, Nair SG, Janakiraman E, Kalidoss L, Mullasari AS Tags: Indian Heart J Source Type: research

Pericardial effusion in prosthetic and native valve infective endocarditis.
Abstract BACKGROUND: Pericardial effusion (PE) is widely believed to signify more advanced infective endocarditis (IE) and a generally worse outcome. PURPOSE: To determine the prevalence and clinical significance of PE in a series of patients with confirmed native and prosthetic valve infections. METHODS: Data were collected from 338 consecutive patients with definite or possible IE who visited a single referral center; these patients were examined for the presence of PE as detected by transthoracic echocardiography. Clinical characteristics, the incidence of complications, and outcomes were compared bet...
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Youssef GS, Mashaal MS, El Remisy DR, Sorour KA, Rizk HH Tags: Indian Heart J Source Type: research

Current status of rheumatic heart disease in India.
Abstract The rheumatic heart disease continues to be an important cause of disease burden in India, affecting the population in their prime and productive phase of the life. The prevalence of rheumatic heart disease is varied in different Indian studies, because of the inclusion of different populations at different point of times and using different screening methods for the diagnosis. The data on incidence and prevalence on a nationally represented sample are lacking. There is a need for establishing a population-based surveillance system in the country for monitoring trends, management practices, and outcomes t...
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Negi PC, Sondhi S, Asotra S, Mahajan K, Mehta A Tags: Indian Heart J Source Type: research

Ambulatory blood pressure monitoring in clinical practice.
This article will focus on the significance of ambulatory BP, its advantages and limitations compared with the standard office BP measurement and a brief outlook on its use and interpretation to diagnose and treat hypertension. PMID: 31000190 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Dadlani A, Madan K, Sawhney JPS Tags: Indian Heart J Source Type: research

Non-cardiac Conditions Which Can Elevate The Serum Levels of sST2.
PMID: 31000191 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - January 1, 2019 Category: Cardiology Authors: Patil TR, Patil ST, Patilsss S, Patil A Tags: Indian Heart J Source Type: research

Incidence of essential hypertension in young adult males followed for over two decades.
CONCLUSION: Our cohort had low incidence rates of hypertension when compared with other studies from abroad. Active military service may offer protection from the hypertension and associated complications. PMID: 30595238 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - December 1, 2018 Category: Cardiology Authors: Kumar KVSH, Patnaik SK Tags: Indian Heart J Source Type: research

Anemia profile in patients with congestive heart failure a hospital based observational study.
CONCLUSION: Iron deficiency is present in substantial number while B12 and folate account for a few number of cases. Substantial number of patients without anemia were found to be iron deficient. PMID: 30595239 [PubMed - in process] (Source: Indian Heart J)
Source: Indian Heart J - December 1, 2018 Category: Cardiology Authors: Arora H, Sawhney JPS, Mehta A, Mohanty A Tags: Indian Heart J Source Type: research

Is C-peptide a predictor of severity of coronary artery disease in metabolic syndrome? An observational study.
Abstract BACKGROUND: Various cardiovascular disease (CVD) risk factors have been implicated to correlate with the severity of the disease. Present study was conducted to correlate one such risk factor i.e. fasting serum C-peptide with the presence or absence and the severity of CVD in Indian population. METHODS: 68 patients with metabolic syndrome who underwent coronary angiogram for suspected CVD were included. Their fasting serum C-peptide levels were measured in addition to routine biochemical and cardiological tests. They were divided into 2 groups - those with a positive coronary angiography findings (Gr...
Source: Indian Heart J - December 1, 2018 Category: Cardiology Authors: Harnishsingh B, Rama B Tags: Indian Heart J Source Type: research