Transient Opening of the Blood-Brain Barrier by Vasoactive Peptides to Increase CNS Drug Delivery: Reality Versus Wishful Thinking?

CONCLUSION: Vasoactive peptides remain an understudied class of drugs with the potential to increase drug delivery and improve treatment in patients with brain tumors and other neurologic diseases. Dozens of vasoactive peptides have yet to be formally evaluated for this important clinical effect. This narrative review summarizes the available data on vasoactive peptides, highlighting agents that deserve further in vitro and in vivo investigations.PMID:35100958 | DOI:10.2174/1570159X20999220131163504

Source: Current Neuropharmacology - February 1, 2022 Category: Drugs & Pharmacology Authors: Matthew A Smith-Cohn Nicholas B Burley Stuart A Grossman Source Type: research