Impact of 18F-2-fluoro-2-deoxy-D-glucose PET/computerized tomography on the initial staging and changing the management intent in head and neck squamous cell carcinoma
Conclusion 18F-FDG-PET/CT is considered a valuable diagnostic test in head and neck squamous cell carcinoma at initial assessment which would change staging and radiotherapy planning and hence proper management. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Whole-body 18-F-FDG-PET in patients with leptomeningeal disease and correlation with MRI
Objective Studies evaluating leptomeningeal disease on whole-body 18F-FDG PET are lacking. The purpose was to evaluate PET imaging of leptomeningeal disease and investigate the incremental utility of newer PET reconstructions in leptomeningeal disease. Methods PET imaging of 56 patients with leptomeningeal disease detected initially on MRI (n = 53) or cytopathology (n = 35) were retrospectively reviewed. Regular 3-dimensional iterative reconstruction (3D IR, n = 56) and advanced reconstruction (AdvRecon, n = 41) PET images were evaluated by readers blinded to clinical and MRI findings for uptake involving cauda ...
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Initial results of the use of a novel semiquantitative parameter in three-phase bone scan to predict 99mTc-HMPAO-labeled leukocyte scintigraphy in patients with unilateral total knee replacement
Conclusions The novel P/BP ratio seems to be a promising semiquantitative parameter to predict septic loosening. These findings warrant confirmation in larger patient samples. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The impact of permanent pacemaker implantation on thallium myocardial perfusion examination detecting ischemic heart disease
Objectives Patients with permanent pacemaker (PPM) implantation may have altered coronary perfusion patterns that may influence the accuracy of myocardial perfusion examination modalities, which was observed in previous studies but with limited statistic power. Our aim was to examine the performance of thallium-201 (TL-201) myocardial perfusion examination in patients with implanted PPM. Methods Data of consecutive patients from our institution who had coronary angiography examination followed by TL-201 myocardial perfusion examination in pairs within 1 year were collected between January 2010 and Decembe...
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prognostic value of left ventricular mechanical dyssynchrony in hypertrophic cardiomyopathy patients with low risk of sudden cardiac death
This study aims to explore the prognostic value of left ventricular mechanical dyssynchrony (LVMD) in hypertrophic cardiomyopathy (HCM) patients with low risk of sudden cardiac death (SCD). Methods This retrospective study was performed in 50 patients with HCM who underwent Tc-99m sestamibi GSPECT-MPI. All patients were at low risk of SCD, defined as HCM risk-SCD scores (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Direct correlation between ischemic burden induced by dipyridamole and stress peak filling rate: a gated perfusion single-photon emission computed tomography study
Aim and patients The aim of the present study was to assess the effects of dipyridamole on stress and rest peak filling rate in consecutive patients who showed perfusion and, or function abnormalities at Gated-SPECT. Were enrolled 96 patients (73 males (76%); mean age 71.7 ± 9.57). Forty patients (41.7%) had an history of myocardial infarction and fifty-seven (59.4%) of previous cardiac revascularization. All patients underwent a 2-day 99mTc-SestaMIBI gated perfusion SPECT protocol. Results Twenty-nine (30.2%) patients showed fixed perfusion defects, 54 (56.2%) showed partially or completely reversible on...
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Accuracy of next-day single-sample measurement for low glomerular filtration rate and comparison with same-day slope-intercept glomerular filtration rate
Conclusions SS-GFR with a 24-h sample is more accurate than same-day SI-GFR in patients with GFR less than 25 mL/min/1.73 m2. Using SS-GFR with a 24-h sample in routine clinical practice will result in clinically insignificant differences in GFR result compared with the reference technique, whereas a same-day SI-GFR measurement could cause large inaccuracies. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of 81mKrypton and 99mTc-Technegas for ventilation single-photon emission computed tomography in severe chronic obstructive pulmonary disease
Conclusion Caution should be taken when replacing 81mKrypton with 99mTc-Technegas as a ventilation tracer in patients with severe COPD as there are significant differences in the distribution of the tracers over the lungs. Furthermore, this patient group is prone to 99mTc-Technegas hot spots and might need additional scanning if hot spots severely hamper image interpretation. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Dosimetry-guided radioiodine therapy of hyperthyroidism: long-term experience and implications for guidelines
Conclusions We advise earlier (2–3 weeks) first follow-up checks after RIT in all Graves’ disease patients and thyroid autonomy under antithyroid drugs (ATD) and re-checks every 2–4 weeks until conversion to hypothyroidism during the first year. The first check in thyroid autonomy without ATD should be after 3–4 weeks with re-checks every 4–6 weeks. After 1 year, both groups can be re-checked every 4–6 months over the next 5 years. The success rate of RIT in thyroid autonomyincreases with age but the history of RIT is rapidly lost duri...
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Impact of COVID-19 on nuclear medicine in the UK
Conclusion The first wave caused a major disruption of NM service delivery and impacted on the workforce. The departmental strategies should tailor services to evolving local and regional differences in prevalence of COVID-19. A blanket shutdown of services with a ‘one size fits all’ strategy would likely have a severe impact on future delivery of NM and health services in general. Timely testing of staff and patients remains of paramount importance. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The COVID-19 pandemic: impact on NHS England PET-CT services and lessons learnt
Conclusions There is no correlation between FDG PET-CT activity (fall and recovery) in England and the ability to provide the service by NHS England. It most likely reflects a combination of changes in health-seeking behaviour, NHS health policy and a decrease in the use of investigations that carry a high risk of COVID-19 transmission. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Osteoblastic and hyperostotic craniofacial lesion detected by 99mTc-labeled methylene diphosphonate bone scintigraphy and single-photon emission computed tomography/computed tomography: a pictorial essay
99mTc-bisphophonates bone scan, planar and single-photon emission computed tomography/computed tomography (SPECT/CT) modalities, is a commonly used technique that provides high sensitivity and specificity for detection of osseous metastases. However, besides bone metastases, SPECT/CT provides an accurate evaluation of the localization of the lesions and supplies anatomic information that can be valuable for diagnosis of nonmalignant bone diseases, occasionally disclosed in the skull. Reporting of craniofacial lesions detected by 99mTc-MDP (99mTc-labeled methylene diphosphonate) bone scintigraphy and SPECT/CT in the literat...
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Review article Source Type: research

What role does 18F-fluorodeoxyglucose PET-computed tomography have in the current pandemic and beyond?
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Editorial Source Type: research

Estimation of CARE Dose 4D quality reference mAs conversion factors for child to adult reference patient in child protocols on Siemens Symbia SPECT-CT systems
Conclusion Conversion factors for child to adult dose modulation references are proposed, allowing comparable delivered mAs to a child. Video abstract: http://links.lww.com/NMC/A178 (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Technical Note Source Type: research

18F-fluorodeoxyglucose uptake on PET/computed tomography in association with androgen receptor expression and other clinicopathologic factors in surgically resected triple-negative breast cancer
Objective To evaluate whether androgen receptor expression in triple-negative breast cancer (TNBC) is associated with 18F-fluorodeoxyglucose (FDG) uptake and to identify predictive factors of 18F-FDG uptake in TNBC. Methods We retrospectively assessed data of 156 surgically resected primary TNBC in 156 consecutive patients who underwent 18F-FDG PET/computed tomography between July 2013 and May 2017. Clinicopathologic features, including androgen receptor expression, were categorized and the distribution of maximum standardized uptake value (SUVmax) was compared between the groups. We also evaluated the correlati...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The frequency and malignancy rate of incidental focal breast lesions identified by 18F-fluorodeoxyglucose positron emission tomography
Conclusion Incidental uptake of FDG in the breast was rare. However, the malignancy rate was high among these patients, particularly among patients who had a follow-up biopsy. We recommend biopsy or thorough follow-up in patients with incidental focal uptake of FDG in the breast. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Feasibility of prognosis assessment for cancer of unknown primary origin using texture analysis of 18F-fluorodeoxyglucose PET/computed tomography images of largest metastatic lymph node
Objective Cancers of unknown primary origin cannot be staged using images, making the prognosis difficult. We attempted to predict prognosis of patients with unknown primary origin using tumour heterogeneity recently introduced in 18F-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT). Methods Overall, 30 patients with unknown primary origin who underwent whole-body 18F-FDG PET/CT scans were retrospectively enrolled for texture analysis. The volume of interest was placed in the largest metastatic lymph nodes and conventional parameters and grey-level co-occurrence matrix (GLCM) were calculated. Statistica...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Examination of metallic impurities of 68Ge/68Ga generators used for radioactive labeling of peptides in clinical PET applications
Conclusion As a result, each generator contains metallic impurities different from its certificate. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Characteristics of different histological subtypes of thyroid nodules classified with 99mTc-methoxy-isobutyl-isonitrile imaging and Thyroid Imaging Reporting And Data System
Conclusion TIRADS is useful to detect PTC, but FVPTC and FTC may be missed. MIBI imaging seems to be more suitable to detect FVPTC and FTC. However, neither TIRADS nor MIBI imaging are able to differentiate between follicular adenoma and FTC or FVPTC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Correction of slope-intercept glomerular filtration rate measurement without scaling for body size
Aim The aim of this study was to evaluate a slope-intercept glomerular filtration rate (GFR) one-compartment correction method based exclusively on the rate constant (α2) of the exponential between 2 and 4 h post-injection that requires no scaling for BSA. Methods The correction factor is 1/([C.α2]+1). C depends on the difference between one-compartment-corrected and uncorrected GFR, so varies with different correction procedures. Patients were in four groups: group 1 (51Cr-EDTA; n = 141) and group 2 (99mTc-DTPA; n = 47) had sampling at 2, 3 and 4 h. Groups 3A (99mTc-DTPA; n = 168) and 3B (99mTc-DTPA...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The value of skeletal standardized uptake values obtained by quantitative single-photon emission computed tomography-computed tomography in differential diagnosis of bone metastases
Purpose The aim of this study was to explore the value of skeletal standardized uptake value (SUV) obtained by quantitative single-photon emission computed tomography-computed tomography (SPECT/CT) in differential diagnosis of bone metastases from benign lesions. Materials and methods Retrospective analysis has been conducted to 51 patients with extraskeletal malignant tumors who underwent whole-body bone scan with quantitative SPECT/CT imaging, and there are no more than three hotspots that were visually detected in the SPECT/CT imaging range. Fifty-one patients were enrolled, including 28 men and 23 women with...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

New gender-specific formulae for estimating extracellular fluid volume from height and weight in adults
Conclusions New formulae are described for estimating eECV. Scaling GFR to eECV is more physiological than scaling to eBSA and accounts for gender. eECV used for measuring GFR from a single blood sample should be gender-specific. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Monitoring jaw osteomyelitis therapy with single-photon emission computed tomography/computed tomography
Conclusion SPECT/CT is a valuable tool to accurately assess therapy response, disease exacerbation and complications of jaw osteomyelitis. Low-grade (grade 1) residual tracer uptake is common in patients with clinically complete remission and is suggestive of ongoing bone remodeling and healing. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Empirical 188Re-HDD/lipiodol intra-arterial therapy based on tumor volume, in patients with solitary inoperable hepatocellular carcinoma
Conclusion After the administration of 1.2–3.7 GBq 188Re-HDD/lipiodol based on empirical activity calculation of 0.8–1.2 mCi/mL of tumor volume, more than half of the patients in the present study had an objective response on imaging and biochemically. No significant adverse side effects were noted and most of the laboratory markers as well as symptoms returned to normal after 48–72 h post-administration. Selective administration of the radiopharmaceutical into the tumor feeding arteries gives a good anti-tumoral effect with minimal side effects and damage to surrounding normal li...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Dual-tracer radionuclide imaging in hyperparathyroidism: thallium-201 parathyroid scintigraphy revisited
Conclusion The results of this pilot study strongly advocate a role for thallium parathyroid SPECT/CT imaging in patients with primary and secondary hyperparathyroidism where the initial 99mTc-sestamibi scan is deemed to be false-negative in the presence of biochemical hyperparathyroidism. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

A review of pediatric neuroendocrine tumors, their detection, and treatment by radioisotopes
Neuroendocrine tumors (NETs) are rare in childhood. Neuroblastoma is the most common pediatric extracranial solid tumor, occurring>90% in children younger than 5 years of age. Pheochromocytoma and paraganglioma are rare NETs, causing hypertension in 0.5–2% of hypertensive children. Gastroenteropancreatic NETs can occur in children and are classified into carcinoids and pancreatic tumors. Nuclear medicine procedures have an essential role both in the diagnosis and treatment of NETs. Metaiodobenzylguanidine (MIBG) labeled with radioiodine has a well-established role in diagnosis as well as therapeutic management of ...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Review Articles Source Type: research

Bone single-photon emission computed tomography/computed tomography in cancer care in the past decade: a systematic review and meta-analysis as well as recommendations for further work
In conclusion, targeted SPECT/CT improves the specificity of diagnosing bone metastases, but efforts need to be made to standardise the thresholds for SPECT/CT, methodology, as well as harmonising the reporting and interpretation criteria. We also make some recommendations for future works. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Review Articles Source Type: research

PET in the diagnostic management of infectious/inflammatory pulmonary pathologies: a revisit in the era of COVID-19
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Editorials Source Type: research

Radionuclide therapy services in an era of COVID-19: the radiation protection challenges, opportunities and considerations
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Editorials Source Type: research

Chromosome aberrations during in-vitro labeling of red blood cells with 99mTc: a study with cytokinesis block micronucleus assay in human peripheral blood lymphocytes
Radiopharmaceuticals are special medicines composed by a radionuclide and a non-radioactive compound characterized by non-pharmacodynamic effects, low prevalence of side effects, and a possible risk of oncogenesis, since its administration to patients supposes a radiation dose to organism. Over these years, radiation damage induced by diagnosis radiopharmaceuticals has been evaluated, including the radiolabeled autologous cells, a group of radiopharmaceuticals where blood cells extracted from patients are labeled in-vitro and readministered for diagnosis. There is not a consensus about the possibility of increasement of ri...
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Technical Notes Source Type: research

Safe practice ventilation technique in lung scanning for pulmonary embolism
Ventilation/Perfusion scanning for suspected pulmonary embolism is undergoing a renaissance due to the advent of single-photon emission computed tomography (SPECT). The scan protocol demands the inhalation of a radioactive gas or vapour for the ventilation scan. The purpose of this article is to report the radioactive environmental contamination that can occur when Tc99m Technegas vapours are administered to patients for the ventilation SPECT scan. This contamination can concentrate within gamma camera heads to degrade images and is also a radiation hazard to staff. A method for sequestrating this airborne contamination wa...
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Technical Notes Source Type: research

Evaluation of dual time-point fluorodeoxyglucose PET/computed tomography imaging in gastric cancer
Background We aimed to evaluate the efficiency of dual time-point fluorodeoxyglucose (FDG) PET/computed tomography (CT) imaging in detecting primary and metastatic lesions in gastric cancer. Methods Between May 2019 and January 2020, 52 patients with gastric carcinoma were prospectively involved in our study. And dual time-point FDG PET/CT imaging performed to the patients. Of detected primary and metastatic lesions, the ones that are better visualized or only appear in delayed imaging were visually identified. Also, maximum standardized uptake value (SUVmax) of the primary and metastatic lesions and the intact ...
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Diagnostic performance of F-18 fluorodeoxyglucose PET/computed tomography for diagnosis of polymyalgia rheumatica: a meta-analysis
Objective The purpose of the current study was to investigate the diagnostic performance of F-18 fluorodeoxyglucose (FDG) PET/computed tomography (CT) for diagnosis of polymyalgia rheumatic (PMR) through a meta-analysis. Methods The PubMed, Cochrane and EMBASE database, from the earliest available date of indexing up to 29 February 2020, were searched for studies evaluating the diagnostic performance of F-18 FDG PET/CT for diagnosis of PMR. Results Across the 11 results of seven studies selected for analysis (684 patients), the pooled sensitivity for F-18 FDG PET/CT was 0.76 [95% confidence interval (CI),...
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The value of 4D fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis of lung lesions
Conclusion The 4D 18F-FDG PET/CT exhibited excellent performance with high accuracy in the dynamic PET/CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of 18F-DCFPyL and 18F-FDG PET/computed tomography for the restaging of clear cell renal cell carcinoma: preliminary results of 15 patients
Conclusions Our preliminary results indicated that 18F-DCFPyL PET/computed tomography is superior to 18F-FDG PET/computed tomography for the detection of local recurrence at both the surgical site and in bone metastasis while the tracers are comparable in the detection of soft tissue metastases. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Pilot study comparing dominant intraprostatic lesion volume using Ga-68 prostate-specific membrane antigen PET-computed tomography and multiparametric MRI
Purpose The standard imaging used for delineation of dominant intraprostatic lesion (DIL) is multiparametric MRI (mpMRI). The use of biologic imaging such as Ga-68 prostate-specific membrane antigen (PSMA) PET-computed tomography (PET-CT) for this purpose is being explored in view of increased sensitivity of this modality and the associated ease of delineation. Materials and methods The primary objective of the study was to compare the autogenerated volumes of the DIL in Ga-68 PSMA PET-CT with the standard volume delineated in mpMRI. Twenty patients with biopsy-proven untreated prostatic adenocarcinoma were incl...
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-FDG PET/computed tomography may predict the outcome of newly diagnosed indolent non-Hodgkin lymphoma in patients managed with initial ‘watch-and-wait’ approach
Conclusion A proportion of patients with NHL might experience spontaneous regression of lymphoma. 18F-FDG PET/CT turned out as a prognostic factor for TLT in patients with NHL under watchful waiting. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-FDG-PET brain imaging may highlight brain metabolic alterations in dysautonomic syndrome after human papilloma virus vaccination
Aim The aim of this study was to evaluate brain glucose metabolism by means of [18F]-fluoro-deoxygluycose (18F-FDG) PET in a group of patients presenting dysautonomic syndrome after human papilloma virus (HPV) immunization. Methods Medical records of patients, referred to the ‘Second Opinion Medical Consulting Network’ Medical Centre (Modena, Italy) diagnosed with dysautonomic syndrome were searched. Inclusion criteria were presence in the medical history of adverse drug reactions following HPV vaccine; a Montreal Cognitive Assessment score (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Effect of blood glucose and body weight on image quality in brain [18F]FDG PET imaging
Conclusions Increasing blood glucose and body weight are associated with increased image noise in standard imaging conditions. Improving count density by prolonging scan time and increasing injected activity significantly improves image quality in hyperglycaemic patients, although the image contrast remains reduced in patients with most pronounced hyperglycaemia. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Preliminary evaluation of 18F-FDG-PET/MRI for differentiation of serous from nonserous pancreatic cystic neoplasms: a pilot study
Conclusion Preliminary results show that PET/MRI utilization is promising for differentiation of pancreatic SCN from non-SCN lesions. This could reduce need for surveillance imaging or avoidance of unnecessary intervention in pancreatic cystic neoplasms with uncertain diagnoses. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Clinical evaluation of kit based Tc-99m-HYNIC-RGD2 for imaging angiogenesis in breast carcinoma patients
Conclusion The single vial cold kit based radiolabeling of Tc-99m HYNIC-RGD2 is facile leading to its easy availability. Tc-99m HYNIC-RGD2 is a promising radiopharmaceutical which can be used for the molecular imaging of angiogenesis in breast carcinoma patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Y90 selective internal radiation therapy and peptide receptor radionuclide therapy for the treatment of metastatic neuroendocrine tumors: combination or not?
Conclusions In the neuroendocrine tumors with liver-dominant metastatic disease, personalized selective internal radiation therapy and peptide receptor radionuclide therapy and their combinations result in increased survival rates. Selective internal radiation therapy alone could be an effective treatment in patients with liver-limited and -dominant disease. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Predictive value of sentinel lymph node imaging and biopsy in early cervical cancers: correlation with scintigraphic uptake patterns and histology
Conclusion SLNI and biopsy in early cervical malignancies are feasible with high detection rate. Scintigraphic patterns of nodal uptake were relevant and found to correlate with the tumor histological grades. We found that nonfocal nodal uptake patterns were mainly encountered in patients with tumors having higher Ki index. Immunohistochemistry further facilitated identification of lymph nodal metastases. The visual grading system, implemented in this study provides a good indication of the degree of impairment of lymphatic drainage. Higher visual scintigraphic grade denotes greater lymphatic tumor burden. (Source: Nuc...
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

131I-6β-iodomethyl-19-norcholesterol adrenal scintigraphy as an alternative to adrenal venous sampling in differentiating aldosterone-producing adenoma from bilateral idiopathic hyperaldosteronism
Conclusion NP-59 scintigraphy can be used as an alternative to AVS if there is a strong lateralisation on NP-59 scintigraphy and adrenal macrotumours observed on the computed tomography when AVS is technically challenging, particularly in the right adrenal vein cannulation, and if contraindications, such as allergy to contrast materials and renal failure, are observed. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Neuro-oncology tracers: an already limited supply impacted by the pandemic?
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Editorial Source Type: research

Correlation between 18F-FDG PET/computer tomography findings and histology in thymic epithelial tumors: current evidences and clinical implications
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 29, 2020 Category: Nuclear Medicine Tags: Letter to the Editor Source Type: research

Management and evaluation of sodium [131I] iodide contamination after oral administration
Radioiodine therapy using oral administration of Iodine-131 (131I) is a widespread employed strategy for the treatment of hyperthyroidism and thyroid cancer. Such a therapy requires well-trained staff, equipment and procedures regarding radiation safety. The aims of this work are to report an incidental experience of radioprotection with a 370 MBq sodium [131I] iodide capsule, which arose following vomiting one minute after the oral administration in a nuclear medicine department and assessment of capsule leakage in a stomach like environment by in vitro experiment. Measurements of the radiation dose rate at the different ...
Source: Nuclear Medicine Communications - October 29, 2020 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Primary metabolic tumor volume from 18F-FDG PET/CT associated with epidermal growth factor receptor mutation in lung adenocarcinoma patients
Purpose To explore the potential parameters from 18F-FDG PET/CT that might be associated with the epidermal growth factor receptor (EGFR) gene mutation status in lung adenocarcinoma (ADC) patients. Methods Data of the test cohort of 191 patients and the validation cohort of 55 patients with newly diagnosed ADC were retrospectively reviewed. All patients underwent 18F-FDG PET/CT scans and EGFR mutation tests prior to treatment. The metabolic parameters obtained from 18F-FDG PET/CT combining with clinical characteristics were analyzed by using univariate and multivariate logistic regression analyses. Then two cohorts we...
Source: Nuclear Medicine Communications - October 29, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-FDG PET/CT for primary staging of patients with testicular germ cell tumors: the predictors of 18F-FDG PET positivity and prognostic value of PET derived metabolic parameters
Purpose The aim of this study was to investigate the role of histopathologic and biochemical parameters for predicting 18F-FDG PET positivity for primary staging in patients with newly diagnosed testicular germ cell tumors (TGCT). It was also aimed to evaluate the prognostic value of PET derived metabolic features in this patient group. Materials and methods The imaging findings of 51 patients who were diagnosed as TGCT and underwent 18F-FDG PET/CT for primary staging after surgery between 2009 and 2019 were evaluated retrospectively. In terms of the presence of 18F-FDG uptake consistent with metastasis, the patients ...
Source: Nuclear Medicine Communications - October 29, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Semiquantitative assessment of fluorodeoxyglucose uptake in primary tumours on dynamic PET/computed tomography for lymph node metastasis evaluation in patients with lung cancer: a prospective study
Objective To semiquantitatively estimate fluorine-18-fluorodeoxyglucose (FDG) uptake in primary lung cancer cells using dynamic and dual-time-point (DTP) PET/computed tomography (PET/CT) to obtain a diagnostic index for lymph node metastasis. Methods Forty-five patients with lung cancer underwent dynamic and DTP PET/CT examinations. All primary lesions and lymph node metastases were evaluated pathologically. At each time phase, we assessed the maximum standardised uptake value (SUVmax), metabolic tumour volume (MTV) and total lesion glycolysis (TLG) of the primary tumours. We investigated the relationship between semi...
Source: Nuclear Medicine Communications - October 29, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research