Is radioiodine scintigraphy still of value in thyroid nodules with indeterminate cytology?: a prospective study in an iodine-sufficient area
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: LETTER TO THE EDITOR Source Type: research

Comparison of the renal dynamic scan performed with 99mTc-L,L-EC and 99mTc-MAG3 in children with pelviureteric junction obstruction
The aim was to compare the renal dynamic scan (RDS) performed with technetium-99-L,L-ethylene dicysteine (99mTc-L,L-EC) and technetium-99-mercaptoacetyltriglycine (99mTc-MAG3) in children with pelviureteric junction (PUJ) obstruction. A retrospective study was carried out and children with PUJ obstruction who had RDS performed with both 99mTc-L,L-EC and 99mTc-MAG3. Children with any intervention in between the two scans or a gap of more than 2 months in between renal scans were excluded. The dose of each radiotracer used was 0.1 mCi/kg (3.7 MBq/kg), with a minimum dose of 1 mCi (37 MBq). RDS was...
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: TECHNICAL NOTE Source Type: research

Evaluation of 18F-FDG PET/CT parameters for reflection of aggressiveness and prediction of prognosis in early-stage cervical cancer
Purpose The aim of this study was to investigate the value of five typical fluorine-18-fluorodeoxyglucose PET/computed tomography (CT) parameters (including SUVmax, SUVmean, SUVpeak, MTV and TLG) in the reflecting aggressiveness and predicting prognosis in patients with early-stage cervical cancer. Patients and methods Our study enrolled 85 primary cervical cancer patients who underwent preoperative fluorine-18-fluorodeoxyglucose PET/CT scans. We investigated the association of five parameters derived from PET/CT with clinicopathological characteristics. Immunohistochemistry was utilized to evaluate the expression of ...
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

New era of PET/CT in breast cancer: high-resolution PET/dfCT
Objective To determine whether breast cancer staging differs between high-resolution (HR) and standard-resolution (SR) PET/computed tomography acquisition. Patients and methods This retrospective study included 39 women with breast cancer referred for staging. Images were assessed for the number of primary breast lesions with the corresponding size and the average maximum standardized uptake value (SUVmax), the anatomical site of fluorine-18-fluorodeoxyglucose-avid lymph nodes (LNs) with their SUVmax, and the number and type (lytic/blastic) of metastatic bone lesions. Results On HR, 42 breast tumor lesions with a s...
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

The feasibility of using 18F-FDG-PET/CT in patients with mucinous breast carcinoma
Conclusion 18F-FDG uptake efficiently distinguishes the pure type from the mixed type and may play a potential role in predicting the aggressiveness of mucinous breast carcinoma. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Normal brain metabolism on FDG PET/MRI during childhood and adolescence
Conclusion This FDG PET/MRI study shows that normal brain metabolism measured by SUVmean and SUVmax increases with age in all regions, proceeding at different rates between distinct anatomical sites. Our results suggest that there is mild asymmetry in SUVmean, but mostly symmetric SUVmax during normal development. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Gallium 68-PSMA PET/CT for lesion characterization in suspected cases of prostate carcinoma
Conclusion 68Ga-PSMA PET/CT can act as a gate keeper in selecting patients with suspected PCa who should undergo an immediate transrectal ultrasonography-guided biopsy and who could be kept on active surveillance. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

18F-FDG-PET metabolic metrics and International Prognostic Score for risk assessment in HIV-infected patients with Hodgkin lymphoma
Conclusion There was no significant difference in 18F-FDG metabolic parameters, IPS, and other risk indicators between HIV-infected and HIV-uninfected patients with Hodgkin lymphoma. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Prognostic significance of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography-derived metabolic parameters in surgically resected clinical-N0 nonsmall cell lung cancer
Objective Our aim was to assess the significance of metabolic positron emission tomography (PET) parameters for the prediction of occult mediastinal lymph node metastasis (OLM) and recurrence in patients with clinical-N0 nonsmall cell lung cancer (NSCLC) after surgical resection and lymph node dissection. Materials and methods We evaluated 98 patients with NSCLC [52 adenocarcinoma (ADC), 46 squamous cell carcinoma (SQCC)] who had undergone initial/preoperative fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). Eligibility criteria for participation were clinically staged ...
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

The efficacy of fluorine-18-choline PET/CT in comparison with 99mTc-MIBI SPECT/CT in the localization of a hyperfunctioning parathyroid gland in primary hyperparathyroidism
Conclusion 18F-FCH PET/CT has a high diagnostic power in primary hyperparathyroidism and can be used for further evaluation of patients with inconclusive neck USG and 99mTc-MIBI SPECT/CT. SUVmax of the hyperfunctioning parathyroid gland seems to be predictive of disease severity in terms of serum PTH and bone mineral densitometry results. Studies with larger patient groups are needed to support these data. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Usefulness of the combination of iodine-123-metaiodobenzylguanidine scintigraphy and iodine-123-ioflupane scintigraphy in new-onset Parkinson’s disease
Conclusion If SBR is greater than 3.8, the SBR×H/M ratio can help diagnose PD. The combined use of the two scintigraphies can improve the diagnosis of PD. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Docking, synthesis, in-vitro evaluation, and optimization of reaction conditions for direct radiolabeling of CGPRPPC with technetium-99m through the GAGG sequence
Conclusion We could radiolabel the fibrin-targeting peptide with high radiochemical purity% and stability during a short incubation period without a boiling step. Compared with the HYNIC-conjugated peptide, a higher binding affinity was found. Therefore, the GAGG chelating moiety possesses a considerable potentiality in Technetium 99m labeling of peptides while CGPRPPC maintains its binding properties to thrombotic lesions. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Indirect assessment of the maximum empirical activity (250 mCi) with respect to dosimetry concepts in radioiodine therapy of metastatic differentiated thyroid cancer
Conclusion Upon to this study, red marrow dose varies with type of preparation as that of medication withdrawal cases was slightly higher than exogenous thyroid-stimulating hormone. Involvement of lesion and red marrow dose assessment through dosimetry protocol seems indeed valuable to optimize safe and effective activity compared with the conventional regime with 250 mCi as maximum empirical activity. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Evaluation of the most commonly used (semi-)quantitative parameters of 18F-FDG PET/CT to detect malignant transformation of neurofibromas in neurofibromatosis type 1
In patients with neurofibromatosis type 1, transformation of neurofibromas into a malignant peripheral nerve sheath tumor (MPNST) is a severe complication of the disease. Fluorine-18-fluorodeoxyglucose PET/computed tomography (PET/CT) is a viable option for detecting malignant tumors in neurofibromatosis type 1 patients. The aim of this review was to assess the diagnostic performance of the most frequently used parameters of PET/CT in detecting MPNST. An extensive computer search was performed using the Cochrane Library, Pubmed, and Medline/Embase databases. Two reviewers independently extracted data of relevant studies an...
Source: Nuclear Medicine Communications - October 16, 2018 Category: Nuclear Medicine Tags: REVIEW ARTICLE Source Type: research

The prognostic and diagnostic value of 18F-FDG PET/CT for assessment of symptomatic osteoarthritis: Erratum
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Erratum Source Type: research

Concentration protocol of rhenium-188 perrhenate eluted from tungsten-188/rhenium-188 generator for the preparation of high-yield rhenium-188-labelled radiopharmaceuticals
Rhenium-188 (188Re) is a β, γ emitter and considered a theranostic radionuclide. It is used for bone pain palliation, treatment of unresectable hepatocellular carcinoma, skin keloids, etc. 188Re perrhenate is eluted from a 188W/188Re generator in large volumes (8–14 ml) of 0.9% normal saline. Concentrating 188Re to 1–2 ml volume is important for high radiolabelling yield of various 188Re radiopharmaceuticals, especially when the generator is old. For this, ion exchange column was prepared in-house, and 188Re was concentrated using silver ion exchange column and QMA cartridge. 188Re perr...
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Role of 11C-choline PET/CT in radiation therapy planning of patients with prostate cancer
Conclusion In our series, Cho-PET had a significant effect on radiotherapy planning of patients affected by prostate cancer, determining a change in management in 48.8% of cases, considering all therapeutic indications. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Quantitative evaluation of normal spinal osseous metabolism with 18F-NaF PET/CT
Conclusion We assessed the metabolic activity of the spine’s osseous tissues with 18F-NaF PET using a global assessment approach in healthy men. Our study provides evidence of differences in spinal metabolism as related to weight, but not age. Our study offers a foundation for future larger studies in symptomatic populations. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Validation of scatter limitation correction to eliminate scatter correction error in oxygen-15 gas-inhalation positron emission tomography images
Conclusion SLC visually eliminated the SC error and increased the quantitative parameters on 15O gas-inhalation images derived from a phantom and from patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prognostic predictive value of preoperative intratumoral 2-deoxy-2-(18F)fluoro-D-glucose uptake heterogeneity in patients with high-grade serous ovarian cancer
Conclusion 2-Deoxy-2-(18F)fluoro-D-glucose-based heterogeneity appears to be a predictive and prognostic factor for patients with HGSC. Parameters of primary tumors have predominant value compared with omental metastatic lesions. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Utility of MAG3 scintigraphy with the use of a 2 min uptake parameter in the assessment of postsurgical renal transplant complications
Objective Major complications including acute tubular necrosis or rejection may occur after renal transplantation. We use a semiquantitative parameter, 2 min uptake (2MU), as part of 99mTc mercaptoacetyltriglycine (MAG3) scintigraphy for transplant evaluation. The aim of this study were (a) to examine the utility of 99mTc MAG3 scintigraphy in the assessment of postsurgical complications using the renal biopsy as the gold standard and (b) examine for any correlation with 2MU with serum creatinine (sCr) at 3 and 12 months. Materials and methods We retrospectively reviewed all 99mTc MAG3 studies at our institution...
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Correlation of radiation dose and activity with clinical outcomes in metastatic colorectal cancer after selective internal radiation therapy using yttrium-90 resin microspheres
Conclusion The prescribed activity of 90Y-resin microspheres may be correlated with radiographic response by RECIST criteria at 4–6 months post-treatment. For a more accurate prediction of response, a valid dose calculation model based on post-90Y PET dosimetry is likely needed given the heterogeneous dose delivery seen in SIRT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The conclusions drawn from ventilation/perfusion single-photon emission computed tomography compared with lung perfusion single-photon emission computed tomography and chest radiography in patients with suspected pulmonary thromboembolism
Conclusion Our study showed that the omission of a ventilation SPECT led to a high rate of false-positive diagnoses and that the ventilation scan cannot be replaced by a chest radiography. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Early predictive value of baseline renal transplant scintigraphy in pediatric patients
Conclusion Our experience in this study underlines the importance of RTS, especially with the use of GI and P : U, which are very valuable in diagnosing DGF/SGF and predicting early transplant outcome in pediatric recipients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Radiation dose reduction in myocardial perfusion imaging single-photon emission computed tomography/computed tomography using a dose-tracking software
We describe our experience with a dose-tracking software (Radimetrics) that was used to optimize, from a dosimetric point of view, the single-photon emission computed tomography/computed tomography protocols used in myocardial perfusion imaging. Patients and methods We extracted and assessed the major dosimetric indices as the administered activity, the computed tomography dose index, the dose length product and the size-specific dose estimates for a large sample of patients before and after an optimization process. We also evaluated both the effective and the equivalent dose to organs for all the procedures. Results ...
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Artificial intelligence in the diagnosis of Parkinson’s disease from ioflupane-123 single-photon emission computed tomography dopamine transporter scans using transfer learning
Conclusion This study has provided proof of concept for the use of transfer learning, from convolutional neural networks pretrained on nonmedical images, for the interpretation of 123I SPECT scans. This has been shown to be possible in this study even with a very small sample size. This technique is likely to be applicable to many areas of diagnostic imaging. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

National survey of gastric emptying studies in the UK
This study was undertaken to investigate the extent of variation in meals, radiopharmaceuticals and methodology used for gastric emptying studies in the UK. Materials and methods Overall, 178 nuclear medicine departments across the UK were contacted by telephone and the gastric emptying protocol was requested. In all, 128 (72%) performed routine gastric emptying studies; 83 protocols were received. Results Liquid meal gastric emptying: 15 departments performed liquid gastric emptying either as a dual isotope technique (27%) or as a separate test using 99mTc-diethylenetriamine pentacetic acid (53%) or 99mTc-colloid (2...
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

68Ga-PSMA PET/CT and PET/MRI in high-risk prostate cancer patients
Treatment of high-risk prostate cancer (HRPCa) is challenging. Local staging and metastatic evaluation are important for the patient management. Recently, prostate-specific membrane antigen (PSMA)-based imaging modalities such as PSMA PET/CT and PET/MRI have received significant attention for detection of recurrent prostate cancer sites with elevated prostate-specific antigen levels, after therapy. Current evidence suggests that these imaging modalities may also have a role for the management of patients with HRPCa. In this review, we discuss PSMA-based imaging modalities in the management of patients with HRPCa. (Source: ...
Source: Nuclear Medicine Communications - September 13, 2018 Category: Nuclear Medicine Tags: Review Article Source Type: research

Fractionated elution of 99Mo/99mTc generators using calibrated vials
This study aims to describe and evaluate straightforward procedures allowing to readily perform fractionated elution on dry and wet columns 99Mo/99mTc generators by using calibrated vials. The main objectives of this study consisted in determining the relationship between eluate volume and elution yield using different vials calibration and assessing repeatability of the procedure. Elution vials were calibrated to obtain different eluate volumes by addition of air for wet column generator (WCG) and subtraction of saline for dry column generator (DCG) (n≥5 for each calibration). The relationship between the eluate volume...
Source: Nuclear Medicine Communications - August 15, 2018 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Optimal timing of fluorine-18-fluoromisonidazole positron emission tomography/computed tomography for assessment of tumor hypoxia in patients with head and neck squamous cell carcinoma
Objectives The aim of this study was to identify the optimal timing of fluorine-18-fluoromisonidazole (18F-MISO) PET/CT imaging to assess hypoxia in patients with head and neck squamous cell carcinoma. Patients and methods Eighteen patients underwent pretreatment 18F-MISO PET/CT imaging after providing written informed consent. PET scans were acquired at 1, 3, and 5 h after injection of the radionuclide. The mean standardized uptake value (SUV) within a spherical region of interest placed on the contralateral neck musculature at the level of the largest tumor dimension was labeled as background. A value 1.5 tim...
Source: Nuclear Medicine Communications - August 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Actual impact of screening for myocardial ischemia with single-photon emission tomography among patients undergoing peripheral vascular interventions
The present study provides actual data with regard to the prevalence of myocardial ischemia among patients under contemporary cardiovascular prevention strategies undergoing peripheral vascular interventions. We included a total of 200 consecutive patients who underwent gated single-photon emission computed tomography myocardial perfusion study between January 2012 and January 2014 as preoperative evaluation for peripheral vascular interventions at our institution. The baseline medical treatment comprised aspirin (81%), statins (79%), and β-blockers (54%). Thirty-two (16%) patients underwent carotid revascularization;...
Source: Nuclear Medicine Communications - August 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Decrease in total lesion glycolysis and survival after yttrium-90-radioembolization in poorly differentiated hepatocellular carcinoma with portal vein tumour thrombosis
This study aims to evaluate the prognostic role of the decrease in total lesion glycolysis (TLG) assessed by fluorine-18-fluorodeoxyglucose (18F-FDG) PET-computed tomography (CT) 1 month after yttrium-90-radioembolization (90Y-RE) in patients affected by hepatocellular carcinoma (HCC) with portal vein tumour thrombosis (PVTT). Patients and methods Twenty-one patients with histologically proven poorly differentiated HCC and evidence of PVTT at the enhanced multislice CT underwent 90Y-RE. All patients underwent an 18F-FDG PET-CT scan at baseline and 1 month after the loco-regional therapy. The variation in TLG (ΔTLG...
Source: Nuclear Medicine Communications - August 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

St. John’s Wort accelerates the liver clearance of technetium-99-sestamibi in rats
Conclusion This study showed that SJW extract accelerates the liver clearance of 99mTc-MIBI and significantly reduces photon scattering from the liver. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Assessment of normal reference values for thyroid uptake of technetium-99m pertechnetate in a single centre UK population
Conclusion The calculated normal reference range in this study was found to be less than that used in our own and many other UK institutions. The results demonstrate the importance of periodic evaluation of normal uptake values and provide support for prospective studies defining the normal reference range to be performed. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

123I-iomazenil whole-body imaging to detect hepatic carboxylesterase drug-metabolizing enzyme activity
Conclusion 123I-iomazenil whole-body imaging has good possibility of direct measurement of hepatic carboxylesterase activity as accumulation of 123I-R-COOH in the gall bladder through bile and in the bladder through urine. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

99mTc-Phy portal perfusion index imaging helps predict the severity of hepatitis B virus cirrhosis: a preliminary study
Objective The aim was to perform exploratory research on the application of technetium phytate (99mTc-Phy) portal perfusion index (PPI) imaging in predicting the complications of hepatitis B cirrhosis and their severity. Patients and methods A total of 65 hepatitis B cirrhosis patients were stratified, respectively, into three groups from classes A to C according to Child–Pugh scores and five groups from stages 1 to 5 according to the five-stage prognostic system. PPIs were compared and analyzed, respectively, among the three and five groups. The correlations between PPIs and major biochemical indices of liver f...
Source: Nuclear Medicine Communications - August 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Hepatic selective internal radiation therapy: how well does pretreatment 99mTc-macroaggregated albumin activity distribution and quantification agree with post-therapy bremsstrahlung imaging?
Conclusions The PLS agreement was sensitive to the 90Y lung background correction ROI, potentially explaining a previously published controversy. The mean activity and absorbed dose agreement for the metastatic lesions was poorer than the healthy liver volumes studied here. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Lutetium-177 tin colloid radiosynovectomy in patients with inflammatory knee joint conditions intractable to prevailing therapy
Objective To evaluate the treatment response of lutetium-177 tin colloid radiosynovectomy (177Lu-RSV) in patients with inflammatory knee joint conditions refractory to conventional treatment. Patients and methods Overall, 29 knee joints in 29 patients with chronic synovitis caused by various inflammatory knee joint diseases refractory to conventional therapy were included in this prospective study. All patients were assessed clinically for pain, tenderness, joint swelling, mobility, analgesic intake, and blood pool activity on bone scan. Different scores were assigned to all these parameters. RSV of knee joint was don...
Source: Nuclear Medicine Communications - August 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Extension of the International Atomic Energy Agency phantom study in image quantification: results of multicentre evaluation in Croatia
To make quantitative methods of nuclear medicine more available, four centres in Croatia participated in the national intercomparison study, following the materials and methods used in the previous international study organized by the International Atomic Energy Agency (IAEA). The study task was to calculate the activities of four 133Ba sources (T1/2=10.54 years; Eγ=356 keV) using planar and single-photon emission computed tomography (SPECT) or SPECT/CT acquisitions of the sources inside a water-filled cylindrical phantom. The sources were previously calibrated by the US National Institute of Standards and Tec...
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Technical Note Source Type: research

177Lu-DOTATATE therapy in patients with neuroendocrine tumours including high-grade (WHO G3) neuroendocrine tumours: response to treatment and long-term survival update
Conclusion 177Lu-DOTATATE therapy is an important treatment option in somatostatin receptor type-2-positive pancreatic, nonpancreatic gastroenteropancreatic-NETs, and lung NETs including metastatic NETs with an unknown primary site and significantly contributed to patients’ OS. Additionally, peptide receptor radionuclide therapy may have a role in a selected subgroup of patients with grade III NET with high somatostatin receptor type-2 expression. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison between visual and numerical metrics for the evaluation of patients with Takayasu arteritis with 18F-FDG-PET
Conclusion In this study, we found that the analysis of the vascular region with the highest 18F-FDG uptake using either visual or numerical metrics provided the best diagnostic performance for the detection of active TAK with PET. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Gallium-68 DOTA-NOC PET/CT as an alternate predictor of disease activity in sarcoidosis
Introduction We evaluated the role of gallium-68-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-Nal3-octreotide (68Ga-DOTA-NOC) PET/CT in assessing sarcoidosis disease activity. Patients and methods Patients diagnosed with sarcoidosis underwent 68Ga-DOTA-NOC-PET/CT. The maximum standardized uptake value (SUVmax) at the pathological site and in the descending thoracic aorta (reference standard, SUVmed) were assessed. A SUVmax/SUVmed ratio (disease activity score) of more than one was considered a marker of active disease and was compared with the clinical symptoms and serum angiotensin-converting ...
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Preoperative omental metastasis-related maximum standardized fluorine-18-fluorodeoxyglucose uptake value can predict chemosensitivity and recurrence in advanced high-grade serous ovarian cancer patients
Objective The aim of this study was to explore the clinical and prognostic implication of preoperative fluorine-18-fluorodeoxyglucose uptake value of omental metastasis-related in advanced high-grade serous ovarian cancer patients (HGSC). Patients and methods We retrospectively investigated HGSC patients with omental metastasis (International Federation of Gynecology and Obstetrics stage IIIB–IV) who underwent PET/CT before primary surgery in our hospital between January 2010 and January 2016. All patients were confirmed omental metastasis by postoperative pathology. None of these patients received neoadjuvant c...
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Evaluation of drug effects on cerebral blood flow and glucose uptake in un-anesthetized and un-stimulated rats: application of free-moving apparatus enabling to keep rats free during PET/SPECT tracer injection and uptake
Conclusion We successfully developed free-moving 18F-FDG-PET and 99mTc-HMPAO-SPECT imaging systems and detected detailed glucose uptake and cerebral blood flow changes in the conscious rat brain with fluoxetine administration. This system is expected to be useful to assess brain activity without the effects of anesthesia and tactual stimulation to evaluate drug effect or animal brain function. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis
Conclusion A negative 18F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, 18F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. 18F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform 18F-FDG-PET/CT in all patients with suspected NVE. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Clinical and prognostic value of 18F-FDG-PET/CT in restaging of pancreatic cancer
Aim The aim of this retrospective multicentre study was to evaluate the clinical and prognostic effect of fluorine-18-fluorodeoxyglucose (18F-FDG)-PET/computed tomography (CT) in the restaging process of pancreatic cancer (PC). Materials and methods Data from patients treated for primary PC, who underwent 18F-FDG-PET/CT for suspicious of disease progression, were collected. Accuracy was assessed employing conventional diagnostic procedures, multidisciplinary team case notes, further 18F-FDG-PET/CT scans and/or follow-up. Receiver operating characteristic curve and likelihood ratio (LR+/−) analyses were used for ...
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Integrated texture parameter of 18F-FDG PET may be a stratification factor for the survival of nonoperative patients with locally advanced non-small-cell lung cancer
Conclusion This study demonstrated that ITP might be a stratification factor for the survival of nonoperative patients with LA-NSCLC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Myocardial stunning-induced left ventricular dyssynchrony on gated single-photon emission computed tomography myocardial perfusion imaging
Objectives Myocardial stunning provides additional nonperfusion markers of coronary artery disease (CAD), especially for severe multivessel CAD. The purpose of this study is to assess the influence of myocardial stunning to the changes of left ventricular mechanical dyssynchrony (LVMD) parameters between stress and rest gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). Patients and methods A total of 113 consecutive patients (88 males and 25 females) who had undergone both stress and rest 99mTc-sestamibi gated SPECT MPI were retrospectively enrolled. Suspected or known patien...
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Applying standardized uptake values in gallium-67-citrate single-photon emission computed tomography/computed tomography studies and their correlation with blood test results in representative organs
Conclusion The physiological uptake in 67Ga-citrate SPECT/CT can be represented as SUVs, which are not significantly correlated with corresponding blood test results. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

A retrospective study of the clinical features in papillary thyroid microcarcinoma depending on age
The aim of this study was to evaluate the clinical features and correlation of neck lymph node involvement of papillary thyroid microcarcinoma (PTMC) according to patients’ age. We divided the patients into three groups according to age: young group ( (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Review Article Source Type: research