Optimization of cross-calibration factor for quantitative bone SPECT without attenuation and scatter correction in the lumbar spine: head-to-head comparison with attenuation and scatter correction
This study aimed to improve the accuracy of quantitative bone SPECT of the lumbar spine with the SPECT-alone system. Methods The cross-calibration factor (CCF) was measured using three kinds of phantoms and the optimal values were determined. The recovery coefficient with and without attenuation and scatter correction (ACSC) were compared. Bone SPECT/CT was performed on 93 consecutive patients with prostate cancer, and the standardized uptake values (SUVs) were compared using the respective CCFs. The first 60 patients were classified according to body weight, and the correlation coefficient between SUVs with and wit...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Efficacy of voxel-based dosimetry map for predicting response to trans-arterial radioembolization therapy for hepatocellular carcinoma: a pilot study
Objective Typical clinical dosimetry models for trans-arterial radioembolization (TARE) assume uniform dose distribution in each tissue compartment. We performed simple voxel-based dosimetry using post-treatment 90Y PET following TARE with 90Y-resin microspheres and investigated its prognostic value in a pilot cohort. Method Ten patients with 14 hepatocellular carcinoma lesions who underwent TARE with 90Y-resin microspheres were retrospectively included. The partition model-based expected target tumor dose (TDp) was calculated using a pretreatment 99mTc-macroaggregated albumin scan. From post-treatment 90Y-micro...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Analysis of absorbed dose in radioimmunotherapy with 177Lu-trastuzumab using two different imaging scenarios: a pilot study
Objectives Internal organ dosimetry is an important procedure to demonstrate the reliable application of 177Lu-trastuzumab radioimmunotherapy for human epidermal growth factor receptor-positive metastatic breast cancers. We are reporting the first human dosimetry study for 177Lu-trastuzumab. Another objective of our study was to calculate and compare the absorbed doses for normal organs and tumor lesions in patients before radioimmunotherapy with 177Lu-trastuzumab using two different imaging scenarios. Methods Eleven patients (48.27 ± 8.95 years) with a history of metastatic breast ca...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Intensity of bone involvement: a quantitative 18F-FDG PET/CT evaluation for monitoring outcome of multiple myeloma
Conclusion Delta IBI provides quantitative data for variations of 18F-FDG uptake in the bone marrow during the follow-up of the patients. In addition, higher IBI values at diagnosis are associated with a higher risk of patient’s death. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The new perspective of PET/CT for axillary nodal staging in early breast cancer patients according to ACOSOG Z0011 trial PET/CT axillary staging according to Z0011
Conclusion Preoperative PET/CT predicts HNB with high accuracy and is useful for evaluating clinical T1-2N0 invasive breast cancer. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Compared to conventional PET/CT scanners, silicon-photomultiplier-based PET/CT scanners show higher arterial 18F-FDG uptake in whole-body 18F-FDG-PET/CT
Objectives To clarify differences in arterial 18F-FDG (fluorodeoxyglucose) uptake between silicon photomultiplier (SiPM)-based and conventional PET/CT scanners, and to compare clinical and phantom results. Patients and methods Twenty-six patients with lung tumours underwent serial SiPM-based and conventional PET/CT scans on the same day. We compared the target-to-background ratios [TBRsi (SiPM), TBRc (conventional)] and the percentage difference between TBRsi and TBRc (ΔTBR) in the carotid artery, aorta and peripheral arteries. The correlation between ΔTBR and vessel size was also investigated. In th...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Head-to-head comparison between 68Ga-PSMA and 18F-FDG-PET/CT in lymphomas: a preliminary analysis
This study compared both tracers in patients with diverse lymphoma subtypes. Methods Ten patients with biopsy-proven-lymphoma underwent 18F-FDG and 68Ga-PSMA-PET/CT (maximum time interval: 6 days). Lymphoma subtypes included Hodgkin’s lymphoma (HL, three patients) and aggressive and indolent non-Hodgkin’s lymphoma (NHL, seven patients). The intensity of PSMA uptake was classified visually as low, intermediate, or high, using blood pool, liver and parotid gland uptake as references. Maximum standardized-uptake value (SUVmax) of each affected site was measured in both sets of images. Results FDG det...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Haralick texture features extracted from Ga-68 PSMA PET/CT to differentiate normal prostate from prostate cancer: a feasibility study
Objective Role of texture parameters on the basis of Ga-68 PSMA PET/CT in prostate cancer (Pca) is largely unexplored. Present work done is a preliminary study that aims to evaluate the role of Haralick texture features on the basis of Ga-68 PSMA PET/CT in Pca in which texture features were used to differentiate between normal prostate and Pca tissue. Methods The study retrospectively enrolled patients in two groups: group 1 included 30 patients with biopsy-proven adenocarcinoma prostate and median age 64 years (range: 50–82 years) who underwent baseline Ga-68 PSMA PET/CT prior to therapy; group 2 included...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Efficacy of 68Ga-PSMA PET/CT-derived whole-body volumetric parameters in predicting response to second-generation androgen receptor axis-targeted therapy, and the prognosis in metastatic hormone-refractory prostate cancer patients
Introduction The present study investigates the role of 68Ga-PSMA PET/CT-derived whole-body metabolic and volumetric parameters in the prediction of treatment response and prognosis among metastatic hormone-refractory prostate cancer patients undergoing second-generation androgen receptor axis-targeted therapy (abiraterone or enzalutamide). Materials and methods This retrospective study included 44 metastatic hormone-refractory prostate cancer patients undergoing 68Ga-PSMA PET/CT, including 29 enzalutamide-treated and 15 abiraterone-treated patients. Results Of the 44 patients included in the study, 29 re...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Preoperative 18F-FDG SUVmax >6.3 or Size >2.3 cm of primary lesions predict lymph nodes metastasis with higher negative predictive value in peripheral cT1 non-small-cell lung cancer
Conclusions The excellent sensitivity and NPV of preoperative of the SUVmax>6.3 or size>2.3 cm of the primary lesions based on 18F-FDG PET-CT might identify the patients at low-risk LNM in peripheral cT1 NSCLC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Correlation of 4′-[methyl-11C]-thiothymidine PET with Ki-67 immunohistochemistry separately in patients with newly diagnosed and recurrent gliomas
Objective 4′-[methyl-11C]-thiothymidine (4DST) uptake on PET was correlated with proliferative activity separately in patients with newly diagnosed and recurrent gliomas. Methods A total of 29 patients, 18 with newly diagnosed gliomas and 11 with recurrent gliomas who underwent 4DST PET/computed tomography (CT) were available for a retrospective analysis of prospectively collected data. The maximum standardized uptake value (SUVmax) of tumor (T) and the mean SUV of normal contralateral hemisphere (N) were calculated, and the tumor-to-normal (T/N) ratio was determined. Proliferative tumor volume (PTV) and t...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Exploring the potential utilities of 99mTc-labeled RBC-equilibrium radionuclide angiocardiography in transfusion-dependent β-thalassemia major patients
Aims 99mTc-labeled RBC-equilibrium radionuclide angiocardiography (ERNA) is done in transfusion-dependent beta-thalassemia major (β-TM) patients routinely for cardiac dysfunction. This prospective study aimed at evaluating the potential of ERNA in demonstrating the bone marrow hyperplasia as an adjunct biomarker for monitoring the adequacy of blood transfusions in transfusion-dependent β-TM patients. Materials and methods One hundred and twenty-six patients of β-TM (study group) and 30 nonthalassemic patients (control) underwent ERNA study with an additional whole-body imaging. We quantitated the ...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

An overview of nuclear medicine research in the UK and the landscape for clinical adoption
Conclusions We hope that by collating this information we will provide stimulus for future discussion and consensus statements around this topic. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-FDG PET and PET/CT for the evaluation of gastric signet ring cell carcinoma: a systematic review
Conclusion Despite some limitations affect our review, GSRCC seems to have low 18F-FDG uptake, and therefore 18F-FDG PET or PET/CT reveals impaired sensitivity for its evaluation. However, a correlation between 18F-FDG uptake and some clinico-pathologic features (such as stage, depth of invasion, size and presence of nodal metastasis) has been demonstrated. Besides, a possible prognostic role of PET/CT features is starting to emerge. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Review Article Source Type: research

False positive pharmacologic myocardial perfusion SPECT study in the setting of a left bundle branch block
We herein report a case of a false positive vasodilatory pharmacologic SPECT stress test in the setting of a left bundle branch block (LBBB). While this is more commonly seen with exercise stress testing, it can also occur with pharmacologic stress testing. In our SPECT exam, we illustrate the commonly mistaken septal/anteroseptal perfusion defects in those patients with a LBBB. PET stress testing may be more reliable for patients with LBBB. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Technical Notes Source Type: research

75SeHCAT whole body retention for unexplained chronic diarrhoea based on early first whole body counting
Background There are many protocol variations in the whole-body 75SeHCAT retention test [whole-body retention (WBR)] for investigation of bile acid diarrhoea. The time between capsule consumption and first count, however, is widely taken, without debate, to be 3 h. In the Covid-19 era, it is desirable to limit the time patients spend in the department. We, therefore, questioned the need for a 3 h interval between capsule administration and the initial count. Methods Using an uncollimated gamma camera, whole-body counting was performed at 5, 30 and 180 min after capsule ingestion in 24 patien...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Technical Notes Source Type: research

Clinical PET/CT utilization during the COVID-19 pandemic: initial experience at Yale University
Objective To determine temporal changes in PET/CT utilization during the COVID-19 pandemic and examine the impact of epidemiologic, demographic and oncologic factors on PET/CT utilization. Methods Clinical PET-CT utilization between 1 January 2020 and 15 June 2020 at a tertiary academic center was assessed using change-point-detection (CPD) analysis. COVID-19 epidemiologic trend was obtained from Connecticut Department of Public Health records. Demographic and oncologic data were gathered from electronic medical records and PET-CT scans by four reviewers in consensus. Results A total of 1685 cases were re...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Incidence and relevance of clinically indeterminate nonregional lymph nodes in the treatment of oesophageal cancer
Conclusions EBUS and US-FNA are effective means of sampling clinically indeterminate nonregional lymph nodes, and can significantly impact prognosis, and management. Further investigations in this context are of value in this cohort and should be pursued. Nonregional clinically indeterminate lymph nodes represent a diagnostic dilemma in oesophageal cancer staging. Additional investigations in the form of endobronchial ultrasound are effective at providing additional staging information, and can substantially influence patient care. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Astrocyte activation imaging with 11C-acetate and amyloid PET in mild cognitive impairment due to Alzheimer pathology
Conclusions While further validation is required, this exploratory pilot study suggests a potential role for 11C-acetate PET as a neuroinflammatory biomarker in MCI and early AD to provide clinical and translational insights into astrocyte activation as a pathological response to amyloid. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Assessment of volumetric parameters derived from 68Ga-PSMA PET/CT in prostate cancer patients with biochemical recurrence: an institutional experience
Objective The aim of this study was to evaluate the relationship between volumetric parameters calculated using semiautomatic quantification of lesions detected in 68Ga-labeled prostate-specific membrane antigen PET-computed tomography (68Ga-PSMA PET/CT) and clinical characteristics in prostate cancer (PCa) patients with biochemical recurrence. Methods A total of 85 consecutive PCa patients with biochemical recurrence who underwent 68Ga-PSMA PET/CT at our institution from January 2019 to March 2020 were retrospectively assessed. 68Ga-PSMA PET/CT-derived volumetric parameters, including whole-body PSMA tumor volu...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The diagnostic value of metabolic, morphological and heterogeneous parameters of 18F-FDG PET/CT in mediastinal lymph node metastasis of non–small cell lung cancer
Objectives To investigate the value of PET/CT metabolic, morphological and heterogeneous parameters in the diagnosis of 18F-FDG positive mediastinal lymph node metastasis in non–small cell lung cancer (NSCLC). Patients and methods A total of 156 patients with pathologically diagnosed NSCLC and underwent 18F-FDG PET/CT scans were enrolled in this study. Mediastinal lymph nodes with 18F-FDG uptake greater than the mediastinum were analyzed. The metabolic parameters of maximum and mean standardized uptake value (SUVmax, SUVmean), SUVratio (node SUVmax/mediastinum SUVmax), metabolic tumor volume (MTV), total l...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The value of intravenous contrast medium in PSMA PET/CT imaging in patients with biochemical recurrence of prostate cancer
Conclusion Diagnostic abdominal ceCT increases the diagnostic certainty and interobserver agreement in Ga-68 PSMA PET/CT in BCR of prostate cancer. The diagnostic performance of cePET/CT is significantly better than ceCT alone but not nePET/CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prognostic significance of 18F-FDG PET/CT parameters in IDH-1 wild-type GBM and correlation with molecular markers
Aim To assess the prognostic role of metabolic parameters on 18F-FDG PET/CT & correlation with molecular markers in IDH-1 wild-type GBM. Methods A total of 129 patients with brain lesions showing equivocal findings on baseline MRI who were referred for fluoro-deoxy-glucose PET/CT were analyzed. Of these, 50 underwent surgery/biopsy and postoperative histopathological diagnosis of IDH-1 wild-type GBM. SUVmax, metabolic tumor volume (MTV), total lesion glycolysis (TLG) & T/w ratio was calculated. Median metabolic parameters were used for stratification. Overall survival was calculated using Kaplan–Me...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Baseline 18F-FDG PET textural features as predictors of response to chemotherapy in diffuse large B-cell lymphoma
Conclusion Increased textural heterogeneity in baseline PET images was found to be associated with incomplete response in DLBCL. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Evaluation of [68Ga]Ga-PSMA PET/CT for therapy response assessment of [177Lu]Lu-PSMA radioligand therapy in metastasized castration refractory prostate cancer and correlation with survival
Conclusion In [177Lu]Lu-PSMA-617-treated mCRPC patients OS of the group of CR/PR/SD was significantly higher compared to the progressive disease group (mPERCIST/EORTC) in ERA. Therefore, [68Ga]Ga-PSMA PET might serve as a complementary diagnostic tool for TRA offering prognostic value regarding OS. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Single scan SeHCAT studies: a model for the prediction of the 3-h counts
Conclusion This work presents a model that was able to predict the counts in the 3 h SeHCAT study for patients on seven gamma cameras. This can enable a single scan study, giving significant savings to patient and staff time and imaging resources. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Clinical impact of targeted single-photon emission computed tomography/computed tomography (SPECT/CT) bone scintigraphy on the assessment of bone metastasis in cancer patients
Conclusions SPECT/CT bone scintigraphy afforded a significant reduction of the number of patients with equivocal findings who needed further evaluation with other imaging modalities, preventing unnecessary delays in diagnosis and potential changes in disease staging and treatment planning. Moreover, SPECT/CT bone scintigraphy slightly increased diagnostic sensitivity. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Ameliorating effects of N-acetyl cysteine against early liver damage of radioiodine in rats
Objective The present study was aimed to explore the potential ameliorating effects of N-acetyl cysteine (NAC) against radioiodine (RAI)-induced early liver damage. Methods Thirty Wistar Albino male rats were arbitrarily allocated into three groups each containing 10 rats: the control group (group 1); the RAI group (group 2), oral 111 MBq/kg radioiodine was administered to rats; the RAI + NAC group (group 3), 150 mg/kg/day intraperitoneal NAC treatment was initiated 3 days prior to the RAI administration and continued for 10 days. Liver samples were obtained 24 h after the last...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Factors predicting the risk of biochemical incomplete response in well-differentiated thyroid cancer after total thyroidectomy
Background Differentiated thyroid cancer (DTC) is the most common endocrine carcinoma with an overall good prognosis. However, persistent or recurrent disease (P/R disease) and incomplete biochemical response (BIR) are causes of morbidity. Histopathology and TNM stage may not predict P/R disease and BIR in all patients. Various clinical parameters, histopathological features and preablative-stimulated thyroglobulin (presTg) have been proposed to predicts P/R disease. However, there is uncertainty for presTg cutoff and diagnostic accuracy. The study’s objective was to predict the BIR before radioiodine ablation fr...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Evaluation of 68Ga-PSMA PET/CT with Volumetric Parameters for Staging of Prostate Cancer Patients: Erratum
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Erratum Source Type: research

British Nuclear Medicine Society Autumn Meeting 2021
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Abstracts Source Type: research

In-house development, implementation and evaluation of machine learning software for automated clinical scan processing
Conclusion This work demonstrates that established machine learning technology and modest hardware can be used to create automated segmentation tools that perform well in the clinic. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-FDG PET/computed tomography scan in patients with suspicion of recurrent neuroendocrine carcinoma of the cervix
Conclusions 18F-FDG PET/CT is an efficient technique for detecting recurrent cervical neuroendocrine carcinoma, and may thus contribute to improving patient management. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Peptide-based 68Ga-PET radiotracer for imaging CD133 expression in colorectal cancer
Conclusion: Rapid tumor CD133 detection and selectivity were demonstrated in vitro and in vivo with PET using the specific CD133 binding peptide 68Ga-DOTA-LS7. A robust correlation was detected in vivo between tumor signals from mouse xenograft models with different cell lines and CD133 expression. The favorable characteristics of 68Ga-DOTA-LS7, such as convenient synthesis and specific uptake, warrant its further investigation for CD133 expression imaging. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Improved 18-FDG PET/CT diagnosis of multiple myeloma diffuse disease by radiomics analysis
Conclusions Radiomics analysis of 18-FDG PET/CT images with machine-learning overcame the limitations of visual analysis, providing a highly accurate and more reliable diagnosis of diffuse bone marrow infiltration in multiple myeloma patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Identification of specific SUVmax ratios enhances diagnostic accuracy for staging of intrathoracic nodes in lung cancer
Conclusion In this relatively small sample, SUVmax LN/MBP 2.3 had a PPV of 100% for diagnosing malignant nodes. Using SUVmax ratios could obviate the need for staging EBUS in selected patients with resultant time and cost savings. Selecting different SUVmax ratios, chosen to provide high accuracies for the parameter of interest to change management, is a potentially powerful diagnostic tool that is overlooked when FDG uptake is only classified as ‘positive’ or ‘negative’. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

68Ga-PSMA-I&T-PET/CT interobserver and intraobserver agreement for prostate cancer: a lesion based and subregional comparison study among observers with different levels of experience
Conclusion Interpretation of prostate-specific membrane antigen (PSMA) for prostate cancer is acceptably consistent among observers, but some details are noteworthy. The evaluation should be done more algorithmically for local tumors, since all observers showed relatively lower agreement. The agreement increased as prostate-specific antigen and Gleason score increased. The observer with PSMA experience (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Usefulness of PET-guided surgery with 64Cu-labeled cetuximab for resection of intrapancreatic residual tumors in a xenograft mouse model of resectable pancreatic cancer
Conclusions OpenPET-guided surgery with 64Cu-labeled-cetuximab enabled intraoperative identification and resection of intrapancreatic small residual tumors. This technology could be useful to prevent tumor residuals during surgery and improve pancreatic cancer survival. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-FDG-PET/CT analysis in hospitalized patients affected by pulmonary disease: The experience of the Nuclear Medicine Unit of “Policlinico Tor Vegata”
Conclusion Data here reported showed the high accuracy of the F-FDG-PET/CT performed in our department, mainly for pulmonary diseases, also highlighting the importance of continuously updating the selection criteria for patients who need PET examinations. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Quantitative evaluation of single-photon emission computed tomography findings in lower extremity possible without computed tomography-based attenuation correction
Conclusions In bone SPECT quantitative examinations of the lower extremity, quantitative evaluation without CTAC is possible without the use of scatter correction or resolution recovery. Thus, quantitative evaluation can be performed with use of a standalone SPECT device without CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of bone SPECT/CT and MRI in detection of pain generator in ankle and foot pain: a retrospective diagnostic study
Objective To study the sensitivity and specificity of MRI and bone SPECT-CT in detecting the pain generator in ankle and foot pain with diagnostic dilemma. Methods Retrospectively data of patients with ankle or foot pain who underwent both MRI and Bone SPECT-CT were analyzed. The lesions and probable pain generator sites were reported as per MRI and bone SPECT-CT findings. These lesions were correlated clinically, managed accordingly and followed up. The patients who had significant improvement in response to the treatment provided were considered to have been diagnosed accurately. The foot and ankle disability ...
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prospective evaluation of organ-specific dose and lesional doses following therapeutic [177Lu]Lu-EDTMP administration in patients with multiple skeletal metastases and its correlation with clinical hematological toxicity
Aim In patients with multiple skeletal metastases, accurate estimation of absorbed doses to radiosensitive bone marrow in bone-directed systemic radionuclide therapies (RNT) is critically important from clinical dose determination standpoint. The primary aim of the present study was to estimate the radiation absorbed doses of therapeutic [177Lu]Lu-EDTMP to bone marrow by two methods viz. Medical Internal Radiation Dose (MIRD) schema and using OLINDA software and correlate with hematological toxicity. Methods A total of 15 patients diagnosed to have multiple painful skeletal metastases being treated with [177Lu]L...
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Reassessment of the lung dose limits for radioembolization
Radioembolization, also known as selective internal radiation therapy (SIRT), is an established treatment for the management of patients with unresectable liver tumors. Advances in liver dosimetry and new knowledge about tumor dose-response relationships have helped promote the well-tolerated use of higher prescribed doses, consequently transitioning radioembolization from palliative to curative therapy. Lung dosimetry, unfortunately, has not seen the same advances in dose calculation methodology and renewed consensus in dose limits as normal liver and tumor dosimetry. Therefore, the efficacy of curative radioembolization ...
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Review Article Source Type: research

BNMS position statement on molecular radiotherapy
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Editorial Source Type: research

Simulation of the distribution of astatine-211 solution dispersion in a lab room
Conclusion We found that the solution of 211At vaporized naturally and was distributed heterogeneously in the cage, and the chemical properties of 211At influenced their behaviors. These results must be considered to minimize the risks of radiation safety. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Technical Note Source Type: research

PET/computed tomography in inpatients: part 1, international survey
Purpose The purposes of this study are to (1) identify patterns of inpatient PET/computed tomography (CT) use in and outside of the USA and (2) characterize inpatient PET/CT use by location and indication. Materials and methods The study was deemed exempt by the Institutional Review Board. A survey link through REDCap was emailed to the Society of Nuclear Medicine and Molecular Imaging (SNMMI) members and PET Centers of Excellence members and posted on the SNMMI website. Data were collected from May 2018 to August 2018. Analyses were conducted using SAS Software 9.4 with the NPAR1WAY procedure. Differences were ...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of an in-house acquired brain F-18 FDG PET normal database with commercially available normal data
Conclusions The three software packages yielded varying Z-score output, partially explained by an age mismatch between our subjects and subjects in their normal databases. A definitive explanation for the remaining differences is lacking. This emphasizes the importance of age-matched normal data and knowledge of the included databases to allow adequate preprocessing. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Production of copper-64 using a hospital cyclotron: targetry, purification and quality analysis
Objectives To construct and evaluate a 64Cu production system that minimises the amount of costly 64Ni, radionuclidic impurities and nonradioactive metal contamination and maximises radiochemical and radionuclidic purity and molar activity; and to report analytical and quality control methods that can be used within typical PET radiochemistry production facilities to measure metal ion concentrations and radiometal molar activities. Methods Low volume was ensured by dissolving the irradiated nickel in a low volume of hydrochloric acid ( (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Feasibility of semiquantitative 18F-fluorodeoxyglucose PET/computed tomography in patients with advanced lung cancer for interim treatment evaluation of combining immunotherapy and chemotherapy
This study aimed to investigate the prognosis value of 18F-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) in advanced lung cancer patients with immunotherapy combined with chemotherapy. Methods Fifty-one advanced lung cancer patients were included in this retrospective study, who underwent 18F-FDG PET/CT imaging before four cycles of immunotherapy combined with chemotherapy at our institution between January 2018 and January 2020. The following PET/CT parameters were calculated: standardized uptake value SUVmax, SUVmean, SUVpeak, SUVsd, metabolic tumor volume (MTV), total lesion glycolysis (TLG), MTV25%...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Can 68Ga-PSMA PET/CT-derived prostate-specific membrane antigen expression parameters predict prostate-specific antigen response to enzalutamide treatment?
Conclusion PSMA-TV values on 68Ga-PSMA PET/CT imaging before starting enzalutamide treatment following docetaxel failure can predict PSA response in patients with mCRPCa. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research