British Nuclear Medicine Society Autumn Meeting 2020
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Abstracts Source Type: research

Bronchopulmonary MDR protein expression may protect against COVID-19 infection
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Letter to the Editor Source Type: research

Red cell volume measurement: using technetium as a replacement for chromium
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Letters to the Editor Source Type: research

Validation protocol for current good manufacturing practices production of [15O]water for hybrid PET/MR studies
Conclusion The multiple batch protocol proved to be a safe and effective means for producing [15O]water. Furthermore, this protocol could be readily adapted by any facility attempting to produce [15O]water for clinical studies. Compared with previous attempts at our site, the protocol outlined here was more consistent and reliable, improved production workflow and led to more available radioactivity for participant injection and QC testing. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Technical Notes Source Type: research

Standardized uptake values and ratios on 68Ga-DOTATATE PET-computed tomography for normal organs and malignant lesions and their correlation with Krenning score in patients with metastatic neuroendocrine tumors
The aim was to estimate the physiological standardized uptake values (SUVs) on 68Ga-DOTATATE PET-computed tomography (CT) in normal organs and metastatic tumor lesions (both standard and delayed), and correlating the uptake values and ratios with Krenning Scores (K-score) in patients with metastatic/advanced neuroendocrine tumors (NETs) undergoing PET-CT studies for their management work-up. A total of 32 patients of metastatic NET with 95 discrete tumor lesions were included in this analysis. These patients underwent standard whole-body PET-CT following injection of 2–3 mCi (74–111 MBq) of 68Ga-D...
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Technical Notes Source Type: research

Role of 18F-FDG PET-derived parameters for predicting complete response to chemoradiotherapy in squamous cell anal carcinoma
Purpose We aimed to evaluate the accuracy of metabolic parameters, calculated on pretreatment positron emission computed tomography (PET/CT) with 18fluorodeoxyglucose (18F-FDG), for predicting complete response to chemoradiotherapy (CRT) of patients affected by squamous cell anal carcinoma (SCAC). Patients and methods Clinical records of 20 patients affected by SCAC and treated with CRT were retrospectively evaluated. 18F-FDG PET/CT was performed at time 0 (baseline) and time 1 (12 weeks after CRT). The following parameters were extracted from PET at time 0: standardized uptake values (SUVmax and SUVmean), metabolic t...
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

99mTc-sestamibi SPECT/CT and 18F-FDG-PET/CT have similar performance but different imaging patterns in newly diagnosed multiple myeloma
Conclusion MIBI SPECT/CT performs similarly to 18F-FDG-PET/CT in identifying sites of active disease in multiple myeloma staging. MIBI is more efficient than FDG for detecting the diffuse involvement of bone marrow but less efficient for detecting focal lesions. Some patients presented a ‘mismatch’ pattern of FDG/MIBI uptake. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Synergic role of preoperative 18F-fluorodeoxyglucose PET and MRI parameters in predicting histopathological features of endometrial cancer
Background The aim of the present study is to explore the correlation between PET and MRI parameters of primary tumour and clinicopathological features and to determine their synergic predictive role in patients with endometrial cancer candidate to surgery. Methods Retrospective study including 27 patients with endometrial cancer and preoperative 18F-fluorodeoxyglucose (18F-FDG)-PET and MRI scan. The following parameters, calculated on the primary tumour, were used for analysis: maximum standardized uptake value (SUVmax), SUVmean, metabolic tumour volume (MTV) and total lesion glycolysis (TLG) for PET scans; mean appa...
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Weight loss as primary indication for FDG-PET/CT
Conclusion FDG-PET/CT appears to have limited value in assessing subjects with weight loss as the leading clinical indication, proving to be five times more often detrimental than beneficial. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Ga-68 DOTATATE PET/CT and F-18 FDG PET/CT in the evaluation of low and intermediate versus high-grade neuroendocrine tumors
Conclusion All patients with high grade, poorly-differentiated NETs had positive DOTATATE PET/CTs. In these patients, DOTATATE PET/CT did not significantly differ from FDG PET/CT in identifying>10 lesions or distant disease. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Role of [68Ga]DOTANOC PET/computed tomography and [131I]MIBG scintigraphy in the management of patients with pheochromocytoma and paraganglioma: a prospective study
Conclusions [68Ga]DOTANOC PET/CT should be considered as a first-line investigation in PCC/PGL especially at high risk of metastasis and screening of persons with familial syndrome. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Does 68Ga-DOTA-NOC-PET/CT impact staging and therapeutic decision making in pulmonary carcinoid tumors?
Conclusion Ga-NOC-PET detects asymptomatic distant metastatic disease in a sizeable number of patients (11.7%) with pulmonary carcinoid and thus contribute to clinical management by precluding futile surgeries. It shows a high sensitivity for tumor detection and can help differentiate between typical and atypical carcinoid variants by virtue of their variable tracer uptake. PET/CT using Ga-labeled DOTA peptides should be an integral part of diagnostic workup of patients with lung carcinoid. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Could the skewness and kurtosis texture parameters of lesions obtained from pretreatment Ga-68 DOTA-TATE PET/CT images predict receptor radionuclide therapy response in patients with gastroenteropancreatic neuroendocrine tumors?
Purpose In our study, tumor heterogeneity was evaluated using the parameters skewness and kurtosis on pretreatment Ga-68 DOTA-TATE PET/CT to assess therapy responses of lesions in patients with gastroenteropancreatic neuroendocrine tumors (GEP NETs) treated with peptide receptor radionuclide therapy (PRRT). Method We retrospectively studied the texture analysis with relatively simple first-order parameters skewness and kurtosis on pretreatment Ga-68 DOTA-TATE PET/CT from 22 patients (eight females, 14 males; with a mean age: 54 ± 11 years) with GEP NETs who were treated with 2–6 therapy cycles of Lu-177 D...
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Functional lung volume mapping with perfusion Single-Photon Emission Computed Tomography scan for radiotherapy planning in patients with locally advanced nonsmall cell lung cancer
Objectives Radical chemotherapy-radiotherapy represents the standard treatment for locally-advanced nonsmall cell lung cancer (NSCLC). Conventional radiotherapy achieves limited local tumor control, but dose escalation to the primary tumor is prevented by radiotherapy-induced toxicity. The aim of this study was to evaluate feasibility of tailored intensity-modulated radiotherapy (IMRT) planning based on lung single-photon emission computed tomography (SPECT) perfusion data and to compare functional and conventional dose-volume parameters. Methods A total of 21 patients were prospectively enrolled. Patients underwent I...
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Renography with a semiautomated algorithm for diuretic decision 7 min postradiopharmaceutical administration: a feasibility study
Conclusion 99mTc-mercaptoacetyltriglycine renography with the F+10 method and the threshold 85% for diuretic decision 7 min into the renography is a feasible and acceptable method in clinical practice. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Head-to-head comparison of the hybrid tracer indocyanine green-99mTc-nanocolloid with 99mTc-Senti-Scint using sentinel node lymphoscintigraphy and single-photon emission computed tomography combined with computer tomography in melanoma
Conclusion A slightly higher SLN visualization accompanied by a tendency to depict more non-SLNs was found for ICG-99mTc-nanocolloid. Excepting the head and neck area, an overall high concordance in drainage was found for both radiotracers. With an additional value for the hybrid tracer due to the combination of preoperative imaging and the additional visual signal in the operation room, added by the fluorescent component of the hybrid tracer, there was a preference for ICG-99mTc-nanocolloid. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Inter- and intraobserver agreement in standard and ultra-fast single-photon emission computed tomography/computed tomography for the assessment of bone metastases
Conclusion Satisfactory inter- and intraobserver agreement was seen for both acquisition methods, emphasizing that the use of SPECT/CT as an add-on to WB-BS is a robust method for the detection of bone metastases even when conducted with a very short acquisition time. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Diagnostic performance of PET/computed tomography versus PET/MRI and diffusion-weighted imaging in the N- and M-staging of breast cancer patients
Conclusion In general, there is a trend toward higher sensitivity and lower specificity of PET/MRI when compared to PET/CT. Results on the diagnostic performance of DWI are conflicting. Rather than evaluating it separate, it seems to have complementary value when combined with other MR sequences. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 17, 2020 Category: Nuclear Medicine Tags: Review Article Source Type: research

Single photon emission computed tomography lung perfusion imaging during the COVID-19 pandemic: does nuclear medicine need to reconsider its guidelines?
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Letter to the Editor Source Type: research

Enhancing capacity and synthesis of [68Ga]68-Ga-PSMA-HBED-CC with the lyophilized ready-to-use kit for nuclear pharmacy applications
Conclusion Using the kit method reduced the labeling time. The cold kit method increased production efficiency because less of the eluted Ga-68 was wasted. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Optimization of the radiosynthesis of [68Ga]Ga-PSMA-11 using a Trasis MiniAiO synthesizer: do we need to heat and purify?
Conclusion: The procedure was completely automated and provided a high radiochemical yield. It can be performed several times a day, facilitating the clinical demand of this radiopharmaceutical. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Radionuclide calibrator intercomparison study of clinical PET centres in England to a single traceable 68Ge syringe source
Conclusions This study demonstrated good repeatability in local device measurements. In total, 70% of English calibrators tested and 88% of all measurements performed achieved 5% accuracy. While statistically significant bias was exhibited between different vendor equipment dependent upon radioisotope selected, our study recommends regular traceability checks for optimum instrument performance conducted within National Metrology Institutes guidelines. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Role of 18F-FDG PET/CT in restaging of esophageal cancer after curative-intent surgical resection
Conclusion FDG PET-CT is highly sensitive in detection of recurrent disease in esophageal cancer patients after surgical resection. It can detect distant metastases in high proportion of patients thus changing the intent of management from radical salvage to palliative chemotherapy/best supportive care. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Fluorodeoxyglucose-avid focal lesions and extramedullary disease on 18F-FDG PET/computed tomography predict the outcomes of newly diagnosed symptomatic multiple myeloma patients
Conclusion This meta-analysis demonstrated that patients with a higher number of FDG-avid focal lesions and EMD on PET/CT may experience a higher risk for progression and a shorter survival time than those with a few focal lesions and no EMD. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Observer agreement and accuracy of 18F-sodium fluoride PET/computed tomography in the diagnosis of skull-base bone invasion and osseous metastases in newly diagnosed nasopharyngeal carcinoma
Conclusion The interobserver agreement of 18F-NaF PET/CT for the detection of SBBI and osseous metastases in patients with NPC were both very high among trained observers. Moreover, the diagnostic performance of NaF PET/CT was satisfactory, rendering NaF PET/CT a robust tool in the diagnostic armamentarium. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Features of IgG4-related lung disease on 18F-FDG PET/computed tomography imaging
Conclusions The image patterns of IgG4-RLD on 18F-FDG PET/CT are varying. Multiple pulmonary manifestations or multiple organ involvement, especially in combination with elevated levels of serum IgG and IgG4, may help to make the diagnosis. A potential major application of PET-CT would be evaluation of response to treatment, and the impact of PET/CT on IgG4-RLD management is worth investigating further in the future. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Role of 18F-FDG PET/computed tomography in prognostication and management of malignant peripheral nerve sheath tumors
Conclusion 18F-FDG PET/CT can be used for staging and restaging in MPNSTs leading to change in management. Texture analysis and quantitative 18F-FDG PET/CT parameters can help in prognostication at both baseline and relapse. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Preoperative 18F-FDG PET/computed tomography predicts survival following resection for colorectal liver metastases
Conclusion Low values of total MTV and TLG were significantly correlated to improved LRFS and CSS and may improve the risk stratification of patients considered for resection for CLM. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Diagnostic performance of F-18 fluciclovine PET/CT in post-radical prostatectomy prostate cancer patients with rising prostate-specific antigen level ≤0.5 ng/mL
Purpose The aim of the study was to assess the diagnostic performance of fluciclovine positron emission tomography (PET)/computerized tomography (CT) in post-radical prostatectomy prostate cancer patients with rising prostate-specific antigen (PSA) ≤0.5 ng/mL, and identify the associated predictive factors of positive studies. Patients and methods From 30 June 2017 to 9 August 2019, patients with post-radical prostatectomy prostate cancer who underwent F-18 fluciclovine PET/CT and had PSA level within 2-week interval (PSAPET) ≤0.5 ng/mL were enrolled into this single-institution retrospective study...
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Dual tracer 68Ga-DOTATOC and 18F-FDG PET/computed tomography radiomics in pancreatic neuroendocrine neoplasms: an endearing tool for preoperative risk assessment
Aim To explore the potentiality of radiomics analysis, performed on 68Ga-DOTATOC and fluorine-18-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) images, in predicting tumour aggressiveness and outcome in patients candidate to surgery for pancreatic neuroendocrine neoplasms (PanNENs). Patients and methods Retrospective study including 61 patients who underwent 68Ga-DOTATOC and 18F-FDG PET/CT before surgery for PanNEN. Semiquantitative variables [SUVmax and somatostatin receptor density (SRD) for 68Ga-DOTATOC PET; SUVmax and MTV for 18F-FDG PET] and texture features [intensity variability, size zone variabilit...
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Assessment of ejection fraction and heart perfusion using myocardial perfusion single-photon emission computed tomography in Finland and Estonia: a multicenter phantom study
Conclusion On average, the EF and heart perfusion were accurately estimated by SPECT/CT, but high errors could be produced if the acquisition and analysis routines were poorly optimized. Eight of the 21 participants altered their imaging protocol after this quality control tour. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Combined versus subtraction-only technique in parathyroid scintigraphy: effect on scan interpretation
Conclusion Based on our findings, the combined parathyroid scintigraphic technique does not improve lesion detection and may be dispensed with. Doing so will enhance patient convenience and comfort and improve departmental workflows without compromising lesion detection. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Performance of radiography and single-photon emission computed tomography/computed tomography in painful total hip arthroplasty and impact on arthroplasty survival
Conclusion In patients with painful hip arthroplasty, positive radiography, and SPECT/CT are associated with poorer arthroplasty survival. Performance regarding loosening is slightly better with SPECT/CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Influence of preoperative breast cancer localization techniques on rates of sentinel lymph node visualization with preoperative lymphoscintigraphy
Conclusion High rates of SLN visualization on preoperative lymphoscintigraphy were noted in all groups, with no significant reduction when breast lesion localization techniques were used. There was; however, an increased rate of delayed imaging required for SLN visualization in women who had undergone either type of preoperative localization compared with those who had not. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Does Tc-99m ECD ictal brain SPECT have incremental value in localization of epileptogenic zone and predicting postoperative seizure freedom in cases with discordant video electroencephalogram and MRI findings?
Conclusion Ictal SPECT showed incremental value and was found necessary for epileptogenic focus localization and subsequent surgery in unilateral/bilateral MTS in this study. Seizure freedom in patients undergoing epilepsy surgery based on ictal SPECT assistance was comparable to the surgical group not requiring ictal SPECT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The diagnostic performance of 99mTc-methionine single-photon emission tomography in grading glioma preoperatively: a comparison with histopathology and Ki-67 indices
Conclusion Quantitative 99mTc-MDM -SPECT provided high sensitivity and specificity to differentiate HGG versus LGG preoperatively and demonstrated a potential role for the differential diagnosis of glial versus nonglial tumors. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The effects of pharmacological interventions, exercise, and dietary supplements on extra-cardiac radioactivity in myocardial perfusion single-photon emission computed tomography imaging
Myocardial perfusion imaging (MPI) as an imaging modality plays a key role in the monitoring of patients with cardiovascular disease. MPI enables the assessment of cardiovascular disease, the effectiveness of therapy, and viable myocardial tissue. However, MPI suffers from some downfalls and limitations, which can influence its clinical applications. These limitations can arise from the patient’s condition, equipment, or the actions of the technologist. In this review, we mainly focused on the different effective parameters on radioactivity uptake of organs including liver, intestines, stomach, and gall bladder and h...
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Review Article Source Type: research

A theranostic approach based on radiolabeled antiviral drugs, antibodies and CRISPR-associated proteins for early detection and treatment of SARS-CoV-2 disease
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 14, 2020 Category: Nuclear Medicine Tags: Editorial Source Type: research

Logistic regression analysis of repeated radioiodine therapy treatments for papillary thyroid carcinoma patients
Conclusion Patients who are older in age, who receive higher administered radioiodine activity, have higher serum thyroglobulin levels and have lymph node uptake reported in their post-ablation WBS are more likely to have unsuccessful treatment outcome and will repeat the treatment. This LRM could help in adjusting RAT options in order to reduce the repeat rate. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Prognostic value of metabolic tumor volume and total lesion glycolysis in breast cancer: a meta-analysis
Objectives PET using 18F-fluorodeoxyglucose (FDG) has proven to be valuable in staging and monitoring of treatment response in breast cancer. We aimed to assess the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in patients with breast cancer. Methods A systematic search of MEDLINE and EMBASE was performed using the keywords of breast cancer, PET, and volume. Inclusion criteria were 18F-FDG PET used as an initial imaging tool; studies limited to patients with breast cancer who had not undergone any treatment before PET scans; and studies reporting survival data. Event-free survival ...
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Freeze-dried microspheres for selective intra-arterial radionuclide therapy: an affordable solution
Conclusion The freeze-dried microspheres may emerge as highly cost-effective candidates for both pre-therapy dosimetry and SIRT and may benefit a large population with inoperable liver cancer. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Molecular subtypes of invasive breast cancer: correlation between PET/computed tomography and MRI findings
Conclusion Results of the present study suggest that SUVmax was superior to MRI findings in predicting molecular subtypes and that MRI was superior to PET/CT in predicting PTV. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Utility of brain fluorodeoxyglucose PET in children with possible autoimmune encephalitis
Conclusions Our findings support the usage of fluorine-18-FDG PET/computed tomography (CT)/MRI with quantitative analysis early in the diagnostic work-up of possible autoimmune encephalitis, particularly in those with normal or nonspecific MRI findings. However, it remains a purpose of further studies, if and to what extent FDG PET/CT or integrated FDG PET/MRI with quantitative analysis can improve the diagnostic workup of children with possible autoimmune encephalitis. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of modified Response Evaluation Criteria in Solid Tumors, European Organization for Research and Treatment of Cancer criteria, and PET Response Criteria in Solid Tumors for evaluation of tumor response to chemotherapy and prognosis prediction in patients with unresectable malignant pleural mesothelioma
Conclusion EORTC and PERCIST are more accurate than mRECIST for evaluation of tumor response to chemotherapy and predicting prognosis in unresectable MPM patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Relation between pharmacological stress ECG, 13NH3-PET/CT outcome and the occurrence of cardiac events during follow-up in women with chest pain
Aim Evaluation of major adverse cardiovascular events (MACE) in women referred for 13NH3-PET/CT in relation to scan outcome and pharmacological stress ECG (PxECG) results. Patients and methods Six hundred twenty-four women, referred for 13NH3-PET/CT between 2012 and 2016, were included. Demographic data and MACE during follow-up (407 ± 207 days) were retrieved from electronic patient charts. 13NH3-PET/CT was scored as either normal or abnormal. PxECG was scored as negative, non-diagnostic or positive. PxECG was compared with 13NH3-PET/CT and related to MACE. Results The 13NH3-PET/CT was normal in 482/624 (77...
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Dynamic 18F-fluorocholine PET/CT for parathyroid imaging in patients with primary hyperparathyroidism
Conclusion Dynamic imaging starting at the early time point of 2 minutes after injection of 18F-fluorocholine is useful for characterization of hyperfunctioning parathyroid glands. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Validation of regional myocardial blood flow quantification using three-dimensional PET with rubidium-82: repeatability and comparison with two-dimensional PET data acquisition
Introduction Three-dimensional (3D) data acquisition is now standard on PET/computed tomography scanners. The aim of this study was to evaluate the repeatability of myocardial blood flow (MBF) estimation with rubidium-82 (82Rb) 3D PET and to validate regional MBF measurements by comparison with two-dimensional (2D) PET. Patients and methods Fifteen healthy individuals (31.6 ± 11.4 years old) were enrolled for the evaluation of the short-term repeatability of rest 3D MBF quantification. Another 19 healthy individuals (35.3 ± 12.6 years old) underwent rest and phar...
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Interobserver and intraobserver agreement on prostate-specific membrane antigen PET/CT images according to the miTNM and PSMA-RADS criteria
Conclusion PSMA PET has a lower interobserver variability and higher reproducibility than other imaging methods used for imaging of prostate cancer do, including CT, MRI, and bone scintigraphy. The miTNM template provides a reporting format that is highly reproducible and has a high level of agreement among readers, but the prostatic template needs development. In contrast, the PSMA-RADS system leads to slightly increased interobserver reporting differences and reduces personal confidence, but at the same time, it still exhibits almost-perfect agreement in terms of scoring. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Improvement of diagnostic accuracy of 18fluorine-fluorodeoxyglucose PET/computed tomography in detection of infective endocarditis using a 72-h low carbs protocol
Conclusion We demonstrated that an LCHPHF diet can adequately suppress the physiological myocardial uptake leading to a significant improvement in the interpretability and diagnostic accuracy of 18F-FDG PET/CT in infective endocarditis. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Whole-body 75SeHCAT retention is determined by entero-hepatic bile acid recycling rate
Conclusion Entero-hepatic bile acid recycling frequency is a major determinant of whole-body 75SeHCAT retention. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 30, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research