Extension of the International Atomic Energy Agency phantom study in image quantification: results of multicentre evaluation in Croatia
To make quantitative methods of nuclear medicine more available, four centres in Croatia participated in the national intercomparison study, following the materials and methods used in the previous international study organized by the International Atomic Energy Agency (IAEA). The study task was to calculate the activities of four 133Ba sources (T1/2=10.54 years; Eγ=356 keV) using planar and single-photon emission computed tomography (SPECT) or SPECT/CT acquisitions of the sources inside a water-filled cylindrical phantom. The sources were previously calibrated by the US National Institute of Standards and Tec...
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Technical Note Source Type: research

177Lu-DOTATATE therapy in patients with neuroendocrine tumours including high-grade (WHO G3) neuroendocrine tumours: response to treatment and long-term survival update
Conclusion 177Lu-DOTATATE therapy is an important treatment option in somatostatin receptor type-2-positive pancreatic, nonpancreatic gastroenteropancreatic-NETs, and lung NETs including metastatic NETs with an unknown primary site and significantly contributed to patients’ OS. Additionally, peptide receptor radionuclide therapy may have a role in a selected subgroup of patients with grade III NET with high somatostatin receptor type-2 expression. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison between visual and numerical metrics for the evaluation of patients with Takayasu arteritis with 18F-FDG-PET
Conclusion In this study, we found that the analysis of the vascular region with the highest 18F-FDG uptake using either visual or numerical metrics provided the best diagnostic performance for the detection of active TAK with PET. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Gallium-68 DOTA-NOC PET/CT as an alternate predictor of disease activity in sarcoidosis
Introduction We evaluated the role of gallium-68-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-Nal3-octreotide (68Ga-DOTA-NOC) PET/CT in assessing sarcoidosis disease activity. Patients and methods Patients diagnosed with sarcoidosis underwent 68Ga-DOTA-NOC-PET/CT. The maximum standardized uptake value (SUVmax) at the pathological site and in the descending thoracic aorta (reference standard, SUVmed) were assessed. A SUVmax/SUVmed ratio (disease activity score) of more than one was considered a marker of active disease and was compared with the clinical symptoms and serum angiotensin-converting ...
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Preoperative omental metastasis-related maximum standardized fluorine-18-fluorodeoxyglucose uptake value can predict chemosensitivity and recurrence in advanced high-grade serous ovarian cancer patients
Objective The aim of this study was to explore the clinical and prognostic implication of preoperative fluorine-18-fluorodeoxyglucose uptake value of omental metastasis-related in advanced high-grade serous ovarian cancer patients (HGSC). Patients and methods We retrospectively investigated HGSC patients with omental metastasis (International Federation of Gynecology and Obstetrics stage IIIB–IV) who underwent PET/CT before primary surgery in our hospital between January 2010 and January 2016. All patients were confirmed omental metastasis by postoperative pathology. None of these patients received neoadjuvant c...
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Evaluation of drug effects on cerebral blood flow and glucose uptake in un-anesthetized and un-stimulated rats: application of free-moving apparatus enabling to keep rats free during PET/SPECT tracer injection and uptake
Conclusion We successfully developed free-moving 18F-FDG-PET and 99mTc-HMPAO-SPECT imaging systems and detected detailed glucose uptake and cerebral blood flow changes in the conscious rat brain with fluoxetine administration. This system is expected to be useful to assess brain activity without the effects of anesthesia and tactual stimulation to evaluate drug effect or animal brain function. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis
Conclusion A negative 18F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, 18F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. 18F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform 18F-FDG-PET/CT in all patients with suspected NVE. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Clinical and prognostic value of 18F-FDG-PET/CT in restaging of pancreatic cancer
Aim The aim of this retrospective multicentre study was to evaluate the clinical and prognostic effect of fluorine-18-fluorodeoxyglucose (18F-FDG)-PET/computed tomography (CT) in the restaging process of pancreatic cancer (PC). Materials and methods Data from patients treated for primary PC, who underwent 18F-FDG-PET/CT for suspicious of disease progression, were collected. Accuracy was assessed employing conventional diagnostic procedures, multidisciplinary team case notes, further 18F-FDG-PET/CT scans and/or follow-up. Receiver operating characteristic curve and likelihood ratio (LR+/−) analyses were used for ...
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Integrated texture parameter of 18F-FDG PET may be a stratification factor for the survival of nonoperative patients with locally advanced non-small-cell lung cancer
Conclusion This study demonstrated that ITP might be a stratification factor for the survival of nonoperative patients with LA-NSCLC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Myocardial stunning-induced left ventricular dyssynchrony on gated single-photon emission computed tomography myocardial perfusion imaging
Objectives Myocardial stunning provides additional nonperfusion markers of coronary artery disease (CAD), especially for severe multivessel CAD. The purpose of this study is to assess the influence of myocardial stunning to the changes of left ventricular mechanical dyssynchrony (LVMD) parameters between stress and rest gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). Patients and methods A total of 113 consecutive patients (88 males and 25 females) who had undergone both stress and rest 99mTc-sestamibi gated SPECT MPI were retrospectively enrolled. Suspected or known patien...
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Applying standardized uptake values in gallium-67-citrate single-photon emission computed tomography/computed tomography studies and their correlation with blood test results in representative organs
Conclusion The physiological uptake in 67Ga-citrate SPECT/CT can be represented as SUVs, which are not significantly correlated with corresponding blood test results. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

A retrospective study of the clinical features in papillary thyroid microcarcinoma depending on age
The aim of this study was to evaluate the clinical features and correlation of neck lymph node involvement of papillary thyroid microcarcinoma (PTMC) according to patients’ age. We divided the patients into three groups according to age: young group ( (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 13, 2018 Category: Nuclear Medicine Tags: Review Article Source Type: research

Study of the peak splitting in an alternative method for the radiochemical purity measurement of 99mTechnetium-sestamibi
One of the alternative methods for the measurement of radiochemical purity (RCP) of 99mTechnetium-sestamibi uses Whatman 3MM paper as the stationary phase and ethyl acetate as the mobile phase. However, alternative method shows peak splitting and shouldering of the radiopharmaceutical. This could be because of higher levels of analyte. We aimed to assess the effect of sample dilution (1 : 1) on this method and to compare these RCP values with the reference method. The diluted samples showed a unique peak in the radiopharmaceutical zone, but the RCP values were significantly different (P (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Technical Note Source Type: research

The prognostic and diagnostic value of 18F-FDG PET/CT for assessment of symptomatic osteoarthritis
The objective of this study was to assess the clinical significance of increased fluorine-18-fluorodeoxyglucose (18F-FDG) uptake on PET/CT in joints for evaluation of symptomatic osteoarthritis (OA) and prediction of progression. Patients and methods In this prospective study, shoulder, hip, and knee joints were imaged in 65 patients undergoing routine 18F-FDG PET/CT imaging. Patients completed the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire to assess joint pain, stiffness, and physical function. Standardized uptake values (SUVs) were measured in hip, knee, acromioclavicular (AC)...
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Clinical impact of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in patients with resectable pancreatic cancer: diagnosing lymph node metastasis and predicting survival
Conclusion 18F-FDG PET/CT showed higher diagnostic accuracy in predicting LN metastasis than CECT in patients with resectable pancreatic cancer. Only the LN/tumor SUV ratio of 18F-FDG PET/CT was an independent prognostic variable in both DFS and OS. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Role of 18F-FDG PET/CT in evaluating molecular subtypes and clinicopathological features of primary breast cancer
In this study, primary tumors’ fluorine-18-fluorodeoxyglucose (18F-FDG) uptake in luminal A, luminal B, triple-negative, and human epidermal growth factor receptor type-2 subtypes of breast cancer was evaluated. In addition, the relationship between the primary tumor maximum standardized uptake value (SUVmax) value and the presence of distant metastasis and axillary involvement was evaluated. Patients and methods Whole-body 18F-FDG PET/computed tomography (CT) imaging of 493 patients (mean age; 54.6±13.2 years) diagnosed with primary breast cancer were analyzed retrospectively. PET/CT imaging was obtained 6...
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Fluorine-18-fluorocholine PET/CT parameters predictive for hematological toxicity to radium-223 therapy in castrate-resistant prostate cancer patients with bone metastases: a pilot study
Conclusion Tumor bone burden calculation is feasible with 18F-FCH PET/CT with freely available open-source software. In this pilot study, baseline 18F-FCH PET/CT markers (TLA, MBTV) have shown abilities to predict Hb and PLT toxicity after 223Ra therapy and could be explored for patient selection and treatment optimization. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Effects of breathing motion on PET acquisitions: step and shoot versus continuous bed motion
Objectives Continuous bed motion (CBM) acquisition recently became available in whole-body PET/CT scanners in addition to the conventional step and shoot (S&S) acquisition. In this work, we compared the image quality between these acquisition methods using a phantom simulating periodic motion to mimic motion from patient breathing in a controlled manner. Methods PET image quality was assessed using the National Electrical Manufacturers Association IQ torso phantom filled with an 18F-FDG solution using a 4 : 1 target-to-background ratio. The phantom was scanned in two states: no motion (stationary) an...
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

A pilot study of pancreatic islet amyloid PET imaging with [18F]FDDNP
Conclusion These results suggested that [18F]FDDNP is a potential tracer for pancreatic islet amyloid PET imaging. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Value of 18F-FDG PET/CT imaging in the staging, restaging, monitoring of response to therapy and surveillance of uterine leiomyosarcomas
Conclusion PET/CT imaging has a high diagnostic yield in the initial staging and restaging of uterine LMS, but seems less sensitive in post-therapy surveillance. Evaluation of the CT part improves the sensitivity of the PET scan. Thus, PET/CT imaging should be considered in patients presenting with LMS. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Limited additional value of cervical ultrasonography over a negative 18F-FDG PET/CT for diagnosing cervical lymph node metastases in patients with esophageal cancer: a systematic review and meta-analysis
Conclusion Cervical ultrasonography has very limited additional diagnostic value as supplement to a negative 18F-FDG PET/CT in the detection of cervical lymph node metastases during the initial staging of patients with esophageal cancer. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Tumor heterogeneity, hypoxia, and immune markers in surgically resected non-small-cell lung cancer
This study aimed to determine the prognostic role of textural features and their association with metabolic parameters, hypoxia, and cancer-related immune markers in non-small-cell lung cancer (NSCLC) patients. Patients and methods The trial was registered at http://www.clinicaltrials.gov (NCT02519062). From January 2010 to May 2014, 44 patients (male : female=33 : 11; median age: 69.5 years), referred to our Institution for NSCLC resection, were enrolled. Tumor specimens were assessed for HIF-1α, CD68-TAMs, CD8-TILs, PD-1-TILs, and PD-L1 expressions. All patients underwent fluorine-18-...
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

A comparative study of quantitative assessment with fluorine-18-fluorodeoxyglucose positron-emission tomography and endoscopic ultrasound in oesophageal cancer
Conclusion Given the strong correlation between EUS and PET parameters, fluorine-18 fluorodeoxyglucose (18F-FDG) PET can provide accurate information on the length and the volume of tumour in patients who either cannot tolerate EUS or have impassable strictures. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Importance of 18F-FDG PET/CT to select patients with nonresectable colorectal liver metastases for liver transplantation
Conclusion The ability of 18F-FDG PET/CT to detect extrahepatic disease before LT for NCLM is vital to establish LT as a treatment option. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

A case series of outcomes in isolated subsegmental pulmonary embolism on ventilation–perfusion imaging
Conclusion In this case series, a large proportion of patients with isolated SSPE on V/Q imaging were not identified on corroborating CTPA performed within 48 h. In patients with isolated SSPE (identified by isolated subsegmental mismatch on V/Q single-photon emission computed tomography), we found no difference in risk of recurrent suspected VTE or all-cause mortality in those treated with anticoagulation and those not treated. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

SPECT-CT versus MRI in localizing active lesions in patients with osteoporotic vertebral compression fractures
This study aimed to evaluate the difference and consistency between single-photon emission computed tomography-computed tomography (SPECT-CT) and MRI in diagnosing osteoporotic vertebral compression fractures (OVCFs) and identifying active lesions. Patients and methods All 46 patients underwent SPECT-CT and MRI examinations. The pain vertebral body and pain sites were determined using both MRI and SPECT-CT during percutaneous kyphoplasty (PKP). The differences before and after treatment were assessed using visual analog scale scores and evaluated using a paired t-test. Furthermore, the difference and conformity of SPECT...
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Fluctuation of quantitative values on acquisition time and the reconstruction conditions in 99mTc-SPECT
Conclusion It is necessary that Quantitative SPECT be acquired at 50 s or more per view per detection, reconstructed using a three-dimensional ordered subset expectation maximization with SC+/AC+, the SI product is 150 times, and the Gaussian Filter is 8–12 mm. This suggested that the quantitative analysis would be carried out with good reproducibility. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Effects of atrial fibrillation on myocardial washout rate of thallium-201 on myocardial perfusion single-photon emission computed tomography
Background Myocardial perfusion single-photon emission computed tomography (SPECT) with thallium (Tl)-201 is an established modality for evaluating myocardial ischemia. We assessed the effects of atrial fibrillation (AF) on the myocardial washout rate (WR) of Tl-201 on myocardial perfusion SPECT. Patients and methods A total of 231 patients with no evidence of myocardial ischemia were enrolled retrospectively in this study. Patients were divided into two groups on the basis of the ECG at the time of myocardial perfusion SPECT. The mean myocardial WR of Tl-201 was calculated from the stress and the redistribution Bull&...
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Physiological parameterization of thyroid radioiodine kinetics
Conclusion The derived parametric function of radioiodine intrathyroid kinetics facilitates the dosimetry, providing the reference standard to assess the simpler, more approximate methods; is applicable to any iodine radioisotope; and set-ups the method for assessment of thyroid and whole-body iodine clearances. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-FDG PET/CT in the evaluation of cancer cervix: Where do we stand today?
The incidence of gynecological malignancies is on the rise partly because of the availability of screening programmes, awareness, higher technological advancements, and availability of better medical care. Early diagnosis of any malignancy leads to prompt treatment. Use of 18Fluorine-Fluorodeoxyglucose (18F-FDG) PET/CT in the treatment and follow-up of patients with Ca cervix considerably improves patient management. The primary diagnosis of Ca cervix is made either by biopsy of a visible tumor on the cervix or by a cone biopsy of a nonvisible malignant cervical focus. The staging procedure is purely clinical (i.e. gynecol...
Source: Nuclear Medicine Communications - June 15, 2018 Category: Nuclear Medicine Tags: Review Article Source Type: research

Improvement to visualization of nodes in breast cancer patients following audit: are we seeing the problem?
Successful localization of nodes in breast cancer patients depends upon the effectiveness of the lymphoscintigraphy technique employed. A benefit of performing imaging as part of this procedure is that it allows sites to audit their technique. An audit of breast cancer patients at the Glasgow Royal Infirmary (GRI) hospital showed nodes to be visualized in only 81% of patients. Current guidelines state that nodes should be seen in more than 95% of patients. A period of investigation and review led to changes being made to the injection and imaging technique employed at the GRI site. Following these changes a re-audit was pe...
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Lactate dehydrogenase levels and 18F-FDG PET/CT metrics differentiate between mediastinal Hodgkin’s lymphoma and primary mediastinal B-cell lymphoma
This study aims to investigate whether clinical, laboratory, and fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT findings can discriminate between mediastinal Hodgkin’s lymphoma and primary mediastinal B-cell lymphoma (PMBCL). Patients and methods This retrospective study included 56 patients (42 with mediastinal Hodgkin’s lymphoma and 14 with PBMCL). Differences in clinical, laboratory, and 18F-FDG PET/CT metrics were assessed between Hodgkin’s lymphoma and PMBCL. Results Lactate dehydrogenase (LDH) and 18F-FDG PET/CT-based maximum tumor diameter, lesion-to-liver ratio maximum standardized uptake v...
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prognostic value of pretreatment PET/CT lean body mass-corrected parameters in patients with hepatocellular carcinoma
Conclusion Pretreatment 18F-FDG-PET/CT lean body mass-corrected parameters can predict the OS in patients with HCC. Moreover, lbmSUVmax and AST, as the independent predictors of OS, could supplement the prognostic value of the BCLC staging system. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prognostic value of metabolic tumor volume and total lesion glycolysis in esophageal carcinoma patients treated with definitive chemoradiotherapy
Conclusion Metabolic volumes (MTV and TLG), regional lymph node metastasis, and concurrent chemotherapy are major prognostic factors for DFS and OS in patients with esophageal carcinoma. In addition, MTV and TLG are important in predicting nodal metastasis, and together with metabolic volumes, SUV are associated significantly with local tumor invasion. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Fluorine-18-fluorodeoxyglucose PET/CT in hematopoietic stem cell transplant patients with fusariosis: initial findings of a case series review
Conclusion Although having a small number of patients and lack of standard approach, 18F-FDG PET/CT seemed useful to discriminate uncomplicated cases of primary bloodstream infections and detect occult foci of metastatic infection in patients with positive cutaneous lesions cultures. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Ageing effect on 18F-DOPA and 123I-MIBG uptake: a cross-sectional study
Conclusion Our findings suggest that both brain 18F-DOPA PET/CT and cardiac 123I-MIBG scintigraphy represent age-independent biomarkers whose analyses of quantitative uptake may not require adjustment for patients’ age. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Minimal starting time of data reconstruction for qualitative myocardial perfusion rubidium-82 positron emission tomography imaging
Objective Qualitative positron emission tomography (PET) myocardial perfusion imaging (MPI) scans are reconstructed with a delay after an injection of rubidium-82 (82Rb) to ensure blood pool clearance and sufficient left ventricle to myocardium contrast. Our aim was to derive the minimal starting time of data reconstruction (STDR) after an injection of 82Rb for which the diagnostic value and image quality remained unaffected. Materials and methods We retrospectively included 23 patients who underwent rest-stress 82Rb PET MPI using 740 MBq. Patients fulfilling one of the two criteria indicating a slow blood pool...
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The effect of kidney volume estimation on dosimetry in lutetium-177 DOTATATE therapy
Conclusion The most accurate method of organ volume estimation would be individual measurements from CT imaging; however, where this is not possible, scaling of organ masses by weight ratio is more accurate than the use of the standard phantom. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Patient-specific lean body mass can be estimated from limited-coverage computed tomography images
Conclusion This study demonstrates that LBM can be estimated from LC CT images with no significant difference from LBMWB. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The scintigraphic, biodistribution and histopathological evaluation of the effect of experimental 131I administration on the gastrointestinal system and the demonstration of the Na+/I− symporter by immunohistochemistry in rats
Conclusion The amount of NIS is important for the absorption of RAI after administration. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Pulmonary aspiration only increases the risk of right-sided pneumonia in children: comparison of salivagrams and chest radiographs
Conclusion Pulmonary aspiration tends to occur in the right side and only increases the risk of right-sided pneumonia. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

An update on ‘dose calibrator’ settings for nuclides used in nuclear medicine
Conclusion In general, current manufacturer-provided calibration settings give activities that agree with National Institute of Standards and Technology standards to within a few percent. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Optimization of the CT component of SPECT-CT and establishment of local CT diagnostic reference levels for clinical practice
Conclusion This work describes a process of optimization and the creation of practical and effective local DRLs. These can be used in local audit of practice. In future, improved descriptors and standardization of SPECT-CT use would allow more practicable UK national DRLs to be created. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Dosimetry-based treatment for Graves’ disease
Conclusion A personalized dosimetric approach delayed the long-term onset of hypothyroidism in 26% of patients. This was achieved using much lower administered activities than currently recommended. Future studies will aim to identify those patients who would benefit most from this approach. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Diagnostic value of 18F-FDG PET/MRI in recurrent pelvis malignancies of female patients: a systematic review and meta-analysis
The aim of this study was to assess the diagnostic performance of fluorine-18-fluorodeoxyglucose (18F-FDG) PET/MRI for suspected recurrence of pelvis malignancies of female patients using a meta-analysis. We performed a systematical literature search for relevant studies in PubMed, Cochrane Library, Google Scholar, and several Chinese databases. Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) was used to assess the quality of all included studies. Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were calculated per patient and per lesion. Summary ...
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Review Articles Source Type: research

The incremental clinical value of cardiac hybrid SPECT/CTA imaging in coronary artery disease
Coronary artery disease (CAD) is a major cause of death worldwide. It is significantly important to assess the coronary lesion and its pathophysiological relevance comprehensively. Coronary computed tomography angiography (CTA) or myocardial perfusion imaging alone suffers from some limitations in the evaluation of CAD. Through the integration and spatial colocalization of complementary morphological and functional information, the results of published hybrid single-photon emission computed tomography (SPECT)/CTA studies in patients with CAD are promising for detecting functionally relevant coronary artery lesion and evalu...
Source: Nuclear Medicine Communications - May 16, 2018 Category: Nuclear Medicine Tags: Review Articles Source Type: research

A comparison of four-sample slope–intercept and single-sample 51Cr-EDTA glomerular filtration rate measurements
This study supports the recommendation of performing single-sample GFR measurements for GFRs greater than 30 ml/min/1.73 m2. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 10, 2018 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Pretherapeutic 124I dosimetry reliably predicts intratherapeutic blood kinetics of 131I in patients with differentiated thyroid carcinoma receiving high therapeutic activities
Conclusion The pretherapeutic blood kinetics derived from diagnostic 124I activities provides a reliable estimation of the intratherapeutic 131I blood kinetics in patients receiving largely high therapy activities, showing its potential for radioiodine treatment planning. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 10, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

A novel method to assess subchondral bone formation using [18F]NaF-PET in the evaluation of knee degeneration
Conclusion Assessment of global activity within the joint is a feasible and clinically useful technique for characterizing disease activity with a single value. Furthermore, a ratio based on systemic bone turnover in a nonarticulating, weight-bearing site adjusts for differences in bone formation related to bodyweight or metabolic bone diseases. We hypothesize that a global knee TBR score may be more sensitive at detecting changes in disease progression, as new spatially distinct lesions with a lower SUV that develop within an region of interest would not be detected by the SUVmax methodology. Longitudinal studies assess...
Source: Nuclear Medicine Communications - April 10, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Effect of thyroid-stimulating hormone in 68Ga-DOTATATE PET/CT of radioiodine-refractory thyroid carcinoma: a pilot study
Conclusion 68Ga-DOTATATE PET/CT presents a high sensitivity in detecting metastatic lesions in patients with RAIR. Detectability increases with iodine-resistance, both with and without higher thyroid-stimulating hormone levels. These findings might improve staging and subsequent treatment planning, especially with radiolabeled somatostatin analogs. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 10, 2018 Category: Nuclear Medicine Tags: Original Articles Source Type: research