Tissue standardized uptake value is a closer surrogate of blood fluorine-18 fluorodeoxyglucose clearance after division by blood standardized uptake value, illustrated in brain and liver
The numerator and denominator of the left-hand side of the Gjedde–Patlak–Rutland (GPR) equation for measurement of blood fluorine-18 fluorodeoxyglucose (18F-FDG) clearance into tissue (Ki) are the standardized uptake values (SUVs) of tissue and blood, respectively. The extent to which normalized time (NT) in the GPR equation exceeds real time depends on half-time of clearance of 18F-FDG from blood. A literature review shows that NT is fairly constant, about 100 min at 60 min postinjection of 18F-FDG, in keeping with our own finding of no significant difference in maximum SUV in blood 60 min...
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: TECHNICAL NOTE Source Type: research

Dynamics of fluorine-18-fluorodeoxyglucose uptake in the liver and its correlation with hepatic fat content and BMI
Conclusion We observed a time-dependent decrease in global hepatic SUVmean and average SUVmax, which was affected by the amount of liver fat. Patients with higher BMI and hepatic fat content tended to retain 18F-FDG. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Value of fluorine-18-fluorodeoxyglucose PET/CT in localizing the primary lesion in adrenocorticotropic hormone-dependent Cushing syndrome
Conclusion Serum ACTH level determines the success rate of localization of the primary ACTH-secreting tumor in ACTH-dependent syndrome. 18F-FDG PET/CT plays a role in localizing the site for EAS, although it plays a limited role in Cushing disease. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Visual and semiquantitative analysis of 82Rb uptake in malignant tumors on PET/CT: first systematic analysis
Conclusion Malignant tumors can be readily depicted and quantified on rubidium PET/CT. Further research is needed. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

A 5-year longitudinal evaluation in patients with mild cognitive impairment by 11C-PIB PET/CT: a visual analysis
Objective The aim of this study was to evaluate the cerebral amyloid distribution in patients with mild cognitive impairment (MCI), assessed by carbon-11-Pittsburgh compound B (11C-PIB) PET/CT, after 5 years of follow-up. Patients and methods Ten amnestic MCI (A-MCI) and four nonamnestic (NA-MCI) patients were studied by 11C-PIB PET/CT and re-evaluated 5 years later by a new 11C-PIB PET/CT. PET/CT scans were acquired 60–90 min after the administration of 555 MBq 11C-PIB and analyzed visually, to obtain a score of the cerebral cortical 11C-PIB retention in the frontal, basal ganglia (BG), temporopar...
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Comparison of (18F)FDG PET/CT and (68Ga)DOTATATE PET/CT imaging methods in terms of detection of histological subtype and related SUVmax values in patients with pulmonary carcinoid tumors
This study was designed to compare the 18-Fluorodeoxyglucose positron emission tomography/computed tomography [(18F)FDG PET/CT] and 1,4,7,10-tetraazacyclododecane-NI,NII,NIII,NIIII-tetraacetic acid (D)-Phe1-thy3-octreotate [(68Ga)DOTATATE PET/CT) findings in patients with pulmonary carcinoid (PC) tumors. Materials and methods A total of 20 patients [mean (SD) age: 52.2 (12.9) years, 60% women] with PC tumors and available records on digital images of (18F)FDG PET/CT and (68Ga)DOTATATE PET/CT and histopathological analysis were included in this retrospective single-center study. Patient characteristics, structural and fu...
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Cost-effectiveness of second-line diagnostic investigations in patients included in the DANTE trial: a randomized controlled trial of lung cancer screening with low-dose computed tomography
Aim The aim of this study was to analyze the economic efficiency of second-line diagnostic investigations in patients with undetermined lung nodules. Participants and methods A retrospective review of all surgical cases included in the DANTE trial from 2001 to 2006 for lung cancer screening was performed. Overall, 217 patients and 261 lung nodules were analyzed. The cohort was divided into patients investigated with PET and/or computed tomography (CT)-guided biopsy (PET-CTB protocol; N=100), compared with those assessed with serial low-dose CT scans (standard protocol; N=161). Outpatient’s and inpatient’s ...
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

The negative correlation between energy consumption and communication efficiency in motor network
Conclusion This study investigated the energy consumption of motor network and found a relationship between energy consumption and communication efficiency. These results may provide insights into the understanding of energy consumption mechanism underlying motor network. Video abstract: http://links.lww.com/NMC/A142 (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Gated single-photon emission computed tomography myocardial perfusion imaging is superior to computed tomography attenuation correction in discriminating myocardial infarction from attenuation artifacts in men and right coronary artery disease
Background In single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) studies, attenuation artifacts frequently cause false positives, which can be partially overcome by computed tomography attenuation correction (CT-AC) or gated acquisition [gated myocardial perfusion imaging (GMPI)]. The purpose of this study is to evaluate their relative diagnostic performances for coronary artery disease (CAD). Patients and methods We enrolled 181 patients who underwent gated SPECT with CT-AC in this study. Two observers who were blinded to the clinical data interpreted the GMPI and CT-AC images. Coro...
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Standardization of the specific binding ratio in [123I]FP-CIT SPECT: study by striatum phantom
Conclusion Direct comparison of the SBR with those of other facilities and sharing other facilities normal values is clinically difficult. We devised countermeasures that do not affect the diagnosis and developed a simple tool to calculate the standardized SBR. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Clinical features and therapeutic outcomes of patients with papillary thyroid microcarcinomas and larger tumors
Objective The aim of this study was to identify clinical features and therapeutic outcomes of patients with papillary thyroid cancer (PTC) according to tumor diameter and evaluate the correlation of neck lymph node (LN) involvement of papillary thyroid microcarcinoma (PTMC) according to patients’ age. Patients and methods We divided 467 patients into two groups according to tumor diameter: PTMC group (≤1 cm) and non-PTMC group (>1 cm). The clinical data were analyzed retrospectively. Thereafter, we divided the PTMC patients into three subgroups according to age: young subgroup ( (Source: Nucl...
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Quantitative analysis of technetium-99m-sestamibi uptake and washout in parathyroid scintigraphy supports dual mechanisms of lesion conspicuity
Purpose Proposed mechanisms of parathyroid localization in ‘dual-phase’ technetium-99m-sestamibi imaging include increased presence of mitochondria leading to greater uptake and slower washout compared with thyroid tissues owing to reduced expression of P-glycoprotein. Using new techniques of quantitative single-photon emission computed tomography (SPECT)/computed tomography (CT), we have measured MIBI uptake and washout to better understand factors related to conspicuity. Patients and methods We retrospectively reviewed 125 consecutive patients. Early and delayed SPECT/CT images were reconstructed using a...
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Comparison of PERCIST and RECIST criteria for evaluation of therapy response after yttrium-90 microsphere therapy in patients with hepatocellular carcinoma and those with metastatic colorectal carcinoma
Conclusion 90Y therapy response can be evaluated by both RECIST and European Organization for Research and Treatment of Cancer criteria. However, RECIST and European Organization for Research and Treatment of Cancer incompatibility can be seen. The anatomic methods for evaluating HCC response is relatively more accurate, whereas the metabolic parameters guided by PET/CT scan showed greater importance in response to evaluation of liver mCRC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Does the dose of iodine-131 influence the incidence of Graves’ ophthalmopathy?
Conclusion RAI is known to exacerbate ophthalmopathy. Our study showed it was not dose-dependent. Patients without a previous history of GO were observed to have a significantly delayed period for the development of symptoms. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 12, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

British Nuclear Medicine Society 47th Annual Spring Meeting, Oxford 1st–3rd April 2019
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ABSTRACTS: PDF Only Source Type: research

Stress test of liver function using technetium-99m-mebrofenin hepatobiliary scintigraphy
Technetium-99m (99mTc) mebrofenin hepatobiliary scintigraphy (HBS) enables a quantitative assessment of liver function. This is normally performed in a fasting state and might therefore reflect the resting liver function. We evaluated the change in liver function using HBS after stimulation with an oral metabolic challenge. Healthy volunteers aged 50–60 (n=12) or older than or equal to 75 (n=12) years underwent two sequential HBS. The first scan was performed after an overnight fast and the second scan was performed after the administration of chocolate milk. Hepatic 99mTc-mebrofenin uptake rate (cMUR) was calculated...
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: TECHNICAL NOTE Source Type: research

Cis-4-[18F]fluoro-D-proline detects neurodegeneration in patients with akinetic-rigid parkinsonism
Conclusion Data suggest that D-cis-[18F]FPro is a sensitive marker of inflammation-associated degenerative processes in parkinsonian syndromes. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications
Conclusion 18F-FDG PET/CT does not appear to be useful in cancer screening for AIM patients compared with conventional screening and carries potential harms associated with follow-up investigations. The risk of cancer in AIM differs by myositis-specific antibodies-defined subsets and cancer screening is likely to be indicated only in high-risk patients, particularly DM. These results, replicated in larger, multicentered studies, may carry significant consequences for optimal management of AIM and health resource utilization. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

18F-PBR06 PET/CT imaging for evaluating atherosclerotic plaques linked to macrophage infiltration
Conclusion TSPO radioligand 18F-PBR06 allows noninvasive PET/CT imaging of macrophage-abundant atherosclerotic plaques as well as positive correlation between PET imagings and ex-vivo immunofluorescence staining of plaques in mice with different ages, thereby representing a potential attractive tool for evaluating the vulnerability of atherosclerotic plaques towards rupture. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Prognostic value of 18F-FDG PET/CT functional parameters in patients with head and neck cancer: a meta-analysis
Purpose We performed this meta-analysis to evaluate the prognostic value of maximum of standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) in patients with head and neck cancer. Methods Articles including prognostic value of PET/CT were searched in PubMed and subsequently analyzed. The primary outcome of interest was event-free survival, and the secondary outcome of interest was overall survival. Statistical analysis was performed using hazard ratio (HR) and odds ratio. Review manager 5.3 was used to generate the eligible data. Results A total of 28 studies with 1871 ...
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

18F-FDG PET/CT and nestin expression as prognostic tools in pulmonary neuroendocrine tumours
Objectives The aim of this study was to investigate the fluorine-18-fluorodeoxyglucose (18F-FDG) uptake on integrated PET [PET/computed tomography (CT)] images and its correlation with nestin expression in a series of neuroendocrine lung tumours. As the incidence of neuroendocrine lung tumours is rising, tools predicting diagnosis, outcome and assisting in the selection of treatment regimens are needed. Patients and methods We reviewed records of patients diagnosed with large cell neuroendocrine lung carcinoma, atypical carcinoid and typical carcinoid who were operated upon in our institution. Into the study, we inclu...
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

An investigation into the accuracy of using serum creatinine estimated glomerular filtration rate to predict measured glomerular filtration rate
Conclusion The eGFR value has a high error when used for predicting the mGFR. Therefore, the study recommends that an eGFR threshold value of ≤40 ml/min/1.73 m2 is used to predict mGFRs of ≤25 ml/min/1.73 m2 in order to optimise the likelihood of identifying all such patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Validation of quantitative salivary gland scintigraphy in relation to the American–European concensus criteria for Sjögren’s syndrome
Conclusion Quantitative SGS is a valuable tool in the diagnostic management of patients with suspected primary SS, especially in those in whom the nonscintigraphic AECC criteria are not conclusive. The straightforward quantitative analysis of SGS used in this study can be implemented in any nuclear medicine department. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Propagation of measurement errors in glomerular filtration rate determination: a comparison of slope–intercept, single-sample and slope-only methods
Conclusion Measurement errors are probably insignificant relative to biological variation for GFR of more than 60 ml/min/1.73 m2, but become significant irrespective of biological variation at lower GFR, particularly in serial studies when GFR less than 25 ml/min/1.73 m2. Limits of precision recommended in the 2018 British Nuclear Medicine Society guideline are appropriate for once-off GFR measurement, whereas slightly more stringent limits are proposed for serial studies. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Impact of hibernating and viable myocardium on improvement in perfusion and left ventricular ejection fraction after coronary artery bypass graft
Conclusion There was no significant relation between the severity and extent of perfusion–metabolism mismatch with improvement in perfusion and LVEF after CABG. After CABG for ischemic left ventricle dysfunction, VM shows a tendency toward better improvement in LVEF. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Predictive risk factors for sentinel lymph node nonvisualization on planar lymphoscintigraphy using an intratumoral injection in patients with primary breast cancer
Objectives Lymphoscintigraphy is considered a useful tool to optimize sentinel lymph node (SLN) identification. Nonvisualization of the SLN is associated with a lower SLN identification rate. The aim of this study was to identify preoperative factors associated with SLN nonvisualization on lymphoscintigraphy. Patients and methods A total of 2050 consecutive SLN procedures were evaluated from clinically node-negative breast cancer patients. Planar lymphoscintigraphy was performed at 3 h after an intratumoral injection of technetium-99m-nanocolloid. This technique was used for extra-axillary SLN identification. P...
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Denoising of iodine-131 images using a median filter
In this study, we have compared the performance of a plus-shape and a square-shape median filter for 131I whole-body images and found the filter with optimum parameter that improves 131I image quality acceptable to nuclear medicine physicians. Materials and methods A total of 150 whole-body 131I images were exported in DICOM format. These images were converted into PNG format and processed with a plus-shape and a square-shape median filter, with each shape mask having sizes of 3, 5, 7, and 9 pixels. The quality of the processed images was assessed by visual assessment by two nuclear medicine physicians and also quantita...
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Practical guidelines for the use of technetium-99m mebrofenin hepatobiliary scintigraphy in the quantitative assessment of liver function
This article provides an overview of the HBS methodology used at some of the largest HBS centers and covers practical details in the application of HBS for the quantitative scintigraphic assessment of liver function. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 16, 2019 Category: Nuclear Medicine Tags: REVIEW ARTICLE Source Type: research

Medical nuclomics: a new order in nuclear medicine practice
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: LETTER TO THE EDITOR Source Type: research

Spatial dependence of activity concentration recovery for a conjugate gradient (Siemens xSPECT) algorithm using manufacturer-defined reconstruction presets
Siemens absolute quantitative reconstruction, xSPECT, is available with manufacturer-defined reconstruction presets to assist with optimization. This phantom study evaluates the impact of these presets on the spatial dependence of activity concentration recovery (ACR). Single-photon emission computed tomography/computed tomography scans of a 5 : 1 and 10 : 1 (sphere : background) contrast NEMA phantom were performed on a Siemens Intevo 6. Three sphere position configurations, achieved by rotating the sphere mount through 0°, 120° and 240°, were used and three replicate ...
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: TECHNICAL NOTE Source Type: research

Synthesis and preclinical evaluation of the 177Lu-DOTA-PSMA(inhibitor)-Lys3-bombesin heterodimer designed as a radiotheranostic probe for prostate cancer
Conclusion The results warrant further preclinical studies to establish the 177Lu-radiotracer theranostic efficacy. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Discovery Molecular Imaging Digital Ready PET/CT performance evaluation according to the NEMA NU2-2012 standard
Conclusion All three Discovery MI DR systems tested in this study exceeded the manufacturer’s NEMA specification, yet variability between scanners was noted. Discovery MI DR showed similar performance to Discovery 690 and Ingenuity TF, but lower sensitivity and spatial resolution than Biograph mCT Flow. The Discovery MI DR showed lower spatial resolution and contrast recovery than the 20-cm field-of-view Digital MI. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Parotid incidentalomas on positron emission tomography: what is their clinical significance?
Conclusion The most common benign salivary tumour in our study was Warthin’s tumour and the majority of these patients had a primary lung carcinoma. Given that the main predisposing factor for both pathologies is smoking, potentially this suggests an association between the incidence of primary lung carcinoma and Warthin’s tumour. Ten (14%) patients in our study had a standardized uptake value of below 3.2 (using the VUE Point HD algorithm). These patients had either no identifiable lesion on ultrasound or no malignant features on histology; therefore, we propose that a cut-off of 3.2 on PET/CT could be used ...
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Sensitivity of fluorine-18-fluoromethylcholine PET/CT to prostate-specific antigen over different plasma levels: a retrospective study in a cohort of 192 patients with prostate cancer
In this study, we wished to confirm this finding and expand it in a large series of patients. Patients and methods We retrospectively analyzed 192 patients with prostate cancer who were recruited from the Nuclear Medicine Department of the Sant’Andrea Hospital of La Spezia, Italy, from March 2013 to March 2018 and who underwent 18F-FCH PET/CT owing to biochemical failure after radical prostatectomy. Results Median trigger PSA was 2.57 ng/ml. The overall positive detection rate of 18F-FCH PET/CT was 60.9%. The percent of positive scans was 30.5% for PSA less than 1 ng/ml, 59.4% (38/64) for PSA betw...
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Quantitative assessment of 18F-FDG PET in patients with Hodgkin lymphoma: is it significantly affected by contrast-enhanced computed tomography attenuation correction?
Conclusion As the use of CT contrast fluids results in a stronger SUV increase within the liver and mediastinal blood pool than within lymphoma tissue, this may have clinical consequences regarding visual and quantitative response assessment. Ideally, CT scans for PET attenuation correction should therefore be performed in the absence of a contrast agent. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Classification of amyloid PET images using novel features for early diagnosis of Alzheimer’s disease and mild cognitive impairment conversion
Conclusion The results presented in this study demonstrate the potential of FD and SE methods for the analysis of brain PET scans in early AD diagnosis and in the prediction of MCI-AD conversion. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Usefulness of respiratory-gated 18F-FDG PET/CT scan protocol in patients having positive myocardial 18F-FDG uptake
Conclusion For a 18F-FDG PET/CT scan for patients with having positive myocardial 18F-FDG uptake, a respiratory-gated PET protocol divided into five phases is recommended, to minimize the influence of internal motion on cardiac accumulation. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Evaluating the potential of kit-based 68Ga-ubiquicidin formulation in diagnosis of infection: a pilot study: 68: Ga
Conclusion The present study concluded that 68Ga-UBI prepared using NOTA-UBI kit is a potential agent in targeting infections associated with disease conditions including diabetic foot, cellulitis and fracture. The patient selection holds significance in accurate diagnosis using 68Ga-UBI PET/CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

The efficacy of pretreatment and after treatment 18F-FDG PET/CT metabolic parameters in patients with locally advanced squamous cell cervical cancer
Conclusion 18F-FDG PET/CT cut-off values may help clinicians with their treatment planning and follow-up in locally advanced squamous cell cervical cancer patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Relationship between regional hepatic glucose metabolism and regional distribution of hepatic fat
Conclusion In addition to systemic influences, hepatic glucose uptake is regionally linked to the distribution of hepatic fat. Increased metabolism could be the cause or result of local fat deposition. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Development and validation of a new method to diagnose apical hypertrophic cardiomyopathy by gated single-photon emission computed tomography myocardial perfusion imaging
Conclusion Our new method has high sensitivity, specificity, and accuracy against CMR diagnosis. It has great promise to become a clinical tool in the diagnosis of AHCM. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Incidence and severity of femoral head avascularity after femoral neck or intertrochanteric fractures on preoperative bone single photon emission computed tomography/computed tomography: preliminary study
Conclusion Although avascular femoral head on bone SPECT/CT does not directly indicate avascular necrosis, assessing the incidence and severity of femoral head avascularity using qualitative and quantitative parameters could give clinically useful information related to the classification. Additional studies with larger sample sizes would be a next step to expand the clinical role of bone SPECT/CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

The relationship between thyroid eye disease and radioiodine treatment
Thyroid eye disease is the most frequent extrathyroidal manifestation of Graves’ disease and it can have a major negative impact on the quality of life of affected patients. Therefore, it is crucial to have a correct and early diagnosis. Thyroid eye disease management should be multidisciplinary. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: REVIEW ARTICLE Source Type: research

Amersham radiopharmaceuticals: a global scientific and industrial legacy for nuclear medicine
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 15, 2019 Category: Nuclear Medicine Tags: EDITORIAL Source Type: research

The British Nuclear Medicine Society and Irish Nuclear Medicine Association Joint meeting 19th November 2018 – The Radisson Blu Hotel, Dublin
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 17, 2019 Category: Nuclear Medicine Tags: ABSTRACTS: PDF Only Source Type: research

Fluorine-18-fluorodeoxyglucose positron emission tomography in thyroid nodules with indeterminate cytology: a prospective study
Conclusion This study suggests a high negative predictive value of 18F-FDG PET in thyroid nodules of more than 1 cm whose cytology is indeterminate and that are not highly suspicious on ultrasonography. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 17, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Celiac ganglia: can they be misinterpreted on multimodal: 68: Ga-PSMA-11 PET/MR?
Conclusion Frequently observed, the nodular, oval and longitudinal (nodular, thick or with oval parts) shape of CG, especially of the thicker left CG, on MR scans may cause mistaking them for lymph nodes, even abnormal or metastatic. On whole-body PET/MRI, evident and sometimes high 68Ga-PSMA-11 uptake in CG increases the risk of a misinterpretation of them as metastases. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 17, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

The use of single-photon emission computed tomography-computed tomography in detecting multiple metastatic lymph nodes in patients with breast cancer
Conclusion This single-center study showed that in patients with BC, a combination of functional and anatomical data that were obtained by using SPECT-CT with 99mTc-MIBI can significantly improve detectability of multiple (>2) axillary metastases. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 17, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

Assessment of therapeutic effects of statin on cardiac sympathetic nerve activity and cardiac events in patients with ischemic cardiomyopathy and mild to moderate heart failure
This study was a subanalysis of our previous report of the result that the serial 123I-MIBG scintigraphic studies were the most useful prognostic indicator in patients with heart failure. Patients with heart failure [left ventricular ejection fraction (LVEF) (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 17, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research

First comparative results about the direct effect of traditional cigarette and e-cigarette smoking on lung alveolocapillary membrane using dynamic ventilation scintigraphy
Introduction Dynamic inhalation scintigraphy (DIS) with technetium-99m-diethylenetriamine-pentaacetate aerosol is a useful nuclear medicine procedure for staging and monitoring the damage of alveolocapillary membrane. The e-cigarette is a new popular smoking device producing vapor from the nicotine solution. Many studies have shown that e-cigarettes appear to be safer than smoking, but there are still debates to what extent e-cigarettes are less harmful than smoking. In this prospective, self-controlled study, we compared DIS results among volunteers smoking an e-cigarette and their results after they returned to tradit...
Source: Nuclear Medicine Communications - January 17, 2019 Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research