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The antimicrobial activity and essential oil constituents of the leaves and trunks of Aquilaria banaensis P.H.H ô (Thymelaeceae) from Vietnam
Nat Prod Res. 2023 Apr 2:1-9. doi: 10.1080/14786419.2023.2196624. Online ahead of print.ABSTRACTThe aim of the present paper was to report the chemical constituents and antimicrobial activity of essential hydrodistilled from the leaves and trunk of Aquilaria banaensis P.H.Hô (Thymelaeceae) from Vietnam. The essential oils were analysed comprehensively for their constituents by using Gas chromatography coupled with Mass spectrometry (GC/MS). The antimicrobial activity was determined by agar well diffusion and broth microdilution methods. The leaf essential oil comprised mainly of sesquiterpenes while fatty acids constitute...
Source: Natural Product Research - April 2, 2023 Category: Biochemistry Authors: Yen Thi Van Dien Dinh Duc Minh Tran Thang Nam Tran Hoi Nguyen Thuy Thanh Duong Tuan Quoc Doan Hoai Thi Nguyen Isiaka A Ogunwande Source Type: research

Phenolics and triterpenoids from stem bark of Calophyllum lanigerum var. austrocoriaceum (Whitmore) P. F. Stevens and their cytotoxic activities
In this study, four known phenolic constituents and two triterpenoids have been isolated from the stem bark of Calophyllum lanigerum. The compounds were two pyranochromanone acids are known as caloteysmannic acid (1), isocalolongic acid (2), a simple dihydroxyxanthone, namely euxanthone (3), one coumarin named calanone (4), and two common triterpenoids, friedelin (5), and stigmasterol (6). Chromanone acids were reported for the first time in this Calophyllum species. Cytotoxic evaluations were carried out on n-hexane extract (87.14 ± 2.04 µg/mL; 81.46 ± 2.42 µg/mL) followed by the chromanone acids (1 [79.96 ± 2.39 µM...
Source: Natural Product Research - April 2, 2023 Category: Biochemistry Authors: Norisha Mokhtar Thiruventhan Karunakaran Rameshkumar Santhanam Mohamad Hafizi Abu Bakar Vivien Yi Mian Jong Source Type: research

Glycoside constituents of Camellia amplexicaulis and their α -glucosidase inhibitory activity
Nat Prod Res. 2023 Apr 2:1-9. doi: 10.1080/14786419.2023.2196724. Online ahead of print.ABSTRACTFour new glycosides, named amplexicosides A-D (1-4), and five known compounds: benzyl 2-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyloxy]-benzoate (5), benzyl 2-neohesperidosyloxy-6-hydroxybenzoate (6), chrysandroside A (7), chrysandroside B (8) and camelliquercetiside C (9) were isolated from the branches and leaves of Camellia amplexicaulis (Pit.) Cohen-Stuart. Their structures were elucidated using HR-ESI-MS and 1D- and 2D-NMR spectra and compared to reported NMR data. All of the isolated compounds were screened in an α-g...
Source: Natural Product Research - April 2, 2023 Category: Biochemistry Authors: Nguyen Thi Cuc Duong Thi Dung Ngo Anh Bang Duong Thi Hai Yen Nguyen Huy Hoang Phan Van Kiem Bui Huu Tai Source Type: research

New benzoquinone pigments from the hydnoid fungus Sarcodontia setosa and their biosynthetic relationship
Nat Prod Res. 2023 Apr 2:1-10. doi: 10.1080/14786419.2023.2195176. Online ahead of print.ABSTRACTChemical investigation of the hydnoid fungus Sarcodontia setosa resulted in the isolation of five compounds, including two new sarcodontic acid derivatives - setosic acid (1) and 7,8-dehydrohomosarcodontic acid (2) along with three known benzoquinone pigments - sarcodontic acid (3), 4,5-dehydrosarcodontic acid (4) and dihydrosarcodontic acid (5). The structures were elucidated using spectroscopic methods (UV, NMR and HR-ESIMS). The biosynthetic relationship of the isolated compounds is proposed and discussed. Antibacterial acti...
Source: Natural Product Research - April 2, 2023 Category: Biochemistry Authors: Andrei K Whaley Anastasiia O Ponkratova Anastasia A Orlova Sergey V Volobuev Natalia V Shakhova Evgeny B Serebryakov Sergey N Smirnov Natalia V Pustovit Liudmila A Kraeva Vladimir G Luzhanin Source Type: research

 In silico and in vitro elastase inhibition assessment assays of rosmarinic acid natural product from Rosmarinus officinalis Linn
Nat Prod Res. 2023 Apr 2:1-6. doi: 10.1080/14786419.2023.2196077. Online ahead of print.ABSTRACTThe use of various herbs and their compounds has been a strategy widely used in the fight against various human diseases. For example, rosmarinic acid, a bioactive phenolic compound commonly found in Rosemary plants (Rosmarinus officinalis Labiatae), has multiple therapeutic benefits in different diseases, such as cancer. Therefore, the study aimed to evaluate in silico and in vitro the inhibition potential of the enzyme Elastase from the porcine pancreas by rosmarinic acid isolated from the plant species R. officinalis Linn. Th...
Source: Natural Product Research - April 2, 2023 Category: Biochemistry Authors: Ester Gon çalves de Jesus Fernanda Fernandes de Souza Jo ão Victor Andrade M árcio Luís Andrade E Silva Wilson R Cunha Rafael Corr êa Ramos Othon Souto Campos Jorge Alexandre Nogueira Santos Mario F C Santos Source Type: research

Parmoferone A, a new depsidone from the lichen Parmotrema cristiferum 
Nat Prod Res. 2023 Mar 31:1-6. doi: 10.1080/14786419.2023.2193746. Online ahead of print.ABSTRACTA new depsidone, parmoferone A (1), together with three known compounds, parmosidone K (2), albifolione (3), and 4-chloroorcinol (4) were isolated from the lichen Parmotrema cristiferum (Taylor) Hale (Parmeliaceae). The structures of isolated compounds were identified from its spectroscopic data and by comparison with the literature. Compounds 1-4 were evaluated for alpha-glucosidase inhibition. Compound 1 was determined to be a potent non-competitive inhibitor against alpha-glucosidase with an IC50 value of 18.1 μM.PMID:36999...
Source: Natural Product Research - March 31, 2023 Category: Biochemistry Authors: Thuc-Huy Duong Tran Nguyen Minh An Thi-Kim-Dung Le Thi-Minh-Dinh Tran Huy Truong Nguyen Thi Hong Anh Nguyen Ngoc-Hong Nguyen Jirapast Sichaem Source Type: research

In silico study of novel marine alkaloid jolynamine and other marine compounds via molecular docking, MM-GBSA binding energy prediction, ADMET evaluation, and molecular dynamics simulation
This study will hopefully facilitate the finding of other natural products and expedite the drug discovery process to screen drug like chemical compounds.PMID:36995020 | DOI:10.1080/14786419.2023.2195177 (Source: Natural Product Research)
Source: Natural Product Research - March 30, 2023 Category: Biochemistry Authors: Sana Gul Abdul Majeed Khan Syed Tahir Ali Samra Rizwan Source Type: research

Synthesis, identification and evaluation of molecular docking and experimental anti-cancer and antioxidant activity of new spiro four membered ring derivatives bearing 5-nitro isatin
Nat Prod Res. 2023 Mar 30:1-8. doi: 10.1080/14786419.2023.2195178. Online ahead of print.ABSTRACTSpiro-5-nitro isatino aza-β-lactams were produced by a [2 + 2] cycloaddition of 5-nitro isatin Schiff bases [1-5] with different aromatic isocyanate and thioisocyanate. 1HNMR and 13CNMR as well as FTIR spectroscopies, were used to identify the structures of the obtained compounds. These spiro-5-nitro isatin aza- β-lactams interest to us due to their potential antioxidant and anticancer properties. The MTT assay was used to examine in vitro bioactivity testing against breast cancer (MCF-7) cell lines. From result data, compoun...
Source: Natural Product Research - March 30, 2023 Category: Biochemistry Authors: Hala Ayad Mohamed Rasheed Suaad M H Al-Majidi Source Type: research

Methoxylated bibenzyls and isoflavones from Baphia massaiensis Taub
Nat Prod Res. 2023 Mar 30:1-7. doi: 10.1080/14786419.2023.2196076. Online ahead of print.ABSTRACTChemical investigation of the stem bark of Baphia massaiensis Taub. led to the isolation of two new natural compounds named 3-hydroxy-2,5,2'-trimethoxybibenzyl (1) and 2'-hydroxy-2,3,5,6-tetramethoxybibenzyl (2), the latter has been previously reported as a synthetic compound, together with twelve known compounds 3-14. The chemical structures of the isolated compounds were elucidated by using NMR analysis and mass spectrometry, as well as comparisons with the reported data in the literature. Known bibenzyls 3-5, bauhinoxepin J ...
Source: Natural Product Research - March 30, 2023 Category: Biochemistry Authors: Nayang A Kgakatsi Runner R T Majinda Ishmael B Masesane Irene Gobe Source Type: research