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Neuroprotective activity of Colocasia esculenta (L.) Schott leaves against monosodium glutamate-induced excitotoxicity in rats: phytochemical and molecular docking study
Nat Prod Res. 2024 Apr 12:1-9. doi: 10.1080/14786419.2024.2340061. Online ahead of print.ABSTRACTColocasia esculenta (L.) Schott is a food crop with long history of use in treatment of various disorders including neurological diseases. The methanolic leaves extract (ME) and its n-butanol fraction (n-BF) demonstrated significant in vivo neuroprotective activity in monosodium glutamate induced excitotoxicity in rats. Sixteen and fifteen polyphenolic compounds were identified in n-BF and ME, respectively, using HPLC. Phytochemical investigation of n-BF followed by 1D (1H and 13C NMR) spectroscopic analyses led to isolation an...
Source: Natural Product Research - April 12, 2024 Category: Biochemistry Authors: Heba T Khazaal Elsayed K El-Sayed Yara E Mansour Reham R Ibrahim Mokhtar Bishr Rabab A El Dib Hesham S M Soliman Source Type: research

Effects of natural waste on in vitro oxidative DNA damage
In this study, the effects of natural waste products such as extracts from C. coggygria leaves and Punica granatum L. peels were investigated against oxidative DNA damage induced by Fenton reaction. 8-OH-2'dG as a general marker of DNA damage on thymus DNA, and the bioactive compounds of extracts were measured by LC-MS/MS. Our results had shown that ethanol extracts of C. coggygria leaf and Punica granatum L. peel had a protective effect on oxidative damaged DNA. It was determined that the bioactive compounds of C. coggygria leaves (gallic acid, protocatechuic acid, myricetin, syringic acid and ethyl gallate as a major com...
Source: Natural Product Research - April 12, 2024 Category: Biochemistry Authors: Dua Danjolli-Hashani Sebnem Selen Isbilir Source Type: research

Flavan-3-ols, flavonoids, anthocyanidins and triterpenoids induces TIE2 phosphorylation -a candidate target for the vascular protective effects
Nat Prod Res. 2024 Apr 12:1-5. doi: 10.1080/14786419.2024.2340049. Online ahead of print.ABSTRACTVascular system is essential for the body to maintain health. Dysregulated vascular system leads to cardiovascular diseases and are observed in ischaemic stroke, Alzheimer's disease, amyotrophic lateral sclerosis, and diabetes. TIE2 is a tyrosine kinase receptor expressed on vascular endothelial cells and contributes to the maintenance of a vascular system. In this paper, we screened for natural products with an activity to induce phosphorylation of TIE2, which will be beneficial for protection of a vascular system. Employing H...
Source: Natural Product Research - April 12, 2024 Category: Biochemistry Authors: Saki Igarashi Sayaka Hioki Naoto Sakamaru Asahi Suzuki Mihoko Kurokawa Eisuke Kato Source Type: research

Testusterol, a new sterol of the sponge species Xestospongia testudinaria from Phu Quoc island, Vietnam
Nat Prod Res. 2024 Apr 11:1-9. doi: 10.1080/14786419.2024.2340757. Online ahead of print.ABSTRACTA new sterol, named testusterol (1), and five known compounds (2-6) were isolated from the n-hexane and dichloromethane extracts of the sponge species Xestospongia testudinaria. Their chemical structures were elucidated based on extensive spectroscopic analyses (1D, 2D NMR, ESIMS and HRESIMS) and comparison with published data. The results of in vitro test (utilizing brine shrimp Artemia salina LEACH) showed that three extracts ethanol, dichloromethane, and ethanol/water, significantly inhibited Artemia salina with LC50 values ...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Phuong Vu Luu Hien Minh Nguyen Phuc Minh Phan An Duy Vo Huong Lien Ton-Nu Source Type: research

Morusacerane: A new gammacerane triterpenoid from the trunk of Morus Alba linn. with α -glucosidase inhibitory activity
Nat Prod Res. 2024 Apr 11:1-10. doi: 10.1080/14786419.2024.2340043. Online ahead of print.ABSTRACTThis phytochemistry investigation on the trunk of Morus alba L. resulted in the isolation of three triterpenoids, including a new gammacerane triterpenoid - morusacerane (1); along with two known compounds of betulinic acid (2) and ursolic acid (3). The structure elucidation was thoroughly conducted based on 1D, 2D-NMR and HRESIMS spectra, followed by a comparison with existing literatures. The evaluation on α-glucosidase inhibitory exhibited the great potential of the application of these isolated compounds in diabetes treat...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Hoang-Vinh-Truong Phan Duy Vu Nguyen Thi-Kim-Dung Le Thi-Anh-Minh Nguyen Phan-Si-Nguyen Dong Thanh-Nha Tran Ngoc-Van-Trang Dao Hieu Cuong Nguyen Hong Truong Luu Warinthorn Chavasiri Le-Thuy-Thuy-Trang Hoang Van-Kieu Nguyen Source Type: research

Sucrose esters of aryldihydronaphthalene-type lignans, and antitumor activity of extracts of Moltkiopsis ciliata (Forssk.) aerial parts
Nat Prod Res. 2024 Apr 11:1-11. doi: 10.1080/14786419.2024.2341307. Online ahead of print.ABSTRACTOne new compound (3f-[(7'R,8'R)-4,4'-dihydroxy-5-methoxy-2,7'-cycloligna-7-en-9-methoxycarbonyl, 9'-carbonyl-O-] -β- D-fructofuranosyl- (2→1)-α- D-glucopyranoside) (Moltkiopsin A) (2) was isolated and identified from the extract of aerial parts of the wild Egyptian plant Moltkiopsis ciliata (Frossk.), family Boraginaceae, for the first time, along with two aryldihydronaphthalene lignans 3f→9':6f→9-[(7'R,8'R)-4,4'- dihydroxy-3,3',5-trimethoxy-2,7'-cycloligna-7-en-9,9'-dicarbonyl]-6g-acetyl-α-D-gluco pyranosyl-(1→2) -...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Amal Mahmoud Youssef Moustafa Mohamed Abdel-Moneim Mohamed E Mostafa Mamdouh Abdel-Mogib Marwa Rabee Abdel-Hak Source Type: research

New steroids with anti-inflammatory activity from the whole plants of Physalis minima 
Nat Prod Res. 2024 Apr 10:1-7. doi: 10.1080/14786419.2024.2340048. Online ahead of print.ABSTRACTTwo new steroids, phyminiolide J (1) and phyministerol A (2), along with three known compounds (3-5) were isolated from the whole plants of Physalis minima. The structures of the new compounds were elucidated by comprehensive spectroscopic analysis and the absolute configurations were determined by using computational ECD calculations. All isolates were evaluated for their anti-inflammatory activity via inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells, and t...
Source: Natural Product Research - April 10, 2024 Category: Biochemistry Authors: Jiangping Wu Qiuyue Lv Jie Yu Yu Zhang Guodong Wang Jun Han Zhongmei Zou Source Type: research

Preparation and characterisation of kaempferol composite carrier solid dispersion: evaluation of its application in preventing soybean oil spoilage
In conclusion, KPF-CC-SD can change the solubility, crystal form and spatial stability of KPF through the carrier, which has a great application prospect in the field of food preservation.PMID:38597177 | DOI:10.1080/14786419.2024.2338811 (Source: Natural Product Research)
Source: Natural Product Research - April 10, 2024 Category: Biochemistry Authors: Tai Gao Honghui Zhao Lingling Wang Danni Song Xu Zhao Source Type: research

Antihyperlipidemic effect and GC-MS analysis of phytoconstituents from Laurus nobilis essential oil in rat
In conclusion, the study demonstrates that L. nobilis essential oils possess antidyslipidemic activity in acute model of hyperlipidaemia.PMID:38597184 | DOI:10.1080/14786419.2024.2340760 (Source: Natural Product Research)
Source: Natural Product Research - April 10, 2024 Category: Biochemistry Authors: Ayoub Amssayef Bouchra Soulaimani Adil Qabouche Abdelaziz Abbad Mohamed Eddouks Source Type: research