Effects of algerian nettle ( < em > Urtica dioica < /em > L.) on benign prostatic hyperplasia and their mechanism of action elucidation: in vivo and in silico approaches
This study investigated the effect of Urtica dioica roots etheric extract (UDEE) on oxidative stress, and urine obstruction with histopathological examinations of prostatic and renal tissues,and suggests computational methods as a complementary method, to make a hypothesis on the overall effect of UDEE in the treatment of benign prostatic hyperplasia (BPH).Gas chromatography/mass spectrometry was utilised to characterise UDEE.BPH was induced in rats through daily subcutaneous injections of testosterone propionate. Rats were also orally administered UDEE or a vehicle. After four weeks, prostate weight, urine output, and bio...
Source: Natural Product Research - October 23, 2023 Category: Biochemistry Authors: Karima Bougueroua Mokhtaria Yasmina Boufadi Batoul Latreche Ismail Celik Miguel Guerrero Gonzalez Amina Doubbi Bounoua Samir Bouras Ahmed Eissa Ahmed Zoeir Source Type: research
Megastigmane glycoside and phenol glycosides from the bark of < em > Mallotus barbatus < /em >
Nat Prod Res. 2023 Oct 22:1-8. doi: 10.1080/14786419.2023.2272284. Online ahead of print.ABSTRACTA new megastigmane glycoside, barbatcoside A (1), and two new phenol glycosides, barbatcosides B (2) and C (3), together with eight known compounds (4-11) were isolated from the bark of Mallotus barbatus Müll. Arg. Their structures were elucidated using extensive 1D and 2D NMR as well as HRESIMS spectroscopic data. The stereochemistry of compounds 1 and 2 were established based on the experimental CD curves. The anti-inflammatory activities of compounds 1-11 from M. barbatus were evaluated using LPS-stimulated RAW 264.7 cell m...
Source: Natural Product Research - October 23, 2023 Category: Biochemistry Authors: Chenyang Ren Ping Hou Jian Li Yan Huang Liwei Pan Liuting Peng Chunqiu Gan Xinlan Guan Jun Li Source Type: research
Structurally diverse indole alkaloids with cytotoxicity from < em > Lonicera Japonica < /em > -associated endophytic fungus < em > Penicillium ochrochloron < /em > YT2022-65
In this study, chemical investigation on Penicillium ochrochloron YT2022-65, an endophytic fungus associated with Lonicera Japonica, led to the isolation of six structurally diversified indole alkaloids, including a new one, namely peniochroloid A (1), as well as five previously reported alkaloids, flavonoid B (2), brocaeloid C (3), isoroquefortine C (4), roquefortine C (5), and dihydrocarneamide A (6). Their structures, including the absolute configuration of 1, were determined by a combined analysis of HRESIMS, NMR spectroscopic data, and calculation of the optical rotation. Their cytotoxicity against A549, HepG2, MCF-7,...
Source: Natural Product Research - October 23, 2023 Category: Biochemistry Authors: Xingjie Liu Ruonan Li Xiaofei Zhou Source Type: research
Antimalarial compounds from the climbing stems of < em > salacia debilis < /em >
Nat Prod Res. 2023 Oct 22:1-10. doi: 10.1080/14786419.2023.2272288. Online ahead of print.ABSTRACTSalacia debilis Walp., (Celastraceae) is used traditionally in West Africa for the treatment of malaria. However, no scientific reports validating these effects and its active constituents are on record. Therefore, this study is aimed at evaluating the antimalarial effects, of its ethanolic extract and isolated compounds against Plasmodium falciparum 3D7 and P. berghei ANKA strains. Using chromatographic, spectrometric and spectroscopic techniques three compounds were isolated and characterised. The extract of S. debilis was a...
Source: Natural Product Research - October 23, 2023 Category: Biochemistry Authors: Michael Konney Laryea Gilbert Boadu Ampomah Edmund Ekuadzi Rita Akosua Dickson Lawrence Sheringham Borquaye Source Type: research
< em > Arctium lappa L. < /em > root polysaccharides ameliorate CCl < sub > 4 < /sub > -induced acute liver injury by suppressing oxidative stress, inflammation and apoptosis
In conclusion, ALP possesses a hepatoprotective effect mediated by attenuating oxidative damage, inflammation and apoptosis in ALI.PMID:37867310 | DOI:10.1080/14786419.2023.2272287 (Source: Natural Product Research)
Source: Natural Product Research - October 23, 2023 Category: Biochemistry Authors: Wen Xiang Jiayi Wei Lifei Lv Xinghui Yu Yan Xie Li Zhang Naiyan Lu Wentao Jiang Source Type: research
Effects of algerian nettle ( < em > Urtica dioica < /em > L.) on benign prostatic hyperplasia and their mechanism of action elucidation: in vivo and in silico approaches
This study investigated the effect of Urtica dioica roots etheric extract (UDEE) on oxidative stress, and urine obstruction with histopathological examinations of prostatic and renal tissues,and suggests computational methods as a complementary method, to make a hypothesis on the overall effect of UDEE in the treatment of benign prostatic hyperplasia (BPH).Gas chromatography/mass spectrometry was utilised to characterise UDEE.BPH was induced in rats through daily subcutaneous injections of testosterone propionate. Rats were also orally administered UDEE or a vehicle. After four weeks, prostate weight, urine output, and bio...
Source: Natural Product Research - October 23, 2023 Category: Biochemistry Authors: Karima Bougueroua Mokhtaria Yasmina Boufadi Batoul Latreche Ismail Celik Miguel Guerrero Gonzalez Amina Doubbi Bounoua Samir Bouras Ahmed Eissa Ahmed Zoeir Source Type: research
Megastigmane glycoside and phenol glycosides from the bark of < em > Mallotus barbatus < /em >
Nat Prod Res. 2023 Oct 22:1-8. doi: 10.1080/14786419.2023.2272284. Online ahead of print.ABSTRACTA new megastigmane glycoside, barbatcoside A (1), and two new phenol glycosides, barbatcosides B (2) and C (3), together with eight known compounds (4-11) were isolated from the bark of Mallotus barbatus Müll. Arg. Their structures were elucidated using extensive 1D and 2D NMR as well as HRESIMS spectroscopic data. The stereochemistry of compounds 1 and 2 were established based on the experimental CD curves. The anti-inflammatory activities of compounds 1-11 from M. barbatus were evaluated using LPS-stimulated RAW 264.7 cell m...
Source: Natural Product Research - October 23, 2023 Category: Biochemistry Authors: Chenyang Ren Ping Hou Jian Li Yan Huang Liwei Pan Liuting Peng Chunqiu Gan Xinlan Guan Jun Li Source Type: research
Structurally diverse indole alkaloids with cytotoxicity from < em > Lonicera Japonica < /em > -associated endophytic fungus < em > Penicillium ochrochloron < /em > YT2022-65
In this study, chemical investigation on Penicillium ochrochloron YT2022-65, an endophytic fungus associated with Lonicera Japonica, led to the isolation of six structurally diversified indole alkaloids, including a new one, namely peniochroloid A (1), as well as five previously reported alkaloids, flavonoid B (2), brocaeloid C (3), isoroquefortine C (4), roquefortine C (5), and dihydrocarneamide A (6). Their structures, including the absolute configuration of 1, were determined by a combined analysis of HRESIMS, NMR spectroscopic data, and calculation of the optical rotation. Their cytotoxicity against A549, HepG2, MCF-7,...
Source: Natural Product Research - October 23, 2023 Category: Biochemistry Authors: Xingjie Liu Ruonan Li Xiaofei Zhou Source Type: research
Antimalarial compounds from the climbing stems of < em > salacia debilis < /em >
Nat Prod Res. 2023 Oct 22:1-10. doi: 10.1080/14786419.2023.2272288. Online ahead of print.ABSTRACTSalacia debilis Walp., (Celastraceae) is used traditionally in West Africa for the treatment of malaria. However, no scientific reports validating these effects and its active constituents are on record. Therefore, this study is aimed at evaluating the antimalarial effects, of its ethanolic extract and isolated compounds against Plasmodium falciparum 3D7 and P. berghei ANKA strains. Using chromatographic, spectrometric and spectroscopic techniques three compounds were isolated and characterised. The extract of S. debilis was a...
Source: Natural Product Research - October 23, 2023 Category: Biochemistry Authors: Michael Konney Laryea Gilbert Boadu Ampomah Edmund Ekuadzi Rita Akosua Dickson Lawrence Sheringham Borquaye Source Type: research
< em > Arctium lappa L. < /em > root polysaccharides ameliorate CCl < sub > 4 < /sub > -induced acute liver injury by suppressing oxidative stress, inflammation and apoptosis
In conclusion, ALP possesses a hepatoprotective effect mediated by attenuating oxidative damage, inflammation and apoptosis in ALI.PMID:37867310 | DOI:10.1080/14786419.2023.2272287 (Source: Natural Product Research)
Source: Natural Product Research - October 23, 2023 Category: Biochemistry Authors: Wen Xiang Jiayi Wei Lifei Lv Xinghui Yu Yan Xie Li Zhang Naiyan Lu Wentao Jiang Source Type: research
One novel alkaloid from the stems of < em > Tinospora crispa < /em >
Nat Prod Res. 2023 Oct 22:1-6. doi: 10.1080/14786419.2023.2272023. Online ahead of print.ABSTRACTThe 6-methoxy-cannabisin I (1), a new alkaloid, together with five known compounds oleraisoindole A (2), cannabisin F (3), apigenin (4), syringin (5) and ethyl-syringin (6) were isolated from Tinospora crispa stems. Their structures were identified by the analysis of spectroscopic data. Compound 2 was isolated from T. crispa for the first time. Anti-inflammatory activity of compound 1 was detected against NO production in LPS-activated RAW 264.7 macrophages. However, no activity was observed.PMID:37865970 | DOI:10.1080/14786419...
Source: Natural Product Research - October 22, 2023 Category: Biochemistry Authors: Fengmei Huang Pianchou Gongpan Kailong Ji Lan Zhou Qishi Song Qingfei Fan Source Type: research
New prenyl flavanone and diarylbutanol from < em > Uvaria siamensis < /em > stem bark and their < em > α < /em > -glucosidase inhibitory activity
Nat Prod Res. 2023 Oct 22:1-7. doi: 10.1080/14786419.2023.2272024. Online ahead of print.ABSTRACTOne new prenyl flavanone (1), (2S)-8-prenyl-5,6-dihydroxy-7-methoxyflavanone, and one new diarylbutanol (2), (7'S)-3'-hydroxy-linderagatin-A, were isolated from the stem bark of Uvaria siamensis (Annonaceae), along with five known compounds, eriodictyol (3), quercetin (4), paprazine (5), N-trans-caffeoyltyramine (6), and N-trans-feruloyltyramine (7). Their structures were determined through extensive spectroscopic analyses and comparison with the literature. The α-glucosidase inhibitory potential of 1-7 was evaluated. Compound...
Source: Natural Product Research - October 22, 2023 Category: Biochemistry Authors: Huong T M Nguyen Duong T T Ngo Phung D N Nguyen Tuyen N K Pham Lien T M Do Jirapast Sichaem Source Type: research
Bioactivities of natural product geodin congeners and their preliminary structure activity relationship
Nat Prod Res. 2023 Oct 22:1-10. doi: 10.1080/14786419.2023.2272022. Online ahead of print.ABSTRACTA series of 6 novel ester derivatives 2-7 of natural product geodin 1 were designed and semi-synthesized through one mild step reaction with high yield. Compounds 2-7 showed strong inhibitory activities against Staphylococcus aureus in the range of 2.35-9.41 μM. Compounds 4 and 7 showed very strong inhibitory activities against antifouling bacteria Aeromonas salmonicida with MICs of 2.42 μM and 4.56 μM respectively. Most notably compounds 3-7 showed potent antifungal activities against Candida albicans in the range of 0.59-...
Source: Natural Product Research - October 22, 2023 Category: Biochemistry Authors: Gulab Said Amjad Ali Muhammad Umair Farooq Ahmad Salma Gul Muhammad Ateeq Source Type: research
Production of bioactive and aroma volatile compounds of < em > Lawsonia inermis < /em > L. cultivated under different growth conditions
This study revealed that GC conditions permit an alternative use of Lawsonia cultivation, because of the increase in the endogenous content of bioactive secondary metabolites with many potential biological activities.PMID:37865973 | DOI:10.1080/14786419.2023.2272279 (Source: Natural Product Research)
Source: Natural Product Research - October 22, 2023 Category: Biochemistry Authors: Laura Pistelli Basma Najar Giulia Di Renzo Maurizio Curadi Luisa Pistelli Beatrice Muscatello Marinella De Leo Andrea Scartazza Source Type: research
Two new sesquiterpenoids from the fruits of Alpinia oxyphylla
Nat Prod Res. 2023 Oct 22:1-7. doi: 10.1080/14786419.2023.2272282. Online ahead of print.ABSTRACTTwo undescribed sesquiterpenoids, including one nor-eudesmane type (1) and one guaiane type (2), together with two known analogues (3-4) have been isolated and identified from the fruits of Alpinia oxyphylla. The structures of these new compounds were elucidated by extensive spectroscopic analyses (1D-, 2D-NMR, HRESIMS, IR, UV) and NMR calculations with DP4+ analysis. The anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on PGE2 production in LPS stimulated RAW 264.7 macrophages.P...
Source: Natural Product Research - October 22, 2023 Category: Biochemistry Authors: Weirong Bai Tuanjie Wang Xiaoming Yang Zhenzhong Wang Haibo Li Jianliang Geng Source Type: research
