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Synthesis, identification and evaluation of molecular docking and experimental anti-cancer and antioxidant activity of new spiro four membered ring derivatives bearing 5-nitro isatin
Nat Prod Res. 2023 Mar 30:1-8. doi: 10.1080/14786419.2023.2195178. Online ahead of print.ABSTRACTSpiro-5-nitro isatino aza-β-lactams were produced by a [2 + 2] cycloaddition of 5-nitro isatin Schiff bases [1-5] with different aromatic isocyanate and thioisocyanate. 1HNMR and 13CNMR as well as FTIR spectroscopies, were used to identify the structures of the obtained compounds. These spiro-5-nitro isatin aza- β-lactams interest to us due to their potential antioxidant and anticancer properties. The MTT assay was used to examine in vitro bioactivity testing against breast cancer (MCF-7) cell lines. From result data, compoun...
Source: Natural Product Research - March 30, 2023 Category: Biochemistry Authors: Hala Ayad Mohamed Rasheed Suaad M H Al-Majidi Source Type: research

Methoxylated bibenzyls and isoflavones from Baphia massaiensis Taub
Nat Prod Res. 2023 Mar 30:1-7. doi: 10.1080/14786419.2023.2196076. Online ahead of print.ABSTRACTChemical investigation of the stem bark of Baphia massaiensis Taub. led to the isolation of two new natural compounds named 3-hydroxy-2,5,2'-trimethoxybibenzyl (1) and 2'-hydroxy-2,3,5,6-tetramethoxybibenzyl (2), the latter has been previously reported as a synthetic compound, together with twelve known compounds 3-14. The chemical structures of the isolated compounds were elucidated by using NMR analysis and mass spectrometry, as well as comparisons with the reported data in the literature. Known bibenzyls 3-5, bauhinoxepin J ...
Source: Natural Product Research - March 30, 2023 Category: Biochemistry Authors: Nayang A Kgakatsi Runner R T Majinda Ishmael B Masesane Irene Gobe Source Type: research

Antiviral activity of curcumin and its analogs selected by an artificial intelligence-supported activity prediction system in SARS-CoV-2-infected VeroE6 cells
Nat Prod Res. 2023 Mar 28:1-6. doi: 10.1080/14786419.2023.2194647. Online ahead of print.ABSTRACTCurcumin has been reported to exert its anti-SARS-CoV-2 activity by inhibiting the binding of spike receptor-binding domain (RBD) to angiotensin-converting enzyme-2 (ACE2). To identify more potent compounds, we evaluated the antiviral activities of curcumin and its analogs in SARS-CoV-2-infected cells. An artificial intelligence-supported activity prediction system was used to select the compounds, and 116 of the 334 curcumin analogs were proposed to have spike RBD-ACE2 binding inhibitory activity. These compounds were narrowed...
Source: Natural Product Research - March 29, 2023 Category: Biochemistry Authors: Koji Teshima Takeshi Tanaka Ye Zhengmao Ken Ikeda Takao Matsuzaki Tamotsu Shiroma Ayumu Muroya Masato Hosoda Mayo Yasugi Hirotsugu Komatsu Source Type: research

Imperatorin from the aerial parts of Cleome viscosa L.: a characterization study and evaluation of the antibacterial activity
Nat Prod Res. 2023 Mar 28:1-8. doi: 10.1080/14786419.2023.2190116. Online ahead of print.ABSTRACTCleome viscosa L., a member of the family Cleomaceae, is a potential medicinal plant, known for several bioactive properties such as: anticancer, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, wound healing, etc. Our study aimed to isolate a bioactive compound and assess its antibacterial activity. The crystal compound imperatorin was isolated and reported for the first time from the aerial parts of C. viscosa. The isolation was made using silica gel (100-200 mesh) column chromatography. The structure of imperator...
Source: Natural Product Research - March 29, 2023 Category: Biochemistry Authors: Govindan Lakshmanan Ammar B Altemimi C Sivaraj Jeyaperumal Selvakumari L Karthik K Saravanan Vijay Viswanathan Arjun Pandian Francesco Cacciola Marwa Rashad Ali Mazin A A Najm Tarek Gamal Abedelmaksoud Source Type: research

Ancistrobrevinium A, the first N -methylated, cationic naphthylisoquinoline alkaloid, from the tropical liana Ancistrocladus abbreviatus (Ancistrocladaceae)
Nat Prod Res. 2023 Mar 29:1-5. doi: 10.1080/14786419.2023.2194648. Online ahead of print.ABSTRACTAncistrobrevinium A (1) is the first N-methylated and non-hydrogenated, and thus cationic naphthylisoquinoline alkaloid. It was discovered in the root bark extract of the phytochemically productive West African liana Ancistrocladus abbreviatus (Ancistrocladaceae). Its constitution was elucidated by HR-ESI-MS and 1D and 2D NMR. Due to the steric hindrance in the proximity of the linkage between the naphthalene and isoquinoline parts, the biaryl axis is rotationally hindered. It thus constitutes a stable element of chirality - th...
Source: Natural Product Research - March 29, 2023 Category: Biochemistry Authors: Nasir Tajuddeen Shaimaa Fayez Prem Prakash Kushwaha Doris Feineis Laurent Ak é Assi Shashank Kumar Gerhard Bringmann Source Type: research

Sphaeranthone A, a new carvotacetone from the leaves of Sphaeranthus africanus 
Nat Prod Res. 2023 Mar 27:1-5. doi: 10.1080/14786419.2023.2193893. Online ahead of print.ABSTRACTA new carvotacetone sphaeranthone A and four known compounds 3-angeloyloxy-5-[2″,3″-epoxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (2), 3-angeloyloxy-5-[3″-chloro-2″-hydroxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (3), chrysosplenol D (4), and 3-O-methylquercetin (5) were isolated from leaves of Sphaeranthus africanus growing in Vietnam. Their chemical structures were elucidated by extensive 1D and 2D NMR analysis and high-resolution mass spectroscopy as well as comparisons in literature. Compounds 1-3 were...
Source: Natural Product Research - March 28, 2023 Category: Biochemistry Authors: Ngoc-Hong Nguyen Thuc-Huy Duong Thi-Minh-Dinh Tran Hoang-Khai Le Ut Dong Thach Khanh-Duy Kieu Nguyen Huy Truong Nguyen Source Type: research

Oryzanigral: a new polyketide from an endophytic fungus Nigrospora oryzae isolated from Coccinia grandis 
Nat Prod Res. 2023 Mar 27:1-8. doi: 10.1080/14786419.2023.2191196. Online ahead of print.ABSTRACTA new heptaketide named oryzanigral (1) was isolated from the fermentation extract of the endophytic fungus Nigrospora oryzae isolated from the leaves of Coccinia grandis, along with five known compounds, (R)-mellein, (R)-O-methylmellein, (3R,4R)-4-hydroxymellein, (3R,4S)-4-hydroxymellein and abscisic acid. The structure of oryzanigral was elucidated by spectroscopic analyses including 2D-NMR. A plausible biosynthetic pathway involving Diels-Alder reaction was proposed for compound 1 and related polyketides previously reported....
Source: Natural Product Research - March 27, 2023 Category: Biochemistry Authors: D Thanabalasingam Dilhara Dissanayake Kavindya Samarakoon N Savitri Kumar Nimal Adikaram Lalith Jayasinghe Hiroshi Araya Yoshinori Fujimoto Source Type: research

Chemical constituents from the aerial parts of Rubia cordifolia L. with their NO inhibitory activity
Nat Prod Res. 2023 Mar 27:1-8. doi: 10.1080/14786419.2023.2192491. Online ahead of print.ABSTRACTA new naphthoquinone derivative (1) together with twenty-three known compounds (2-24), were isolated from the aerial parts of Rubia cordifolia L. Their structures were elucidated on the basis of NMR and HR-ESIMS data. Compounds 1-13 were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 2-6 exhibited significant inhibitory activities with IC50 values of 21.37, 13.81, 24.56, 20.32, and 30.08 μmol·L-1, respectively.PMID:36971058 | DOI:10.1080/14786419.2023.2192491 (So...
Source: Natural Product Research - March 27, 2023 Category: Biochemistry Authors: Hong Zhang Wen-Tao Fang Yan Li Qing-Hua Kong Cheng-Wu Fang Han Luo Shou-Jin Liu Source Type: research

A new monocyclic monoterpene derivative from volva of Phallus dongsun 
Nat Prod Res. 2023 Mar 24:1-8. doi: 10.1080/14786419.2023.2193744. Online ahead of print.ABSTRACTA new monoterpene derivative namely dongsunol A (1) and sixteen known compounds (2-17) were isolated from the volva of Phallus dongsun. All compounds were isolated from this fungus for the first time. Their structures and absolute configurations were determined by nuclear magnetic resonance (NMR), HRESIMS spectral data, and electronic circular dichroism (ECD). The new monoterpene derivative (1) exhibited antibacterial activity with a MIC of 200 μg/mL. Other compounds have inhibitory effects on Staphylococcus aureus and Pseudom...
Source: Natural Product Research - March 25, 2023 Category: Biochemistry Authors: Shihao Qian Guangdi Wang Meiling Lu Xian Zhang Tingchi Wen Source Type: research

Yet another in vitro evidence that natural compounds introduced by diet have anti-amyloidogenic activities and can counteract neurodegenerative disease depending on aging
Nat Prod Res. 2023 Mar 24:1-6. doi: 10.1080/14786419.2023.2192493. Online ahead of print.ABSTRACTA major issue in Alzheimer's disease (AD) research is to find some new therapeutic drug which decrease Amyloid-beta (Aβ) aggregation. From a therapeutic point of view the major question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease. Natural compounds are capable of binding to different targets implicated in AD and exert neuroprotective effects. Aim of this study was to evaluate the in vitro inhibition of Aβ1-42 fibrillogenesis in presence of Gallic ...
Source: Natural Product Research - March 25, 2023 Category: Biochemistry Authors: Anna Lia Asti Stefania Crespi Teresa Rampino Paola Zelini Marilena Gregorini Alessia Pascale Nicoletta Marchesi Stefania Saccucci Carla Colombani Sara Vitalini Marcello Iriti Source Type: research