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Characterization of phenolic compounds in Eugenia uniflora leaves by ESI(-) FT-ICR MS, analysis of cytotoxic activity on gastric adenocarcinoma (AGS cells), and anti- Helicobacter pylori activity
This study aimed to determine if the ethanol extract and other derivatives are effective cytotoxic agents against gastric adenocarcinoma (AGS cells) and anti-H. pylori agent, its chemical composition, and mass spectrometry characterization of the more abundant compounds. The results were compared with the literature. The aqueous fraction, rich in Oenothein B and Gemin D/Hippomanin A, showed anti-H. pylori activity and higher cytotoxicity on AGS cells compared to the other samples analysed. Furthermore, the ESI(-) FT-ICR MS characterized the more abundant phenolic compounds, including Quinic Acid, Myricitrin, Gemin D/Hippom...
Source: Natural Product Research - November 17, 2023 Category: Biochemistry Authors: Fernanda M G de Oliveira J éssica Rodrigues Pereira de Oliveira Borlot Rodrigo Rezende Kitagawa Rita de C ássia Ribeiro Gonçalves Rita Carolina Batista de Oliveira Filpo Ricardo Machado Kuster Source Type: research

Assessment of soy genotype and processing method on trypsin inhibitors, urease and lectins content of tofu
Nat Prod Res. 2023 Nov 17:1-8. doi: 10.1080/14786419.2023.2280858. Online ahead of print.ABSTRACTTofu has a high nutritional value, but it may also contain components that may have an antinutritional effect, such as trypsin inhibitors (TI), lectins and ureases. The aim of this study was to investigate the influence of the hydrothermal-cooking process of soybean in combination with commercial chymosin-pepsin rennet on the content and activity of TI, urease and lectins in tofu. High total TI content was found in tofu (5.00-16.87%). In addition, Kunitz (KTI = 3.52-4.32%) and Bowman-Birk (BBI = 5.00-12.53%) TI were registered,...
Source: Natural Product Research - November 17, 2023 Category: Biochemistry Authors: Sladjana P Stanojevi ć Aleksandar Ž Kostić Danijel D Milin čić Mirjana B Pe šić Source Type: research

Chemical profiling by UHPLC-Q-TOF-HRESI-MS/MS and antibacterial properties of Entada abyssinica (Fabaceae) constituents
Nat Prod Res. 2023 Nov 17:1-11. doi: 10.1080/14786419.2023.2280171. Online ahead of print.ABSTRACTA rapid untargeted UHPLC-Q-TOF-ESI-MS/MS-Based metabolomic profiling of the medicinal plant Entada abyssinica was performed. A total of 18 metabolites were detected, of which 10 could not be identified. Based on this result, an extensive chemical investigation of the CH2Cl2-MeOH (1:1) extract of this plant was carried out, leading to the isolation of a new ceramide, named entadamide (1), together with nine known compounds: monomethyl kolavate (2), 24-hydroxytormentic acid (3) chondrillasterol (4), 3-O-β-D glucopyranosylstigma...
Source: Natural Product Research - November 17, 2023 Category: Biochemistry Authors: Larissa M Magnibou Steven C N Wouamba Abel J G Yaya Judith F Mbougnia Guy S S Njateng Ghislain W Fotso Celine Henoumont Sophie Laurent Talla Emmanuel Source Type: research

Natural colour extraction from horticultural crops, advancements, and applications-a review
Nat Prod Res. 2023 Nov 17:1-19. doi: 10.1080/14786419.2023.2280796. Online ahead of print.ABSTRACTThe scope for natural colours is increasing because of the awareness of allergic, toxic, and hazardous reactions associated with synthetic dyes. Natural colours are extracted from sources that are naturally available, such as flora, fauna, and minerals. Nature sourced us multiple possibilities of colours with varied shades and hues that are subtle and harmonious when combined. Reasons like the instability of natural colours during industrial processing, seasonal availability of raw materials, fading of colour over time, cost o...
Source: Natural Product Research - November 17, 2023 Category: Biochemistry Authors: Gokiladevi R P Ellampirai M Ramesh Kumar A Srivignesh S K Rama Krishna Source Type: research

GC-MS profiling and evaluation of acute oral toxicity, anti-tumour, antimicrobial and antioxidant activities of Croton socotranus Balf.f. aerial parts: in-vitro , in-vivo and in-silico studies
Nat Prod Res. 2023 Nov 16:1-10. doi: 10.1080/14786419.2023.2280820. Online ahead of print.ABSTRACTCroton socotranus Balf.f. shrub is widely used traditionally in Asia as an anti-infective. The study was conducted for metabolite profiling, oral acute toxicity and antioxidant studies, antimicrobial activity and anticancer effect against human hepatoma (HepG2), breast cancer (MCF-7) and rhabdomyosarcoma (RD) cells. Gas chromatography-mass spectrometry analysis revealed the presence of 39 compounds, predominantly comprising fatty acids (57.76%), sesquiterpenes (24.56%) and triterpenes (9.54%). The n-hexane fraction exhibited p...
Source: Natural Product Research - November 16, 2023 Category: Biochemistry Authors: Ibrahim Ali Al-Hakami Amina El-Shaibany Hassan Al-Mahbashi Ahmed S Abdelkhalek Mahmoud M Elaasser Ali E Raslan Source Type: research

First report on the chemical composition and the free radical scavenging and antimicrobial activities of the essential oil of Ononis aurasiaca , an endemic plant of Algeria
This study represents the first investigation of the chemical composition and the antioxidant and antimicrobial activities of Ononis aurasiaca Förther & Podlech, a plant species endemic to the Aures Mountains of Algeria. The essential oil of the plant aerial parts was analysed using GC-MS. The in vitro antioxidant activity was evaluated using three methods. A total of 44 compounds were identified. The major constituents were dodecanal, hexahydrofarnesylacetone, 2-tridecanone, phytol, 1-heneicosene, and n-heneicosane. The oil displayed significant activity in the β-carotene bleaching assay, moderate scavenging activit...
Source: Natural Product Research - November 16, 2023 Category: Biochemistry Authors: Khadidja Messaoudi Tarek Benmeddour Guido Flamini Source Type: research

Characterisation and skin protection activities of polysaccharides from Schnabelia terniflora 
Nat Prod Res. 2023 Nov 16:1-5. doi: 10.1080/14786419.2023.2280791. Online ahead of print.ABSTRACTThe bioactivities of crude polysaccharides from leaves (L-Ps) and flowers (F-Ps) of Schnabelia terniflora (Maxim.) P. D. Cantino were studied, and the characteristics of purified fractions were analysed by HPLC, HP-GPC and NMR. L-Ps exhibited strong DPPH radical scavenging activity (IC50 value of 251.53 ± 4.62 μg/mL) and tyrosinase inhibition (IC50 value of 163.52 ± 2.59 μg/mL). However, the maximum moisture absorption (74.67 ± 1.53%) and retention (68.00 ± 3.61%) abilities were observed in F-Ps. Two main fractions separa...
Source: Natural Product Research - November 16, 2023 Category: Biochemistry Authors: Ying Zhao Yixian Liu Huoxiang Zhou Wei Guo Weidong Wang Huiping Chen Source Type: research

"Effect of total phenol on the control of leafminer ( Phytomyza horticola ) infestation in Pea plants"
Nat Prod Res. 2023 Nov 16:1-7. doi: 10.1080/14786419.2023.2282115. Online ahead of print.ABSTRACTTo determine how vulnerable various pea genotypes are to leafminer infestation, a field experiment was conducted. On the basis of the presence of mines on five randomly selected leaflets from the upper, middle and lower parts of the plant, observations of larvae were made throughout the growing season. The total phenols were determined using the method described by Bray and Thorpe (1954, Analysis of phenolic compounds of interest in metabolism. Methods Biochem Anal. 52:1-27) and absorbance at 650 nm was measured using a spectro...
Source: Natural Product Research - November 16, 2023 Category: Biochemistry Authors: Gunjali Dengta Tanuja Banshtu Subhash Chander Verma Neha Gautam Priyanka Sharma Source Type: research

Structure-based virtual screening, ADMET analysis, and molecular dynamics simulation of Moroccan natural compounds as candidates for the SARS-CoV-2 inhibitors
In this study, an extensive investigation was conducted to gather a collection of phytoconstituents extracted from Moroccan plants, aiming to evaluate their ability to inhibit the proliferation of the SARS-CoV-2 virus. Molecular docking of the studied compounds was performed at the active sites of the main protease (6lu7) and spike (6m0j) proteins to assess their binding affinity to these target proteins. Compounds exhibiting high affinity to the proteins underwent further evaluation based on Lipinski's rule and ADME-Tox analysis to gain insights into their oral bioavailability and safety. The results revealed that the two...
Source: Natural Product Research - November 15, 2023 Category: Biochemistry Authors: Oussama Abchir Hassan Nour Ossama Daoui Imane Yamari Souad ElKhattabi Mhammed El Kouali Mohammed Talbi Abdelkbir Errougui Samir Chtita Source Type: research