Siamfuranones A-C, three novel furanone derivatives from the flowers of < em > Uvaria siamensis < /em > and their biological activities
Nat Prod Res. 2024 Mar 5:1-10. doi: 10.1080/14786419.2024.2324370. Online ahead of print.ABSTRACTThree previously undescribed furanone derivatives named siamfuranones A-C (1-3), together with 11 known compounds (4-14), were isolated from the flowers of Uvaria siamensis. Their planar structures were determined through analysis of spectrometric and spectroscopic evidence, while electronic circular dichroism (ECD) calculations were used to determine their absolute configurations. In addition, gauge-including atomic orbitals (GIAO) NMR chemical shift calculation, supported by the advanced statistical method DP4 plus, was used ...
Source: Natural Product Research - March 5, 2024 Category: Biochemistry Authors: Florian T Schevenels Supachai Jadsadajerm Ratsami Lekphrom Nuttapon Yodsin Thanapat Suebrasri Thanaset Senawong Awat Wisetsai Source Type: research
The investigation of hawthorn ( < em > Crataegus orientalis < /em > ) plant's inhibition effect on angiotensin converting enzyme and < em > in silico < /em > studies
Nat Prod Res. 2024 Mar 5:1-7. doi: 10.1080/14786419.2024.2324467. Online ahead of print.ABSTRACTHawthorn plant is used among people due to its cardiovascular, anti-inflammatory, and antihistamine properties. But no scientific study has been done about Crataegus orientalis (Mill.) M.Bieb. The presented study was planned to determine the effects of ethanol and n-hexane extracts of Crataegus orientalis leaves on human plasma ACE enzyme. In the study, the effect of plant extracts on ACE was studied by the spectrophotometric method. The chemical composition of the plant extracts was determined by HPLC-DAD analyses. In addition,...
Source: Natural Product Research - March 5, 2024 Category: Biochemistry Authors: Mahmut Yavuz Fatih Çağlar Çelikezen Mehmet Firat Zehra Ba ş Vedat T ürkoğlu Source Type: research
Molecular modelling approaches can reveal the Molecular interactions established between antimalarial targets of hemozoin pathway and the organic phytochemicals of < em > Artocarpus < /em > species
Nat Prod Res. 2024 Mar 5:1-9. doi: 10.1080/14786419.2024.2324468. Online ahead of print.ABSTRACTAyurveda, the traditional Indian medical system, has potential applications in early malaria treatment. In an in silico docking study, 50 phytochemicals from two plants Artocarpus lakoocha Roxb. (AL) And Artocarpus heterophyllus Lam. (AH), were examined for their interactions with anti-malarial proteins (PDB IDs: 3BWK, 3BPF, 1LF3). The nucleotide analogue Artemisinin, a current malaria treatment, served as a positive control. Result showed that phytochemicals from AL and AH exhibited binding affinities as high as -9.6 kcal/mol, ...
Source: Natural Product Research - March 5, 2024 Category: Biochemistry Authors: Surabhi Chaurasia Anima Pandey Source Type: research
Determination of the volatile chemical profile of < em > Momordica charantia < /em > (bitter melon) leaf and fruit by GC-MS
Nat Prod Res. 2024 Mar 5:1-8. doi: 10.1080/14786419.2024.2325595. Online ahead of print.ABSTRACTThe plant Momordica charantia (Cucurbitaceae), popularly known as bitter melon, snake fruit, Saint Vincent's herb, or little melon, is an African species that has developed in tropical and subtropical biomes in various parts of Brazil. The fruit is used in various traditional medicinal applications. The study aimed to identify the compounds of the essential oil of the leaves obtained by hydrodistillation and in the fruit through Solid-Phase Microextraction by headspace mode (HS-SPME) coupled to gas chromatography-mass spectromet...
Source: Natural Product Research - March 5, 2024 Category: Biochemistry Authors: Nat ália Ferreira Almeida Edenilson Dos Santos Niculau Pedro Cordeiro Toledo Lima Wanderson Ferreira da Silva Source Type: research
Phytochemical composition of the diethyl ether extract of < em > Artemisia lactiflora < /em > Wall. ex DC and its antimetastatic activity in human lung cancer cells
Nat Prod Res. 2024 Mar 5:1-7. doi: 10.1080/14786419.2024.2324114. Online ahead of print.ABSTRACTArtemisia lactiflora Wall. ex DC. is a traditional Chinese medicinal plant used in the treatment of menstrual and hepatic disorders due to its antioxidant and anti-inflammatory properties. However, its anti-metastatic activity, which is the clinical challenge of lung cancer treatment, has not yet been reported. From the diethyl ether extract of Artemisia lactiflora, the four terpenoids, including dihydroactinidiolide, megastigmatrienone, alpha-curcumene, and dehydrovomifoliol, were the most intense peaks observed using LC-MS/MS,...
Source: Natural Product Research - March 5, 2024 Category: Biochemistry Authors: Nateelak Kooltheat Kunwadee Noonong Karl M Hanson Udom Lao-On Source Type: research
Phytochemical profiles and evaluation of the biological potential of ethyl acetate and < em > n < /em > -butanol fractions of the aerial parts of < em > Cistus albidus < /em > L
Nat Prod Res. 2024 Mar 5:1-7. doi: 10.1080/14786419.2024.2324116. Online ahead of print.ABSTRACTThe phytochemical profiles of the ethyl acetate (EAFCA) and n-butanol (BFCA) fractions of the aerial parts of Cistus albidus L., were characterised by a developed LC-ESI-MS/MS method, using 53 fingerprint phytochemicals, revealing the presence of 26 and 22 compounds, respectively with quinic acid, gallic acid, protocatechuic acid, catechin, gentisic acid, tannic acid, ellagic acid, quercitrin, astragalin as the major compounds of the EAFCA, in very higher amounts than in the BFCA. The antioxidant activity was evaluated using six...
Source: Natural Product Research - March 5, 2024 Category: Biochemistry Authors: Ouissem Gherboudj Naima Boutaghane Zahia Kabouche Lamia Djeblia Leila Zerrougui Manel Bekrar Source Type: research
Siamfuranones A-C, three novel furanone derivatives from the flowers of < em > Uvaria siamensis < /em > and their biological activities
Nat Prod Res. 2024 Mar 5:1-10. doi: 10.1080/14786419.2024.2324370. Online ahead of print.ABSTRACTThree previously undescribed furanone derivatives named siamfuranones A-C (1-3), together with 11 known compounds (4-14), were isolated from the flowers of Uvaria siamensis. Their planar structures were determined through analysis of spectrometric and spectroscopic evidence, while electronic circular dichroism (ECD) calculations were used to determine their absolute configurations. In addition, gauge-including atomic orbitals (GIAO) NMR chemical shift calculation, supported by the advanced statistical method DP4 plus, was used ...
Source: Natural Product Research - March 5, 2024 Category: Biochemistry Authors: Florian T Schevenels Supachai Jadsadajerm Ratsami Lekphrom Nuttapon Yodsin Thanapat Suebrasri Thanaset Senawong Awat Wisetsai Source Type: research
The investigation of hawthorn ( < em > Crataegus orientalis < /em > ) plant's inhibition effect on angiotensin converting enzyme and < em > in silico < /em > studies
Nat Prod Res. 2024 Mar 5:1-7. doi: 10.1080/14786419.2024.2324467. Online ahead of print.ABSTRACTHawthorn plant is used among people due to its cardiovascular, anti-inflammatory, and antihistamine properties. But no scientific study has been done about Crataegus orientalis (Mill.) M.Bieb. The presented study was planned to determine the effects of ethanol and n-hexane extracts of Crataegus orientalis leaves on human plasma ACE enzyme. In the study, the effect of plant extracts on ACE was studied by the spectrophotometric method. The chemical composition of the plant extracts was determined by HPLC-DAD analyses. In addition,...
Source: Natural Product Research - March 5, 2024 Category: Biochemistry Authors: Mahmut Yavuz Fatih Çağlar Çelikezen Mehmet Firat Zehra Ba ş Vedat T ürkoğlu Source Type: research
Molecular modelling approaches can reveal the Molecular interactions established between antimalarial targets of hemozoin pathway and the organic phytochemicals of < em > Artocarpus < /em > species
Nat Prod Res. 2024 Mar 5:1-9. doi: 10.1080/14786419.2024.2324468. Online ahead of print.ABSTRACTAyurveda, the traditional Indian medical system, has potential applications in early malaria treatment. In an in silico docking study, 50 phytochemicals from two plants Artocarpus lakoocha Roxb. (AL) And Artocarpus heterophyllus Lam. (AH), were examined for their interactions with anti-malarial proteins (PDB IDs: 3BWK, 3BPF, 1LF3). The nucleotide analogue Artemisinin, a current malaria treatment, served as a positive control. Result showed that phytochemicals from AL and AH exhibited binding affinities as high as -9.6 kcal/mol, ...
Source: Natural Product Research - March 5, 2024 Category: Biochemistry Authors: Surabhi Chaurasia Anima Pandey Source Type: research
Determination of the volatile chemical profile of < em > Momordica charantia < /em > (bitter melon) leaf and fruit by GC-MS
Nat Prod Res. 2024 Mar 5:1-8. doi: 10.1080/14786419.2024.2325595. Online ahead of print.ABSTRACTThe plant Momordica charantia (Cucurbitaceae), popularly known as bitter melon, snake fruit, Saint Vincent's herb, or little melon, is an African species that has developed in tropical and subtropical biomes in various parts of Brazil. The fruit is used in various traditional medicinal applications. The study aimed to identify the compounds of the essential oil of the leaves obtained by hydrodistillation and in the fruit through Solid-Phase Microextraction by headspace mode (HS-SPME) coupled to gas chromatography-mass spectromet...
Source: Natural Product Research - March 5, 2024 Category: Biochemistry Authors: Nat ália Ferreira Almeida Edenilson Dos Santos Niculau Pedro Cordeiro Toledo Lima Wanderson Ferreira da Silva Source Type: research
Two new glycosides from the root bark of < em > Paeonia ostii < /em >
Nat Prod Res. 2024 Mar 3:1-7. doi: 10.1080/14786419.2024.2324372. Online ahead of print.ABSTRACTTwo new glycosides, ethyl-O-β-D-furanosyl-(1→6)-O-β-D-glucopyranoside (1) and (5-'')-galloyl-ethyl-O-β-D-furanosyl-(1→6)-O-β-D-glucopyranoside (2), together with eight known compounds (3-10) were obtained from the n-BuOH extraction of Paeonia ostii. Their structures were identified via the extensive spectroscopic analysis. Compounds 1, 3-10 exhibited the anti-inflammation activities, which inhibited the production of NO, TNF-α and IL-1β in LPS-induced RAW264.7 cells with IC50 values ranging from 6.00 to 86.78 µΜ.PMID...
Source: Natural Product Research - March 4, 2024 Category: Biochemistry Authors: Chuihao Kong Kaidi Wang Lei Sun Shihui Qin Renzhong Wang Fengqing Xu Source Type: research
Synthesis of xylan and lignin based hydrogels and their use as growth media for rice ( < em > Oryza sativa < /em > )
Nat Prod Res. 2024 Mar 3:1-10. doi: 10.1080/14786419.2024.2324463. Online ahead of print.ABSTRACTDifferent hydrogels were synthesised using lignin and xylan (extracted from rice straw) as the raw material, PVA as matrix template, citric acid, and succinic acid as crosslinkers and were structurally characterised by FT-IR and SEM analysis. Citric acid cross-linked hydrogels caused loose bonding between polymers and resulted in formation of large pores whereas succinic acid cross-linked hydrogels were observed to have less porosity and tight bonding network. The swelling ratio and reswelling capacity of hydrogels revealed tha...
Source: Natural Product Research - March 4, 2024 Category: Biochemistry Authors: Japanpreet Kaur Isha Dudeja Gagandeep Kaur Chahal Ramandeep Kaur Mankoo Ramandeep Kaur Source Type: research
Chemical constituents of < em > Penicillium ferraniaense < /em > GE-7 and their cytotoxicities
Nat Prod Res. 2024 Mar 4:1-8. doi: 10.1080/14786419.2024.2324113. Online ahead of print.ABSTRACTPhytochemical investigation on the plant endophytic fungus Penicillium ferraniaense GE-7 led to the isolation of 18 compounds including one new α-pyrone derivative, peniferranige A (1). The structure including the absolute configuration of compound 1 was elucidated by NMR, HRMS, and ECD data. Demethoxyfumitremorgin C (16) and meleagrin (17) possessed moderate activities against the human lung cancer cell line H1975 with IC50 values of 28.52 ± 1.07 and 13.94 ± 1.92 μM, respectively.PMID:38436324 | DOI:10.1080/14786419.2024.23...
Source: Natural Product Research - March 4, 2024 Category: Biochemistry Authors: Yan Wang Shao-Hua Song Lei-Ming Wu Xue Zhou Qing-Ren Lu Ai-Ping Yin Sheng Yin Gui-Hua Tang Source Type: research
Production, physico-chemical properties and antioxidant activity of melanin from < em > Annulohypoxylon stygium < /em > (L év.) Y.M. Ju, J.D. Rogers and H.M. Hsieh
Nat Prod Res. 2024 Feb 29:1-10. doi: 10.1080/14786419.2024.2320741. Online ahead of print.ABSTRACTTo obtain higher melanin production in liquid culture, culture conditions of Annulohypoxylon stygium (Lév.) Y.M. Ju, J.D. Rogers and H.M. Hsieh were optimised. The results showed that using single factor experiment and orthogonal test, the optimised production of melanin reached 2.20 g/L, which was 2.06 times higher than that of the control group. In addition, it was speculated that A. stygium melanin (AsM) was 3,4-dihydroxyphenylalanine (DOPA) melanin and showed an amorphous irregular structure. Moreover, it had good solubil...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Ruofan Liu Cuiyuan Mo Xianfu Meng Xuetuan Wei Aimin Ma Source Type: research
Characterisation of bioactive compounds from leaves of < em > Smilax fluminensis < /em > Steud. by gc-MS and LC-DAD-MS, and analysis of its antioxidant and ecotoxicological activities
Nat Prod Res. 2024 Feb 29:1-9. doi: 10.1080/14786419.2024.2324375. Online ahead of print.ABSTRACTSmilax fluminensis Steud. is distributed in Central and South America, commonly named as 'salsaparilha' or 'japicanga'. In the present work, the chemical composition was determined, antioxidant and cytotoxic effects were evaluated for the ethanol extract (EE) and fractions from leaves. Fatty acid esters and phytol were characterised in the hexane (HEX) fraction. O-glycosylated flavonols and flavones, caffeic acid derivatives, and steroidal saponins were annotated for EE, and dichloromethane (DCM), ethyl acetate (AC), and hydroe...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Lucas Santos Azevedo Juliana Costa Fonseca Ana Hort ência Fonsêca Castro Katyuce de Souza Farias Vanessa Sam údio Santos Zanuncio Denise Brentan Silva Luciana Alves Rodrigues Dos Santos Lima Source Type: research
