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Optimal extraction of polysaccharides from Stevia rebaudiana roots for protection against hydrogen peroxide-induced oxidative damage in RAW264.7 cells
In this study, we optimised the extraction of a polysaccharide (SRRP) from S. rebaudiana roots by employing a Box-Behnken design and response surface methodology. The optimal extraction conditions were as follows: 93.57 min, 71.67 °C, and a water-to-raw material ratio of 21.40 mL/g. Under these conditions, 14.00 ± 0.35% of crude polysaccharide was obtained. Treatment of RAW264.7 cells with SRRP prior to the addition of H2O2, a major contributor to oxidative damage, significantly increased cell viability. In addition, SRRP increased the levels of superoxide dismutase, catalase, and glutathione and reduced the levels of ma...
Source: Natural Product Research - October 4, 2023 Category: Biochemistry Authors: Zhiyan Tang Mingrui Zhang Lan Gao Yulong Bao Ping Li Ming Wang Taili Shao Guodong Wang Chunyan Liu Source Type: research

Unleashing the bioactive potential of Capsicum chinense cv Bhut Jolokia: a comparison of microwave- and ultrasound-mediated extraction techniques for lipophilic capsaicin
This study investigated the extraction of capsaicin from Capsicum chinense cv Bhut Jolokia using rice bran oil (RBO) as a 'green solvent' via microwave- and ultrasound-mediated techniques (MME and UME) as an alternative to hazardous organic solvents. Extraction conditions were optimised using MME at 180 and 300 W for 2 and 8 min and UME at 300 and 400 W for 10 and 30 min. The maximum capsaicin yield obtained was 12.47 mg/mL, with a corresponding gamma oryzanol content of 8.46 mg/mL. The peroxide value of the extract (capsaicin-infused RBO) was found to be within permissible limits as per Codex Alimentarius specifications. ...
Source: Natural Product Research - October 3, 2023 Category: Biochemistry Authors: Vikono Ksh Vishnu Anand Virendra Singh Rana Jigni Mishra Manoj Kumar Neelam Upadhyay Charanjit Kaur Source Type: research

Thin layer chromatography-direct bioautography for investigation of antibacterial activities of Artemisia sieversiana Ehrhart ex Willd. essential oil
Nat Prod Res. 2023 Oct 3:1-6. doi: 10.1080/14786419.2023.2260072. Online ahead of print.ABSTRACTThe aim of the study was to characterise the chemical composition of the essential oil extracted from a Chinese traditional aromatic herb, Artemisia sieversiana Ehrhart ex Willd and investigate its antimicrobial activities against Staphylococcus aureus, the test bacterium, using thin-layer chromatography-direct bioautography (TLC-DB). Gas chromatography-mass spectrometry analysis showed that the essential oil was dominated by chamazulene (44.44%). Undeveloped TLC-DB enabled the measurement of zone of inhibition as valid as and m...
Source: Natural Product Research - October 3, 2023 Category: Biochemistry Authors: Li Ma Jiayi Xu Wencui Wang Jing Lu Yuhong Li Lei Yao Source Type: research

Potent ROS inhibitors from Zanthoxylum armatum DC of Nepali origin
Nat Prod Res. 2023 Oct 3:1-9. doi: 10.1080/14786419.2023.2261608. Online ahead of print.ABSTRACTA bioassay-guided isolation on the plant Zanthoxylum armatum DC yielded compounds tambulin (1), and prudomestin (2), from ethyl acetate fraction which showed the highest ROS inhibiting activity (IC50 = 17.8 ± 1.1 µg/mL). Structure elucidation of pure compounds was done using mass and NMR spectroscopic techniques. Compounds 1 and 2 revealed potent ROS inhibition with IC50 = 7.5 ± 0.3 and 1.5 ± 0.3 µg/mL, respectively, as compared to standard ibuprofen (IC50 = 11.2 ± 1.9 µg/mL). Likewise, both compounds 1 and 2 showed poten...
Source: Natural Product Research - October 3, 2023 Category: Biochemistry Authors: Janaki Baral Dipesh Shrestha Hari Prasad Devkota Achyut Adhikari Source Type: research

Monoterpene indole alkaloids from Gelsemium elegans 
Nat Prod Res. 2023 Oct 2:1-8. doi: 10.1080/14786419.2023.2261070. Online ahead of print.ABSTRACTTwo new monoterpene indole alkaloids, Eleganine A (1) and Eleganine B (2), along with 11 known compounds (3-13) were isolated from the stems and leaves of Gelsemium elegans. Compound 1 is a gelsenicine-related monoterpenoid indole alkaloid possessing an iridoid unit. Their structures and absolute configurations of 1-2 were established by UV, IR, HR-ESI-MS, NMR spectroscopy, and electronic circular dichroism data analyses. All isolated compounds were evaluated for their anti-inflammatory and inhibiting glucose-induced mesanginal ...
Source: Natural Product Research - October 2, 2023 Category: Biochemistry Authors: Quan-Hao Wei Jin-Ping Zhang Zhi-Yuan Lu Xian-Hui Jia Xiao-Dong Zhao Zhi-Wei Wang Xiao-Jing Wang Source Type: research

Screening of the compositions of essential oils and volatiles of Perovskia abrotanoides Karel. along with antioxidant, antibacterial and cytotoxic impacts of its methanol extract
Nat Prod Res. 2023 Sep 28:1-5. doi: 10.1080/14786419.2023.2260065. Online ahead of print.ABSTRACTIn the present report, a combination of classical and advanced methods, namely classical hydrodistillation (HD) and solvent free microwave extraction (SFME) have been used for the extraction of essential oils from flowers, leaves and stems of Perovskia abrotanoides Karel. as an endemic plant to Golestan Province, Iran. The volatile fractions from the same plant organs have been separated using a solid phase microextraction (SPME) fibre and characterised using a GC/MS apparatus. Moreover, oxygenated monoterpenes, for example, 1,...
Source: Natural Product Research - September 28, 2023 Category: Biochemistry Authors: Mohammad Reza Kianasab Majid Mohammadhosseini Mehdi Nekoei Behnam Mahdavi Tahmineh Baheri Source Type: research

Synthesis and diverse biological activities of substituted indole β-carbolines: a review
Nat Prod Res. 2023 Sep 28:1-14. doi: 10.1080/14786419.2023.2261141. Online ahead of print.ABSTRACTβ-Carboline bearing indole is one of the heterocyclic compounds that play a vital role in medicinal chemistry with various pharmacological effects such as anticancer, anti-acetylcholinesterase, anti-inflammation, antimalarial, antibacterial, anti-diabetic, and antioxidant. Over the last two decades, many studies on the synthesis and biological activity of indole β-carboline compounds have been conducted yet there is no appropriate data summary has been presented. Thus, the goal of this review was to highlight the synthesis p...
Source: Natural Product Research - September 28, 2023 Category: Biochemistry Authors: Siti Zafirah Zulkifli Noor Hidayah Pungot Aimi Suhaily Saaidin Nor Akmalazura Jani Mohd Fazli Mohammat Source Type: research