Systematic characterisation, and effect of nutritional and physical parameters on culturability, laccase production and dye decolorisation potential by < em > P. pistillaris < /em > from Pakistan
Nat Prod Res. 2023 Sep 4:1-9. doi: 10.1080/14786419.2023.2253558. Online ahead of print.ABSTRACTPodaxis pistillaris is neutraceutically, cosmoceutically and medicinally recognised macrofungus. During this research work, this edible mushroom was systematically characterised. Its culturability, laccase production, and dye decolorisation potential were evaluated and optimised. Among the different media tested, PDA proved as most efficient medium for culturability of P. pistillaris. Conditions for laccase production were optimised in submerged state fermentation. Maximum laccase secretion was noted after 14th day of Incubation...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Abdul Rehman Niazi Aneeqa Ghafoor Asma Mushtaq Source Type: research
Cytotoxic and anti-bacterial evaluation of two new aromatic A-ring steroids isolated from the Red Sea soft coral < em > Dendronephthya spp < /em >
Nat Prod Res. 2023 Sep 4:1-9. doi: 10.1080/14786419.2023.2254452. Online ahead of print.ABSTRACTA successful column chromatography of a CHCl3/MeOH crude extract of Dendronephthya spp. soft coral led to the isolation of two new aromatic A-ring steroids (1-2), together with three known compounds (3-5). Both 1 and 2 are 19-norsteroids. The chemical structures were elucidated based on extensive 1D, 2D NMR, and EIMS analyses. In cytotoxic bioassays, compounds 1-5 were tested against three cancer cell lines: MCF-7, NCI-1299, and HepG2, with IC50 in the ranges of 22.1-85.4, 26.9-88.7, and 25.9-93.7 μM, respectively. Compounds 1,...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Ahmed H Eissa Asmaa M Abdel-Tawab Fawzia Z El-Ablack Seif-Eldin N Ayyad Source Type: research
A new biphenanthrene with cytotoxic activity from < em > Liparis nervosa < /em > (Thunb.) Lindl
Nat Prod Res. 2023 Sep 3:1-7. doi: 10.1080/14786419.2023.2233670. Online ahead of print.ABSTRACT2,7,2'-Trihydroxy-3,4,4'7'-tetramethoxy-1,1'-biphenanthrene (1), a previously undescribed biphenanthrene, and five known phenanthrenes, i.e. 2,5-dihydroxy-4-methoxy-9,10-dihydroxyphenanthrene (2), 2,4-dihydroxy -7-methoxy-9,10-dihydroxyphenanthrene (3), 7-hydroxy-2-methoxy-phenanthrene-1,4-dione (4), 7-hydroxy-2-methoxy-9,10-dihydro-phenanthrene-1,4-dione (5), and 4,4',7,7'-tetrahydroxy-2,2'-dimethoxy-9,9',10,10'-tetrahydro-1,1'-biphenanthrene (6) were isolated from the whole plant (stems, leaves, roots and fruits) of Liparis ne...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Liang Liu Qi-Meng Yin Qi-Jun Dai Xuan-Yuan Chen Xi-Qing Chen Jian-Bin Wang Han-Qing Pang Xian-Wen Zhang Source Type: research
Diversity of Agaricomycetes in southern South America and their bioactive natural products
Nat Prod Res. 2023 Sep 3:1-15. doi: 10.1080/14786419.2023.2244126. Online ahead of print.ABSTRACTFungi have a unique metabolic plasticity allowing them to produce a wide range of natural products. Since the discovery of penicillin, an antibiotic of fungal origin, substantial efforts have been devoted globally to search for fungal-derived natural bioactive products. Andean region forests represent one of the few undisturbed ecosystems in the world with little human intervention. While these forests display a rich biological diversity, mycological and chemical studies in these environments have been scarce. This review aims ...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Jonhatan G ómez-Espinoza Cristian Riquelme Enzo Romero-Villegas Ram ón Ahumada-Rudolph Vanessa Novoa Paola M éndez Camila Millar Naomi Fern ández-Alarcón Sigisfredo Garnica Mario Rajchenberg Jaime R Cabrera-Pardo Source Type: research
Systematic elucidation of the multi-target pharmacological mechanism of < em > Terminalia arjuna < /em > against congestive cardiac failure via network pharmacology and molecular modelling approaches
In this study, a network pharmacology technique was used to explore the active ingredients, potential targets in T. arjuna for the treatment of CCF. In the framework of this study, we explored the active ingredient-target-pathway network and figured out that oleanolic acid, arjunolic acid, luteolin, kaempferol, cholesterol, ellagic acid 4-O-xylopyranoside 3,3'-dimethyl ether, and cyclohexyl (2,4-dimethyl phenyl) methanone contributed significantly to the development of CCF by affecting AKT1, MAPK14, TNF, IL6, ESR1, and HSP90AA1 genes. Molecular docking analysis further validated the activities of these compounds against po...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Aqsa Asghar Muhammad Qasim Fatima Noor Usman Ali Ashfaq Muhammad Tahir Ul Qamar Muhammad Shareef Masoud Rashid Bhatti Ahmad Almatroudi Faris Alrumaihi Khaled S Allemailem Source Type: research
Comparative analysis of α-pinene alone and combined with temozolomide in human glioblastoma cells
Nat Prod Res. 2023 Sep 4:1-6. doi: 10.1080/14786419.2023.2252152. Online ahead of print.ABSTRACTα-Pinene (PEN) is a phyto compound present in terpene plants. In traditional medicine, PEN has been used for its anti-inflammatory, pain-relieving, and bronchodilator properties. The effect of PEN in combination with temozolomide (TMZ) in glioblastoma multiforme (GBM) cells has been evaluated. The action of the PEN + TMZ combination on cell migration, soft-agar, and cell death was determined in LN229 and U87MG human glioblastoma cells. In combination, PEN with TMZ showed a synergistic inhibitory effect in the GBM cells. The PEN...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Megha Gautam Reema Gabrani Source Type: research
Two new 2-arylbenzo[ < em > b < /em > ]furans from < em > Itea indochinensis < /em > and their anti-hepatocellular carcinoma and anti-oxidant effects
Nat Prod Res. 2023 Sep 4:1-9. doi: 10.1080/14786419.2023.2252975. Online ahead of print.ABSTRACTTwo new 2-arylbenzo[b]furans (1-2) and ten known compounds (3-12) were identified from the 95% EtOH extract of the branches and leaves of Itea indochinensis for the first time. Their structures were determined mainly based on extensive analyses of UV, IR, 1D/2D NMR and HRMS spectra. The results of MTT assays demonstrated the anti-tumor potential of compound 1 with good selectivity, which displayed moderate inhibitory effects on proliferation of SK-hep-1 cells with IC50 value of 22.3 μM, while weak inhibitory effect on prolifera...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Fang-Fang Xu Jin-Zhen Jian Yi-Jv Li Zhi-Wei Wang Guo-Yong Luo Wu-De Yang Source Type: research
Two new naphthoquinone derivatives from < em > Sinningia conspicua < /em > (Gesneriaceae)
Nat Prod Res. 2023 Sep 4:1-6. doi: 10.1080/14786419.2023.2253971. Online ahead of print.ABSTRACTTwo new naphthoquinones, 7-hydroxy-2-O-methyldunniol (1) and 7-methoxy-2-O-methyldunniol (2) were isolated from the tubers of Sinningia conspicua (Seem.) G. Nicholson (Gesneriaceae). Nine known compounds were also obtained: 7-methoxydunniol (3), dunniol (4), 7-methoxy-α-dunnione (5), 7-hydroxydunnione (6), 2,4,4',6-tetramethoxychalcone (7), loureirin B (8), allo-calceolarioside A (9), β-sitosterol (10) and stigmasterol (11). This is the first report of compounds 3 and 5 in Sinningia. n-Hexane, ethyl acetate and ethanol extract...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Vanessa Winiewski Maria Helena Verdan Cristhian Santos Oliveira Tayn á Eloyane Barreto Rodrigues Marcos Jos é Salvador Maria Élida Alves Stefanello Source Type: research
Systematic characterisation, and effect of nutritional and physical parameters on culturability, laccase production and dye decolorisation potential by < em > P. pistillaris < /em > from Pakistan
Nat Prod Res. 2023 Sep 4:1-9. doi: 10.1080/14786419.2023.2253558. Online ahead of print.ABSTRACTPodaxis pistillaris is neutraceutically, cosmoceutically and medicinally recognised macrofungus. During this research work, this edible mushroom was systematically characterised. Its culturability, laccase production, and dye decolorisation potential were evaluated and optimised. Among the different media tested, PDA proved as most efficient medium for culturability of P. pistillaris. Conditions for laccase production were optimised in submerged state fermentation. Maximum laccase secretion was noted after 14th day of Incubation...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Abdul Rehman Niazi Aneeqa Ghafoor Asma Mushtaq Source Type: research
Cytotoxic and anti-bacterial evaluation of two new aromatic A-ring steroids isolated from the Red Sea soft coral < em > Dendronephthya spp < /em >
Nat Prod Res. 2023 Sep 4:1-9. doi: 10.1080/14786419.2023.2254452. Online ahead of print.ABSTRACTA successful column chromatography of a CHCl3/MeOH crude extract of Dendronephthya spp. soft coral led to the isolation of two new aromatic A-ring steroids (1-2), together with three known compounds (3-5). Both 1 and 2 are 19-norsteroids. The chemical structures were elucidated based on extensive 1D, 2D NMR, and EIMS analyses. In cytotoxic bioassays, compounds 1-5 were tested against three cancer cell lines: MCF-7, NCI-1299, and HepG2, with IC50 in the ranges of 22.1-85.4, 26.9-88.7, and 25.9-93.7 μM, respectively. Compounds 1,...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Ahmed H Eissa Asmaa M Abdel-Tawab Fawzia Z El-Ablack Seif-Eldin N Ayyad Source Type: research
Two new prenylated flavonol glycosides from < em > Epimedium koreanum < /em > Nakai leaves and their anti-pulmonary fibrosis activities
Nat Prod Res. 2023 Sep 3:1-8. doi: 10.1080/14786419.2023.2246631. Online ahead of print.ABSTRACTTwo new prenylated flavonol glycosides, namely Desmethylicaritin-3-O-β-D-glucopyranosyl-(1→3)-α-L(4″-O-acetyl) rhamnopyranosyl-7-O-β-D(6''''-O-acetyl)-glucopyranoside (1) and 5,7,3',4'-tetrahydroxyl-8-(3,3-dimethylallyl)-flavonol-3-O-α-L-rhamnopyranoside (2), and one with no NMR spectral data reported (3) were isolated from Epimedium koreanum Nakai. Their structures were elucidated by 1D, 2D NMR and HRESIMS analysis. The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of...
Source: Natural Product Research - September 3, 2023 Category: Biochemistry Authors: Yudan Zhao Linxuan Teng Ruiqi Zhang Chongning Lv Jincai Lu Source Type: research
Two new prenylated flavonol glycosides from < em > Epimedium koreanum < /em > Nakai leaves and their anti-pulmonary fibrosis activities
Nat Prod Res. 2023 Sep 3:1-8. doi: 10.1080/14786419.2023.2246631. Online ahead of print.ABSTRACTTwo new prenylated flavonol glycosides, namely Desmethylicaritin-3-O-β-D-glucopyranosyl-(1→3)-α-L(4″-O-acetyl) rhamnopyranosyl-7-O-β-D(6''''-O-acetyl)-glucopyranoside (1) and 5,7,3',4'-tetrahydroxyl-8-(3,3-dimethylallyl)-flavonol-3-O-α-L-rhamnopyranoside (2), and one with no NMR spectral data reported (3) were isolated from Epimedium koreanum Nakai. Their structures were elucidated by 1D, 2D NMR and HRESIMS analysis. The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of...
Source: Natural Product Research - September 3, 2023 Category: Biochemistry Authors: Yudan Zhao Linxuan Teng Ruiqi Zhang Chongning Lv Jincai Lu Source Type: research
Preparation of medicinally active extracts and phytochemical characterisation of phytoconstituents from medicinal plants
This study described the Soxhlet and the maceration methods that are used to process extracts from the inert materials of medicinal plants using appropriate biocompatible solvents, the phytochemical screening assays, and TLC, UV spectrometry, FT-IR, and GC-MS techniques used in phytochemical studies. These techniques are crucial in studies that are meant to explore the active components of medicinal plants and their relative pharmacological effects. This information can be used as a guide when formulating effective yet less toxic plant-derived drugs and provide opportunities to upgrade while reducing further complexity in ...
Source: Natural Product Research - September 1, 2023 Category: Biochemistry Authors: Festus S Shafodino Julien M Lusilao Lamech M Mwapagha Source Type: research
Phytochemical analysis, antibacterial and antifungal effect of < em > Lavandula dentata < /em > L. essential oil and methanol extract
Nat Prod Res. 2023 Sep 1:1-10. doi: 10.1080/14786419.2023.2252973. Online ahead of print.ABSTRACTThe aim of this study was to analyse the essential oil of Lavandula dentata from Algeria and to test the antioxidant and antimicrobial properties of this plant. The essential oil (EO) (57 constituents) included mainly α-pinene, β-pinene, nopinone, linalool, cryptone, and limonene. The plant polyphenolic contents and the antioxidant activity were determined. The antimicrobial effect of the EO and the methanolic extract (ME) was assessed against referenced and clinical bacterial strains, and also foodborne fungal isolates. The ...
Source: Natural Product Research - September 1, 2023 Category: Biochemistry Authors: Noui Hendel Madani Sarri Djamel Sarri Soumia Seghiour Edoardo Napoli Mounir Selloum Giuseppe Ruberto Source Type: research
Preparation of medicinally active extracts and phytochemical characterisation of phytoconstituents from medicinal plants
This study described the Soxhlet and the maceration methods that are used to process extracts from the inert materials of medicinal plants using appropriate biocompatible solvents, the phytochemical screening assays, and TLC, UV spectrometry, FT-IR, and GC-MS techniques used in phytochemical studies. These techniques are crucial in studies that are meant to explore the active components of medicinal plants and their relative pharmacological effects. This information can be used as a guide when formulating effective yet less toxic plant-derived drugs and provide opportunities to upgrade while reducing further complexity in ...
Source: Natural Product Research - September 1, 2023 Category: Biochemistry Authors: Festus S Shafodino Julien M Lusilao Lamech M Mwapagha Source Type: research
