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Sesquiterpenoids and steroids from Eupatorium fortunei and their inhibitory effects on NO production
Nat Prod Res. 2024 Apr 5:1-10. doi: 10.1080/14786419.2024.2335665. Online ahead of print.ABSTRACTTwo heterodimers including a clovane-phenylpropanoid hybrid (1) and a clovane-menthane hybrid (2), five linear sesquiterpenoids incorporating a tetrahydrofuran ring (3-6 & 8), and four steroids (7 & 9-11), were separated from the ethanolic extract of a well-known aromatic and medicinal herb Eupatorium fortunei. Their structures were characterised by detailed analyses of spectroscopic data and comparison with known analogues, with seven (1-7) of them being described for the first time. The hybrids 1 and 2 represent the f...
Source: Natural Product Research - April 5, 2024 Category: Biochemistry Authors: Lei Miao Yin-Bo Pan Shu-Ting Wang Jun-Sheng Zhang Hua Zhang Source Type: research

Antifungal activity of extracts from Justicia species against Fusarium graminearum 
Nat Prod Res. 2024 Apr 5:1-6. doi: 10.1080/14786419.2024.2334334. Online ahead of print.ABSTRACTFusarium graminearum causes destructive ear rot diseases in maize and wheat. New antifungals are essential to combat this pathogen, and aerial parts of Justicia species (Acanthaceae) are a potential source. We investigated the antifungal activity of extracts from stems and leaves of five Justicia species native to Northwest Argentina. The aerial parts were subjected to sequential extractions with dichloromethane, ethyl acetate, and methanol. The resulting extracts were tested by the disc diffusion method against F. graminearum s...
Source: Natural Product Research - April 5, 2024 Category: Biochemistry Authors: Mariana Del H Sanchez Mat ías Anal ía de Los A Gómez Cristina M Jim énez Sarah Tanguy Guillo Mar ía Eugenia Del M Aristimuño Ficoseco C ésar A N Catalán Rapha ël Grougnet Marina Kritsanida Diego A Sampietro Source Type: research

C 19 -diterpene alkaloids from delphinium turkmenum lipsky
Nat Prod Res. 2024 Apr 5:1-5. doi: 10.1080/14786419.2024.2327618. Online ahead of print.ABSTRACTThe genus Delphinium is a rich source of diterpene alkaloids. Chemical investigation on an alkaloid rich extract of the whole parts of Delphinium turkmenum resulted in the isolation of three C19-diterpene alkaloids (1-3) and a palmitic acid derivative (4). The chemical structures were elucidated by analysis of 1D and 2D-NMR and comparison the data with those reported in the literature. Notably, all isolated compounds were reported for the first time from D. turkmenum.PMID:38579282 | DOI:10.1080/14786419.2024.2327618 (Source: Nat...
Source: Natural Product Research - April 5, 2024 Category: Biochemistry Authors: Abolfazl Shakeri Maryam Samaei Judit Hohmann Milad Iranshahy Javad Asili Source Type: research

Rakicidin J and K, two cytotoxic and antibacterial cyclic depsipeptides from the marine bacterium Micromonospora chalcea 
Nat Prod Res. 2024 Apr 3:1-7. doi: 10.1080/14786419.2024.2335354. Online ahead of print.ABSTRACTRakicidin J (1) and rakicidin K (2), two new cyclic depsipeptides, were isolated from culture broth of Micromonospora chalcea FIM-R150103. Their structures were elucidated by extensive analysis of NMR, HR-ESI-MS, and electronic circular dichroism (ECD) data. The two compounds showed strong cytotoxic activity against human colon carcinoma HCT-8 and human pancreatic cancer PANC-1 cells under normoxic and hypoxic conditions in the range of IC50 values from 0.024 to 0.79 μg/mL. Moreover, compounds 1 and 2 also showed moderate antib...
Source: Natural Product Research - April 4, 2024 Category: Biochemistry Authors: Li Chen Lijun Xie Jian Zhou Dongsheng Fang Honglei Jiang Wei Liu Yuqiu Ye Wei Zhao Hong Jiang Feng Lin Source Type: research

New anti-inflammatory limonoids from the fruits of Melia azedarach 
Nat Prod Res. 2024 Apr 4:1-8. doi: 10.1080/14786419.2024.2335667. Online ahead of print.ABSTRACTThe phytochemical study of the fruits of Melia azedarach (Meliaceae) led to the isolation and characterisation of two novel natural limonoids1-deoxy- 3, 20-dicinnamoyl-11-methoxy-meliacarpinin (1) and 12β- O- methyl nimbolinin A (2), along with twelve known limonoids. Its structure was identified by 1D- and 2D-NMR, HR-ESI-MS and comparison with published data. The anti-inflammatory effect of the compounds was measured in vitro in RAW 264.7 cells by evaluating the production of NO stimulated by LPS. Compounds 1, 8 and 14 indicat...
Source: Natural Product Research - April 4, 2024 Category: Biochemistry Authors: Fan Cao Jin-Huang Shen Zhi-Jun Li Wen-Lu Wang Zhen-Wei Chen Yong-Hong Zhang Xin-Hua Ma Source Type: research

Three new pterosins from Pteris semipinnata 
Nat Prod Res. 2024 May;38(9):1591-1598. doi: 10.1080/14786419.2022.2162895. Epub 2023 Jan 12.ABSTRACTThree new pterosins, named as semipterosin A (1), B (2) and C (3), together with 11 known pterosins (4-14), were isolated from the aerial parts of Pteris semipinnata. Their structures were elucidated by HRESI-MS, NMR spectral data, CD and literature comparisons. Three new pterosins were assessed for their anti-inflammatory activity. Compounds 1-3 inhibited the NF-kB induction by 40.7%, 61.9% and 34.0%, respectively. This is the first report of the isolation of compounds 6-14 from this plant.PMID:38573587 | DOI:10.1080/14786...
Source: Natural Product Research - April 4, 2024 Category: Biochemistry Authors: Weiren Lu Huajun Li Lan Cao Yanfen Xiong Xiaobin Huang Jianqun Liu Caiying Peng Jicheng Shu Source Type: research

Fucoidan extract from brown seaweed ( Sargassum echinocarpum ): molecular weight, elemental composition, selectivity and anticancer activity against breast cancer cells
Nat Prod Res. 2024 Apr 3:1-9. doi: 10.1080/14786419.2024.2326978. Online ahead of print.ABSTRACTMolecular weight and elemental composition contribute to fucoidan bioactivity. Fucoidan extract from S. echinocarpum had three fractions varying in molecular weights (Mw), whereas crude fucoidan extract had a moderate Mw of 2,034.31 kDa. The fucoidan extract contained several elements, including C (38.19%), O (44.46%), and S (2.61%). Moreover, the fucoidan extract exhibited toxicity to breast cancer cells (MCF-7) at 297.58 ± 2.40 ppm. The extract induced apoptosis by 49.78%, 72.05%, and 89.35% after incubation for 24, 48, and 7...
Source: Natural Product Research - April 3, 2024 Category: Biochemistry Authors: Yunianta Yunianta Rosalina Ariesta Laeliocattleya Siti Narsito Wulan Yenny Risjani Source Type: research

Chemical characterisation of essential oil from Sambucus williamsii Hance leaves and its hepatoprotective effects
This study is the first to examine the effect of leaves of Sambucus williamsii Hance essential oil on acute liver injury. According to gas chromatography-mass spectrometry analysis, the major constituents of S. williamsii essential oil (SEO)were (S)-falcarinol (62.66%), 17-pentatriacontene (7.78%) and tetrapentacontane (8.64%). Mice were pre-treated with SEO for 6 days followed by inducing liver injury with CCl4. The results indicated that SEO protected the liver against CCl4-induced injuries. Elevated levels of alanine-aminotransferase (ALT), aspartate amino-transferase (AST), alkaline phosphatase (ALP) in serum were sign...
Source: Natural Product Research - April 3, 2024 Category: Biochemistry Authors: Xianqun Meng Dan Wang Qiushi Hu Shanshan Liang Qing Wei Tingguo Kang Xiansheng Meng Source Type: research

Citronellal: a natural aldehyde with important properties
Nat Prod Res. 2024 Apr 3:1-14. doi: 10.1080/14786419.2024.2332949. Online ahead of print.ABSTRACTAmong the several terpenes existing in nature, Citronellal, a monoterpene aldehyde, deserves to be highlighted for its biological properties that have been pointed out in numerous studies. This work aimed to conduct a literature review on its biological properties. Citronellal is a prominent compound in the essential oils of Cymbopogon genus plants. Apart from being employed as a fragrance ingredient in aromas, fragrances, and cosmetics, it is also used as an intermediate in synthesising (-)-menthol. Various studies have demons...
Source: Natural Product Research - April 3, 2024 Category: Biochemistry Authors: Aldino N Venancio Marcio J Silva Luciana A Parreira Armanda A J úlio Gustavo R Souza Mario F Concei ção Santos Luciano Menini Source Type: research

The essential oil composition of Phlomis bovei subsp. maroccana Maire, an endemic species of Morocco
Nat Prod Res. 2024 Apr 3:1-6. doi: 10.1080/14786419.2024.2334881. Online ahead of print.ABSTRACTPhlomis L. is a genus belonging to the Lamiaceae family, distributed in Macaronesia, the Mediterranean basin, Northeast Africa, Central Asia, and Western Himalaya. Plants of this genus are used against various diseases in the ethno-medicine of several countries and some of them are also utilised for culinary purposes. In the present study, the essential oil chemical composition of the aerial parts of Phlomis bovei subsp. maroccana Maire, an endemic species of Morocco, was analysed by GC-MS. No previous paper has been previously ...
Source: Natural Product Research - April 3, 2024 Category: Biochemistry Authors: Natale Badalamenti Vincenzo Ilardi Maurizio Bruno Source Type: research

Thrombin-induced platelet inhibition by 2',4'-dihydroxychalcone and 2',4'-dihydroxydihydrochalcone is mediated by inhibition of ROS production and Thromboxane synthase a activity: structure-activity relationship of polyphenol secondary metabolites from Empetrum nigrum 
In this study, we expanded our previous work by testing compounds 1-12 for their ability to inhibit platelet activation at low (30 µM) concentration by inhibition of ROS production, thromboxane synthase (TxS) activity, and activation of cyclic nucleotide pathways. We also investigated whether some of these compounds could potentiate the effects of P2Y12 ADP receptor inhibitor action and discussed possible structure-activity relationships of the tested compounds. We showed that at this concentration only compounds 7 and 12 significantly inhibited thrombin-induced platelet activation which was accompanied by inhibition of R...
Source: Natural Product Research - April 3, 2024 Category: Biochemistry Authors: Ekaterina Fock Nikita Pronin Natalia Rukoyatkina Anastasiia Whaley Stepan Gambaryan Andrei Whaley Source Type: research

Exploration and evaluation of antioxidant activity in isolated phenolics from Jasminum scandens (retz) vahl
Nat Prod Res. 2024 Apr 3:1-5. doi: 10.1080/14786419.2024.2334883. Online ahead of print.ABSTRACTGiven the widespread and established use of Jasminum scandens (Retz) Vahl, a member of the Oleacea family, this study aimed to identify and characterise secondary metabolites derived from the plant, with the objective of evaluating their potential biological activities. Using chromatographic separations techniques based on molecular weight and polarity, various VLC fractions of the plant were purified. These fractions yielded seven compounds- 2-(4-hydroxyphenyl)-ethanol (1), 2-(4-hydroxy-3-methoxy-phenyl)-ethanol (2), 1-(4-hydro...
Source: Natural Product Research - April 3, 2024 Category: Biochemistry Authors: Afsin Malik Faria Mannan Mithi Sania Ashrafi Muhammad Abdullah Al-Mansur Monira Ahsan Choudhury Mahmood Hasan A T M Zafrul Azam Source Type: research