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One undescribed glycoside benzofuran derivative and a new p -hydroxybenzoate glycoside from the leaves of Illicium dunnianum Tutcher
Nat Prod Res. 2023 Jun 2:1-10. doi: 10.1080/14786419.2023.2216348. Online ahead of print.ABSTRACTOne undescribed benzofuran derivative (illiciumphenolicacid A, 1) and one new phenolic glycoside (illiciumphenolicacid B, 2), together with six known compounds (3-8) were isolated from the leaves of Illicium dunnianum Tutcher. Their structures were elucidated by detailed spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR). In addition, we determined the α-glucosidase inhibitory activity of the isolates in vitro using spectrophotometric methods. Compared with the positive control acarbose (IC50 306.2 ± 4.1 μM), compounds 1-...
Source: Natural Product Research - June 2, 2023 Category: Biochemistry Authors: Xiao-Qing He Hai-Bo Li Ting Li Xin-Yin Chen Zhen-Zhong Wang Xin-Sheng Yao Wei Xiao Yang Yu Source Type: research

Efomycine U, a new C 2 -asymmetric elaiophylin derivative from Streptomyces malaysiensis DSM 4137
Nat Prod Res. 2023 Jun 2:1-6. doi: 10.1080/14786419.2023.2214839. Online ahead of print.ABSTRACTChemical examination of an actinomycete strain Streptomyces malaysiensis DSM 4137 derived from a soil sample derived isolate Streptomyces sp. DSM 3816, yielded a new C2-asymmetric elaiophylin derivative efomycine U (1) and a known analogue halichoblelide D (2). These structures were unambiguously elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses. All compounds isolated were subjected to antimicrobial, cytotoxic and immnosuppressive activities evaluation.PMID:37265103 | DOI:10.1080/14786419.20...
Source: Natural Product Research - June 2, 2023 Category: Biochemistry Authors: Jing Xu Jingwan Wu Dongdong Zhou Xuexia Zhang Peter F Leadlay Source Type: research

Identification of lignans as ATP citrate lyase (ACLY) inhibitors from the roots of Pouzolzia zeylanica 
Nat Prod Res. 2023 Jun 2:1-8. doi: 10.1080/14786419.2023.2219816. Online ahead of print.ABSTRACTA new lignan, named pouzolignan P (1), together with 14 known ones (2 - 15) were isolated from the roots of Pouzolzia zeylanica (L.) Benn. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates were evaluated for their inhibitory activities toward the ATP citrate lyase (ACLY). Among them, four lignans, isopouzolignan K (3), gnemontanins E (5), gnetuhainin I (6), and styraxlignolide D (15) showed excellent ACLY inhibitory effect with IC50 values of 9.06, 0.59, 2.63, and 7.62 μM, respectively...
Source: Natural Product Research - June 2, 2023 Category: Biochemistry Authors: Jin-Long Li Jia-Yi Jiang Shan-Shan Gu Lei Zhang Yan Sun Xue-Han Wang Dan-Yu Li Zhe-Yu Chen Sheng-Shi Jiang Wei-Zhong Zhu Hao-Wen Jiang Hong-Jie Zhang Source Type: research

Three new furanones from endophytic fungus Hypoxylon vinosopulvinatum DYR-1-7 from Cinnamomum cassia with their antifungal activity
Nat Prod Res. 2023 Jun 2:1-8. doi: 10.1080/14786419.2023.2218530. Online ahead of print.ABSTRACTHypoxylon vinosopulvinatum DYR-1-7 is a endophytic fungus isolated from the Cinnamomum cassia Presl and has an inhibitory effect on Lasiodiplodia pseudotheobromae. Three new furanones, hypoxylonone A-C (1-3), as well as three known compounds (4-6), were isolated from an EtOAc extract of H. vinosopulvinatum DYR-1-7. The structures were determined by spectroscopic data analysis using UV, IR, 1D-, 2D-NMR and HR-ESI-MS. The absolute configurations of 1-3 were elucidated by electronic circular dichroism (ECD) analyses. In the antifun...
Source: Natural Product Research - June 2, 2023 Category: Biochemistry Authors: Jia Lv Hong Zhou Limei Dong Hao Wang Li Yang Haiqian Yu Peixi Wu Le Zhou Quan Yang Yongqian Liang Bi Luo Source Type: research

Drimane-type sesquiterpenoids and their anti-inflammatory evaluation from Pyrrhoderma noxium HNNU0524
Nat Prod Res. 2023 Jun 1:1-8. doi: 10.1080/14786419.2023.2218008. Online ahead of print.ABSTRACTChemical investigation of a culture broth from the marine-derived fungus Pyrrhoderma noxium HNNU0524 yielded two new compounds including a drimane-type sesquiterpenoid named pyrrnoxin A (1) and a benzoic acid derivative, pyrrnoxin B (5), together with three related known analogues (2-4). The chemical structures of 1 and 5 were determined by detailed analysis of spectroscopic data, single-crystal X-ray crystallography, quantum mechanics-based DP4+ and ECD calculations. Compounds 2 and 3 moderately inhibited NO production of lipop...
Source: Natural Product Research - June 1, 2023 Category: Biochemistry Authors: Jing-Wen Wang Dong-Yun Liu Hou-Ze Zhang Zhen Tan Cai-Juan Zheng Guang-Ying Chen Xu-Hua Nong Source Type: research

Synthesised thymoquinone-oxime induces cytotoxicity, genotoxicity and apoptosis in hepatocellular cancer cells: in vitro study
In this study, we synthesised the oxime derivative of thymoquinone and investigated cytotoxicity, genotoxicity, and apoptosis in hepatocellular cancer cells. The synthesised thymoquinone-oxime structure was confirmed by NMR. After incubating the hepatocellular cancer cell line for 24 h, the cytotoxicity ATP by luminometric, intracellular reactive oxygen species, and intracellular calcium by fluorometric. The mitochondrial membrane potential was determined by flow cytometry. DNA damage by alkaline single-cell gel electrophoresis, and apoptosis damage by acridine orange/ethidium bromide double dye method. Concentrations of t...
Source: Natural Product Research - May 31, 2023 Category: Biochemistry Authors: Eray Metin Guler Kubra Bozali Source Type: research

Water-soluble essential oil components of flowers of Paeonia × suffruticosa cultivars and in silico analysis with antidepressant targets
Nat Prod Res. 2023 May 31:1-4. doi: 10.1080/14786419.2023.2217706. Online ahead of print.ABSTRACTThe present study focused on water-soluble essential oil recovered from the hydrolate of ten Paeonia × suffruticosa cultivars. Thirty-seven components, mostly oxygenated compounds (94.6-99.6%), were detected by gas chromatography-mass spectrometry (GC-MS) and GC-flame ionisation detector (GC-FID). The geranic acid chemotype was discovered (in cultivar 'Lan BaoShi'). Eight key oxygenated components were analysed in silico with antidepressant targets sodium-dependent serotonin transporter (SERT), 5-hydroxytryptamine receptor 1 A...
Source: Natural Product Research - May 31, 2023 Category: Biochemistry Authors: Gaoming Lei Guoyu Gao Mengke Zhou Jianqi Guo Yuting Chen Source Type: research

Isoryanodane diterpene derivatives from Barringtonia macrocarpa 
Nat Prod Res. 2023 May 31:1-6. doi: 10.1080/14786419.2023.2217467. Online ahead of print.ABSTRACTFrom the MeOH residue of Barringtonia macrocarpa branches and leaves, one new isoryanodane diterpene, barringisol (1), and two new isoryanodane diterpene glucosides, barringisosides A and B (2 and 3), were obtained using various chromatographic isolations. The structural characterization was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-QTOF-MS. This is the first isolation of isoryanodane diterpene derivatives from Barringtonia species. Moreover, the in vitro cytotoxicity of 1-3 on three human cancer cell l...
Source: Natural Product Research - May 31, 2023 Category: Biochemistry Authors: Pham Thi Mai Huong Pham Thi Cham Le Thi Vien Tran Thi Hong Hanh Nguyen The Cuong Dang Vu Luong Tran Hong Quang Nguyen Xuan Cuong Nguyen Hoai Nam Chau Van Minh Source Type: research

Alkaloids from the stems of Fissistigma maclurei Merr. inhibit the proliferation of synoviocytes
Nat Prod Res. 2023 May 31:1-7. doi: 10.1080/14786419.2023.2218006. Online ahead of print.ABSTRACTTwo new aporphine-derived alkaloids, aporaloids C and D (1 and 2), along with eight known biogenetically related alkaloids (3-10) were isolated from the stems of Fissistigma maclurei Merr. Their structures were elucidated by detailed analysis of NMR, HRESIMS, MS, IR, UV and Optical rotations data. Compounds 1 and 2 represent a rare example of N-methylol aporphine-derived alkaloids from natural sources. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed potent i...
Source: Natural Product Research - May 31, 2023 Category: Biochemistry Authors: Mu-Tao Liang Xiao-Zheng Zhang Zi-Hao Chen Chuan-Shan Fu Duo-Jiang Li Guo-Ze Chen Ji-Ling Yi Xue-Ming Zhou Source Type: research

Synthesis, isolation, characterization of C 3 -C 11 bridge-bond isomer of paclitaxel and its antitumor effect via inducing A549 cells pyroptosis
Nat Prod Res. 2023 May 31:1-10. doi: 10.1080/14786419.2023.2218011. Online ahead of print.ABSTRACTDuring the chemical manufacturing control processing of new paclitaxel formulations, a photodegradation impurity called C3-C11 bridge-bond isomer appeared. Our work describes the synthesis, isolation, purification, and structural characterization methods using four spectroscopies: FT-IR, UV, NMR (1H and 13 C), and LC-MS. In addition, we discovered that the C3-C11 bridge-bond isomer can promote A549 cells pyroptosis, and increase pyroptosis-related proteins, including cleaved-caspase 3, cleaved-PARP, GSDME-N, and lactate dehydr...
Source: Natural Product Research - May 31, 2023 Category: Biochemistry Authors: Wen Yang Qiming Yin Jing Tian Qiang Jia Jifeng Wang Fengju Niu Source Type: research

 Angelica sylvestris L. (Apiaceae) of the Isle of Skye (Scotland): chemical composition of essential oil from the aerial flowering parts
In this study, the chemical composition of the essential oil (EO) from aerial flowering parts of Angelica sylvestris L., a plant distributed in Europe, North and Central Asia, collected in the Isle of Skey (Scotland), was analyzed by GC and GC-MS. No one report has been previously published on this accession. The result showed the presence of a large quantity of monoterpene hydrocarbons with limonene (51.89%), by far, as the most abundant component. Other metabolites present in lesser quantity were β-pinene (4.61%), α-pinene (3.54%), and thymol (3.33%). Considerations with respect to all the other EOs of A. sylvestris ta...
Source: Natural Product Research - May 28, 2023 Category: Biochemistry Authors: Antonella Porrello Rosalia Merra Natale Badalamenti Maurizio Bruno Source Type: research

Study on 2-arylbenzo[ b ]furans from Itea omeiensis and their fragmentation patterns with Q-Orbitrap mass spectrometry
Nat Prod Res. 2023 May 28:1-12. doi: 10.1080/14786419.2023.2216344. Online ahead of print.ABSTRACTOne new 2-arylbenzo[b]furan named iteafuranal F (1) as well as two known analogues (2-3) were isolated from the 95% EtOH extract of aerial parts of Itea omeiensis. Their chemical structures were constructed based on extensive analyses of UV, IR, 1D/2D NMR and HRMS spectra. Antioxidant assays revealed significant superoxide anion radical scavenging capacity of 1 with IC50 value of 0.66 mg/mL, which was comparable to the efficiency of positive control of luteolin. In addition, the preliminary MS fragmentation patterns in negativ...
Source: Natural Product Research - May 28, 2023 Category: Biochemistry Authors: Yun-Qian Feng Pan Zhang Jin-Zhen Jian Zhi-Wei Wang Xiao-Long Tian Guo-Yong Luo Wu-De Yang Source Type: research