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Production of exopolysaccharides from Bacillus licheniformis , a thermophilic bacteria from hot spring of Jharkhand
This study provides information based on isolation of thermophilic strain from Surajkund and Ramkund, hot spring of Jharkhand at 50, 60 and 70 °C. Two of the best isolates were used for the extraction of exopolysaccharides. Additionally, the lyophilized product obtained was further analyzed for protein and total sugar estimation. The FTIR analysis revealed the presence of different functional groups such as hydroxyl, C-H stretching, vibration of aliphatic CH2 and glycosidic linkage, thus proving the product obtained from bacteria was an exopolysaccharides The FESEM analysis of exopolysaccharides show varying surface morph...
Source: Natural Product Research - April 19, 2023 Category: Biochemistry Authors: Usha Lakra Shubha Rani Sharma Source Type: research

Exploration of limonoids for their broad spectrum antiviral potential via DFT, molecular docking and molecular dynamics simulation approach
Nat Prod Res. 2023 Apr 19:1-6. doi: 10.1080/14786419.2023.2202398. Online ahead of print.ABSTRACTLimonoids serve as vital secondary metabolites. Citrus limonoids show a wide range of pharmacological potential. As a result of which limonoids from citrus are of considerable research interest. Identification of new therapeutic molecules from natural origins has been widely adopted as a successful strategy in drug discovery. This work mainly focused on the high-throughput computational exploration of the antiviral potential of three vital limonoids, i.e. Obacunone, Limonin and Nomilin against spike proteins of SARS CoV-2 (PDB:...
Source: Natural Product Research - April 19, 2023 Category: Biochemistry Authors: Sneha Rochlani Manish Bhatia Sanket Rathod Prafulla Choudhari Rakesh Dhavale Source Type: research

Profiling of semiochemicals from three stored product beetles by headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry
Nat Prod Res. 2023 Apr 18:1-7. doi: 10.1080/14786419.2023.2200945. Online ahead of print.ABSTRACTThis work focuses on the profiling of semiochemicals (SCS) from Callosobruchus maculatus, Sitophilus oryzae and Tribolium castaneum by headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS) technique. Totally, 6, 9 and 8 volatile compounds (VCS) were detected from C. maculatus, S. oryzae and T. castaneum, respectively. As a result of pherobase analysis and preference bioassay, stearic acid (C. maculatus); nonanal, lauric acid and stearic acid (S. oryzae); stearic acid (T. casta...
Source: Natural Product Research - April 18, 2023 Category: Biochemistry Authors: Madhurya Lokesh Arunkumar Panneerselvam Pratiksha Prabhakar Gawali Aswathi Kozhissery Sreekrishnakumar Urvashi Sahu Subramanian Ezhil Vendan Source Type: research

Caffeoylquinic acids protect against alcoholic liver injury and rare C 10 acetylenic acids from Erigeron breviscapus 
Nat Prod Res. 2023 Apr 18:1-6. doi: 10.1080/14786419.2023.2201886. Online ahead of print.ABSTRACTThree new compounds (1-2, 4) along with ten known ones (3, 5-13), were isolated from the whole plant of Erigeron breviscapus. Compounds 1 and 2, two novel C10 acetylenic acids and compound 4, a jasmone glucoside were elucidated by the detailed analysis of 1D and 2D NMR, HRESIMS spectra, and experimental and calculated electronic circular dichroism (ECD). Compounds 1-3 represent the first example of acetylenic acids incorporating C10 skeleton from E. breviscapus. In addition, the antioxidant effects of all compounds were evaluat...
Source: Natural Product Research - April 18, 2023 Category: Biochemistry Authors: Xuefen Hou Tongtong Yu Shuang Han Xin Chen Kai Wang Pinyi Gao Lingzhi Li Source Type: research

Four new compounds isolated from the rhizomes of Phedimus aizoon (L.) 't Hart
Nat Prod Res. 2023 Apr 17:1-9. doi: 10.1080/14786419.2023.2198711. Online ahead of print.ABSTRACTOne new coumarin, one new flavonoid, two new distinctive compounds with characteristics of an iriflophene unit and a flavonoid unit connecting via a furan ring, together with five known compounds were isolated from the rhizomes of Phedimus aizoon (L.) 't Hart. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 4, 5 and 8 increased the survival rate of H9c2 cells induced by doxorubicin in vitro, which was capable of further drug exploration.PMID:37067197 | DOI:10.1080/14786419.2023.2198711 (Source...
Source: Natural Product Research - April 17, 2023 Category: Biochemistry Authors: Xin Zhang Lu Gao Qiao Li Yang Yu Chongning Lv Jincai Lu Source Type: research

New steroidal saponins from the roots of Paris verticillata 
Nat Prod Res. 2023 Apr 17:1-9. doi: 10.1080/14786419.2023.2200184. Online ahead of print.ABSTRACTFour new polyhydroxylated steroidal saponins, parisverticillatosides A-D (1-4), together with four known spirostanol saponins (5-8) were isolated from the roots of Paris verticillata. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidences. The discovery of the new compounds 1-4 extended the diversity and complexity of this spirostanol saponin family. The saponins 5 and 6 exhibited cytotoxicities against two human glioma cell lines.PMID:37067218 | DOI:10.1080/14786419.2023.220018...
Source: Natural Product Research - April 17, 2023 Category: Biochemistry Authors: Yang Liu Na Tang Xiao-Ying Qian Tian-Yi Li Qian Zhang Peng-Cheng Qiu Hai-Feng Tang Yun-Yang Lu Bang-Le Zhang Source Type: research

New secondary metabolites and volatile constituents from the leaves of Ocimum gratissimum Linn
Nat Prod Res. 2023 Apr 17:1-7. doi: 10.1080/14786419.2023.2200943. Online ahead of print.ABSTRACTThe phytochemical investigation on the ethanolic extract of the leaves of Ocimum gratissimum (syn. O. viride) has led to the isolation of a new alkaloid, diazovirid or 1,1'-(diazeno1,2-diyl) bis (ethane-1,2-diol) (1) and 2-hydroxy-D-glucal or (2 R, 3S, 4S)-2-(hydroxymethyl)-3,4-dihydro-2H-pyran-3,4,5-triol (2), reported for the first time as a natural product. Their structures were determined by spectroscopic analyses. The volatile constituents have also been studied by GC-FID and GC-MS leading to the characterization of compou...
Source: Natural Product Research - April 17, 2023 Category: Biochemistry Authors: Muhammad Shaiq Ali Almas Hashmi Ngoupayo Joseph Source Type: research

A new butylphthalide from Ligusticum striatum DC
Nat Prod Res. 2023 Apr 12:1-8. doi: 10.1080/14786419.2023.2200944. Online ahead of print.ABSTRACTOne new butylphthalide ligusticumolide H (1), together with the known butylphthalides senkyunolide I (2), senkyunolide H (3), (3 R,3'S)-3'-hydroxy-3-butylphthalide (4), (3 R)-4-hydroxy-3-butylphthalide (5) and senkyunolide C (6) was isolated from the rhizome of Ligusticum striatum DC. Their structures were determined by extensive spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR, and the absolute configuration of 1 was established by NMR and ECD calculations. Their effect on NO production in IL-1β-stimulated chondrocyt...
Source: Natural Product Research - April 12, 2023 Category: Biochemistry Authors: Xue Xie Hongda Zhang Lina Liu Fuyong Ni Xiao Yu Yan Zhong Ming Yan Chenfeng Zhang Zhenzhong Wang Nan Xu Wei Xiao Source Type: research

Three undescribed coumarins from the roots of Angelica pubescens 
Nat Prod Res. 2023 Apr 12:1-7. doi: 10.1080/14786419.2023.2200185. Online ahead of print.ABSTRACTThree undescribed coumarins, 6-(3-hydroxy-3-methyl-2-oxobutyl)-7-methoxycoumarin (1), (R)-6-(1,3-dihydroxy-3-methyl-2-oxobutyl)-7-methoxycoumarin (2), angelol N (6), together with four known coumarins were isolated from the roots of Angelica pubescens. Their structures were determined by extensive spectroscopic analyses. The absolute configurations of compounds 2 and 6 were assigned via electronic circular dichroism (ECD). Their inhibitory effects on lipopoly-saccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cel...
Source: Natural Product Research - April 12, 2023 Category: Biochemistry Authors: Fuyong Ni Xue Xie Xue Huai Xiao Yu Hongda Zhang Ming Li Jianhui Wen Ming Yan Chenfeng Zhang Zhenzhong Wang Wei Xiao Source Type: research