Analysis of metabolic compounds and antitumorigenic effects of < em > Albizia niopoides < /em > and < em > Senegalia polyphylla < /em > leaves
The objective of this study was to quantify metabolic compounds in leaves of A. niopoides and S. polyphylla and to evaluate the antitumor potential of extracts from both species in cervical tumour cells. The physiological analyses performed were quantification of starch, sucrose, phenolic compounds and proteins. An aqueous extract was prepared and added to the SiHa cell line at concentrations of 10, 100 and 1000 μg/mL at 4h, 24h, 48h and 72h. Cell morphology, proliferation and viability were analysed. The species showed a large amount of starch and phenolic compounds. Treatment with the extract of both species caused morp...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Thalissa Cagnin Pereira Luana Pereira Cardoso Wesller da Silva de Paiva Liliane Santos de Camargos Fl ávia Cristina Rodrigues-Lisoni Aline Redondo Martins Source Type: research
Combination of tenuigenin-based < em > Polygala tenuifolia < /em > willd. root extract and forsythoside a improved Alzheimer's disease
Nat Prod Res. 2024 Mar 26:1-5. doi: 10.1080/14786419.2024.2332945. Online ahead of print.ABSTRACTTenuigenin is a kind of the main active ingredients in roots of Polygala tenuifolia Willd. (a species in the genus Polygala, family Polygalaceae) and forsythoside A (FA) is one of the main active ingredients of Forsythia suspensa (Thunb.) Vahl. (a species in the genus Forsythia, family Meliaceae). The studies have shown that tenuigenin-based Polygala tenuifolia Willd. extract (YZ) and FA have protective effects on nervous damage. In the study the combination (YF) of YZ and FA showed synergistic neuro-protective effects on PC12 ...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Guocui Liang Chengxia Gao Liwei Zhang Huizhi Du Source Type: research
Endophytic fungus from < em > Gynura japonica < /em > : phytochemical screening, biological activities, and characterisation of its bioactive compound
Nat Prod Res. 2024 Mar 26:1-9. doi: 10.1080/14786419.2024.2332947. Online ahead of print.ABSTRACTThe research aims to identify the chemical constituents of endophytic fungi associated with Gynura japonica and their biological activities. Two endophytic fungi, labelled as GS-1 and GS-2, have been isolated from the leaves of G. japonica. They were cultivated on white rice media for their optimum cultivation time. Cultivated fungi were extracted with ethyl acetate and concentrated to give a crude extract. All crude extracts were evaluated for their phytochemical screening and assayed for their antibacterial and antioxidant ac...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Riga Riga Ridha Wardatillah Okta Suryani Benny Ryplida Suryelita Suryelita Minda Azhar Dian Handayani Muh Ade Artasasta Sonni Maurit Benu Ahadul Putra Source Type: research
Synthesis and antifungal activity of hexahydropyrrolidoindole alkaloids
Nat Prod Res. 2024 Mar 26:1-9. doi: 10.1080/14786419.2024.2333047. Online ahead of print.ABSTRACTTwenty-one hexahydropyrrolidoindole alkaloids were designed and synthesised via acylation reaction at the 3-N position from the commercially available indole-3-acetonitrile as the starting material in excellent yields. The effects of all target compounds against Verticillium dahlia, Fusarium oxysperium sp., Cytospora juglandis, Aspergillu sflavu, Aspergillus niger and Fusarium oxysporum were determined. The results of bioassays indicated that the majority of tested compounds displayed comparable or better in vitro bioactivity t...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Yujie Zhou Shoude Ma Xiaohan Li Xinye Liu Jie Gao Dingding L ü Ya Wang Shaojun Zheng Source Type: research
Analysis of metabolic compounds and antitumorigenic effects of < em > Albizia niopoides < /em > and < em > Senegalia polyphylla < /em > leaves
The objective of this study was to quantify metabolic compounds in leaves of A. niopoides and S. polyphylla and to evaluate the antitumor potential of extracts from both species in cervical tumour cells. The physiological analyses performed were quantification of starch, sucrose, phenolic compounds and proteins. An aqueous extract was prepared and added to the SiHa cell line at concentrations of 10, 100 and 1000 μg/mL at 4h, 24h, 48h and 72h. Cell morphology, proliferation and viability were analysed. The species showed a large amount of starch and phenolic compounds. Treatment with the extract of both species caused morp...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Thalissa Cagnin Pereira Luana Pereira Cardoso Wesller da Silva de Paiva Liliane Santos de Camargos Fl ávia Cristina Rodrigues-Lisoni Aline Redondo Martins Source Type: research
Antiviral and cytotoxic indole diterpenoids from the antarctic sponge-derived fungus < em > Aspergillus candidus < /em > HDN15-152
Nat Prod Res. 2024 Mar 25:1-8. doi: 10.1080/14786419.2024.2333050. Online ahead of print.ABSTRACTOne new indole diterpenoid, ascandinine T (1), and three known analogues (2-4) were isolated from an Antarctic sponge-derived fungus Aspergillus candidus HDN15-152. The structures, including absolute configurations, were established based on NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. All isolated compounds were tested for antiviral and anticancer activity. Compound 4 displayed antiviral activity against influenza A virus (IAV) of A/PR/8/34(H1N1) strain with an IC50 value of 39.2 μM, while compound 2 sh...
Source: Natural Product Research - March 25, 2024 Category: Biochemistry Authors: Bingying Tang Runfang Zhang Falei Zhang Tianjiao Zhu Qian Che Dehai Li Guojian Zhang Source Type: research
Antiviral and cytotoxic indole diterpenoids from the antarctic sponge-derived fungus < em > Aspergillus candidus < /em > HDN15-152
Nat Prod Res. 2024 Mar 25:1-8. doi: 10.1080/14786419.2024.2333050. Online ahead of print.ABSTRACTOne new indole diterpenoid, ascandinine T (1), and three known analogues (2-4) were isolated from an Antarctic sponge-derived fungus Aspergillus candidus HDN15-152. The structures, including absolute configurations, were established based on NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. All isolated compounds were tested for antiviral and anticancer activity. Compound 4 displayed antiviral activity against influenza A virus (IAV) of A/PR/8/34(H1N1) strain with an IC50 value of 39.2 μM, while compound 2 sh...
Source: Natural Product Research - March 25, 2024 Category: Biochemistry Authors: Bingying Tang Runfang Zhang Falei Zhang Tianjiao Zhu Qian Che Dehai Li Guojian Zhang Source Type: research
Fructose-induced hyperuricaemia - protection factor or oxidative stress promoter?
Nat Prod Res. 2024 Mar 24:1-13. doi: 10.1080/14786419.2024.2327624. Online ahead of print.ABSTRACTAccumulating evidence suggests that dietary fructose may play a role in the hyperuricaemia development, but the precise mechanism remains unclear. Hyperuricaemia is characterised by excessive production and deposition of urate crystals, and the metabolism of fructose has been implicated in the elevation of serum urate levels. The association between fructose intake and the risk of hyperuricaemia is explained by the metabolism of fructose in the liver, small intestine, and kidney. Many studies have confirmed the correlation bet...
Source: Natural Product Research - March 24, 2024 Category: Biochemistry Authors: Amelia Tero-Vescan Ruxandra Ștefănescu Tudor-Ionu ț Istrate Amalia Pu șcaș Source Type: research
Molecular docking of quercetin: a promising approach for the development of new anti-inflammatory and analgesic drugs
Nat Prod Res. 2024 Mar 23:1-10. doi: 10.1080/14786419.2024.2333053. Online ahead of print.ABSTRACTThe aim of this study is to investigate the antinociceptive, anti-inflammatory and antipyretic effects of quercetin. Additionally, molecular docking studies were conducted to evaluate potential interactions between quercetin and various molecular targets. Animal models were used to conduct a comprehensive pharmacological investigation of quercetin. Evaluation of analgesic activity revealed a reduction in the number of abdominal cramps during the twisting test and inhibition of pain during the second phase of the formaldehyde t...
Source: Natural Product Research - March 23, 2024 Category: Biochemistry Authors: Amina Ettitaou Hamid Kabdy Khadija Oubella Karima Raoui Mehdi Oubahmane Rachida Aboufatima Loubna Elyazouli Stefania Garzoli Abderrahman Chait Source Type: research
Impacts of microwave-assisted extraction parameters on total phenolic compounds yield from Algerian < em > Moringa oleifera < /em > leaves, using response surface methodology
Nat Prod Res. 2024 Mar 23:1-9. doi: 10.1080/14786419.2024.2333044. Online ahead of print.ABSTRACTThe study aimed to optimise the microwave-assisted extraction (MAE) of total phenolic compounds (TPC) from Moringa oleifera Lam. leaves using response surface methodology (RSM) and Box-Behnken designs (BBD). Factors such as ethanol concentration, microwave power, irradiation time, and solvent to solid ratio were assessed in single-factor tests. Under optimal extraction conditions (48.86% ethanol, 626.53 W microwave power, 99.48 s irradiation, 29.67 mL/g solvent to solid ratio and 21.12 W/mL power density), TPC was 58.45 ± 0.68...
Source: Natural Product Research - March 23, 2024 Category: Biochemistry Authors: Farida Kheyar Naoual Kheyar Malek Amiali Lila Boulekbache-Makhlouf Ahcene Kadi Ahmed Benchabane Arezki Bitam Source Type: research
A new cucurbitane - type triterpenoid from the bark of < em > Elaeocarpus hygrophilus < /em > Kurz
Nat Prod Res. 2024 Mar 23:1-7. doi: 10.1080/14786419.2024.2330539. Online ahead of print.ABSTRACTA new cucurbitacin, 3β-(β-D-glucopyranosyloxy)-5β,6β:16α,23α-diepoxycucurbit-24-en-11-one or hygrocucurbin A (1), along with two known compounds, including 3β-(β-D-glucopyranosyloxy)-16α,23α-epoxycucurbita-5,24-dien-11-one (2) and (+)-lyoniresinol (3), were isolated from the bark of Elaeocarpus hygrophilus. Their chemical structures were elucidated by spectroscopic NMR, HR-IDA- TOF-MS analysis, and by comparison with the spectral data of corresponding compounds in the literature. Two cucurbitacins (1) and (2) were eva...
Source: Natural Product Research - March 23, 2024 Category: Biochemistry Authors: Thi-Ngoc-Nuong Nguyen Thi-Nga Vo Kim-Phi-Phung Nguyen Tri-Hieu Nguyen Thi-Anh-Tuyet Nguyen Source Type: research
A new sesquiterpene coumarins from < em > Ferula bungeana < /em > Kitagawa
Nat Prod Res. 2024 Mar 23:1-5. doi: 10.1080/14786419.2024.2332490. Online ahead of print.ABSTRACTA new sesquiterpene coumarin, bungeanin A (1), together with four known sesquiterpene coumarins, were isolated from the whole plants of Ferula bungeana Kitagawa. The structure of bungeanin A was elucidated by analysis of its spectroscopic data, including UV, IR, HR-ESI-MS, and extensive 1D and 2D NMR spectroscopy.PMID:38520263 | DOI:10.1080/14786419.2024.2332490 (Source: Natural Product Research)
Source: Natural Product Research - March 23, 2024 Category: Biochemistry Authors: Xiurong Kang Lili Wu Chaoliang Zhao Chaolumeng Zhang Qinghu Wang Source Type: research
Development and synthesis of a novel salen-type ligand based on phenylalanine for Mizoroki-Heck, and < em > S < /em > -arylation cross-coupling reactions
Nat Prod Res. 2024 Mar 23:1-9. doi: 10.1080/14786419.2024.2326853. Online ahead of print.ABSTRACTIn this article, we introduced a novel salen-type ligand precursor and applied it in the Pd-catalyzed Mizoroki-Heck and Cu-catalyzed S-arylation cross-coupling reactions. For the preparation of this structure, (DL)-phenyl alanine was employed as a starting material. These ligand precursor and related catalytic system can be readily synthesised. Various aryl halides (-I, -Br) and alkenes were applied successfully in this protocol to give the corresponding Mizoroki-Heck cross-coupling and S-arylated products in high to excellent ...
Source: Natural Product Research - March 23, 2024 Category: Biochemistry Authors: Bahnood Salmani Nezhad Azizollah Habibi Ahmad Takallou Elham Badali Satya Kumar Avula Ahmed Al-Harrasi Source Type: research
A new phenolic compound from < em > Persicaria capitata < /em >
In this study, one new phenolic compound, capitaone A (1) together with 20 known ones, were isolated from the whole herb of P. capitata. Among them, 7 components (4, 9-11, 15-16, 20-21) were discovered from P. capitata for the first time. Their chemical structures were elucidated on the basis of extensive NMR and MS spectrum. Furthermore, three compounds (15, 20, 21) displayed remarkable cytotoxic activities against two human cancer cell lines (A549 and HepG2).PMID:38520719 | DOI:10.1080/14786419.2024.2332485 (Source: Natural Product Research)
Source: Natural Product Research - March 23, 2024 Category: Biochemistry Authors: Lei He Fei Zhong Xing-Jun Chen Ya-Ru Yang Xue-Long Yan Ming-Hui He Xu Zhang Mu-Zhen Wang Yong-Qin Zeng Qin-Feng Zhu Zhu Zeng Bo Tu Qing-De Long Yan Lin Source Type: research
Molecular docking of quercetin: a promising approach for the development of new anti-inflammatory and analgesic drugs
Nat Prod Res. 2024 Mar 23:1-10. doi: 10.1080/14786419.2024.2333053. Online ahead of print.ABSTRACTThe aim of this study is to investigate the antinociceptive, anti-inflammatory and antipyretic effects of quercetin. Additionally, molecular docking studies were conducted to evaluate potential interactions between quercetin and various molecular targets. Animal models were used to conduct a comprehensive pharmacological investigation of quercetin. Evaluation of analgesic activity revealed a reduction in the number of abdominal cramps during the twisting test and inhibition of pain during the second phase of the formaldehyde t...
Source: Natural Product Research - March 23, 2024 Category: Biochemistry Authors: Amina Ettitaou Hamid Kabdy Khadija Oubella Karima Raoui Mehdi Oubahmane Rachida Aboufatima Loubna Elyazouli Stefania Garzoli Abderrahman Chait Source Type: research
