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Chemical composition and biological activities of the Algerian Cymbalaria muralis aerial parts
Nat Prod Res. 2024 Apr 1:1-5. doi: 10.1080/14786419.2024.2334318. Online ahead of print.ABSTRACTIn the present study we report data about antioxidant (DPPH, β-Carotene, reducing power), anti-inflammatory (xylene-induced ear oedema in mice (76 ± 1.0%) and membrane stabilisation (100%)) and antimicrobial (Escherichia coli ATCC25922, Staphylococcus aureus ATCC25923, Pseudomonas arugenosa ATCC27853 and Fusarium oxysporum ATCC62506) activities of the ethanolic extract from the Algerian Cymbalaria muralis P. Gaertn., B. Mey. & Scherb (CME). The LC-ESIMS analysis of CME chemical profile allowed to identify antirrhinoside (1...
Source: Natural Product Research - April 1, 2024 Category: Biochemistry Authors: Thamere Cheriet Abdallah Kherbache Ines Mancini Ramdane Seghiri Source Type: research

Prophylactic and therapeutic inhalation of two essential oils ameliorates scopolamine-induced cognitive impairment in mice
Nat Prod Res. 2024 Apr 1:1-9. doi: 10.1080/14786419.2024.2334335. Online ahead of print.ABSTRACTClover and lemongrass essential oils of contrasting composition, at three concentration levels (1%, 5%, 10%), were administrated via prophylactic and therapeutic inhalation to scopolamine-treated mice. Chemical analysis showed that clover oil was dominant in eugenol (47.69%) and lemongrass free of eugenol but mainly containing monoterpenoids of comparable proportions. Animal behavioural and brain biochemical tests showed that injection of scopolamine caused memory and learning deficit in mice while prophylactic and therapeutic i...
Source: Natural Product Research - April 1, 2024 Category: Biochemistry Authors: Wencui Wang Jingqi Yang Decheng Liang Lei Yao Li Ma Source Type: research

 Cistus incanus : a natural source of antimicrobial metabolites
In this study, we analysed the spectrum of molecules composing a commercial hydroalcoholic extract of C. incanus finding ellagitannins as the most abundant. The effect of the extract and its main constituents (gallic acid, ellagic acid and punicalin) was assessed as co-treatment during viral (HSV-1, HCoV-229E, SARS-CoV-2) and bacterial infection (Staphylococcus aureus and Escherichia coli) of cells and as pre-treatment before virus infections. The results indicated a remarkable antiviral activity of punicalin against SARS-CoV-2 by pre-treating both the viral and the host cells, and a major sensitivity of S. aureus to the C...
Source: Natural Product Research - April 1, 2024 Category: Biochemistry Authors: Anna De Filippis Vincenzo D'Amelia Veronica Folliero Carla Zannella Gianluigi Franci Massimiliano Galdiero Antonio Di Loria Carmen Laezza Simona Maria Monti Anna Lisa Piccinelli Rita Celano Maria Manuela Rigano Source Type: research

Isolation, characterization and SARS-CoV-2 3CL protease inhibitory activity of a new methylsulfinyl-butanyl derivative from Raphani Semen
Nat Prod Res. 2024 Apr 1:1-6. doi: 10.1080/14786419.2024.2335668. Online ahead of print.ABSTRACTA new compound named raphanised A (1), along with two known methylsulfinyl -butanyl derivatives (2-3) and seven known indole derivatives (4-10), were isolated from the Raphani Semen. Among the indole derivatives, 5 was identified as a new natural product, and 4, 6, 7, 8, 9, 10 were isolated from the genus of Raphanus for the first time. Their structures were elucidated based on the NMR and HR-EI-MS analysis. Additionally, the inhibitory activity of methylsulfinyl-butanyl derivatives 1-3 on SARS CoV-2 3CL protease was evaluated. ...
Source: Natural Product Research - April 1, 2024 Category: Biochemistry Authors: Huanjun Wang Bingqing Chi Caiyu Li Zhenhua Tian Yuecheng Liu Source Type: research

Effect of geographical origin on the chemical characteristics of Q. canariensis acorns: profiling fatty acids, tocopherols, and phenolic composition
In conclusion, this study's finding should significance for the industry, offering valuable insights into the potential production of bioactive compounds from Q. canariensis acorns, which could have various applications.PMID:38557271 | DOI:10.1080/14786419.2024.2335355 (Source: Natural Product Research)
Source: Natural Product Research - April 1, 2024 Category: Biochemistry Authors: Sondes Fkiri Bagues Mohamed Mariem Khouja Boutheina Stiti Ridha Ben Salem Zouhair Nasr Las âad Ben Slimane Kamel Nagaz Rigane Ghayth Abdelhamid Khaldi Source Type: research

Synthesis and cytotoxic evaluation of glycosyl derivatives of icaritin
Nat Prod Res. 2024 Apr 1:1-8. doi: 10.1080/14786419.2024.2334333. Online ahead of print.ABSTRACTA series of glycosyl alkyl/triazol-linked icaritin derivatives have been designed and synthesised. The target glycosyl derivatives were evaluated for their anticancer activity against three human cancer cell lines. The results of preliminary anticancer tests in vitro revealed that mannose derivatives 10a-10c (100 μM) with different aliphatic chain lengths exhibited increased cytotoxicity against HepG2 and SK-OV-3 cells compared with the parent compound icaritin. The data indicated that the kind of glycosyl groups and linkers af...
Source: Natural Product Research - April 1, 2024 Category: Biochemistry Authors: Chunyong Wei Xun Sun Lei Zhang Source Type: research

Utilising UPLC-QTOF-MS/MS to determine the phytochemical profile and in vitro cytotoxic potential of Ziziphora capitata L. with molecular docking simulation
Nat Prod Res. 2024 Apr 1:1-9. doi: 10.1080/14786419.2024.2335666. Online ahead of print.ABSTRACTZiziphora capitata (Lamiaceae family) aerial parts extract contains 57 metabolites, including flavonoids, phenolic acids, anthocyanins, and coumarins, as assessed by UPLC-QTOF-MS/MS. Successive extracts (hexane, chloroform, ethyl acetate, ethanol 95%, and water) were tested in vitro cytotoxic activity against HepG-2, MCF-7, HCT-116, A549, and PC3 cell lines. The results revealed that hexane extract exhibited the most potent cytotoxic activity among PC3 and A549 cell lines, IC50 = 47.1 ± 1.75 and 49.2 ± 1.08 µg/mL compared to ...
Source: Natural Product Research - April 1, 2024 Category: Biochemistry Authors: Youssif M Youssif Gameel A M Elhagali Medhat A Zahran Fatma A Ahmed Ahmed Ragab Source Type: research

Two undescribed compounds from Aspergillus Niger , an endophytic fungus isolated from Camellia flavida 
Nat Prod Res. 2024 Mar 29:1-8. doi: 10.1080/14786419.2024.2334325. Online ahead of print.ABSTRACTA new naphtho-γ-pyrone dimer, asperosperma A, and a new methyl nicotinate derivative, asperosperma B, with 12 known compounds were isolated from the endophytic fungus Aspergillus niger from the stem of Camellia flavida. Their structure was elucidated by NMR, ECD spectrum, and HR-ESI-MS data. Asperosperma A exhibited a highly cytotoxicity against H460 and 4T1 cancer cells with the IC50 values were 0.37 ± 0.06 and 2.04 ± 0.79 μM, respectively. Moreover, it showed a highly sensitive against Staphylococcus aureus, Escherichia c...
Source: Natural Product Research - March 29, 2024 Category: Biochemistry Authors: Siyuan Ma Li Ge Hongyu Lu Jianhua Yan Kedi Yang Source Type: research

Serbian Artemisia species - chemical composition, acute toxicity and larvicidal activity of the essential oils
Nat Prod Res. 2024 Mar 27:1-12. doi: 10.1080/14786419.2024.2334312. Online ahead of print.ABSTRACTThe chemical composition and biological activities of the essential oils obtained from Serbian Artemisia species (A. alba, A. absinthium, A. annua, A. vulgaris, and A. scoparia) were analysed. The essential oil was obtained by merging several samples (same plant species, different localities) and the chemical composition was compared with pre-merging results. In the merged A. scoparia sample four components were not found in any pre-merging sample and one of those is present in the highest percentage (capillin 35.7%). The leas...
Source: Natural Product Research - March 28, 2024 Category: Biochemistry Authors: Jovana D Ickovski Vladimir J Cvetkovi ć Nikola M Jovanovi ć Tatjana Lj Mitrovi ć Gordana S Stojanovi ć Source Type: research

Valorisation of olive pomace: phenolic prospecting and biological potential
Nat Prod Res. 2024 Mar 27:1-6. doi: 10.1080/14786419.2024.2332948. Online ahead of print.ABSTRACTPhenolic compounds were extracted from biphasic olive pomace and their biological potential was characterised. Two different extracts were prepared, E1 (40% methanol) and E2 (80% methanol), both subjected to agitation (180 min) and 70 °C. LC-ESI-qTOF-MS was used for individual quantification of the extracted phenolic compounds. The antioxidant activity was determined using different methods, including nitric oxide, DPPH (2,2-diphenyl-1-picrylhydrazyl) and hydroxyl radical. The enzymes α-amylase and α-glucosidase were used to...
Source: Natural Product Research - March 28, 2024 Category: Biochemistry Authors: Bruna Wendt B öhmer-Maas Deborah Murowaniecki Otero P âmela Inchauspe Corrêa Alves Nathalia Stark Pedra Marjana Rad ünz Eli ézer Ávila Gandra Rui Carlos Zambiazi Source Type: research

Chemical composition of the White Sea sponge Halichondri а panicea 
Nat Prod Res. 2024 Mar 28:1-8. doi: 10.1080/14786419.2024.2333049. Online ahead of print.ABSTRACTThe extract of the White Sea sponge Halichondria panicea (Pallas, 1766) exhibits cytotoxic and cytostatic effects. The main part of the extract consists of hydrophilic low molecular weight compounds: free amino acids (13.9%), glucose (19.9%), polyatomic alcohols (glycerin and others) (6.1%), carboxylic acids (0.7%) and nitrogenous heterocycles (1.2%). Of the substances specific to the metabolome, bicyclic diketopiperazines (four derivatives), pyroglutamic acid, phenylacetic acid, and two steroids (3β,5α)cholest-7-en-3-ol and ...
Source: Natural Product Research - March 28, 2024 Category: Biochemistry Authors: Konstantin A Krasnov Alexander Yu Gorbunov Nadezhda Yu Rogovskaja Viktor A Utsal Vladimir T Papp Alexandra A Krasnova Semen S Gaft Vyacheslav V Khalaman Source Type: research