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Effect of Gracilaria changii extract and its fraction in reverse cholesterol transport by targeting SR-BI gene
Nat Prod Res. 2024 Mar 14:1-8. doi: 10.1080/14786419.2024.2327851. Online ahead of print.ABSTRACTThis present study aimed to investigate the effects of Gracilaria changii (Red seaweed) extract and its fraction on scavenger receptor class B type I (SR-BI) gene expressions. In vitro studies of the activity of G. changii extract and its fraction against the therapeutic target for hypocholesterolemia were conducted using high-density lipoprotein (HDL) receptor SR-BI via luciferase assay in HepG2 cells. In the current study, methanol crude extract (MCE) and Fraction-2 of G. changii showed the highest expression levels of the SR...
Source: Natural Product Research - March 15, 2024 Category: Biochemistry Authors: Mohd Rahaizuddin Rani Ahmad Khusairi Azemi Kamariah Bakar Luqman Abu-Bakar Tengku Sifzizul Tengku Muhammad Noraznawati Ismail Source Type: research

Anti-vibriosis bioactive molecules from marine-derived variant Streptomyces sp. ZZ741A
In this study, six compounds (1-6) were isolated from the Streptomyces sp. ZZ741A, a marine-derived Streptomyces variant, including one new compound, 2-carbamoylphenyl isobutyrate (1), five known ones, nocardamine (2), dehydroxynocardamine (3), phenylacetic acid (4), thiophenol (5) and 2,3-dihydroxybenzoic acid (6). The anti-vibriosis assay showed that compounds 2 and 3 had specific inhibition activity against Vibrio vulnificus, Vibrio alginolyticus, and Vibrio parahaemolyticus with the MIC values ranging from 8 to 128 μg/mL. The molecular docking study of their possible mechanism of anti-vibriosis activity showed that th...
Source: Natural Product Research - March 15, 2024 Category: Biochemistry Authors: Di Zhang Yao Feng Mingyi Chu Yujiang Dai Lu Jiang Huifang Li Source Type: research

Two novel ketone alkaloids from Portulaca oleracea L. and their anti-inflammatory activities
Nat Prod Res. 2024 Mar 12:1-8. doi: 10.1080/14786419.2024.2325593. Online ahead of print.ABSTRACTEleven compounds were obtained from Portulaca oleracea L., including two novel ketone alkaloids, (1, 2), 4-hydroxy-3-methoxybenzamide (3) (isolated for the first time), β-adenosine (4), oleracrylimide A and B (5, 6), oleracein H, C, D, Q and A (7-11). The two novel ketone alkaloids were identified as 5-acetyl-5-methylcyclopent-2-ene-1-carboxamide (1), named oleraciamide H, and (2 R,3S,4R,5R)-5-((R)-1,2-dihydroxyethyl)-3,4-dihydroxytetrahydrofuran-2-yl glycinate (2), named oleracone Q by spectroscopic methods, including 1D, 2D ...
Source: Natural Product Research - March 13, 2024 Category: Biochemistry Authors: Hongzhe Zhang Jing Liu Junjie Yao Fan He Xixiang Ying Source Type: research

Separation of crude methanol extract of Plantago major root: identification of phytochemicals and assessment of biological activities
Nat Prod Res. 2024 Mar 12:1-5. doi: 10.1080/14786419.2024.2326993. Online ahead of print.ABSTRACTPlantago major root extracts were used for analysis by Gas Chromatography-Mass Spectrometry (GC-MS). The anticancer and antibacterial functions of extracts were also investigated. The dichloromethane extract of P. major had the highest inhibitory effect against Salmonella paratyphi (18.00 ± 1.4 mm) at 100 mg/mL concentration. The lowest MIC was also achieved for S. paratyphi treated with dichloromethane extract of P. major (1.5 mg/mL). The minimum MBC (2 mg/mL) was observed for dichloromethane extract of P. major root against ...
Source: Natural Product Research - March 12, 2024 Category: Biochemistry Authors: Samaneh Rahamouz-Haghighi Ali Sharafi Source Type: research

Antioxidant constituents from Ribes glaciale Wall.: bioassay targeted in-vitro and in-silico evaluation
Nat Prod Res. 2024 Mar 10:1-4. doi: 10.1080/14786419.2024.2326955. Online ahead of print.ABSTRACTBioassay targeted phyto-investigation of dried green walnut husk of Ribes glaciale Wall. yielded one new compound as β-D-glucopyrano (4'→3)-β-D-glucopyranose (1) and four known compounds namely scoparone (2), apigenin (3), β-sitosterol (4) and β-sitosterol-D-glucoside (5). The structure of new compound was elucidated with the help of 1D, 2D and HRESIMS analysis. The antioxidant activity of extract, fractions and pure were evaluated using 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), 2, 2-diphenyl-1-pic...
Source: Natural Product Research - March 11, 2024 Category: Biochemistry Authors: Rajendra Singh Rohit Verma Nitin Sati Waseem Ahmad Ansari Mohammad Faheem Khan Source Type: research

Design, semi-synthesis of soft coral-derived Aspergillus sp. secondary metabolite geodin derivatives and their antibacterial activities
Nat Prod Res. 2024 Mar 10:1-9. doi: 10.1080/14786419.2024.2326990. Online ahead of print.ABSTRACTA series of novel ester derivatives 2 - 7, of natural product geodin 1, isolated from the soft coral-derived fungus Aspergillus sp., were designed and semi-synthesised through one step reaction with high yield. Compound 5 showed strong antifouling inhibitory activities with MIC of 4.80 μM while compound 4 showed selective inhibitory activities with MICs values 8.59 μM against Aeromonas salmonicida and Pseudomonas aeruginosa (Sea-Nine 211, MIC = 0.27 μM). Compounds 3, 4 and 6 showed potent anti-pathogenic inhibitory activitie...
Source: Natural Product Research - March 11, 2024 Category: Biochemistry Authors: Gulab Said Amjad Ali Latif Ahmad Source Type: research

Two new alkaloids from the roots of Cocculus hirsutus (L.) W. Theob
Nat Prod Res. 2024 Mar 10:1-12. doi: 10.1080/14786419.2024.2326979. Online ahead of print.ABSTRACTTwo undescribed alkaloids, 15-carboxydihydroerysotrine (1) and (14 R)-4-methoxy-13,14-dihydrooxypalmatine (2), along with six known compounds, 1,6-didehydro-3,15,16-trimethoxy-9-methylerythrinanium (3), 8-oxytetrahydropalmatine (4), 20-hydroxyecdysone (5), makisterone A (6) turkesterone (7) and magnoflorine (8) were isolated from the root part of Cocculus hirsutus (L.) W. Theob. Their structures were established based on detailed analysis of NMR, UV-Vis, HRESIMS, and single-crystal XRD spectroscopic experiments. Compounds 3, 4...
Source: Natural Product Research - March 11, 2024 Category: Biochemistry Authors: None Shivani Surekha Kumari Prithvi Pal Singh Prateek Singh Bora Upendra Sharma Source Type: research

Pharmacognostic standardization and evaluation of antiulcer potential of Olax psittacorum leaf extract
Nat Prod Res. 2024 Mar 10:1-9. doi: 10.1080/14786419.2024.2327613. Online ahead of print.ABSTRACTThe modern medicine has received many plants as a gift from ethnobotany. It is an efficient method of discovering new medicines. The leaves of Olax psittacorum (Lam.) Vahl. were extracted with ethanol, and the phytoconstituents present in the leaf extract were identified using Gas chromatography-mass spectrometric analysis (GC-MS), followed by determination of physico-chemical parameters and anti-ulcer properties. The leaf ethanolic extract (LEE) yield was observed to be 43.2%. The quantitative surface microscopy analysis revea...
Source: Natural Product Research - March 11, 2024 Category: Biochemistry Authors: Pragyan Parimita Mansingh Lopamudra Adhikari Moonmun Dhara Source Type: research