A new flavonoid from < em > Epimedium brevicornu < /em > Maxim
In conclusion, we isolated and purified compound 1 (15.4 mg) and determined its chemical structure.PMID:37029621 | DOI:10.1080/14786419.2023.2199213 (Source: Natural Product Research)
Source: Natural Product Research - April 8, 2023 Category: Biochemistry Authors: Juan Jiang Bao-Guo Jiang Bing Liu Source Type: research
Phenolic composition, antioxidant, cytotoxic activities and cardioprotective effect of hydroalcoholic extract from aerial-parts of < em > Hypericum attenuatum < /em > Fisch. ex Choisy
This study investigated phenolic metabolites, antioxidant, cytotoxic and cardioprotective effects of the hydroalcoholic extract from the aerial parts of Hypericum attenuatum Fisch. ex Choisy. The total phenolic and flavonoid contents of the extract were 132.40 ± 2.06 mg GAE/g and 101.46 ± 1.47 mg QE/g respectively. The extract exhibited antioxidant activities with an EC50 value against DPPH radical of 0.099 ± 0.03 mg/mL and a FRAP value of 1.22 ± 0.086 mmol/L Fe2+. The extract could protect H9c2 cardiomyoblasts from the injury of H2O2, while it restored the H9c2 cell viability to 82.69 ± 2.33% at 100 μg/mL. The extra...
Source: Natural Product Research - April 8, 2023 Category: Biochemistry Authors: Du-Xin Jin Jun-Fang He Ke-Qin Zhang Nan-Yi Zhang Source Type: research
Antiplasmodial and anticancer activities of xanthones isolated from < em > Garcinia bancana < /em > Miq
This report describes the isolation and characterization of xanthones from Garcinia bancana Miq. and evaluates their antiplasmodial and anticancer activities. Macluraxanthone (1), isojacareubin (2), and gerontoxanthone C (3) were isolated from the stem bark of G. bancana Miq. for the first time. In silico molecular docking studies revealed the hydrogen bonding and steric interactions between xanthones (1-3) and PfLDH/VEGFR2. The in vitro antiplasmodial activity was assayed against the chloroquine-sensitive Plasmodium falciparum strain 3D7 by the lactate dehydrogenase (LDH) method. The anticancer evaluation was evaluated ag...
Source: Natural Product Research - April 8, 2023 Category: Biochemistry Authors: None Rifaldi Arif Fadlan Sri Fatmawati Adi Setyo Purnomo Taslim Ersam Source Type: research
Anti-inflammatory effect of a pomegranate extract on LPS-stimulated HepG2 cells
Nat Prod Res. 2023 Apr 8:1-8. doi: 10.1080/14786419.2023.2196622. Online ahead of print.ABSTRACTPomegranate is an important source of bioactive molecules with proven beneficial effects on human health. The aim of this study was to investigate the potential anti-inflammatory effect of a pomegranate extract (PE), obtained from the whole fruit and previously characterized by Reversed Phase-Ultra High-Pressure Liquid Chromatography-High Resolution Mass Spectrometry (RP-UHPLC-HRMS), on HepG2 human hepatocellular carcinoma cells challenged with the lipopolysaccharide (LPS). In LPS-treated cells (1 µg/ml, 24h), the PE treatment ...
Source: Natural Product Research - April 8, 2023 Category: Biochemistry Authors: Maria Pierdomenico Costanza Riccioni Barbara Benassi Source Type: research
A new flavonoid from < em > Epimedium brevicornu < /em > Maxim
In conclusion, we isolated and purified compound 1 (15.4 mg) and determined its chemical structure.PMID:37029621 | DOI:10.1080/14786419.2023.2199213 (Source: Natural Product Research)
Source: Natural Product Research - April 8, 2023 Category: Biochemistry Authors: Juan Jiang Bao-Guo Jiang Bing Liu Source Type: research
Phenolic composition, antioxidant, cytotoxic activities and cardioprotective effect of hydroalcoholic extract from aerial-parts of < em > Hypericum attenuatum < /em > Fisch. ex Choisy
This study investigated phenolic metabolites, antioxidant, cytotoxic and cardioprotective effects of the hydroalcoholic extract from the aerial parts of Hypericum attenuatum Fisch. ex Choisy. The total phenolic and flavonoid contents of the extract were 132.40 ± 2.06 mg GAE/g and 101.46 ± 1.47 mg QE/g respectively. The extract exhibited antioxidant activities with an EC50 value against DPPH radical of 0.099 ± 0.03 mg/mL and a FRAP value of 1.22 ± 0.086 mmol/L Fe2+. The extract could protect H9c2 cardiomyoblasts from the injury of H2O2, while it restored the H9c2 cell viability to 82.69 ± 2.33% at 100 μg/mL. The extra...
Source: Natural Product Research - April 8, 2023 Category: Biochemistry Authors: Du-Xin Jin Jun-Fang He Ke-Qin Zhang Nan-Yi Zhang Source Type: research
Antiplasmodial and anticancer activities of xanthones isolated from < em > Garcinia bancana < /em > Miq
This report describes the isolation and characterization of xanthones from Garcinia bancana Miq. and evaluates their antiplasmodial and anticancer activities. Macluraxanthone (1), isojacareubin (2), and gerontoxanthone C (3) were isolated from the stem bark of G. bancana Miq. for the first time. In silico molecular docking studies revealed the hydrogen bonding and steric interactions between xanthones (1-3) and PfLDH/VEGFR2. The in vitro antiplasmodial activity was assayed against the chloroquine-sensitive Plasmodium falciparum strain 3D7 by the lactate dehydrogenase (LDH) method. The anticancer evaluation was evaluated ag...
Source: Natural Product Research - April 8, 2023 Category: Biochemistry Authors: None Rifaldi Arif Fadlan Sri Fatmawati Adi Setyo Purnomo Taslim Ersam Source Type: research
Chryroxosides A-E: five new triterpene saponins from the leaves of < em > Chrysophyllum roxburghii < /em > G.Don. and their cytotoxic activity
Nat Prod Res. 2023 Apr 6:1-9. doi: 10.1080/14786419.2023.2196623. Online ahead of print.ABSTRACTFive undescribed oleanane triterpene glycosides named chryroxosides A-D (1-5), together with five known compounds (6-10) were isolated from the leaves of Chrysophyllum roxburghii G.Don. Their chemical structures were elucidated by extensive spectroscopic data analyses including IR, HR-ESI-MS, 1D and 2D NMR). Compounds 1, 3, and 5 showed cytotoxic effects against KB, HepG2, HL60, P388, HT29, and MCF7 cell lines with the IC50 values ranging from 14.40 to 52.63 μM compared to the positive control compound (ellipticine) with the IC...
Source: Natural Product Research - April 6, 2023 Category: Biochemistry Authors: Pham Thi Hang Nguyen Thi Hue Nguyen Hoang Nam Nguyen Le Tuan Pham Van Cuong Nguyen Quoc Vuong Nguyen Huy Hoang Bui Huu Tai Phan Van Kiem Source Type: research
The antifungal metabolites from coculture of < em > Aspergillus fumigatus < /em > and < em > Alternaria alternata < /em > associated with < em > Coffea arabica < /em >
Nat Prod Res. 2023 Apr 6:1-6. doi: 10.1080/14786419.2023.2196722. Online ahead of print.ABSTRACTOne new cyclohexenone derivative, asperfumtone A (1) along with six known compounds were obtained from the coculture of Aspergillus fumigatus and Alternaria alternata associated with Coffea arabica. The configuration of 2 was first reported in the research. The structures were determined by extensive spectroscopic analyses, and ECD calculation. Compounds 3, 4 and 7 showed significant antifungal activities against coffee phytopathogens A. alternata and Fusarium incarnatum with MICs of 1 μg/mL. Compounds 1 and 2 showed weak antif...
Source: Natural Product Research - April 6, 2023 Category: Biochemistry Authors: Ya-Mei Wu Xue-Qiong Yang Ya-Bin Yang Le Cai Fei-Fei He Zhong-Tao Ding Source Type: research
Characterization of polyphenols in the methanol leaf extract of < em > Bathysa gymnocarpa < /em > (Rubiaceae) by HPLC-DAD-ESI-MS/MS
Nat Prod Res. 2023 Apr 6:1-4. doi: 10.1080/14786419.2023.2192932. Online ahead of print.ABSTRACTThe species Bathysa gymnocarpa K.Schum is a tree belonging to the Rubiaceae family, endemic in Brazil. So far, there are reports neither of phytochemical work nor of biological evaluation of it. The analysis by High Performance Liquid Chromatography coupled to a Diode Array Detector and a tandem Mass Spectrometer with an Electrospray Ionization source (HPLC-DAD-ESI-MS/MS) of its crude extract allowed to characterize in a complex mixture, without isolation, fourteen compounds, being two as cinnamic acid derivatives, and the other...
Source: Natural Product Research - April 6, 2023 Category: Biochemistry Authors: Ariel M Araujo Lucas M Cruz M ário Gomes Blanca Gallo Ligia M M Valente Luis A Berrueta Source Type: research
Isolation and identification of antioxidant constituents from the flowers of < em > Salvia miltiorrhiza < /em >
Nat Prod Res. 2023 Apr 6:1-5. doi: 10.1080/14786419.2023.2198710. Online ahead of print.ABSTRACTA new salvianolic acid derivative, (7'E)-(7S, 8S)-salvianolic acid V (1), together with four previously described compounds (2-5) were obtained from the n-butanol fraction of Salvia miltiorrhiza flowers. Their structures were established by a series of spectroscopic methods, and the absolute configuration of 1 was determined by electronic circular dichroism (ECD) calculation. Salvianolic acids (1) and phenolic acids (2-4) showed stronger DPPH free radical scavenging abilities and certain protective effects against H2O2-induced h...
Source: Natural Product Research - April 6, 2023 Category: Biochemistry Authors: Xue Jiang Jun Chi Qingmei Feng Hong Wu Zhimin Wang Liping Dai Source Type: research
Phytoconstituents from < em > Piliostigma foveolatum < /em > (Dalzell) Thoth. leaves induce antiproliferative effect, apoptosis, and cell cycle arrest in Hop-62 cells
Nat Prod Res. 2023 Apr 4:1-5. doi: 10.1080/14786419.2023.2197228. Online ahead of print.ABSTRACTThe study evaluated the therapeutic potential of ethanolic leaf extract of Piliostigma foveolatum (Dalzell) Thoth. (EEBF), its toluene, ethylacetate, methanol soluble fractions (viz. TFBF, EFBF, MFBF), and isolated phytoconstituents against lung cancer. Four compounds were isolated from MFBF by column chromatography and preparative HPLC. Structures were elucidated by IR, 13C-NMR, 1H-NMR, mass spectroscopy and identified as Quercetin, Kaempferol, Isorhamnetin, and ß-glucogallin. EEBF and its biofractions exhibited remarkable ant...
Source: Natural Product Research - April 4, 2023 Category: Biochemistry Authors: Liesl Maria Fernandes E Mendon ça Arun Bhimrao Joshi Anant Bhandarkar Himanshu Joshi Shrinivas Joshi Source Type: research
Phytoconstituents from < em > Piliostigma foveolatum < /em > (Dalzell) Thoth. leaves induce antiproliferative effect, apoptosis, and cell cycle arrest in Hop-62 cells
Nat Prod Res. 2023 Apr 4:1-5. doi: 10.1080/14786419.2023.2197228. Online ahead of print.ABSTRACTThe study evaluated the therapeutic potential of ethanolic leaf extract of Piliostigma foveolatum (Dalzell) Thoth. (EEBF), its toluene, ethylacetate, methanol soluble fractions (viz. TFBF, EFBF, MFBF), and isolated phytoconstituents against lung cancer. Four compounds were isolated from MFBF by column chromatography and preparative HPLC. Structures were elucidated by IR, 13C-NMR, 1H-NMR, mass spectroscopy and identified as Quercetin, Kaempferol, Isorhamnetin, and ß-glucogallin. EEBF and its biofractions exhibited remarkable ant...
Source: Natural Product Research - April 4, 2023 Category: Biochemistry Authors: Liesl Maria Fernandes E Mendon ça Arun Bhimrao Joshi Anant Bhandarkar Himanshu Joshi Shrinivas Joshi Source Type: research
New benzoquinone pigments from the hydnoid fungus < em > Sarcodontia setosa < /em > and their biosynthetic relationship
Nat Prod Res. 2023 Apr 2:1-10. doi: 10.1080/14786419.2023.2195176. Online ahead of print.ABSTRACTChemical investigation of the hydnoid fungus Sarcodontia setosa resulted in the isolation of five compounds, including two new sarcodontic acid derivatives - setosic acid (1) and 7,8-dehydrohomosarcodontic acid (2) along with three known benzoquinone pigments - sarcodontic acid (3), 4,5-dehydrosarcodontic acid (4) and dihydrosarcodontic acid (5). The structures were elucidated using spectroscopic methods (UV, NMR and HR-ESIMS). The biosynthetic relationship of the isolated compounds is proposed and discussed. Antibacterial acti...
Source: Natural Product Research - April 2, 2023 Category: Biochemistry Authors: Andrei K Whaley Anastasiia O Ponkratova Anastasia A Orlova Sergey V Volobuev Natalia V Shakhova Evgeny B Serebryakov Sergey N Smirnov Natalia V Pustovit Liudmila A Kraeva Vladimir G Luzhanin Source Type: research
< em > In silico < /em > and < em > in vitro < /em > elastase inhibition assessment assays of rosmarinic acid natural product from < em > Rosmarinus officinalis < /em > Linn
Nat Prod Res. 2023 Apr 2:1-6. doi: 10.1080/14786419.2023.2196077. Online ahead of print.ABSTRACTThe use of various herbs and their compounds has been a strategy widely used in the fight against various human diseases. For example, rosmarinic acid, a bioactive phenolic compound commonly found in Rosemary plants (Rosmarinus officinalis Labiatae), has multiple therapeutic benefits in different diseases, such as cancer. Therefore, the study aimed to evaluate in silico and in vitro the inhibition potential of the enzyme Elastase from the porcine pancreas by rosmarinic acid isolated from the plant species R. officinalis Linn. Th...
Source: Natural Product Research - April 2, 2023 Category: Biochemistry Authors: Ester Gon çalves de Jesus Fernanda Fernandes de Souza Jo ão Victor Andrade M árcio Luís Andrade E Silva Wilson R Cunha Rafael Corr êa Ramos Othon Souto Campos Jorge Alexandre Nogueira Santos Mario F C Santos Source Type: research
