< em > Paeonia mascula < /em > subsp. < em > russoi < /em > (biv.) Cullen & amp; Heywood: the chemical composition of the aerial parts essential oils of two different populations collected in Sicily (Italy)
Nat Prod Res. 2024 Apr 13:1-8. doi: 10.1080/14786419.2024.2340759. Online ahead of print.ABSTRACTIn the present study, the chemical composition of the essential oil from aerial parts of two populations of Paeonia mascula subsp. russoi, collected in Sicily, was evaluated by GC-MS. No previously phytochemical investigation has been reported for this subspecies. The main components of the essential oil of the population with pink flowers were salicylaldehyde (34.31%), nonanal (16.95%) and 2-hexenal (10.17%), whereas essential oil of the population with white flowers, was shown to be rich of myrtanal (14.14%), eugenol (14.02%)...
Source: Natural Product Research - April 13, 2024 Category: Biochemistry Authors: Francesco Sgadari Alessandro Vaglica Antonella Porrello Dario Savoca Rosario Schicchi Maurizio Bruno Source Type: research
A novel polycyclic quinazoline and three quinolines alkaloids from marine-derived fungus < em > trichoderma longibrachiatum < /em > QD01 with anti-bacterial and anti-quorum sensing activities
Nat Prod Res. 2024 Apr 13:1-10. doi: 10.1080/14786419.2024.2341277. Online ahead of print.ABSTRACTA novel polycyclic quinazoline alkaloid (1) along with one new natural quinoline alkaloid (2) and two known quinoline alkaloids (3,4) were isolated from the marine-derived fungus Trichoderma longibrachiatum QD01. Structural determinations of those isolates were established by comprehensive spectroscopic analyses and literature comparison. Single-crystal X-ray diffraction analysis of novel compound verified its structure and stereochemistry, representing the first characterised crystal structure of a trimeric-type of tetrahydro...
Source: Natural Product Research - April 13, 2024 Category: Biochemistry Authors: Chaoyi Lv Zhizhou Li Shaohua Sun Jiaying Ma Hui Wang Hu Zhu Shiwei Sun Wei Wang Source Type: research
Three new constituents from the stems of < em > Knema globularia < /em > and their < em > α < /em > -glucosidase inhibitory activity
Nat Prod Res. 2024 Apr 13:1-9. doi: 10.1080/14786419.2024.2341994. Online ahead of print.ABSTRACTThree new metabolites (1-3) were isolated from the stems of Knema globularia, along with five known compounds, including kaempferol (4), quercetin (5), isovanillic acid (6), protocatechuic acid (7), and gallic acid (8). Their structures were deduced using NMR spectroscopic, mass spectrometric analyses, and literature data. The absolute configurations of 1-3 were established by electronic circular dichroism (ECD) spectroscopy. α-Glucosidase inhibitory activities of those compounds were evaluated using a spectrophotometric metho...
Source: Natural Product Research - April 13, 2024 Category: Biochemistry Authors: Thi-Kim-Dung Le Thuc-Huy Duong Warinthorn Chavasiri Source Type: research
Essential oil of the leaves of < em > psychotria asiatica < /em > L.: chemical composition, antioxidant, anti-inflammatory, and cytotoxic properties
This study is focused on investigating the chemical composition and bioactive properties of the essential oil extracted from Psychotria asiatica L., a plant species known for its medicinal properties. Utilising gas chromatography-mass spectrometry (GC-MS) analysis, the essential oil from P. asiatica was found to contain 53 distinct constituents. Major compounds identified include (E)-citral (20.6%), 10-epi-γ-eudesmol (15.9%), (Z)-citral (10.5%), geraniol (7.4%), α-cadinol (6.7%), 7-epi-α-eudesmol (4.4%), linalool (3.7%), and α-muurolol (3.4%). The essential oil did not exhibit antioxidant activity, as indicated by an I...
Source: Natural Product Research - April 13, 2024 Category: Biochemistry Authors: Tien Dong Tran Anh Tuan Le Dat Van Tran Thang Quoc Le Ty Viet Pham Source Type: research
Neuroprotective activity of < em > Colocasia esculenta < /em > (L.) Schott leaves against monosodium glutamate-induced excitotoxicity in rats: phytochemical and molecular docking study
Nat Prod Res. 2024 Apr 12:1-9. doi: 10.1080/14786419.2024.2340061. Online ahead of print.ABSTRACTColocasia esculenta (L.) Schott is a food crop with long history of use in treatment of various disorders including neurological diseases. The methanolic leaves extract (ME) and its n-butanol fraction (n-BF) demonstrated significant in vivo neuroprotective activity in monosodium glutamate induced excitotoxicity in rats. Sixteen and fifteen polyphenolic compounds were identified in n-BF and ME, respectively, using HPLC. Phytochemical investigation of n-BF followed by 1D (1H and 13C NMR) spectroscopic analyses led to isolation an...
Source: Natural Product Research - April 12, 2024 Category: Biochemistry Authors: Heba T Khazaal Elsayed K El-Sayed Yara E Mansour Reham R Ibrahim Mokhtar Bishr Rabab A El Dib Hesham S M Soliman Source Type: research
Effects of natural waste on in vitro oxidative DNA damage
In this study, the effects of natural waste products such as extracts from C. coggygria leaves and Punica granatum L. peels were investigated against oxidative DNA damage induced by Fenton reaction. 8-OH-2'dG as a general marker of DNA damage on thymus DNA, and the bioactive compounds of extracts were measured by LC-MS/MS. Our results had shown that ethanol extracts of C. coggygria leaf and Punica granatum L. peel had a protective effect on oxidative damaged DNA. It was determined that the bioactive compounds of C. coggygria leaves (gallic acid, protocatechuic acid, myricetin, syringic acid and ethyl gallate as a major com...
Source: Natural Product Research - April 12, 2024 Category: Biochemistry Authors: Dua Danjolli-Hashani Sebnem Selen Isbilir Source Type: research
Flavan-3-ols, flavonoids, anthocyanidins and triterpenoids induces TIE2 phosphorylation -a candidate target for the vascular protective effects
Nat Prod Res. 2024 Apr 12:1-5. doi: 10.1080/14786419.2024.2340049. Online ahead of print.ABSTRACTVascular system is essential for the body to maintain health. Dysregulated vascular system leads to cardiovascular diseases and are observed in ischaemic stroke, Alzheimer's disease, amyotrophic lateral sclerosis, and diabetes. TIE2 is a tyrosine kinase receptor expressed on vascular endothelial cells and contributes to the maintenance of a vascular system. In this paper, we screened for natural products with an activity to induce phosphorylation of TIE2, which will be beneficial for protection of a vascular system. Employing H...
Source: Natural Product Research - April 12, 2024 Category: Biochemistry Authors: Saki Igarashi Sayaka Hioki Naoto Sakamaru Asahi Suzuki Mihoko Kurokawa Eisuke Kato Source Type: research
Neuroprotective activity of < em > Colocasia esculenta < /em > (L.) Schott leaves against monosodium glutamate-induced excitotoxicity in rats: phytochemical and molecular docking study
Nat Prod Res. 2024 Apr 12:1-9. doi: 10.1080/14786419.2024.2340061. Online ahead of print.ABSTRACTColocasia esculenta (L.) Schott is a food crop with long history of use in treatment of various disorders including neurological diseases. The methanolic leaves extract (ME) and its n-butanol fraction (n-BF) demonstrated significant in vivo neuroprotective activity in monosodium glutamate induced excitotoxicity in rats. Sixteen and fifteen polyphenolic compounds were identified in n-BF and ME, respectively, using HPLC. Phytochemical investigation of n-BF followed by 1D (1H and 13C NMR) spectroscopic analyses led to isolation an...
Source: Natural Product Research - April 12, 2024 Category: Biochemistry Authors: Heba T Khazaal Elsayed K El-Sayed Yara E Mansour Reham R Ibrahim Mokhtar Bishr Rabab A El Dib Hesham S M Soliman Source Type: research
Effects of natural waste on in vitro oxidative DNA damage
In this study, the effects of natural waste products such as extracts from C. coggygria leaves and Punica granatum L. peels were investigated against oxidative DNA damage induced by Fenton reaction. 8-OH-2'dG as a general marker of DNA damage on thymus DNA, and the bioactive compounds of extracts were measured by LC-MS/MS. Our results had shown that ethanol extracts of C. coggygria leaf and Punica granatum L. peel had a protective effect on oxidative damaged DNA. It was determined that the bioactive compounds of C. coggygria leaves (gallic acid, protocatechuic acid, myricetin, syringic acid and ethyl gallate as a major com...
Source: Natural Product Research - April 12, 2024 Category: Biochemistry Authors: Dua Danjolli-Hashani Sebnem Selen Isbilir Source Type: research
Flavan-3-ols, flavonoids, anthocyanidins and triterpenoids induces TIE2 phosphorylation -a candidate target for the vascular protective effects
Nat Prod Res. 2024 Apr 12:1-5. doi: 10.1080/14786419.2024.2340049. Online ahead of print.ABSTRACTVascular system is essential for the body to maintain health. Dysregulated vascular system leads to cardiovascular diseases and are observed in ischaemic stroke, Alzheimer's disease, amyotrophic lateral sclerosis, and diabetes. TIE2 is a tyrosine kinase receptor expressed on vascular endothelial cells and contributes to the maintenance of a vascular system. In this paper, we screened for natural products with an activity to induce phosphorylation of TIE2, which will be beneficial for protection of a vascular system. Employing H...
Source: Natural Product Research - April 12, 2024 Category: Biochemistry Authors: Saki Igarashi Sayaka Hioki Naoto Sakamaru Asahi Suzuki Mihoko Kurokawa Eisuke Kato Source Type: research
Testusterol, a new sterol of the sponge species < em > Xestospongia testudinaria < /em > from Phu Quoc island, Vietnam
Nat Prod Res. 2024 Apr 11:1-9. doi: 10.1080/14786419.2024.2340757. Online ahead of print.ABSTRACTA new sterol, named testusterol (1), and five known compounds (2-6) were isolated from the n-hexane and dichloromethane extracts of the sponge species Xestospongia testudinaria. Their chemical structures were elucidated based on extensive spectroscopic analyses (1D, 2D NMR, ESIMS and HRESIMS) and comparison with published data. The results of in vitro test (utilizing brine shrimp Artemia salina LEACH) showed that three extracts ethanol, dichloromethane, and ethanol/water, significantly inhibited Artemia salina with LC50 values ...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Phuong Vu Luu Hien Minh Nguyen Phuc Minh Phan An Duy Vo Huong Lien Ton-Nu Source Type: research
Morusacerane: A new gammacerane triterpenoid from the trunk of < em > Morus Alba < /em > linn. with < em > α < /em > -glucosidase inhibitory activity
Nat Prod Res. 2024 Apr 11:1-10. doi: 10.1080/14786419.2024.2340043. Online ahead of print.ABSTRACTThis phytochemistry investigation on the trunk of Morus alba L. resulted in the isolation of three triterpenoids, including a new gammacerane triterpenoid - morusacerane (1); along with two known compounds of betulinic acid (2) and ursolic acid (3). The structure elucidation was thoroughly conducted based on 1D, 2D-NMR and HRESIMS spectra, followed by a comparison with existing literatures. The evaluation on α-glucosidase inhibitory exhibited the great potential of the application of these isolated compounds in diabetes treat...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Hoang-Vinh-Truong Phan Duy Vu Nguyen Thi-Kim-Dung Le Thi-Anh-Minh Nguyen Phan-Si-Nguyen Dong Thanh-Nha Tran Ngoc-Van-Trang Dao Hieu Cuong Nguyen Hong Truong Luu Warinthorn Chavasiri Le-Thuy-Thuy-Trang Hoang Van-Kieu Nguyen Source Type: research
Sucrose esters of aryldihydronaphthalene-type lignans, and antitumor activity of extracts of < em > Moltkiopsis ciliata < /em > (Forssk.) aerial parts
Nat Prod Res. 2024 Apr 11:1-11. doi: 10.1080/14786419.2024.2341307. Online ahead of print.ABSTRACTOne new compound (3f-[(7'R,8'R)-4,4'-dihydroxy-5-methoxy-2,7'-cycloligna-7-en-9-methoxycarbonyl, 9'-carbonyl-O-] -β- D-fructofuranosyl- (2→1)-α- D-glucopyranoside) (Moltkiopsin A) (2) was isolated and identified from the extract of aerial parts of the wild Egyptian plant Moltkiopsis ciliata (Frossk.), family Boraginaceae, for the first time, along with two aryldihydronaphthalene lignans 3f→9':6f→9-[(7'R,8'R)-4,4'- dihydroxy-3,3',5-trimethoxy-2,7'-cycloligna-7-en-9,9'-dicarbonyl]-6g-acetyl-α-D-gluco pyranosyl-(1→2) -...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Amal Mahmoud Youssef Moustafa Mohamed Abdel-Moneim Mohamed E Mostafa Mamdouh Abdel-Mogib Marwa Rabee Abdel-Hak Source Type: research
Testusterol, a new sterol of the sponge species < em > Xestospongia testudinaria < /em > from Phu Quoc island, Vietnam
Nat Prod Res. 2024 Apr 11:1-9. doi: 10.1080/14786419.2024.2340757. Online ahead of print.ABSTRACTA new sterol, named testusterol (1), and five known compounds (2-6) were isolated from the n-hexane and dichloromethane extracts of the sponge species Xestospongia testudinaria. Their chemical structures were elucidated based on extensive spectroscopic analyses (1D, 2D NMR, ESIMS and HRESIMS) and comparison with published data. The results of in vitro test (utilizing brine shrimp Artemia salina LEACH) showed that three extracts ethanol, dichloromethane, and ethanol/water, significantly inhibited Artemia salina with LC50 values ...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Phuong Vu Luu Hien Minh Nguyen Phuc Minh Phan An Duy Vo Huong Lien Ton-Nu Source Type: research
Morusacerane: A new gammacerane triterpenoid from the trunk of < em > Morus Alba < /em > linn. with < em > α < /em > -glucosidase inhibitory activity
Nat Prod Res. 2024 Apr 11:1-10. doi: 10.1080/14786419.2024.2340043. Online ahead of print.ABSTRACTThis phytochemistry investigation on the trunk of Morus alba L. resulted in the isolation of three triterpenoids, including a new gammacerane triterpenoid - morusacerane (1); along with two known compounds of betulinic acid (2) and ursolic acid (3). The structure elucidation was thoroughly conducted based on 1D, 2D-NMR and HRESIMS spectra, followed by a comparison with existing literatures. The evaluation on α-glucosidase inhibitory exhibited the great potential of the application of these isolated compounds in diabetes treat...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Hoang-Vinh-Truong Phan Duy Vu Nguyen Thi-Kim-Dung Le Thi-Anh-Minh Nguyen Phan-Si-Nguyen Dong Thanh-Nha Tran Ngoc-Van-Trang Dao Hieu Cuong Nguyen Hong Truong Luu Warinthorn Chavasiri Le-Thuy-Thuy-Trang Hoang Van-Kieu Nguyen Source Type: research
