Nutritional composition assessment and antimicrobial activity of < em > Catostylus perezi < /em > , jellyfish blooms along the coast of Pakistan: an awareness to avoid food neophobia in Pakistan
This study highlighted the nutritional importance of Catostylus perezi (an edible jellyfish) in Pakistan; a society where a large proportion of the population suffers from malnutrition, while C. perezi, a blessing of the sea, is wasted or exported. In the present study, the amino acid and fatty acid profiles of the oral arms and umbrella of C. perezi were determined by HPLC. The total amino acid concentration (ΣAA) in the oral arms was 151.19 mg/100g, while in the umbrella it was 100.17 mg/100g. The ratio of total essential amino acids to total non-essential amino acids (TEAA/TNEAA) was 0.72 in the oral arms, while it was...
Source: Natural Product Research - October 18, 2023 Category: Biochemistry Authors: Muhammad Naveed Malik Wajid Hussain Chan Sadar Aslam Fenghuan Wang Anas Sajjad Asad Ullah Nida Saleem Muhammad Samee Haider Victoria Arija Source Type: research
Design, synthesis and neuroprotective evaluation of nitrogen heterocyclic and triazole derivatives of sarracinic acid
Nat Prod Res. 2023 Oct 18:1-10. doi: 10.1080/14786419.2023.2269464. Online ahead of print.ABSTRACTNovel sarracinic acid derivatives bearing triazole or N-heterocyclic moiety were prepared via two separate reaction schemes. The triazoles and the N-heterocyclic derivatives were synthesised using standard click chemistry approach and amination of 2-bromoethyl ester of sarracinic acid respectively. All the synthesised derivatives were screened for in vitro neuroprotective activity against corticosterone induced impairment in neuroblastoma cell line SH-SY5Y. Two analogs SA-2 and SA-12 exhibited strong neuroprotective activity. ...
Source: Natural Product Research - October 18, 2023 Category: Biochemistry Authors: Salman Jameel Loveleena Kaur Henna Amin Showkat Ahmad Bhat Fayaz A Malik Khursheed Ahmad Bhat Source Type: research
Alternaphenol B2, a new IDH1 inhibitor from the coral-derived fungus < em > Parengyodontium album < /em > SCSIO SX7W11
Nat Prod Res. 2023 Oct 18:1-7. doi: 10.1080/14786419.2023.2269462. Online ahead of print.ABSTRACTA new aromatic polyketide, alternaphenol B2 (1), and four known compounds (2-5) were isolated from the coral-derived fungus Parengyodontium album SCSIO SX7W11. Their structures were elucidated by high-resolution mass spectrometry, 1D and 2D NMR spectroscopy and comparison with reported literatures. Compounds 1 and 2 exhibited selective inhibitory activity against isocitrate dehydrogenase mutant R132H (IDH1m), with IC50 values of 41.9 and 27.7 μM, respectively. Our findings thus provide a fresh incentive for investigation on ID...
Source: Natural Product Research - October 18, 2023 Category: Biochemistry Authors: Xiaoyue Li Wenbin Shen Guochao Li Yongxiang Song Xinhua Lu Nai-Kei Wong Yan Yan Source Type: research
Bisabolane-type sesquiterpenoids and bacillibactin from the marine-derived fungus < em > Aspergillus sydowii < /em > SCSIO 41041 and their enzyme inhibiting activity
Nat Prod Res. 2023 Oct 18:1-4. doi: 10.1080/14786419.2023.2269470. Online ahead of print.ABSTRACTTwelve compounds, including eleven bisabolane-type sesquiterpenoids (1 - 11), and one bacillibactin (12) were identified from marine-derived fungus Aspergillus sydowii SCSIO 41041 isolated from Creseis acicula. The chemical structures were elucidated by the basis of spectroscopic evidences, including HRESIMS, NMR and optical rotation. Biologically, all compounds were evaluated for their acetyl cholin-esterase (AChE) enzyme, pancreatic lipase (PL) enzyme, neuraminidase (NA) and phosphodiesterase 4 (PDE4) inhibitory activities. C...
Source: Natural Product Research - October 18, 2023 Category: Biochemistry Authors: Ying-Ying Song Qing-Xia Liu Xiao-Yan Pang Zhi-Yun Chen Hong-Hui Huang Jun-Feng Wang Yong-Hong Liu Source Type: research
Two new flavanones from < em > Polytrichum commune < /em > Hedw
Nat Prod Res. 2023 Oct 18:1-7. doi: 10.1080/14786419.2023.2272030. Online ahead of print.ABSTRACTSeven flavanones, including two new compounds coupled with styryl units, communins C (1) and D (2), as well as five known compounds, were isolated from Polytrichum commune Hedw. The planar structures of all compounds were determined using extensive spectroscopic analysis. The absolute configurations of two new compounds were assigned by comparing experimental ECD with calculated ECD. The cytotoxicity of all isolates against HCT-116, BGC803, MCF7 and PANC-1 cell lines was evaluated. Communin D exhibited significant cytotoxic act...
Source: Natural Product Research - October 18, 2023 Category: Biochemistry Authors: Hao Cheng Yan-Lei Su Meng-Tong Liu Shi-Nong Yuan Shao-Nan Wang Fang-Jie Hou Ma Dong-Lai Duan Xu-Hong Source Type: research
Polyphenolic characterisation and antiprotozoal effect of extracts obtained by maceration, ultrasound, microwave and ultrasound/microwave of < em > Porophyllum ruderale < /em > (Jacq.) Cass
Nat Prod Res. 2023 Oct 15:1-5. doi: 10.1080/14786419.2023.2265532. Online ahead of print.ABSTRACTPorophyllum ruderale (Jacq.) Cass. (Asteraceae) has antiprotozoal properties and contains extractable phenolic compounds by the maceration method (M). However, new extraction proposals such as ultrasound (U), microwaves (MW), and ultrasound/microwaves (U/MW) have emerged to optimise yields, but it is unknown if these methods modify effectiveness. Therefore, the study consisted of extracting the aerial part of P. ruderale with ethanol using the M, U, MW and U/MW methods to study its composition by RP-HPLC-ESI-MS, its total polyp...
Source: Natural Product Research - October 16, 2023 Category: Biochemistry Authors: Jacqueline Renovato-N úñez Luis Enrique Cobos-Puc Juan Alberto Ascacio-Vald és Ra úl Rodríguez-Herrera Anna Ilin á Mar ía Porfiria Barrón-González Crystel Aleyvick Sierra-Rivera Sonia Yesenia Silva-Belmares Source Type: research
Metabolomic profiling and antidiabetic activity of < em > Callerya speciosa < /em >
This study was to reveal the similarities and differences between phytochemicals in different parts of C. speciosa using a combination of ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS), principal component analysis (PCA) and orthogonal projection to latent structures discriminant analysis (OPLS-DA). In addition, the anti-diabetic activity of C. speciosa extracts was explored. A total of 141 compounds were identified and 34 robustly known chemical markers were marked. PCA and heat map analyses revealed that the stems, leaves and pods had similar phytochemical comp...
Source: Natural Product Research - October 16, 2023 Category: Biochemistry Authors: Qing Yang Qinglong Wang Zhunian Wang Zhiying Li Huan Tang Xiaoxia Yan Shixiu Feng Maoyuan Wang Source Type: research
Metabolomic and antioxidant analyses of < em > Salvia miltiorrhiza < /em > Bunge and < em > Salvia prattii < /em > Hemsl. seeds
In this study, UPLC-MS and GC-MS based on extensively focused metabolomics were used to compare the seed metabolomics of the two species. LC-MS detected 118 metabolites, primarily Lipids and phenylpropanoids. GC- MS detected a total of 188 metabolites, mainly organic acids and their derivatives, of which Salvia prattii seeds contain high levels of nutrients. In addition, we experimentally determined antioxidant activity of two Salvia species, and the results showed that the antioxidant activity of Salvia prattii seeds was about twice as high as that of Salvia miltiorrhiza seeds. We used WGCNA to group the metabolites, and ...
Source: Natural Product Research - October 16, 2023 Category: Biochemistry Authors: Yuting Xia Lan Zhang Xinyu Hong Yanbo Huang Ganggui Lou Zhuoni Hou Ann Abozeid Yukun Wei Dongfeng Yang Source Type: research
Naturally occurring organosulfur compounds effectively inhibits PCSK-9 activity and restrict PCSK-9-LDL-receptor interaction via < em > in-silico < /em > and < em > in-vitro < /em > approach
In conclusion, the presented data illustrated that SEC, SAC, and DAT were the best inhibitors of PCSK-9 activity and may have the potential to improve the LDL-R function and lower the circulatory LDL-C level.PMID:37842787 | DOI:10.1080/14786419.2023.2269465 (Source: Natural Product Research)
Source: Natural Product Research - October 16, 2023 Category: Biochemistry Authors: Parvej Ahmad Sahir S Alvi Mohd Waiz Mohd Shahnawaz Khan Saheem Ahmad M Salman Khan Source Type: research
Polyphenolic characterisation and antiprotozoal effect of extracts obtained by maceration, ultrasound, microwave and ultrasound/microwave of < em > Porophyllum ruderale < /em > (Jacq.) Cass
Nat Prod Res. 2023 Oct 15:1-5. doi: 10.1080/14786419.2023.2265532. Online ahead of print.ABSTRACTPorophyllum ruderale (Jacq.) Cass. (Asteraceae) has antiprotozoal properties and contains extractable phenolic compounds by the maceration method (M). However, new extraction proposals such as ultrasound (U), microwaves (MW), and ultrasound/microwaves (U/MW) have emerged to optimise yields, but it is unknown if these methods modify effectiveness. Therefore, the study consisted of extracting the aerial part of P. ruderale with ethanol using the M, U, MW and U/MW methods to study its composition by RP-HPLC-ESI-MS, its total polyp...
Source: Natural Product Research - October 16, 2023 Category: Biochemistry Authors: Jacqueline Renovato-N úñez Luis Enrique Cobos-Puc Juan Alberto Ascacio-Vald és Ra úl Rodríguez-Herrera Anna Ilin á Mar ía Porfiria Barrón-González Crystel Aleyvick Sierra-Rivera Sonia Yesenia Silva-Belmares Source Type: research
Metabolomic profiling and antidiabetic activity of < em > Callerya speciosa < /em >
This study was to reveal the similarities and differences between phytochemicals in different parts of C. speciosa using a combination of ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS), principal component analysis (PCA) and orthogonal projection to latent structures discriminant analysis (OPLS-DA). In addition, the anti-diabetic activity of C. speciosa extracts was explored. A total of 141 compounds were identified and 34 robustly known chemical markers were marked. PCA and heat map analyses revealed that the stems, leaves and pods had similar phytochemical comp...
Source: Natural Product Research - October 16, 2023 Category: Biochemistry Authors: Qing Yang Qinglong Wang Zhunian Wang Zhiying Li Huan Tang Xiaoxia Yan Shixiu Feng Maoyuan Wang Source Type: research
Metabolomic and antioxidant analyses of < em > Salvia miltiorrhiza < /em > Bunge and < em > Salvia prattii < /em > Hemsl. seeds
In this study, UPLC-MS and GC-MS based on extensively focused metabolomics were used to compare the seed metabolomics of the two species. LC-MS detected 118 metabolites, primarily Lipids and phenylpropanoids. GC- MS detected a total of 188 metabolites, mainly organic acids and their derivatives, of which Salvia prattii seeds contain high levels of nutrients. In addition, we experimentally determined antioxidant activity of two Salvia species, and the results showed that the antioxidant activity of Salvia prattii seeds was about twice as high as that of Salvia miltiorrhiza seeds. We used WGCNA to group the metabolites, and ...
Source: Natural Product Research - October 16, 2023 Category: Biochemistry Authors: Yuting Xia Lan Zhang Xinyu Hong Yanbo Huang Ganggui Lou Zhuoni Hou Ann Abozeid Yukun Wei Dongfeng Yang Source Type: research
Naturally occurring organosulfur compounds effectively inhibits PCSK-9 activity and restrict PCSK-9-LDL-receptor interaction via < em > in-silico < /em > and < em > in-vitro < /em > approach
In conclusion, the presented data illustrated that SEC, SAC, and DAT were the best inhibitors of PCSK-9 activity and may have the potential to improve the LDL-R function and lower the circulatory LDL-C level.PMID:37842787 | DOI:10.1080/14786419.2023.2269465 (Source: Natural Product Research)
Source: Natural Product Research - October 16, 2023 Category: Biochemistry Authors: Parvej Ahmad Sahir S Alvi Mohd Waiz Mohd Shahnawaz Khan Saheem Ahmad M Salman Khan Source Type: research
Polyphenolic characterisation and antiprotozoal effect of extracts obtained by maceration, ultrasound, microwave and ultrasound/microwave of < em > Porophyllum ruderale < /em > (Jacq.) Cass
Nat Prod Res. 2023 Oct 15:1-5. doi: 10.1080/14786419.2023.2265532. Online ahead of print.ABSTRACTPorophyllum ruderale (Jacq.) Cass. (Asteraceae) has antiprotozoal properties and contains extractable phenolic compounds by the maceration method (M). However, new extraction proposals such as ultrasound (U), microwaves (MW), and ultrasound/microwaves (U/MW) have emerged to optimise yields, but it is unknown if these methods modify effectiveness. Therefore, the study consisted of extracting the aerial part of P. ruderale with ethanol using the M, U, MW and U/MW methods to study its composition by RP-HPLC-ESI-MS, its total polyp...
Source: Natural Product Research - October 16, 2023 Category: Biochemistry Authors: Jacqueline Renovato-N úñez Luis Enrique Cobos-Puc Juan Alberto Ascacio-Vald és Ra úl Rodríguez-Herrera Anna Ilin á Mar ía Porfiria Barrón-González Crystel Aleyvick Sierra-Rivera Sonia Yesenia Silva-Belmares Source Type: research
Metabolomic profiling and antidiabetic activity of < em > Callerya speciosa < /em >
This study was to reveal the similarities and differences between phytochemicals in different parts of C. speciosa using a combination of ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS), principal component analysis (PCA) and orthogonal projection to latent structures discriminant analysis (OPLS-DA). In addition, the anti-diabetic activity of C. speciosa extracts was explored. A total of 141 compounds were identified and 34 robustly known chemical markers were marked. PCA and heat map analyses revealed that the stems, leaves and pods had similar phytochemical comp...
Source: Natural Product Research - October 16, 2023 Category: Biochemistry Authors: Qing Yang Qinglong Wang Zhunian Wang Zhiying Li Huan Tang Xiaoxia Yan Shixiu Feng Maoyuan Wang Source Type: research
