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Effect of saline stress on the metabolic profile and antidiabetic potential of Physalis peruviana 
This study aimed to evaluate the effects of applying NaCl (0, 10, 20, 30, and 40 mM) to goldenberry plants on the metabolite profile and hypoglycaemic potential of both fruit and leaf decoctions. The findings demonstrated that NaCl increases the phenolic content, flavonoids, and hydrolysable polyphenols in leaf decoctions. Additionally, four alkaloids previously unreported in Physalis peruviana were identified. Saline stress improved the profile of extractable and non-extractable phenolic compounds in both leaves and fruits. Furthermore, incubation with decoctions of stressed leaves at a concentration of 0.50 mg/mL reduced...
Source: Natural Product Research - March 19, 2024 Category: Biochemistry Authors: Nayely Gonz ález-Buenrostro Iza F P érez-Ramírez Ofelia Mora Alejandro Rios-Lozano Ma Estela V ázquez-Barrios Rosal ía Reynoso-Camacho Marely G Figueroa-P érez Source Type: research

Two new megastigmane glycosides from the leaves of Nicotiana tabacum and their anti-inflammatory activities
Nat Prod Res. 2024 Mar 19:1-5. doi: 10.1080/14786419.2024.2331042. Online ahead of print.ABSTRACTTwo new megastigmane glycosides, (6 R,7E,9R)-3-oxo-α-ionyl-9-O-α-L-rhamnopyranosyl-(1''→4')-β-D-glucopyranoside (1) and (6 R,7E,9R)-3-oxo-α-ionyl-9-O-β-D-glucopyranosyl-(1''→6')-β-D-glucopyranoside (2), together with six known analogues (3-8) were isolated from the leaves of Nicotiana tabacum. The structures of all metabolites were determined by comprehensive analysis of NMR and MS spectroscopic data as well as by comparison with those of previously reported. The in vitro anti-inflammatory activity of all isolates was...
Source: Natural Product Research - March 19, 2024 Category: Biochemistry Authors: Peng-Fei Yang Wei Wu Hang-Hang Han Qing-Fu Wang Lei Li Ze-Ning Wang Duo-Bin Mao Zhi-Fei Chen Source Type: research

High perillaldehyde content from essential oils of Ammodaucus leucotrichus subsp . leucotrichus Cosson & amp; Durieu fruits from Aougrout (Algeria)
Nat Prod Res. 2024 Mar 19:1-6. doi: 10.1080/14786419.2024.2331043. Online ahead of print.ABSTRACTThe chemical composition of the essential oil produced by hydrodistillation from the fruits of Ammodaucus leucotrichus subsp. leucotrichus Cosson & Durieu collected from southern Algeria, precisely in Aougrout District (Adrar Province), was determined by GC-MS analysis. Nineteen (19) compounds, representing 85.71% of the essential oil, were found. The essential oil contained a high percentage of perillaldehyde (80.69%). This composition is compared to numerous reported essential oils of A. leucotrichus subsp. leucotrichus f...
Source: Natural Product Research - March 19, 2024 Category: Biochemistry Authors: Zineb Louail Nadjette Djemouai Karima Bouti Hassina Tounsi Abdelkrim Kameli Source Type: research

Could lactose-free foods influence the gut microbiome?
Nat Prod Res. 2024 Mar 18:1-2. doi: 10.1080/14786419.2024.2325584. Online ahead of print.NO ABSTRACTPMID:38497246 | DOI:10.1080/14786419.2024.2325584 (Source: Natural Product Research)
Source: Natural Product Research - March 18, 2024 Category: Biochemistry Authors: Eleonora Di Salvo Nicola Cicero Source Type: research

A lupeol derivative and other isolates with antiplasmodial activity from the stem root of Rauvolfia mannii Stapf. (Apocynaceae)
Nat Prod Res. 2024 Mar 18:1-5. doi: 10.1080/14786419.2024.2327623. Online ahead of print.ABSTRACTRauvolfia mannii is a plant from western and eastern areas of African continent and is widely used in folk medicine for the treatment of various diseases including malaria. Herein, one previously undescribed acylated triterpene (1), together with five already published natural products (2-6) were removed from its roots. The chemical structures of these compounds were determined by spectroscopic and spectrometric means (NMR, HRESIMS, IR and UV). In addition to the isolated triterpenoids, components 5 and 6 are also newly reporte...
Source: Natural Product Research - March 18, 2024 Category: Biochemistry Authors: Fred Alain Zoua Daniela Ntomi Djipmegne Mc J ésus Kinyok Auguste Abouem A Zintchem Andr é Néhémie Bitombo Rostanie Dongmo Zeukang Solenn Ferron Dominique Serge Ngono Bikobo Sophie Tomasi Dieudonn é Emmanuel Pegnyemb Source Type: research

Multiple integrated computational approach to analyse wound healing potential of Symplocos racemosa bark as Matrix metalloproteinase inhibitors
Nat Prod Res. 2024 Mar 18:1-10. doi: 10.1080/14786419.2024.2321488. Online ahead of print.ABSTRACTThe healing of wounds is the flagging concern in chronic wound cases especially when accompanied by pathogenic, diabetic comorbidities. Matrix metalloproteinases are associated with widespread pathological ailments, and the selective inhibitors for metalloproteinases can be of great interest in wound healing strategies. In the present research study, six constituents of Symplocos racemosa Roxb were evaluated for the docking aptitudes on human matrix metalloproteinase MMP 2 (PDB ID: 1QIB) and MMP 9 (PDB ID: 4H1Q) utilising Auto...
Source: Natural Product Research - March 18, 2024 Category: Biochemistry Authors: Hafiz Abdul Rafey Adnan Amin Samir Anis Ross Mohamed El-Shazly Muhammad Ammar Zahid Shah Iram Niaz Fakhar Ul Mahmood Hammad Ullah Source Type: research

Flavonoids, biphenyls and xanthones from the genus Clusia : chemistry, biological activities and chemophenetics relevance
Nat Prod Res. 2024 Mar 18:1-14. doi: 10.1080/14786419.2024.2330515. Online ahead of print.ABSTRACTClusia is one of the most important genera of the Clusiaceae family, comprising up to 400 species. This review describes the identification of twenty-two flavonoids from Clusia species, which includes five flavonols (1-4 and 11), six flavones (5-10), one catechin (12), one flavanone (13), and nine biflavonoids (14-22). O- and C-glycosylation are frequently observed amongst these flavonoids. Furthermore, seven biphenyls (23-29) and nine xanthones (30-38) have been isolated from Clusia species. Biphenyls and xanthones show limit...
Source: Natural Product Research - March 18, 2024 Category: Biochemistry Authors: Ismirna I P Dos Santos Maria do Carmo C Silva Caline G Ferraz Paulo R Ribeiro Source Type: research

The chemical composition of the aerial parts' essential oil of matthiola fruticulosa (L.) maire growing in Sicily, Italy
Nat Prod Res. 2024 Mar 18:1-7. doi: 10.1080/14786419.2024.2330521. Online ahead of print.ABSTRACTMatthiola Aiton is a genus belonging to the Brassicaceae family, distributed in Macaronesia, the Mediterranean basin, and the Saharo-Sindian region. Plants of this genus are used against various diseases in the ethno-medicine of several countries and a complete review of their usage has been carried out in this paper. In the present study, the essential oil chemical composition of the aerial parts of the Sicilian accession of Matthiola fruticulosa (L.) Maire, a species growing in South-Western Europe, Northern Africa, and Weste...
Source: Natural Product Research - March 18, 2024 Category: Biochemistry Authors: Natale Badalamenti Alessandro Vaglica Antonella Porrello Vincenzo Ilardi Maurizio Bruno Source Type: research

Steroidal saponins and homoisoflavonoids from the fibrous roots of ophiopogon japonicus and their anti-pulmonary fibrosis activities
Nat Prod Res. 2024 Mar 18:1-11. doi: 10.1080/14786419.2024.2331044. Online ahead of print.ABSTRACTThe chemical investigation of the fibrous roots of Ophiopogon japonicus afforded two new steroidal saponins, named ophiojaponin F (1) and ophiojaponin G (2), together with twelve known steroidal saponins (3-14) and ten known homoisoflavonoids (15-24). The structures of the isolated compounds were established unambiguously via spectroscopic analyses (NMR and HR-ESI-MS). Ophiojaponin F (1) is a 23-hydroxylated spirostanol saponin, and this type of steroidal saponin rarely been reported in liriopogons. All isolates were evaluated...
Source: Natural Product Research - March 18, 2024 Category: Biochemistry Authors: Hang-Yi Pu Yu Cao Xi-Lang Jiang Lin-Han Yang Ming-Kui Wang Fei Wang Lun Wang Source Type: research

Anti-vibriosis bioactive molecules from marine-derived variant Streptomyces sp. ZZ741A
In this study, six compounds (1-6) were isolated from the Streptomyces sp. ZZ741A, a marine-derived Streptomyces variant, including one new compound, 2-carbamoylphenyl isobutyrate (1), five known ones, nocardamine (2), dehydroxynocardamine (3), phenylacetic acid (4), thiophenol (5) and 2,3-dihydroxybenzoic acid (6). The anti-vibriosis assay showed that compounds 2 and 3 had specific inhibition activity against Vibrio vulnificus, Vibrio alginolyticus, and Vibrio parahaemolyticus with the MIC values ranging from 8 to 128 μg/mL. The molecular docking study of their possible mechanism of anti-vibriosis activity showed that th...
Source: Natural Product Research - March 15, 2024 Category: Biochemistry Authors: Di Zhang Yao Feng Mingyi Chu Yujiang Dai Lu Jiang Huifang Li Source Type: research

Effect of Gracilaria changii extract and its fraction in reverse cholesterol transport by targeting SR-BI gene
Nat Prod Res. 2024 Mar 14:1-8. doi: 10.1080/14786419.2024.2327851. Online ahead of print.ABSTRACTThis present study aimed to investigate the effects of Gracilaria changii (Red seaweed) extract and its fraction on scavenger receptor class B type I (SR-BI) gene expressions. In vitro studies of the activity of G. changii extract and its fraction against the therapeutic target for hypocholesterolemia were conducted using high-density lipoprotein (HDL) receptor SR-BI via luciferase assay in HepG2 cells. In the current study, methanol crude extract (MCE) and Fraction-2 of G. changii showed the highest expression levels of the SR...
Source: Natural Product Research - March 15, 2024 Category: Biochemistry Authors: Mohd Rahaizuddin Rani Ahmad Khusairi Azemi Kamariah Bakar Luqman Abu-Bakar Tengku Sifzizul Tengku Muhammad Noraznawati Ismail Source Type: research