Withaperuvin O, a new withanolide from < em > Physalis peruviana < /em > L
In this study, a new withanolide named withaperuvin O (1) and seven known ones, including physalolactone B-3-O-β-D-glucopyranoside (2), withanolide J (3), physapruin A (4), physaperuvin G (5), withaperuvin (6), withaperuvin C (7) and 28-hydroxywithaperuvin C (8), were isolated from the whole plants of P. peruviana. Their structures were elucidated based on extensive spectroscopic analyses including NMR and HR-ESI-MS. The bioactivities of these compounds against lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells and cytotoxicity against HepG2 were tested. Compound 3 showed strong anti-inflammatory activities ...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Pham Van Cong Vu Thi Trang Le Quynh Lien Vu Xuan Hoan Tran Minh Ngoc Do Thanh Tuan Do Thi Thu Hien Ngo Van Hieu Ngo Viet Duc Hoang Le Tuan Anh Source Type: research
Effects of trigonelline, diosgenin, and < em > Cistanche deserticola < /em > polysaccharide on the culture of female germline stem cells < em > in vitro < /em >
Nat Prod Res. 2024 Mar 1:1-8. doi: 10.1080/14786419.2024.2319661. Online ahead of print.ABSTRACTFemale germline stem cells (FGSCs) are renewable sources of oocytes that play an indispensable role in re-establishing mammal fertility. Here, we have established FGSCs from neonatal mice, which exhibit characteristics of germline stem cells. We show that compared with monomeric trigonelline and diosgenin, macromolecular compounds Cistanche deserticola polysaccharides (CDPs) in Chinese herbal medicine can enhance the ability of FGSCs to differentiate into oocytes at appropriate concentrations while maintaining self-renewal in vi...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Xiaoli Yu Yikai Qiu Jinhua Li Yanping Zhang Qian Wang Zehua Jin Xinrui Liu Xiuying Pei Source Type: research
Production, physico-chemical properties and antioxidant activity of melanin from < em > Annulohypoxylon stygium < /em > (L év.) Y.M. Ju, J.D. Rogers and H.M. Hsieh
Nat Prod Res. 2024 Feb 29:1-10. doi: 10.1080/14786419.2024.2320741. Online ahead of print.ABSTRACTTo obtain higher melanin production in liquid culture, culture conditions of Annulohypoxylon stygium (Lév.) Y.M. Ju, J.D. Rogers and H.M. Hsieh were optimised. The results showed that using single factor experiment and orthogonal test, the optimised production of melanin reached 2.20 g/L, which was 2.06 times higher than that of the control group. In addition, it was speculated that A. stygium melanin (AsM) was 3,4-dihydroxyphenylalanine (DOPA) melanin and showed an amorphous irregular structure. Moreover, it had good solubil...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Ruofan Liu Cuiyuan Mo Xianfu Meng Xuetuan Wei Aimin Ma Source Type: research
Characterisation of bioactive compounds from leaves of < em > Smilax fluminensis < /em > Steud. by gc-MS and LC-DAD-MS, and analysis of its antioxidant and ecotoxicological activities
Nat Prod Res. 2024 Feb 29:1-9. doi: 10.1080/14786419.2024.2324375. Online ahead of print.ABSTRACTSmilax fluminensis Steud. is distributed in Central and South America, commonly named as 'salsaparilha' or 'japicanga'. In the present work, the chemical composition was determined, antioxidant and cytotoxic effects were evaluated for the ethanol extract (EE) and fractions from leaves. Fatty acid esters and phytol were characterised in the hexane (HEX) fraction. O-glycosylated flavonols and flavones, caffeic acid derivatives, and steroidal saponins were annotated for EE, and dichloromethane (DCM), ethyl acetate (AC), and hydroe...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Lucas Santos Azevedo Juliana Costa Fonseca Ana Hort ência Fonsêca Castro Katyuce de Souza Farias Vanessa Sam údio Santos Zanuncio Denise Brentan Silva Luciana Alves Rodrigues Dos Santos Lima Source Type: research
Withaperuvin O, a new withanolide from < em > Physalis peruviana < /em > L
In this study, a new withanolide named withaperuvin O (1) and seven known ones, including physalolactone B-3-O-β-D-glucopyranoside (2), withanolide J (3), physapruin A (4), physaperuvin G (5), withaperuvin (6), withaperuvin C (7) and 28-hydroxywithaperuvin C (8), were isolated from the whole plants of P. peruviana. Their structures were elucidated based on extensive spectroscopic analyses including NMR and HR-ESI-MS. The bioactivities of these compounds against lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells and cytotoxicity against HepG2 were tested. Compound 3 showed strong anti-inflammatory activities ...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Pham Van Cong Vu Thi Trang Le Quynh Lien Vu Xuan Hoan Tran Minh Ngoc Do Thanh Tuan Do Thi Thu Hien Ngo Van Hieu Ngo Viet Duc Hoang Le Tuan Anh Source Type: research
Effects of trigonelline, diosgenin, and < em > Cistanche deserticola < /em > polysaccharide on the culture of female germline stem cells < em > in vitro < /em >
Nat Prod Res. 2024 Mar 1:1-8. doi: 10.1080/14786419.2024.2319661. Online ahead of print.ABSTRACTFemale germline stem cells (FGSCs) are renewable sources of oocytes that play an indispensable role in re-establishing mammal fertility. Here, we have established FGSCs from neonatal mice, which exhibit characteristics of germline stem cells. We show that compared with monomeric trigonelline and diosgenin, macromolecular compounds Cistanche deserticola polysaccharides (CDPs) in Chinese herbal medicine can enhance the ability of FGSCs to differentiate into oocytes at appropriate concentrations while maintaining self-renewal in vi...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Xiaoli Yu Yikai Qiu Jinhua Li Yanping Zhang Qian Wang Zehua Jin Xinrui Liu Xiuying Pei Source Type: research
Production, physico-chemical properties and antioxidant activity of melanin from < em > Annulohypoxylon stygium < /em > (L év.) Y.M. Ju, J.D. Rogers and H.M. Hsieh
Nat Prod Res. 2024 Feb 29:1-10. doi: 10.1080/14786419.2024.2320741. Online ahead of print.ABSTRACTTo obtain higher melanin production in liquid culture, culture conditions of Annulohypoxylon stygium (Lév.) Y.M. Ju, J.D. Rogers and H.M. Hsieh were optimised. The results showed that using single factor experiment and orthogonal test, the optimised production of melanin reached 2.20 g/L, which was 2.06 times higher than that of the control group. In addition, it was speculated that A. stygium melanin (AsM) was 3,4-dihydroxyphenylalanine (DOPA) melanin and showed an amorphous irregular structure. Moreover, it had good solubil...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Ruofan Liu Cuiyuan Mo Xianfu Meng Xuetuan Wei Aimin Ma Source Type: research
Characterisation of bioactive compounds from leaves of < em > Smilax fluminensis < /em > Steud. by gc-MS and LC-DAD-MS, and analysis of its antioxidant and ecotoxicological activities
Nat Prod Res. 2024 Feb 29:1-9. doi: 10.1080/14786419.2024.2324375. Online ahead of print.ABSTRACTSmilax fluminensis Steud. is distributed in Central and South America, commonly named as 'salsaparilha' or 'japicanga'. In the present work, the chemical composition was determined, antioxidant and cytotoxic effects were evaluated for the ethanol extract (EE) and fractions from leaves. Fatty acid esters and phytol were characterised in the hexane (HEX) fraction. O-glycosylated flavonols and flavones, caffeic acid derivatives, and steroidal saponins were annotated for EE, and dichloromethane (DCM), ethyl acetate (AC), and hydroe...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Lucas Santos Azevedo Juliana Costa Fonseca Ana Hort ência Fonsêca Castro Katyuce de Souza Farias Vanessa Sam údio Santos Zanuncio Denise Brentan Silva Luciana Alves Rodrigues Dos Santos Lima Source Type: research
If speed is of the essence: rapid analysis of ambergris by APCI compact mass spectrometry
Nat Prod Res. 2024 Feb 28:1-7. doi: 10.1080/14786419.2024.2321496. Online ahead of print.ABSTRACTThe use of atmospheric pressure chemical ionisation (APCI) compact mass spectrometry (CMS) was investigated for the analysis of jetsam and museum-archived ambergris and of ambergris components in perfumes. The data were compared with those from existing methods. Authentic samples of some individual ambergris constituents (ambrein, coprostanol, epicoprostanol and coprostanone), were also examined. Rapid APCI CMS was achieved using either a solids probe or a probe with solutions held in capillary melting point tubes. Interpretati...
Source: Natural Product Research - February 29, 2024 Category: Biochemistry Authors: Steven J Rowland Michael J Wilde Paul A Sutton Sabena J Blackbird George A Wolff Source Type: research
New dammarane-type triterpenoids from the whole plant of < em > Euphorbia hypericifolia < /em >
Nat Prod Res. 2024 Feb 28:1-6. doi: 10.1080/14786419.2024.2324106. Online ahead of print.ABSTRACTEuphorhypenoids A (1) and B (2), two new dammarane-type triterpenoids, along with four known tetracyclic triterpenoids (3-6), were isolated from the whole plant of Euphorbia hypericifolia. The structures of new compounds were mainly elucidated by a series of extensive spectroscopic methods, including HR-ESI-MS, NMR, IR, and UV. Compound 1 exhibited significant inhibitory effect on platelet aggregation at concentrations of 10 - 200 µM.PMID:38419300 | DOI:10.1080/14786419.2024.2324106 (Source: Natural Product Research)
Source: Natural Product Research - February 29, 2024 Category: Biochemistry Authors: Mengke Xu Jiacheng Liu Wenrui Sun Yutian Chen Mengyu Wang Yangfan Zhou Source Type: research
Identification and < em > α < /em > -glucosidase inhibitory activity evaluation of two new coumarins derived from < em > Mansonia gagei < /em > J. R. Drumm
Nat Prod Res. 2024 Feb 29:1-6. doi: 10.1080/14786419.2024.2324367. Online ahead of print.ABSTRACTFive coumarins were isolated from the heartwood of Mansonia gagei, which included two newly discovered compounds, namely 11-hydroxypopulene E (1) and mansorin D (2), along with three previously identified compounds. The structures were determined through the utilisation of comprehensive spectroscopic data, ECD calculations, and a thorough comparison with existing literature data. The α-glucosidase inhibitory activities of all isolated compounds were assessed in yeast. Out of the compounds tested, compound 2 exhibited the most ...
Source: Natural Product Research - February 29, 2024 Category: Biochemistry Authors: Huong Thi Thu Le Yusuke Hioki Duy Vu Nguyen Thi-Kim-Dung Le Van-Kieu Nguyen Tien T Dang Thi-Anh-Tuyet Nguyen Thi-Hoai-Thu Nguyen Thi-Hai-Duyen Vu Thi-Kim-Ngan Pham Masaki Kita Warinthorn Chavasiri Source Type: research
Phytochemical study of'< em > taiji' < /em > ( < em > Handroanthus impetiginosus < /em > (Mart.) Mattos) and < em > 'ka'a ovet ĩ' < /em > ( < em > Luehea divaricata < /em > Mart.) extracts
This study explores the phytochemical composition of leaf extracts from Handroanthus impetiginosus (Mart.) Mattos and Luehea divaricata Mart., used in a contraceptive decoction by Mbya-Guarani women. The phytocompounds were identified by gas chro-matography-mass spectrometry, while Fourier-transform infrared spectroscopy, multi-elemental, and thermal analyses were used to characterise plant biomass. Notably, no phytoconstituent supporting the efficacy of these extracts as female contraceptives was found, except for a small amount (0.3%) of sitosterol. Conversely, L. divaricata leaves contained compounds like 1,3-dihydroxya...
Source: Natural Product Research - February 28, 2024 Category: Biochemistry Authors: Eva S ánchez-Hernández Claudia C áceres-González Jos é Ignacio García-Valdecasas Sintya Valdez-Ayala Jes ús Martín-Gil Pablo Mart ín-Ramos Source Type: research
Evaluation of traditional uses, phytochemical constituents, therapeutic uses and future prospects of Pyracantha genus: a systematic review
In this study, 189 research and review articles were scanned to provide summarised research of phytochemical composition, pharmacological effects and future prospects of the species which can benefit the plant as a therapeutic drug or as a functional food.PMID:38414268 | DOI:10.1080/14786419.2024.2319660 (Source: Natural Product Research)
Source: Natural Product Research - February 28, 2024 Category: Biochemistry Authors: Aishna Chauhan Ritesh Banerjee Source Type: research
A comparative study of secondary metabolites profiling and biological activity of < em > Smyrnium olusatrum < /em > L. leaf, flower and fruit
Nat Prod Res. 2024 Feb 28:1-15. doi: 10.1080/14786419.2024.2321484. Online ahead of print.ABSTRACTEssential oil (EO) composition of Smyrnium olusatrum was characterised by high proportion of furanosesquiterpenes (51.66-69.35%). The leaf methanolic extract composition was found to be rich with Quercetin-O-hexoside (39.78%). Apigenin 6,8-di-Chexoside represent the major component of flower (18.2%) and fruits (18.82%). Flower extract exhibited the highest contents of total phenolic (48.97 mg GAE/g) and flavonoid (52.63 mg RE/g). The β-carotene and lycopene contents were in the order of 4.55-26.14 mg/100g, and 8.00-49.45 mg/1...
Source: Natural Product Research - February 28, 2024 Category: Biochemistry Authors: Dhouha Hamdi Aziz Hafidi Jean Jacques Lemaire Chokri Messaoud Source Type: research
Phytochemical study of'< em > taiji' < /em > ( < em > Handroanthus impetiginosus < /em > (Mart.) Mattos) and < em > 'ka'a ovet ĩ' < /em > ( < em > Luehea divaricata < /em > Mart.) extracts
This study explores the phytochemical composition of leaf extracts from Handroanthus impetiginosus (Mart.) Mattos and Luehea divaricata Mart., used in a contraceptive decoction by Mbya-Guarani women. The phytocompounds were identified by gas chro-matography-mass spectrometry, while Fourier-transform infrared spectroscopy, multi-elemental, and thermal analyses were used to characterise plant biomass. Notably, no phytoconstituent supporting the efficacy of these extracts as female contraceptives was found, except for a small amount (0.3%) of sitosterol. Conversely, L. divaricata leaves contained compounds like 1,3-dihydroxya...
Source: Natural Product Research - February 28, 2024 Category: Biochemistry Authors: Eva S ánchez-Hernández Claudia C áceres-González Jos é Ignacio García-Valdecasas Sintya Valdez-Ayala Jes ús Martín-Gil Pablo Mart ín-Ramos Source Type: research
