Natural Product Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A new monocyclic monoterpene derivative from volva of Phallus dongsun 
Nat Prod Res. 2023 Mar 24:1-8. doi: 10.1080/14786419.2023.2193744. Online ahead of print.ABSTRACTA new monoterpene derivative namely dongsunol A (1) and sixteen known compounds (2-17) were isolated from the volva of Phallus dongsun. All compounds were isolated from this fungus for the first time. Their structures and absolute configurations were determined by nuclear magnetic resonance (NMR), HRESIMS spectral data, and electronic circular dichroism (ECD). The new monoterpene derivative (1) exhibited antibacterial activity with a MIC of 200 μg/mL. Other compounds have inhibitory effects on Staphylococcus aureus and Pseudom...
Source: Natural Product Research - March 25, 2023 Category: Biochemistry Authors: Shihao Qian Guangdi Wang Meiling Lu Xian Zhang Tingchi Wen Source Type: research

Yet another in vitro evidence that natural compounds introduced by diet have anti-amyloidogenic activities and can counteract neurodegenerative disease depending on aging
Nat Prod Res. 2023 Mar 24:1-6. doi: 10.1080/14786419.2023.2192493. Online ahead of print.ABSTRACTA major issue in Alzheimer's disease (AD) research is to find some new therapeutic drug which decrease Amyloid-beta (Aβ) aggregation. From a therapeutic point of view the major question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease. Natural compounds are capable of binding to different targets implicated in AD and exert neuroprotective effects. Aim of this study was to evaluate the in vitro inhibition of Aβ1-42 fibrillogenesis in presence of Gallic ...
Source: Natural Product Research - March 25, 2023 Category: Biochemistry Authors: Anna Lia Asti Stefania Crespi Teresa Rampino Paola Zelini Marilena Gregorini Alessia Pascale Nicoletta Marchesi Stefania Saccucci Carla Colombani Sara Vitalini Marcello Iriti Source Type: research

Chemical composition and biological activities of Lonicera caprifolium L. (Caprifoliaceae) essential oil
Nat Prod Res. 2023 Mar 24:1-8. doi: 10.1080/14786419.2023.2193745. Online ahead of print.ABSTRACTThis work aimed to investigate the chemical composition, antioxidant activity, antinociceptive effect, and wound healing activity of the Lonicera caprifolium L. flower essential oil (LCEO). Linalool (16.42%), d-limonene (9.99%), and α-cadinol (10.65%) were the most prevalent components of the LCEO. The LCEO revealed moderate DPPH and ABTS radical-scavenging activity. LCEO exhibited potent antinociceptive activity in acetic acid-induced writhing and hot plate-induced pain model; LCEO reduced 73.88 ± 2.78% of writhing and signi...
Source: Natural Product Research - March 24, 2023 Category: Biochemistry Authors: Anjali A Gavit Manish B Gagrani Shailendra S Gurav M Ayyanar Vishal G Beldar Anilkumar U Tatiya Sanjay J Surana Sandip D Firke Mohan G Kalaskar Source Type: research

Studies on 1-deoxynojirimycin biosynthesis in mulberry ( Morus alba L.) seeds through comparative transcriptomics
In conclusion, DNJ biosynthesis in mulberry seeds appears to be mediated by upregulation of polyphenol oxidase, tyrosine aminotransferase, aromatic-L-amino-acid decarboxylase, and tropinone reductase.PMID:36945193 | DOI:10.1080/14786419.2023.2190114 (Source: Natural Product Research)
Source: Natural Product Research - March 22, 2023 Category: Biochemistry Authors: Xiangdong Xin Xueping Jiang Attaribo Thomas Baoxin Niu Minqi Zhang Xueming Xu Ran Zhang Hao Li Zhongzheng Gui Source Type: research

Network pharmacology based pharmacokinetic assessment and evaluation of the therapeutic potential of catechin derivatives as a potential myostatin inhibitor: A special view on Sarcopenic Obesity
Nat Prod Res. 2023 Mar 20:1-5. doi: 10.1080/14786419.2023.2191197. Online ahead of print.ABSTRACTSarcopenic obesity has become a significant age-related metabolic problem. Catechins are flavanol, derivatives which poses a strong antioxidant activity. The major components of catechin derivatives. were identified through our physicochemical and pharmacokinetic parameters estimation. Therefore, in this study, network pharmacology was used to explore the multiple targets related to Sarcopenia, Metabolic syndrome, and obesity. The targets were identified from network analysis. The catechin derivatives were screened using Lipins...
Source: Natural Product Research - March 21, 2023 Category: Biochemistry Authors: Sarvesh Sabarathinam Satish Kumar Rajappan Chandra Sanjana Satheesh Source Type: research

Cytotoxic pyrone derivatives from the deep-sea-derived fungus Cladosporium halotolerans FS702
Nat Prod Res. 2023 Mar 20:1-7. doi: 10.1080/14786419.2023.2187794. Online ahead of print.ABSTRACTTwo new compounds (R)-6-((8S)-hydroxypropyl)-2-methyl-5,6-dihydro-4H-pyran-4-one (1) and (R)-6-((8R)-hydroxypropyl)-2-methyl-5,6-dihydro-4H-pyran-4-one (2), together with four known compounds were isolated from the marine-derived fungus Cladosporium halotolerans FS702. The structures of these compounds were determined on the basis of extensive spectroscopic analysis including 1D/2D NMR, IR, UV, HRESIMS, ECD calculations as well as the modified Mosher's method. Cytotoxic assay results showed that compound 2 had significant cytot...
Source: Natural Product Research - March 20, 2023 Category: Biochemistry Authors: Xuejiao Li Yuchan Chen Zhaoming Liu Saini Li Hongxin Liu Yanlin Wang Weimin Zhang Hanjing Yan Source Type: research

 In silico toxicologic profile and in vivo trypanocidal activity of estafietin, a sesquiterpene lactone isolated from Stevia alpina Griseb
Nat Prod Res. 2023 Mar 20:1-6. doi: 10.1080/14786419.2023.2188208. Online ahead of print.ABSTRACTChagas disease is an infection caused by the protozoan Trypanosoma cruzi, affecting 6-8 million people worldwide. Only two drugs are available for its treatment, having a limited efficacy and adverse side-effects. Estafietin is a sesquiterpene lactone isolated from Stevia alpina with in vitro activity against T. cruzi and low cytotoxicity against mammalian cells. The aim of this work was to predict the toxicologic profile of estafietin by in silico methods and assess its in vivo activity on a murine model of Chagas disease. Est...
Source: Natural Product Research - March 20, 2023 Category: Biochemistry Authors: Orlando G Elso Natacha Cerny Laura C Laurella Augusto E Bivona Andr és Sánchez Alberti Celina Morales Cesar A N Catal án Emilio L Malchiodi Valeria P S ülsen Source Type: research

Two new indole alkaloids from Nauclea officinalis and their evaluation for cytotoxic activities
Nat Prod Res. 2023 Mar 20:1-7. doi: 10.1080/14786419.2023.2189707. Online ahead of print.ABSTRACTTwo new indole alkaloids, naucleamide H (1) and (±)-19-O-butylangustoline (8), along with seven known alkaloids, 3,14-dihydroangustine (2), (-)-naucleofficine D (3a), (+)-naucleofficine D (3b), nauclefine (4), angustidine (5),19-O-ethylangustoline (6) and angustine (7) were isolated from the water extract of Nauclea officinalis. The structures of these compounds were established by spectroscopic analysis. Among them, the cytotoxicity of 1, 2, 6 and 8 were evaluated against six human cancer cell lines (HepG-2, SKOV3, HeLa, SGC ...
Source: Natural Product Research - March 20, 2023 Category: Biochemistry Authors: Yue Wang Huan Liu Lijuan Hou Jinhong Liao Peng Zhang Hao Zhang Guanghou Wang Lixin Sun Source Type: research

Reassignment of NMR spectroscopic data of oleana-9(11),12-diene-3 β -ol isolated from Jeffreycia zeylanica and its wound healing potential in terms of cell migration and proangiogenic activity 1 
Nat Prod Res. 2023 Mar 20:1-8. doi: 10.1080/14786419.2023.2190112. Online ahead of print.ABSTRACTJeffreycia zeylanica (Asteraceae), a plant endemic to Sri Lanka, is used for the treatment of wounds. The scratch wound assay (SWA) guided fractionation of hexanes extract of J. zeylanica led to the isolation of oleana-9(11),12-diene-3β-ol (1) which showed enhanced cell migration in SWA and significant proangiogenic response in chorioallantoic membrane (CAM) assay. Since the reported 1H NMR assignments of 1 were incomplete, and some 13C NMR assignments were inconsistent with our observations, reassignment of NMR spectroscopic ...
Source: Natural Product Research - March 20, 2023 Category: Biochemistry Authors: W M Priyantha Samarasinghe G M Kamal B Gunaherath Chandani Ranasinghe K Hector Jayawardana Source Type: research

A new biphenyl from the stem bark of Garcinia macrantha A.C.Sm
Nat Prod Res. 2023 Mar 20:1-6. doi: 10.1080/14786419.2023.2190113. Online ahead of print.ABSTRACTIn our continuation of exploring antidiabetic agents from Garcinia species, we found that the methanolic extract of G. macrantha A.C.Sm. exhibited considerable α-glucosidase inhibition of 58.20 ± 0.37% in sucrose substrate and 39.86 ± 2.07% in maltose substrate at 100 μg/mL. Phytochemical investigation on the extract revealed the presence of a new biphenyl, macrabiphenyl A, which was successfully elucidated by means of spectroscopic methods (HRESIMS and 1D and 2D NMR). The α-glucosidase inhibitory evaluation indicated that...
Source: Natural Product Research - March 20, 2023 Category: Biochemistry Authors: None Rifaldi Edwin R Sukandar Arif Fadlan Sri Fatmawati Adi S Purnomo Johanis Wairata Taslim Ersam Source Type: research