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Valorisation of olive pomace: phenolic prospecting and biological potential
Nat Prod Res. 2024 Mar 27:1-6. doi: 10.1080/14786419.2024.2332948. Online ahead of print.ABSTRACTPhenolic compounds were extracted from biphasic olive pomace and their biological potential was characterised. Two different extracts were prepared, E1 (40% methanol) and E2 (80% methanol), both subjected to agitation (180 min) and 70 °C. LC-ESI-qTOF-MS was used for individual quantification of the extracted phenolic compounds. The antioxidant activity was determined using different methods, including nitric oxide, DPPH (2,2-diphenyl-1-picrylhydrazyl) and hydroxyl radical. The enzymes α-amylase and α-glucosidase were used to...
Source: Natural Product Research - March 28, 2024 Category: Biochemistry Authors: Bruna Wendt B öhmer-Maas Deborah Murowaniecki Otero P âmela Inchauspe Corrêa Alves Nathalia Stark Pedra Marjana Rad ünz Eli ézer Ávila Gandra Rui Carlos Zambiazi Source Type: research

Ethnomedical uses, biocompounds and biological properties of Cereus Jamacaru DC. (Cactaceae): a comprehensive review
Nat Prod Res. 2024 Mar 27:1-15. doi: 10.1080/14786419.2024.2330541. Online ahead of print.ABSTRACTCereus jamacaru, popularly known as mandacaru, is a Cacactacea native to the Caatinga of Brazil, but it is distributed in arid and semiarid regions worldwide. This plant is used for various purposes, such as food, animal fodder, civil construction, and as an ornamental and medicinal plant. Traditional medicine uses the cladodes, roots, and seeds of C. jamacaru to treat various diseases. This review discusses the ethnobotanical uses, phytochemical composition, and biological properties of C. jamacaru. The data demonstrate that ...
Source: Natural Product Research - March 27, 2024 Category: Biochemistry Authors: Leila Magda Rodrigues Almeida Luzimar Gonzaga Fernandez Source Type: research

Isolation, purification and structure elucidation of eight saponin compounds from Calotropis gigantea 
In this study we selected Calotropis gigantea for the separation of the saponin. In the present study we successfully isolated, purified, elucidated the structure and identified the saponin compounds using HPLC and HR LC-MS techniques.PMID:38534095 | DOI:10.1080/14786419.2024.2331605 (Source: Natural Product Research)
Source: Natural Product Research - March 27, 2024 Category: Biochemistry Authors: Sudha Kulkarni Ajit Gaikwad Nilesh Bhoi Amit Hade Mona Kokwar Manali Gulwade Source Type: research

Genetic activity and cytotoxic effect of Silybum marianum extract in comparison with the impact of antitumor drugs etoposide and methotrexate: a study on Drosophila melanogaster 
Nat Prod Res. 2024 Mar 27:1-4. doi: 10.1080/14786419.2024.2334315. Online ahead of print.ABSTRACTOne of the most important directions in medical practice involves the exploration of protectors and adaptogens to mitigate side effects associated with the use of antitumor and potent medications. The extracts of medicinal plants are actively tested as protectors. In connection with this, the aim of the research was to determine the effectiveness of the protective properties of Silybum marianum extract against the drugs 'etoposide' and 'methotrexate' at concentrations of 800 μg/kg using the model object Drosophila melanogaster...
Source: Natural Product Research - March 27, 2024 Category: Biochemistry Authors: Olga Nikolaevna Antosyuk Elena Aleksandrovna Sharova Anastasiya Konstantinovna Verbitskaya Source Type: research

Trichothecenes with cytotoxic activity and benzene derivatives with hypolipidemic activity from trichothecium sp
Nat Prod Res. 2024 Mar 27:1-7. doi: 10.1080/14786419.2024.2332488. Online ahead of print.ABSTRACTFive trichothecenes including a new one, together with two previously undescribed benzene derivatives were isolated from the solid culture of Trichothecium sp. Their structures were established by 1D and 2D NMR data in conjunction with HR-ESI-MS analysis. Compounds 1-5 exhibited cytotoxicity against MCF-7 cell lines at various levels ranging from IC50 of 7.23 to 16.95 μM. Compound 6 decreased the concentration of blood lipids in zebra fish at the concentration of 20 μM.PMID:38534130 | DOI:10.1080/14786419.2024.2332488 (Source...
Source: Natural Product Research - March 27, 2024 Category: Biochemistry Authors: An-An Yang Yi-Fan Guo Ke-Ran Hao Yi-Ting Wu Liang Xing Source Type: research

Extraction and detection of mitragynine in Kratom leaves by high-performance liquid chromatography
Nat Prod Res. 2024 Mar 27:1-6. doi: 10.1080/14786419.2024.2331602. Online ahead of print.ABSTRACTMitragyna speciosa, also known as Kratom, is an evergreen tree native to Southeast Asia that has been used in traditional medicine to relieve pain. The primary active alkaloid, mitragynine, found in Kratom leaves affects the same µ-receptor as the opioids. The potential effects of Kratom leaves on humans draw international concerns. The purpose of this study is to develop an efficient extraction method for mitragynine from dried Kratom leaves. Mitragynine was extracted from grounded Kratom leaves by liquid-liquid extraction an...
Source: Natural Product Research - March 27, 2024 Category: Biochemistry Authors: Karno Ng Taehoon Ha Source Type: research

Isolation of two peptaibols with potent antimicrobial and cytotoxic activities from the mangrove endophytic fungus Trichoderma lentiforme ML-P8-2
Nat Prod Res. 2024 Mar 27:1-6. doi: 10.1080/14786419.2024.2334880. Online ahead of print.ABSTRACTTrichorzin PA is a family of 18-residue peptaibols with linear and flexible peptide chains. The three-dimensional structures and biological activities of trichorzin PA peptaibols are largely uncharacterised. In this work, two previously identified peptaibols, trichorzin PA VI (1) and II (2), were isolated from Trichoderma lentiforme ML-P8-2. While for the first time, we report here the X-ray crystallographic structure of 1, antimicrobial activities against a panel of common pathogenic bacteria and fungi, and cytotoxicities of 1...
Source: Natural Product Research - March 27, 2024 Category: Biochemistry Authors: Yihao Yin Ge Zhu Jianying Wu Zhigang She Jie Yuan Bo Wang Source Type: research

Highly selective alkylcoumarates and diterpenoids isolated from leaves of Baccharis quitensis : a search for new hit compounds against Trypanosoma cruzi 
Nat Prod Res. 2024 Mar 27:1-7. doi: 10.1080/14786419.2024.2335362. Online ahead of print.ABSTRACTIn the present work, the hexane extract of aerial parts of Baccharis quitensis Kunth. was subjected to chromatographic fractionation to afford two alkyl phenylpropanoids: n-docosyl (E)-p-coumarate (1) and n-tetracosyl (E)-p-coumarate (2) as well as five diterpenes: ent-kaurenoic acid (3), grandifloric acid (4), 15β-senecioyl-oxy-ent-kaur-16-en-19-oic acid (5), and 15-oxo-ent-kaurenoic acid (6). Using an ex-vivo assay with macrophages infected with Trypanosoma cruzi, compounds 1 and 2 demonstrated high potency against intracell...
Source: Natural Product Research - March 27, 2024 Category: Biochemistry Authors: Nathalia Peres Matheus L Silva Anderson K Ueno Guilherme M Antar Erica V C Levatti Andre G Tempone Jo ão Henrique G Lago Source Type: research

Combination of tenuigenin-based Polygala tenuifolia willd. root extract and forsythoside a improved Alzheimer's disease
Nat Prod Res. 2024 Mar 26:1-5. doi: 10.1080/14786419.2024.2332945. Online ahead of print.ABSTRACTTenuigenin is a kind of the main active ingredients in roots of Polygala tenuifolia Willd. (a species in the genus Polygala, family Polygalaceae) and forsythoside A (FA) is one of the main active ingredients of Forsythia suspensa (Thunb.) Vahl. (a species in the genus Forsythia, family Meliaceae). The studies have shown that tenuigenin-based Polygala tenuifolia Willd. extract (YZ) and FA have protective effects on nervous damage. In the study the combination (YF) of YZ and FA showed synergistic neuro-protective effects on PC12 ...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Guocui Liang Chengxia Gao Liwei Zhang Huizhi Du Source Type: research

Endophytic fungus from Gynura japonica : phytochemical screening, biological activities, and characterisation of its bioactive compound
Nat Prod Res. 2024 Mar 26:1-9. doi: 10.1080/14786419.2024.2332947. Online ahead of print.ABSTRACTThe research aims to identify the chemical constituents of endophytic fungi associated with Gynura japonica and their biological activities. Two endophytic fungi, labelled as GS-1 and GS-2, have been isolated from the leaves of G. japonica. They were cultivated on white rice media for their optimum cultivation time. Cultivated fungi were extracted with ethyl acetate and concentrated to give a crude extract. All crude extracts were evaluated for their phytochemical screening and assayed for their antibacterial and antioxidant ac...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Riga Riga Ridha Wardatillah Okta Suryani Benny Ryplida Suryelita Suryelita Minda Azhar Dian Handayani Muh Ade Artasasta Sonni Maurit Benu Ahadul Putra Source Type: research

Synthesis and antifungal activity of hexahydropyrrolidoindole alkaloids
Nat Prod Res. 2024 Mar 26:1-9. doi: 10.1080/14786419.2024.2333047. Online ahead of print.ABSTRACTTwenty-one hexahydropyrrolidoindole alkaloids were designed and synthesised via acylation reaction at the 3-N position from the commercially available indole-3-acetonitrile as the starting material in excellent yields. The effects of all target compounds against Verticillium dahlia, Fusarium oxysperium sp., Cytospora juglandis, Aspergillu sflavu, Aspergillus niger and Fusarium oxysporum were determined. The results of bioassays indicated that the majority of tested compounds displayed comparable or better in vitro bioactivity t...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Yujie Zhou Shoude Ma Xiaohan Li Xinye Liu Jie Gao Dingding L ü Ya Wang Shaojun Zheng Source Type: research

Analysis of metabolic compounds and antitumorigenic effects of Albizia niopoides and Senegalia polyphylla leaves
The objective of this study was to quantify metabolic compounds in leaves of A. niopoides and S. polyphylla and to evaluate the antitumor potential of extracts from both species in cervical tumour cells. The physiological analyses performed were quantification of starch, sucrose, phenolic compounds and proteins. An aqueous extract was prepared and added to the SiHa cell line at concentrations of 10, 100 and 1000 μg/mL at 4h, 24h, 48h and 72h. Cell morphology, proliferation and viability were analysed. The species showed a large amount of starch and phenolic compounds. Treatment with the extract of both species caused morp...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Thalissa Cagnin Pereira Luana Pereira Cardoso Wesller da Silva de Paiva Liliane Santos de Camargos Fl ávia Cristina Rodrigues-Lisoni Aline Redondo Martins Source Type: research