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Preussiate, a new urease inhibitory chalcone from Dioscorea preussii Pax
Nat Prod Res. 2023 Aug 21:1-8. doi: 10.1080/14786419.2023.2248350. Online ahead of print.ABSTRACTThe phytochemical investigation of the aqueous methanolic extract of the aerial parts of Dioscorea preussii, led to the isolation of a new chalcone preussiate (1) along with 10 other compounds including xanthomicrol (2), cholestan-3-one (3), arjunolic acid (4), tormentic acid (5), ursolic acid (6), betulin (7), lupeol (8), p-hydroxybenzoic acid (9), isovanillin (10) and vanillic acid (11), being reported for the first time from this plant. Their structures were established by spectroscopic techniques including 2D NMR spectrosco...
Source: Natural Product Research - August 21, 2023 Category: Biochemistry Authors: Muhammad Shaiq Ali Seerat Iqbal Mehreen Lateef Ngoupayo Joseph Source Type: research

Evaluation of pharmaceutical compounds at vegetative and reproductive growth stages of Marrubium vulgare , a medicinal plant to cleanse the body
Nat Prod Res. 2023 Aug 21:1-5. doi: 10.1080/14786419.2023.2245116. Online ahead of print.ABSTRACTMarrubium vulgareis a plant with high bioactive potential. The rich bioactive compounds of medicinal horehound, as well as their antioxidant activity have led to its wider application in the pharmaceutical, cosmetic, and food industries. The present work aimed to determine the phenolic compounds, total phenols, flavonoids, and antioxidant activity at vegetative and reproductive growth stages of Marrubium vulgare. The experiments were performed in Eram Garden with five replications and using SPSS software (v. 13) and Mann-Whitne...
Source: Natural Product Research - August 21, 2023 Category: Biochemistry Authors: Mahdi Aeineh Sharareh Najafian Mehdi Hosseinifarahi Source Type: research

Rare diphenylheptanoid-phenylheptanoid hybrids with α-glucosidase inhibitory effects from the pollen of Typha angustifolia 
Nat Prod Res. 2023 Aug 21:1-11. doi: 10.1080/14786419.2023.2248352. Online ahead of print.ABSTRACTTwo rarely occurring diphenylheptanoid-phenylheptanoid hybrid dimers (1 and 2) and one new oxygenated fatty acid (3), as well as two known fatty acid analogues (4 and 5), were isolated from the 70% EtOH extract of the pollen of Typha angustifolia. Their planar structures were established by interpretation of MS and NMR spectroscopic data, and the absolute configurations of 1 and 2 were determined by Mosher's method and quantum chemical TD-DFT calculations of ECD spectra. An in vitro anti-diabetic evaluation of these isolates r...
Source: Natural Product Research - August 21, 2023 Category: Biochemistry Authors: Chao Wang Yu-Peng Li Xu Gong Li-She Gan Hua Zhang Source Type: research

Miliutine A acid, a new cyclofarnesane sesquiterpene from the stems of Miliusa velutina 
Nat Prod Res. 2023 Aug 21:1-8. doi: 10.1080/14786419.2023.2248540. Online ahead of print.ABSTRACTSix compounds were isolated from the ethyl acetate extract of the stems of Miliusa velutina, including miliutine A acid (1), a new cyclofarnesane sesquiterpenoid; miliutine B methyl ester (2), a cyclofarnesane sesquiterpenoid which was determined the absolute configuration for the first time and four known phenol derivatives (3-6). NMR spectroscopic and mass spectrometry were used for identifying relative configurations. The assignments of the absolute configurations were determined based on Electronic Circular Dichroism (ECD) ...
Source: Natural Product Research - August 21, 2023 Category: Biochemistry Authors: Hoang Khang Le Thanh Tung Phan Thi Kieu Loan Vo Thi Thuy Duong Ngo Hoang Long Ngo Poul Erik Hansen Quang Ton That Source Type: research

Two new 30-norfriedelane triterpenes from Caloncoba glauca (P. Beauv.) Gilg (Achariaceae)
Nat Prod Res. 2023 Aug 21:1-11. doi: 10.1080/14786419.2023.2248351. Online ahead of print.ABSTRACTThe chemical investigation of the methanolic root extract of Caloncoba glauca (P. Beauv.) Gilg exhibited two new 30-norfriedelane triterpenes, glaucalactones A and B (1-2), together with eight known compounds, caloncobalactone (3), friedelin (4), friedelanol (5), 3-oxo-friedelan-28-oic acid (6), stigmasterol (7), β-sitosterol (8), β-sitosterol-3-O-β-D-glucopyranoside (9) and pentacosanoic acid (10). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) a...
Source: Natural Product Research - August 21, 2023 Category: Biochemistry Authors: Charlemagne Ndoumbe Tamba Willifred Dongmo Tekapi Tsopgni Bernard Samuel Hodjie Fotso Jean Pierre Longue Ekon Mohamed Foundikou Nsangou Judith Caroline Ngo Nyobe Norbert Sewald Jean Claude Ndom Source Type: research

Identification of potential antiviral compounds from Egyptian Red Sea soft corals against Middle East respiratory syndrome coronavirus
Nat Prod Res. 2023 Aug 17:1-7. doi: 10.1080/14786419.2023.2247535. Online ahead of print.ABSTRACTThe ongoing threat of Middle East respiratory syndrome coronavirus (MERS-CoV) underscores the importance of developing effective antiviral treatments. Current research was conducted to identify potential antiviral compounds from soft corals: Sinularia leptoclados, Sarcophyton ehrenbergi, Nephthea sp., Sarcophyton glaucum and Sarcophyton regulare. The antiviral activities of soft corals extracts were evaluated against MERS-CoV. Gas chromatography-mass spectrometry (GC-MS) was used to identify bioactive compounds. The molecular d...
Source: Natural Product Research - August 17, 2023 Category: Biochemistry Authors: Mariam M Abdelfattah Montaser A El-Hammady Ahmed Mostafa Omnia Kutkat Noura M Abo Shama Mohamed S Nafie Dalia A El-Ebeedy Ahmed Z Abdel Azeiz Source Type: research

Anti-infective potential of the endophytic fungus Aspergillus sp. associated with Aptenia cordifolia root supported by metabolomics analysis and docking studies
In this study, Aptenia cordifolia associated endophytic fungi were explored for the first time. Seven isolates were identified morphologically followed by screening of these fungi by plug diffusion assay which revealed their potential activity against Staphylococcus aureus (ATCC 9144), Bacillus cereus (ATCC 14579), Serratia marcescens (ATCC 14756), Fusarium oxysporum (ATCC 48112), and Aspergillus flavus (ATCC 22546). Additionally, the crude ethyl acetate extract of the most potent three isolates in plug diffusion assay showed that Aspergillus sp. ACEFR2 was the most potent as anti-infective in disc diffusion assay; Accordi...
Source: Natural Product Research - August 17, 2023 Category: Biochemistry Authors: Miram Magdy Yousef Omnia Hesham Abdelhafez Faisl Alsenani Abdulaziz K Al Mouslem Mohamed Hisham Amr El Zawily Stefanie P Glaeser Peter K ämpfer Usama Ramadan Abdelmohsen Mo'men Hamed El-Katatnye Source Type: research

 In vitro and in silico studies of antibacterial activities of secofriedelane derivatives from Senna alata (L) Roxb
In this study, six compounds were obtained from a methanolic extract of air-dried leaves of Senna alata and one of them, a triterpenoid (secofriedelane) named as 7-(2-carboxyethyl)-3, 4b, 6a, 8, 10a, 12a-hexamethyl-8-vinyloctadecahydrochrysene-3-carboxylic acid (5) was isolated for the first time from this plant. Then, its chemical structure was detailed and characterised by FT-IR, 1H and 13C- NMR and ESI-MS. Besides, two chemical-modified derivatives of secofriedelane (5a, 5b) were synthesised by methylation and allylation reactions, respectively, and their in vitro antibacterial activities were also evaluated. The result...
Source: Natural Product Research - August 17, 2023 Category: Biochemistry Authors: Simplice F Chimi Monique B Ewonkem Eunice N Tiakouang Jean O Moto Abel I Adjieufack Pascaline M Deussom Michel A Mbock Duplex J Wansi Alfred F A Toze Source Type: research

A rare phytosterol, stigmast-5-en-3 β ,7 α ,22 α -triol and other secondary metabolites from Leea indica showing enhanced in vitro cell migration and proangiogenic activity
Nat Prod Res. 2023 Aug 17:1-5. doi: 10.1080/14786419.2023.2247538. Online ahead of print.ABSTRACTLeea indica (Burm. f.) Merr. (Vitaceae) is used for the treatment of wounds in traditional medicine practiced in Sri Lanka. The current study is carried out to investigate its wound healing potential in terms of in vitro cell migration and proangiogenic activity. The scratch wound assay (SWA) guided fractionation of dichloromethane extract of L. indica led to the isolation of a rare phytosterol, stigmast-5-en-3β,7α,22α-triol (1), betulin (2), lupeol (3), and β-sitosterol (4) all of which showed enhanced cell migration in SW...
Source: Natural Product Research - August 17, 2023 Category: Biochemistry Authors: W M Priyantha Samarasinghe Chandani Ranasinghe K Hector Jayawardana Seneviratnage Somaratne G M Kamal B Gunaherath Source Type: research