Natural alkaloids from < em > Dicranostigma leptopodum < /em > (Maxim.) Fedde and their G5. NHAc-PBA dendrimer-alkaloid complexes for targeting chemotherapy in breast cancer MCF-7 cells
Nat Prod Res. 2024 Apr 8:1-18. doi: 10.1080/14786419.2024.2335669. Online ahead of print.ABSTRACTHerein, we isolated five natural alkaloids, iso-corydine (iso-CORY), corydine (CORY), sanguinarine (SAN), chelerythrine (CHE) and magnoflorine (MAG), from traditional medicinal herb Dicranostigma leptopodum (Maxim.) Fedde (whole herb) and elucidated their structures. Then we synthesised G5. NHAc-PBA as targeting dendrimer platform to encapsulate the alkaloids into G5. NHAc-PBA-alkaloid complexes, which demonstrated alkaloid-dependent positive zeta potential and hydrodynamic particle size. G5. NHAc-PBA-alkaloid complexes demonst...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Ye Tian Zhiqiang Wang Xu Xu Yunqi Guo Yanni Ma Yanqi Lu Mingwu Shen Yang Geng Helena Tom ás Jo ão Rodrigues Ruilong Sheng Source Type: research
20-esterification of 5-spiro CPT and their anticancer activity in vitro
Nat Prod Res. 2024 Apr 8:1-9. doi: 10.1080/14786419.2024.2337115. Online ahead of print.ABSTRACT20-ester of 5-spirocycle campthothecin derivatives were successfully constructed and synthesised by Steglich esterification in a moderate yield. These derivatives showed a better solubility. Compared to parent compound, most of these 20-ester-5-spirocycle campthothecin derivatives (besides 3g) showed a better inhibition activity against HepG2 cell line.PMID:38586944 | DOI:10.1080/14786419.2024.2337115 (Source: Natural Product Research)
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Yuan Liu Changkuo Zhao Huimin Liu Xianheng Wang Source Type: research
Effects of plant extracts and derivatives on cardiac K < sup > + < /sup > , Nav, and Ca < sub > v < /sub > channels: a review
Nat Prod Res. 2024 Apr 8:1-28. doi: 10.1080/14786419.2024.2337112. Online ahead of print.ABSTRACTNatural products (NPs) are endless sources of compounds for fighting against several pathologies. Many dysfunctions, including cardiovascular disorders, such as cardiac arrhythmias have their modes of action regulation of the concentration of electrolytes inside and outside the cell targeting ion channels. Here, we highlight plant extracts and secondary metabolites' effects on the treatment of related cardiac pathologies on hERG, Nav, and Cav of cardiomyocytes. The natural product's pharmacology of expressed receptors like alph...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Insa Seck Samba Fama Ndoye Michelle Vanessa Kamga Kapchoup Filomain Nguemo Ismaila Ciss Lalla Aicha Ba Abda Ba Seynabou Sokhna Matar Seck Source Type: research
Rapid identification and determination of chemical components of huai yam based on UPLC-Q-Exactive-MS and fragmentation patterns
In this study, an efficient method for the classification and rapid identification of yam components was established based on UPLC-Q-Exactive-MS and data post-processing techniques. First, the mass spectrometry information including the characteristic fragmentations (CFs) and neutral losses (NLs) of yam reported in the literature were summarised and a database of compounds was established. Then, the mass spectrometry data detected by the yam sample are compared with those described in database for rapid identification of target compounds. Finally, 60 compounds were identified, including 18 flavones, 2 saponins, 10 amino ac...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Huiru Liu Xia Li Haowei Xu Xiaowen Wang Zhimin Gong Yanyan Xu Lexin Shu Yubo Li Source Type: research
Discovery of olimycin E from < em > Streptomyces < /em > sp. 11695
Nat Prod Res. 2024 Apr 8:1-6. doi: 10.1080/14786419.2024.2337131. Online ahead of print.ABSTRACTA new natural product olimycin E (1), together with two known compounds of divergolide R (2) and olimycin B (3), were obtained from the marine-derived Streptomyces sp. 11695. The structures of 1-3 were established on the basis of HRESIMS as well as 1D and 2D NMR datasets. The absolute configuration of 1 is identified as 4 R, 6S, 7S, 10 R by comparison the experiment ECD with that of the theoretical ECD. Antibacterial results showed that compound 2 have antibacterial activities against Staphylococcus aureus and MRSA with the MIC ...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Lirong Tu Shumei Shen Zhenyang Yan Xiaoxia Li Kai Liu Jin Xu Minghe Luo Source Type: research
Salvia rosmarinus: a possible role in unmet therapeutic needs in the prevention and care of immunological disorders
Nat Prod Res. 2024 Apr 8:1-5. doi: 10.1080/14786419.2024.2338815. Online ahead of print.NO ABSTRACTPMID:38587141 | DOI:10.1080/14786419.2024.2338815 (Source: Natural Product Research)
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Fabiana Furci Nicola Cicero Alessandro Allegra Sebastiano Gangemi Source Type: research
A new illudane sesquiterpene from the edible fungus < em > Pholiota nameko < /em >
Nat Prod Res. 2024 Apr 8:1-6. doi: 10.1080/14786419.2024.2338821. Online ahead of print.ABSTRACTFungi have different genetic expression abilities and biosynthetic pathways under different cultivation conditions, which can produce various secondary metabolites. The "one strain many compounds" strategy is used to activate silent biosynthetic genes of fungi to produce various compounds, which is an effective method. In order to discover various new compounds in the edible fungus Pholiota nameko, a fermentation strategy involving precursor feeding and enzyme inhibitor addition has been employed. A new illudane sesquiterpene (1...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Lian Yang Huan Zhang Shu-Hang He Ju Xu Xiao-Long Li Fei-Xing Li Dong-Mei Lin Deng-Ji Lou Xiao-Yan Yang Source Type: research
Cytotoxicity phenylpropanoid amides from the seed of < em > Cannabis sativa < /em > L
Nat Prod Res. 2024 Apr 8:1-8. doi: 10.1080/14786419.2024.2338800. Online ahead of print.ABSTRACTTwo novel phenylpropanoid amides, namely huomarenamide A (1) and huomarenamide B (2), along with twelve known compounds (3-14), were isolated from the seeds of Cannabis sativa L. The structures with absolute configurations of new compounds were unequivocally determined by spectroscopic analyses and the ECD method. The identification of the known compounds was based on a comparison of their 1D NMR data with literature references. All compounds were assessed for cytotoxic activity against LN229 cells, revealing that compounds 2, 1...
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Ao-Fei Wang Juan Pan Xiang Liu Xin-Yuan Li Peng Jiang Meng-Meng Li Wei Guan Qing-Shan Chen Li-Li Zhang Hai-Xue Kuang Yan Liu Bing-You Yang Source Type: research
Artificial intelligence and natural product research
Nat Prod Res. 2024 Apr 8:1-3. doi: 10.1080/14786419.2024.2333048. Online ahead of print.NO ABSTRACTPMID:38588438 | DOI:10.1080/14786419.2024.2333048 (Source: Natural Product Research)
Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Crist N Filer Source Type: research
Sesquiterpenoids and steroids from < em > Eupatorium fortunei < /em > and their inhibitory effects on NO production
Nat Prod Res. 2024 Apr 5:1-10. doi: 10.1080/14786419.2024.2335665. Online ahead of print.ABSTRACTTwo heterodimers including a clovane-phenylpropanoid hybrid (1) and a clovane-menthane hybrid (2), five linear sesquiterpenoids incorporating a tetrahydrofuran ring (3-6 & 8), and four steroids (7 & 9-11), were separated from the ethanolic extract of a well-known aromatic and medicinal herb Eupatorium fortunei. Their structures were characterised by detailed analyses of spectroscopic data and comparison with known analogues, with seven (1-7) of them being described for the first time. The hybrids 1 and 2 represent the f...
Source: Natural Product Research - April 5, 2024 Category: Biochemistry Authors: Lei Miao Yin-Bo Pan Shu-Ting Wang Jun-Sheng Zhang Hua Zhang Source Type: research
Antifungal activity of extracts from < em > Justicia < /em > species against < em > Fusarium graminearum < /em >
Nat Prod Res. 2024 Apr 5:1-6. doi: 10.1080/14786419.2024.2334334. Online ahead of print.ABSTRACTFusarium graminearum causes destructive ear rot diseases in maize and wheat. New antifungals are essential to combat this pathogen, and aerial parts of Justicia species (Acanthaceae) are a potential source. We investigated the antifungal activity of extracts from stems and leaves of five Justicia species native to Northwest Argentina. The aerial parts were subjected to sequential extractions with dichloromethane, ethyl acetate, and methanol. The resulting extracts were tested by the disc diffusion method against F. graminearum s...
Source: Natural Product Research - April 5, 2024 Category: Biochemistry Authors: Mariana Del H Sanchez Mat ías Anal ía de Los A Gómez Cristina M Jim énez Sarah Tanguy Guillo Mar ía Eugenia Del M Aristimuño Ficoseco C ésar A N Catalán Rapha ël Grougnet Marina Kritsanida Diego A Sampietro Source Type: research
C < sub > 19 < /sub > -diterpene alkaloids from < em > delphinium turkmenum < /em > lipsky
Nat Prod Res. 2024 Apr 5:1-5. doi: 10.1080/14786419.2024.2327618. Online ahead of print.ABSTRACTThe genus Delphinium is a rich source of diterpene alkaloids. Chemical investigation on an alkaloid rich extract of the whole parts of Delphinium turkmenum resulted in the isolation of three C19-diterpene alkaloids (1-3) and a palmitic acid derivative (4). The chemical structures were elucidated by analysis of 1D and 2D-NMR and comparison the data with those reported in the literature. Notably, all isolated compounds were reported for the first time from D. turkmenum.PMID:38579282 | DOI:10.1080/14786419.2024.2327618 (Source: Nat...
Source: Natural Product Research - April 5, 2024 Category: Biochemistry Authors: Abolfazl Shakeri Maryam Samaei Judit Hohmann Milad Iranshahy Javad Asili Source Type: research
Sesquiterpenoids and steroids from < em > Eupatorium fortunei < /em > and their inhibitory effects on NO production
Nat Prod Res. 2024 Apr 5:1-10. doi: 10.1080/14786419.2024.2335665. Online ahead of print.ABSTRACTTwo heterodimers including a clovane-phenylpropanoid hybrid (1) and a clovane-menthane hybrid (2), five linear sesquiterpenoids incorporating a tetrahydrofuran ring (3-6 & 8), and four steroids (7 & 9-11), were separated from the ethanolic extract of a well-known aromatic and medicinal herb Eupatorium fortunei. Their structures were characterised by detailed analyses of spectroscopic data and comparison with known analogues, with seven (1-7) of them being described for the first time. The hybrids 1 and 2 represent the f...
Source: Natural Product Research - April 5, 2024 Category: Biochemistry Authors: Lei Miao Yin-Bo Pan Shu-Ting Wang Jun-Sheng Zhang Hua Zhang Source Type: research
Antifungal activity of extracts from < em > Justicia < /em > species against < em > Fusarium graminearum < /em >
Nat Prod Res. 2024 Apr 5:1-6. doi: 10.1080/14786419.2024.2334334. Online ahead of print.ABSTRACTFusarium graminearum causes destructive ear rot diseases in maize and wheat. New antifungals are essential to combat this pathogen, and aerial parts of Justicia species (Acanthaceae) are a potential source. We investigated the antifungal activity of extracts from stems and leaves of five Justicia species native to Northwest Argentina. The aerial parts were subjected to sequential extractions with dichloromethane, ethyl acetate, and methanol. The resulting extracts were tested by the disc diffusion method against F. graminearum s...
Source: Natural Product Research - April 5, 2024 Category: Biochemistry Authors: Mariana Del H Sanchez Mat ías Anal ía de Los A Gómez Cristina M Jim énez Sarah Tanguy Guillo Mar ía Eugenia Del M Aristimuño Ficoseco C ésar A N Catalán Rapha ël Grougnet Marina Kritsanida Diego A Sampietro Source Type: research
C < sub > 19 < /sub > -diterpene alkaloids from < em > delphinium turkmenum < /em > lipsky
Nat Prod Res. 2024 Apr 5:1-5. doi: 10.1080/14786419.2024.2327618. Online ahead of print.ABSTRACTThe genus Delphinium is a rich source of diterpene alkaloids. Chemical investigation on an alkaloid rich extract of the whole parts of Delphinium turkmenum resulted in the isolation of three C19-diterpene alkaloids (1-3) and a palmitic acid derivative (4). The chemical structures were elucidated by analysis of 1D and 2D-NMR and comparison the data with those reported in the literature. Notably, all isolated compounds were reported for the first time from D. turkmenum.PMID:38579282 | DOI:10.1080/14786419.2024.2327618 (Source: Nat...
Source: Natural Product Research - April 5, 2024 Category: Biochemistry Authors: Abolfazl Shakeri Maryam Samaei Judit Hohmann Milad Iranshahy Javad Asili Source Type: research
