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Chemical composition, antioxidant activity and toxicity of the essential oil from Clinopodium mexicanum 
This study presents the first evaluation of the antioxidant activity of the essential oil (EO) obtained through hydrodistillation of the aerial parts of CM. NaCl, CaCl2, and Tween 20 were used as additives and the yield, chemical composition, and toxicity of the EO were evaluated. The findings revealed that the highest yield of EO was obtained through hydrodistillation without additives, and the additives significantly influenced the antioxidant activity of the EO. The main components of the EO were found to be pulegone and menthone. The toxicity of the EO was determined using the brine shrimp assay, with an LD50 of 32 mg/...
Source: Natural Product Research - September 7, 2023 Category: Biochemistry Authors: Anette Gisela Botello-Ojeda Zaida Nelly Ju árez Nancy Tepale Jos é Antonio Rivera-Márquez Lilia Alejandra Conde-Hern ández Source Type: research

Polyphenols of white lupin ( Lupinus albus L.) seeds cultivated in Southern Italy by a LC-HRMS method
Nat Prod Res. 2023 Sep 7:1-5. doi: 10.1080/14786419.2023.2245535. Online ahead of print.ABSTRACTIn this work we examined the contents of 14 polyphenols in white lupin (Lupinus albus L.) samples cultivated in Southern Italy by the optimisation and validation of a LC-HRMS method. The validation of the LC-HRMS method showed linearity results r2 > 0.989 and recovery values between 71 and 119% for a very wide range of concentrations. Ellagic acid was the most abundant polyphenol, with mean concentrations of 16271.86 ± 19798.53 μg/Kg, followed by apigenin (2749.51 ± 889.95 μg/Kg). A significant variability in ellagic acid...
Source: Natural Product Research - September 7, 2023 Category: Biochemistry Authors: Gaetano Cammilleri Vittorio Calabrese Licia Pantano Mariagrazia Brunone Francesco Giuseppe Galluzzo Andrea Pulvirenti Tilman Fritsch Carmelo Bongiorno Andrea Macaluso Vincenzo Ferrantelli Source Type: research

Identification of natural lead molecules as potential Trypanosoma cruzi cruzipain inhibitors and decoding the interaction mechanism for the treatment of Chagas disease: a computational biology analysis
Nat Prod Res. 2023 Sep 7:1-5. doi: 10.1080/14786419.2023.2256018. Online ahead of print.ABSTRACTChagas disease has grown into a serious public health threat, with a high morbidity rate, major social impact, and global neglect. Therapeutic adhesion, unwanted side-effects, and resistance make its present therapy ineffective. Discovery of more effective drugs is hence needed. Using natural compounds conjointly with computational methods helps better to find promising compounds, speeding up drug discovery process and reducing its cost. In the present study, a docking protocol against cruzipain (PDB: 3l06), an important druggab...
Source: Natural Product Research - September 7, 2023 Category: Biochemistry Authors: Rati Kailash Prasad Tripathi Rajarshi Dey Nirupam Das Source Type: research

The potential of Acmella oleracea as a nutraceutical source for the symptomatic treatment of Burning Mouth Syndrome
This study analysed the phytochemical profile of Acmella oleracea extract and the molecular interactions of its main compounds with TRPV1 and CB2, target receptors in the Burning Mouth Syndrome (BMS) pathogenesis. The phytochemical profile of A. oleracea's floral buds extract treated with activated charcoal (TCEE) was analysed by High-Performance Liquid Chromatography (HPLC) coupled to Mass Spectrometry (LC-MS). The quantification of spilanthol was analysed by HPLC coupled to a Diode-Array Detector (HPLC-DAD). The phytochemical analysis revealed the presence of nine alkylamides and phenolic compounds. The TCEE showed a sig...
Source: Natural Product Research - September 6, 2023 Category: Biochemistry Authors: Joanilda Paolla Raimundo E Silva Joanda Paolla Raimundo E Silva Priscilla Guimar ães Silva Vasconcelos Let ícia Targino Campos Juliana de Medeiros Gomes Manoel Tolentino Leite Filho Renata Priscila Barros de Menezes Marcus Tullius Scotti Josean Fechine Source Type: research

Sesquiterpenoids from the whole plants of Elephantopus mollis with cytotoxicity activities
Nat Prod Res. 2023 Sep 6:1-9. doi: 10.1080/14786419.2023.2254456. Online ahead of print.ABSTRACTFive new sesquiterpenoids (1-5), elephantmollides A-E, along with four known compounds (6-9), were isolated from the whole plants of E. mollis. Their planar structures were elucidated using the spectroscopic methods, including HRESIMS, IR, UV, and NMR (1H, 13C, DEPT, HSQC, HMBC, 1H-1H COSY). The relative configurations of them were partially deduced by the NOESY experiment, and the absolute configurations were assigned by comparing the calculated electronic circular dichroism (ECD) results with the experimental data. In addition...
Source: Natural Product Research - September 6, 2023 Category: Biochemistry Authors: Qiang Lin Jing-Yi Du Si-Yu Yang Zhao-Chun Zhan Qing Tang Hui Sun Jin-Lin Tan Hai-Yue Zhao Yao-Lan Li Yu-Bo Zhang Guo-Cai Wang Source Type: research

A new ocotillol-type ginsenoside from American ginseng berry
Nat Prod Res. 2023 Sep 4:1-6. doi: 10.1080/14786419.2023.2252566. Online ahead of print.ABSTRACTA new ocotillol-type ginsenoside, named pseudoginsenoside F12 (1), was isolated from American ginseng berry, whose structure was elucidated as 6-O-[α-L-2,3-epoxy-rhamnopyranosyl-(1-2)-β-D-glucopyranosyl]-dammar-20S,24R-epoxy-3β, 6α,12β,25-tetraol. In addition, the known alkaloids β-carboline-1-carboxylic acid (2) and anoectochine (3) were isolated for the first time from the Araliaceae family. The new compound 1 was evaluated for cytotoxicity against MDA-MB-231 breast cancer cell line.PMID:37667570 | DOI:10.1080/14786419.2...
Source: Natural Product Research - September 5, 2023 Category: Biochemistry Authors: Yinping Jin Zhengyi Qu Shifeng Pang Zheng Li Yingping Wang Hao Zhang Source Type: research

A new biphenanthrene with cytotoxic activity from Liparis nervosa (Thunb.) Lindl
Nat Prod Res. 2023 Sep 3:1-7. doi: 10.1080/14786419.2023.2233670. Online ahead of print.ABSTRACT2,7,2'-Trihydroxy-3,4,4'7'-tetramethoxy-1,1'-biphenanthrene (1), a previously undescribed biphenanthrene, and five known phenanthrenes, i.e. 2,5-dihydroxy-4-methoxy-9,10-dihydroxyphenanthrene (2), 2,4-dihydroxy -7-methoxy-9,10-dihydroxyphenanthrene (3), 7-hydroxy-2-methoxy-phenanthrene-1,4-dione (4), 7-hydroxy-2-methoxy-9,10-dihydro-phenanthrene-1,4-dione (5), and 4,4',7,7'-tetrahydroxy-2,2'-dimethoxy-9,9',10,10'-tetrahydro-1,1'-biphenanthrene (6) were isolated from the whole plant (stems, leaves, roots and fruits) of Liparis ne...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Liang Liu Qi-Meng Yin Qi-Jun Dai Xuan-Yuan Chen Xi-Qing Chen Jian-Bin Wang Han-Qing Pang Xian-Wen Zhang Source Type: research

Diversity of Agaricomycetes in southern South America and their bioactive natural products
Nat Prod Res. 2023 Sep 3:1-15. doi: 10.1080/14786419.2023.2244126. Online ahead of print.ABSTRACTFungi have a unique metabolic plasticity allowing them to produce a wide range of natural products. Since the discovery of penicillin, an antibiotic of fungal origin, substantial efforts have been devoted globally to search for fungal-derived natural bioactive products. Andean region forests represent one of the few undisturbed ecosystems in the world with little human intervention. While these forests display a rich biological diversity, mycological and chemical studies in these environments have been scarce. This review aims ...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Jonhatan G ómez-Espinoza Cristian Riquelme Enzo Romero-Villegas Ram ón Ahumada-Rudolph Vanessa Novoa Paola M éndez Camila Millar Naomi Fern ández-Alarcón Sigisfredo Garnica Mario Rajchenberg Jaime R Cabrera-Pardo Source Type: research

Systematic elucidation of the multi-target pharmacological mechanism of Terminalia arjuna against congestive cardiac failure via network pharmacology and molecular modelling approaches
In this study, a network pharmacology technique was used to explore the active ingredients, potential targets in T. arjuna for the treatment of CCF. In the framework of this study, we explored the active ingredient-target-pathway network and figured out that oleanolic acid, arjunolic acid, luteolin, kaempferol, cholesterol, ellagic acid 4-O-xylopyranoside 3,3'-dimethyl ether, and cyclohexyl (2,4-dimethyl phenyl) methanone contributed significantly to the development of CCF by affecting AKT1, MAPK14, TNF, IL6, ESR1, and HSP90AA1 genes. Molecular docking analysis further validated the activities of these compounds against po...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Aqsa Asghar Muhammad Qasim Fatima Noor Usman Ali Ashfaq Muhammad Tahir Ul Qamar Muhammad Shareef Masoud Rashid Bhatti Ahmad Almatroudi Faris Alrumaihi Khaled S Allemailem Source Type: research

Comparative analysis of α-pinene alone and combined with temozolomide in human glioblastoma cells
Nat Prod Res. 2023 Sep 4:1-6. doi: 10.1080/14786419.2023.2252152. Online ahead of print.ABSTRACTα-Pinene (PEN) is a phyto compound present in terpene plants. In traditional medicine, PEN has been used for its anti-inflammatory, pain-relieving, and bronchodilator properties. The effect of PEN in combination with temozolomide (TMZ) in glioblastoma multiforme (GBM) cells has been evaluated. The action of the PEN + TMZ combination on cell migration, soft-agar, and cell death was determined in LN229 and U87MG human glioblastoma cells. In combination, PEN with TMZ showed a synergistic inhibitory effect in the GBM cells. The PEN...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Megha Gautam Reema Gabrani Source Type: research

Two new 2-arylbenzo[ b ]furans from Itea indochinensis and their anti-hepatocellular carcinoma and anti-oxidant effects
Nat Prod Res. 2023 Sep 4:1-9. doi: 10.1080/14786419.2023.2252975. Online ahead of print.ABSTRACTTwo new 2-arylbenzo[b]furans (1-2) and ten known compounds (3-12) were identified from the 95% EtOH extract of the branches and leaves of Itea indochinensis for the first time. Their structures were determined mainly based on extensive analyses of UV, IR, 1D/2D NMR and HRMS spectra. The results of MTT assays demonstrated the anti-tumor potential of compound 1 with good selectivity, which displayed moderate inhibitory effects on proliferation of SK-hep-1 cells with IC50 value of 22.3 μM, while weak inhibitory effect on prolifera...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Fang-Fang Xu Jin-Zhen Jian Yi-Jv Li Zhi-Wei Wang Guo-Yong Luo Wu-De Yang Source Type: research

Two new naphthoquinone derivatives from Sinningia conspicua (Gesneriaceae)
Nat Prod Res. 2023 Sep 4:1-6. doi: 10.1080/14786419.2023.2253971. Online ahead of print.ABSTRACTTwo new naphthoquinones, 7-hydroxy-2-O-methyldunniol (1) and 7-methoxy-2-O-methyldunniol (2) were isolated from the tubers of Sinningia conspicua (Seem.) G. Nicholson (Gesneriaceae). Nine known compounds were also obtained: 7-methoxydunniol (3), dunniol (4), 7-methoxy-α-dunnione (5), 7-hydroxydunnione (6), 2,4,4',6-tetramethoxychalcone (7), loureirin B (8), allo-calceolarioside A (9), β-sitosterol (10) and stigmasterol (11). This is the first report of compounds 3 and 5 in Sinningia. n-Hexane, ethyl acetate and ethanol extract...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Vanessa Winiewski Maria Helena Verdan Cristhian Santos Oliveira Tayn á Eloyane Barreto Rodrigues Marcos Jos é Salvador Maria Élida Alves Stefanello Source Type: research