Two new alkaloids from the roots of < em > Cocculus hirsutus < /em > (L.) W. Theob

Nat Prod Res. 2024 Mar 10:1-12. doi: 10.1080/14786419.2024.2326979. Online ahead of print.ABSTRACTTwo undescribed alkaloids, 15-carboxydihydroerysotrine (1) and (14 R)-4-methoxy-13,14-dihydrooxypalmatine (2), along with six known compounds, 1,6-didehydro-3,15,16-trimethoxy-9-methylerythrinanium (3), 8-oxytetrahydropalmatine (4), 20-hydroxyecdysone (5), makisterone A (6) turkesterone (7) and magnoflorine (8) were isolated from the root part of Cocculus hirsutus (L.) W. Theob. Their structures were established based on detailed analysis of NMR, UV-Vis, HRESIMS, and single-crystal XRD spectroscopic experiments. Compounds 3, 4 and 7 were reported for the first time from the genus Cocculus. All the compounds were analysed in silico to investigate their human acetylcholinesterase inhibition potential. This analysis revealed that compounds 1 and 8 interacted well with the selected protein, which suggested their further exploration as acetylcholinesterase inhibitors via in vitro and in vivo investigation.PMID:38462768 | DOI:10.1080/14786419.2024.2326979

Source: Natural Product Research - March 11, 2024 Category: Biochemistry Authors: None Shivani Surekha Kumari Prithvi Pal Singh Prateek Singh Bora Upendra Sharma Source Type: research