Two novel ketone alkaloids from < em > Portulaca oleracea < /em > L. and their anti-inflammatory activities

Nat Prod Res. 2024 Mar 12:1-8. doi: 10.1080/14786419.2024.2325593. Online ahead of print.ABSTRACTEleven compounds were obtained from Portulaca oleracea L., including two novel ketone alkaloids, (1, 2), 4-hydroxy-3-methoxybenzamide (3) (isolated for the first time), β-adenosine (4), oleracrylimide A and B (5, 6), oleracein H, C, D, Q and A (7-11). The two novel ketone alkaloids were identified as 5-acetyl-5-methylcyclopent-2-ene-1-carboxamide (1), named oleraciamide H, and (2 R,3S,4R,5R)-5-((R)-1,2-dihydroxyethyl)-3,4-dihydroxytetrahydrofuran-2-yl glycinate (2), named oleracone Q by spectroscopic methods, including 1D, 2D NMR and compound fingerprints. Additionally, their anti-inflammatory activities were tested via RAW 264.7 cells induced by LPS and found that they could significantly inhibit the release of IL-1β and TNF-α.PMID:38472190 | DOI:10.1080/14786419.2024.2325593

Source: Natural Product Research - March 13, 2024 Category: Biochemistry Authors: Hongzhe Zhang Jing Liu Junjie Yao Fan He Xixiang Ying Source Type: research